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All Outputs (682)

Cost effectiveness of epidural steroid injections to manage chronic lower back pain (2012)
Journal Article
Whynes, D. K., McCahon, R. A., Ravenscroft, A., & Hardman, J. (2012). Cost effectiveness of epidural steroid injections to manage chronic lower back pain. BMC Anesthesiology, 12(26), Article 26. https://doi.org/10.1186/1471-2253-12-26

Background
The efficacy of epidural steroid injections in the management of chronic low back pain is disputed, yet the technique remains popular amongst physicians and patients alike. This study assesses the cost effectiveness of injections administ... Read More about Cost effectiveness of epidural steroid injections to manage chronic lower back pain.

Reliability of quantitative echocardiography in adult sheep and goats (2012)
Journal Article
Hallowell, G. D., Potter, T. J., & Bowen, I. M. (2012). Reliability of quantitative echocardiography in adult sheep and goats. BMC Veterinary Research, 8(Septem), Article 11. https://doi.org/10.1186/1746-6148-8-181

Background
Echocardiography is a non-invasive method for assessment of the ovine and caprine heart. Complete reference ranges for cardiac dimensions and time indices for both species are not currently available and reliability of these measurements... Read More about Reliability of quantitative echocardiography in adult sheep and goats.

Targeting of CD34+CD38- cells using Gemtuzumab ozogamicin (Mylotarg) in combination with tipifarnib (Zarnestra) in acute Myeloid Leukaemia (2012)
Journal Article
Jawad, M., Yu, N., Seedhouse, C., Tandon, K., Russell, N. H., & Pallis, M. (2012). Targeting of CD34+CD38- cells using Gemtuzumab ozogamicin (Mylotarg) in combination with tipifarnib (Zarnestra) in acute Myeloid Leukaemia. BMC Cancer, https://doi.org/10.1186/1471-2407-12-431

Background
The CD34+CD38- subset of AML cells is enriched for resistance to current chemotherapeutic agents and considered to contribute to disease progression and relapse in Acute Myeloid Leukaemia (AML) patients following initial treatment.

Met... Read More about Targeting of CD34+CD38- cells using Gemtuzumab ozogamicin (Mylotarg) in combination with tipifarnib (Zarnestra) in acute Myeloid Leukaemia.

Perceptual learning reconfigures the effects of visual adaptation (2012)
Journal Article
McGovern, D. P., Roach, N. W., & Webb, B. S. (2012). Perceptual learning reconfigures the effects of visual adaptation. Journal of Neuroscience, 32(39), https://doi.org/10.1523/JNEUROSCI.1363-12.2012

Our sensory experiences over a range of different timescales shape our perception of the environment. Two particularly striking short-term forms of plasticity with manifestly different time courses and perceptual consequences are those caused by visu... Read More about Perceptual learning reconfigures the effects of visual adaptation.

Cognitive control over motor output in Tourette syndrome (2012)
Journal Article
Jung, J., Jackson, S. R., Parkinson, A., & Jackson, G. M. (2013). Cognitive control over motor output in Tourette syndrome. Neuroscience and Biobehavioral Reviews, 37(6), https://doi.org/10.1016/j.neubiorev.2012.08.009

Tourette syndrome [TS] is a neurodevelopmental disorder characterised by chronic vocal and motor tics. TS has been associated with dysfunctional cognitive (inhibitory) control of behaviour, however the evidence for this, beyond the occurrence of tics... Read More about Cognitive control over motor output in Tourette syndrome.

WNT/β-catenin pathway activation in Myc immortalised cerebellar progenitor cells inhibits neuronal differentiation and generates tumours resembling medulloblastoma (2012)
Journal Article
Rogers, H., Sousa, S., Salto, C., Arenas, E., Coyle, B., & Grundy, R. G. (2012). WNT/β-catenin pathway activation in Myc immortalised cerebellar progenitor cells inhibits neuronal differentiation and generates tumours resembling medulloblastoma. British Journal of Cancer, 107, https://doi.org/10.1038/bjc.2012.377

Background: Medulloblastoma is the most common malignant childhood brain tumour. Aberrant activation of the WNT/β-catenin pathway occurs in approximately 25% of medulloblastomas. However, its role in medulloblastoma pathogenesis is not understood.... Read More about WNT/β-catenin pathway activation in Myc immortalised cerebellar progenitor cells inhibits neuronal differentiation and generates tumours resembling medulloblastoma.

Mapping the laminin receptor binding domains of Neisseria meningitidis PorA and Haemophilus influenzae OmpP2 (2012)
Journal Article
Abouseada, N. M., Assafi, M. S. A., Mahdavi, J., Oldfield, N. J., Wheldon, L. M., Wooldridge, K. G., & Ala'Aldeen, D. A. (2012). Mapping the laminin receptor binding domains of Neisseria meningitidis PorA and Haemophilus influenzae OmpP2. PLoS ONE, 7(9), Article 10. https://doi.org/10.1371/journal.pone.0046233

Neisseria meningitidis, Haemophilus influenzae and Streptococcus pneumoniae are major bacterial agents of meningitis. They each bind the 37/67-kDa laminin receptor (LamR) via the surface protein adhesins: meningococcal PilQ and PorA, H. influenzae Om... Read More about Mapping the laminin receptor binding domains of Neisseria meningitidis PorA and Haemophilus influenzae OmpP2.

Why are family carers of people with dementia dissatisfied with general hospital care?: a qualitative study (2012)
Journal Article
Jurgens, F. J., Clissett, P., Gladman, J. R., & Harwood, R. H. (2012). Why are family carers of people with dementia dissatisfied with general hospital care?: a qualitative study. BMC Geriatrics, 12(57), Article 1. https://doi.org/10.1186/1471-2318-12-57

Background
Families and other carers report widespread dissatisfaction with general hospital care for confused older people.

Methods
We undertook a qualitative interviews study of 35 family carers of 34 confused older patients to ascertain their... Read More about Why are family carers of people with dementia dissatisfied with general hospital care?: a qualitative study.

Why is the Liverpool care pathway used for some dying cancer patients and not others? Healthcare professionals’ perspectives (2012)
Journal Article
Freemantle, A., & Seymour, J. (2012). Why is the Liverpool care pathway used for some dying cancer patients and not others? Healthcare professionals’ perspectives. BMC Research Notes, 5(524), https://doi.org/10.1186/1756-0500-5-524

Background:
Despite evidence suggesting that the Liverpool Care Pathway for the Dying Patient is a structured and proficient means of supporting care delivery in the last hours or days of life, discrepancies in uptake are widespread. This explorator... Read More about Why is the Liverpool care pathway used for some dying cancer patients and not others? Healthcare professionals’ perspectives.

Embryonic NANOG activity defines colorectal cancer stem cells and modulates through AP1- and TCF-dependent mechanisms (2012)
Journal Article
Ibrahim, E. E., Babaei-Jadidi, R., Saadeddin, A., Spencer-Dene, B., Hossaini, S., Abuzinadah, M., Li, N., Fadhil, W., Ilyas, M., Bonnet, D., & Nateri, A. S. (2012). Embryonic NANOG activity defines colorectal cancer stem cells and modulates through AP1- and TCF-dependent mechanisms. STEM CELLS, 30(10), 2076-2087. https://doi.org/10.1002/stem.1182

Embryonic NANOG (NANOG1) is considered as an important regulator of pluripotency while NANOGP8 (NANOG-pseudogene) plays a role in tumorigenesis. Herein, we show NANOG is expressed from both NANOG1 and NANOGP8 in human colorectal cancers (CRC). Enforc... Read More about Embryonic NANOG activity defines colorectal cancer stem cells and modulates through AP1- and TCF-dependent mechanisms.

Regulation of Anopheles gambiae male accessory gland genes influences postmating response in female (2012)
Journal Article
Dottorini, T., Persampieri, T., Palladino, P., Baker, D. A., Spaccapelo, R., Senin, N., & Crisanti, A. (2013). Regulation of Anopheles gambiae male accessory gland genes influences postmating response in female. FASEB Journal, 27(1), 86-97. https://doi.org/10.1096/fj.12-219444

In Drosophila, the accessory gland proteins (Acps) secreted from the male accessory glands (MAGs) and transferred along with sperm into the female reproductive tract have been implicated in triggering postmating behavioral changes, including refracto... Read More about Regulation of Anopheles gambiae male accessory gland genes influences postmating response in female.

A unique protein phosphatase with kelch-like domains (PPKL) in plasmodium modulates ookinete differentiation, motility and invasion (2012)
Journal Article
Guttery, D. S., Poulin, B., Ferguson, D. J. P., Szöőr, B., Wickstead, B., Carroll, P. L., …Tewari, R. (2012). A unique protein phosphatase with kelch-like domains (PPKL) in plasmodium modulates ookinete differentiation, motility and invasion. PLoS Pathogens, 8(9), Article e1002948. https://doi.org/10.1371/journal.ppat.1002948

Protein phosphorylation and dephosphorylation (catalysed by kinases and phosphatases, respectively) are post-translational modifications that play key roles in many eukaryotic signalling pathways, and are often deregulated in a number of pathological... Read More about A unique protein phosphatase with kelch-like domains (PPKL) in plasmodium modulates ookinete differentiation, motility and invasion.

A cooperative instinct (2012)
Journal Article
Gaechter, S. (2012). A cooperative instinct. Nature, 489(7416), https://doi.org/10.1038/489374a

Acting on a gut feeling may sometimes lead to poor decisions, but it will usually support the common good, according to a study showing that human intuition favours cooperative, rather than selfish, behaviour.

Coping with and factors impacting upon the experience of lung cancer in patients and primary carers (2012)
Journal Article
Ellis, J., Lloyd-williams, M., Wagland, R., Bailey, C., & Molassiotis, A. (in press). Coping with and factors impacting upon the experience of lung cancer in patients and primary carers. European Journal of Cancer Care, 22(1), https://doi.org/10.1111/ecc.12003

There is a paucity of research exploring patients' and their informal carers' experience of coping with and factors impacting on the lung cancer experience. This study aims to explore how patients and their informal carers cope with a diagnosis of lu... Read More about Coping with and factors impacting upon the experience of lung cancer in patients and primary carers.

A Bayesian elicitation of veterinary beliefs regarding systemic dry cow therapy: variation and importance for clinical trial design (2012)
Journal Article
Higgins, H., Dryden, I. L., & Green, M. J. (2012). A Bayesian elicitation of veterinary beliefs regarding systemic dry cow therapy: variation and importance for clinical trial design. Preventive Veterinary Medicine, 106(2), https://doi.org/10.1016/j.prevetmed.2012.01.017

The two key aims of this research were: (i) to conduct a probabilistic elicitation to quantify the variation in veterinarians’ beliefs regarding the efficacy of systemic antibiotics when used as an adjunct to intra-mammary dry cow therapy and (ii) to... Read More about A Bayesian elicitation of veterinary beliefs regarding systemic dry cow therapy: variation and importance for clinical trial design.

The essential iron-sulfur protein Rli1 is an important target accounting for inhibition of cell growth by reactive oxygen species (2012)
Journal Article
Alhebshi, A., Sideri, T. C., Holland, S. L., & Avery, S. V. (2012). The essential iron-sulfur protein Rli1 is an important target accounting for inhibition of cell growth by reactive oxygen species. Molecular Biology of the Cell, 23(18), https://doi.org/10.1091/mbc.E12-05-0413

Oxidative stress mediated by reactive oxygen species (ROS) is linked to degenerative conditions in humans and damage to an array of cellular components. However, it is unclear which molecular target(s) may be the primary “Achilles’ heel” of organisms... Read More about The essential iron-sulfur protein Rli1 is an important target accounting for inhibition of cell growth by reactive oxygen species.

The impact of individual budgets on the targeting of support: Findings from a national evaluation of pilot projects in England (2012)
Journal Article
Jones, K., Netten, A., Fernández, J. L., Knapp, M., Challis, D., Glendinning, C., …Wilberforce, M. (2012). The impact of individual budgets on the targeting of support: Findings from a national evaluation of pilot projects in England. Public Money and Management, 32(6), 417-424. https://doi.org/10.1080/09540962.2012.728781

Individual or personal budgets are part of a growing international trend to encourage greater choice and control over social care services at a time of financial austerity. The authors' evaluation of individual budgets found that levels of allocated... Read More about The impact of individual budgets on the targeting of support: Findings from a national evaluation of pilot projects in England.

The linear spin-up of a stratified, rotating fluid in a square cylinder (2012)
Journal Article
Foster, M., & Munro, R. J. (2012). The linear spin-up of a stratified, rotating fluid in a square cylinder. Journal of Fluid Mechanics, 712, https://doi.org/10.1017/jfm.2012.402

Here we present experimental and theoretical results for how a stratified fluid, initially rotating as a solid body with constant angular velocity, , within a closed cylinder of square cross-section, is spun up when subject to a small, impulsive incr... Read More about The linear spin-up of a stratified, rotating fluid in a square cylinder.

Demographics and economic burden of un-owned cats and dogs in the UK: results of a 2010 census (2012)
Journal Article
Stavisky, J., Brennan, M. L., Downes, M. J., & Dean, R. S. (2012). Demographics and economic burden of un-owned cats and dogs in the UK: results of a 2010 census. BMC Veterinary Research, 8, Article 163. https://doi.org/10.1186/1746-6148-8-163

Background

The population of dogs and cats passing through rescue shelters may be subject to compromised welfare and increased susceptibility to disease. Little information exists to describe this population, its dynamics and associated management... Read More about Demographics and economic burden of un-owned cats and dogs in the UK: results of a 2010 census.