All Outputs (474)

Testing the FMR1 promoter for mosaicism in DNA methylation among CpG sites, strands, and cells in FMR1-expressing males with fragile X syndrome (2011)
Journal Article

Variability among individuals in the severity of fragile X syndrome (FXS) is influenced by epigenetic methylation mosaicism, which may also be common in other complex disorders. The epigenetic signal of dense promoter DNA methylation is usually assoc... Read More about Testing the FMR1 promoter for mosaicism in DNA methylation among CpG sites, strands, and cells in FMR1-expressing males with fragile X syndrome.

What factors influence smoking prevalence and smoke free policy enactment across the European Union Member States (2011)
Journal Article

Background Smoking prevention should be a primary public health priority for all governments, and effective preventive policies have been identified for decades. The heterogeneity of smoking prevalence between European Union (EU) Member States the... Read More about What factors influence smoking prevalence and smoke free policy enactment across the European Union Member States.

Synthesis and characterization of high-affinity 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for human ?-adrenoceptors (2011)
Journal Article

The growing practice of exploiting noninvasive fluorescence-based techniques to study G protein-coupled receptor pharmacology at the single cell and single molecule level demands the availability of high-quality fluorescent ligands. To this end, this... Read More about Synthesis and characterization of high-affinity 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for human ?-adrenoceptors.

The kinesin-13 MCAK has an unconventional ATPase cycle adapted for microtubule depolymerization (2011)
Journal Article

Unlike other kinesins, members of the kinesin-13 subfamily do not move directionally along microtubules but, instead, depolymerize them. To understand how kinesins with structurally similar motor domains can have such dissimilar functions, we elucida... Read More about The kinesin-13 MCAK has an unconventional ATPase cycle adapted for microtubule depolymerization.

Can human amblyopia be treated in adulthood? (2011)
Journal Article

Amblyopia is a common visual disorder that results in a spatial acuity deficit in the affected eye. Orthodox treatment is to occlude the unaffected eye for lengthy periods, largely determined by the severity of the visual deficit at diagnosis. Althou... Read More about Can human amblyopia be treated in adulthood?.

Drawing to learn in science (2011)
Journal Article

Carbon nanotube/titanium dioxide (CNT/TiO2) core-shell nanocomposites with tailored shell thickness, CNT content and photocatalytic/photoelectrocatalytic properties (2011)
Journal Article

Combining carbon nanotubes (CNTs) with TiO2 at the nano-scale level can promote the separation of the electron-hole charges generated upon irradiation. However, charge separation capability depends on the quality of the interfacial contact between CN... Read More about Carbon nanotube/titanium dioxide (CNT/TiO2) core-shell nanocomposites with tailored shell thickness, CNT content and photocatalytic/photoelectrocatalytic properties.

A technology selection framework for integrating manufacturing within a supply chain (2011)
Journal Article

This paper describes a structured analytical approach for selecting a manufacturing technology. A framework consisting of six integrated steps is proposed by considering the growing importance of supply chains in manufacturing organisations. The fram... Read More about A technology selection framework for integrating manufacturing within a supply chain.

Variation in surgical resection for lung cancer in relation to survival: Population-based study in England 2004-2006 (2011)
Journal Article

Background: Compared with some European countries, England has low lung cancer survival and low use of surgical resection for lung cancer. The use of surgical resection varies within England. We assessed the relationship between surgical resection ra... Read More about Variation in surgical resection for lung cancer in relation to survival: Population-based study in England 2004-2006.

Ergonomically sound (2011)
Other

Medical devices are used by a multiplicity of users and in a variety of environments. Manufacturers of these devices will therefore need to be aware of differences in skills, needs, abilities and preferences among users, as well as the requirements t... Read More about Ergonomically sound.

Maize grain and soil surveys reveal suboptimal dietary selenium intake is widespread in Malawi (2011)
Journal Article

Selenium is an essential element in human diets but the risk of suboptimal intake increases where food choices are narrow. Here we show that suboptimal dietary intake (i.e. 20–30 mg Se person21 d21) is widespread in Malawi, based on a spatial integra... Read More about Maize grain and soil surveys reveal suboptimal dietary selenium intake is widespread in Malawi.

Application of a bacteriophage cocktail to reduce Salmonella Typhimurium U288 contamination on pig skin (2011)
Journal Article

Multidrug-resistant Salmonella Typhimurium U288 is a significant pathogen of pigs, accounting for over half of all outbreaks on UK pig production premises. The potential of this serovar, and other salmonellae, to enter the food chain during the slaug... Read More about Application of a bacteriophage cocktail to reduce Salmonella Typhimurium U288 contamination on pig skin.

Influence of Combined Biotic and Abiotic Stress on Nutritional Quality Parameters in Tomato (Solanum lycopersicum) (2011)
Journal Article

Induction of abiotic stress in tomato plants has been proposed as a mechanism for improving the nutritional quality of fruits. However, the occurrence of biotic stress can interfere with normal abiotic stress responses. In this study, the combined ef... Read More about Influence of Combined Biotic and Abiotic Stress on Nutritional Quality Parameters in Tomato (Solanum lycopersicum).

Developing a model for online support group use, empowering processes and psychosocial outcomes for individuals living with HIV/AIDS (2011)
Journal Article

This study examined the mechanism through which online support group (OSG) participation may promote patient empowerment among 340 individuals living with HIV/AIDS. Results from structural equation modelling revealed that greater use of OSGs was asso... Read More about Developing a model for online support group use, empowering processes and psychosocial outcomes for individuals living with HIV/AIDS.

Servicing the super-rich: new financial elites and the rise of the private wealth management retail ecology (2011)
Journal Article

The ways in which individuals' everyday lives have become increasingly tied into the international financial system has become a widely studied dimension of research on financialization. However, the ways in which financial elites consume financial s... Read More about Servicing the super-rich: new financial elites and the rise of the private wealth management retail ecology.

A song and dance: Branded entertainment and mobile promotion (2011)
Journal Article

This article considers the rise of branded entertainment within the contemporary marketing and media environment. Specifically, it examines how mobile phone marketing in the UK has sought to engage consumers and perform the social use of mobile techn... Read More about A song and dance: Branded entertainment and mobile promotion.

Assessing the benefits of hybrid cycloconverters (2011)
Journal Article

Power converters consisting of naturally commutated thyristors such as cycloconverters and current source inverters were the first to be used in driving electrical motors with variable speed, but now, due to their inferior performance compared to for... Read More about Assessing the benefits of hybrid cycloconverters.

Novel expression and regulation of voltage-dependent potassium (KV7) channels in placentae from women with preeclampsia (2011)
Journal Article

Preeclampsia is associated with structural/functional alterations in placental and maternal vasculature. KV7 (voltage-dependant potassium channels encoded by KCNQ1-5 genes) have been detected in several types of blood vessels where they promote vascu... Read More about Novel expression and regulation of voltage-dependent potassium (KV7) channels in placentae from women with preeclampsia.

Curcumin modulates nuclear factor kB (NF-KB)-mediated inflammation in human tenocytes in vitro: Role of the PHOSPHATIDYLINOSITOL 3-KINASE/Akt PATHWAY (2011)
Journal Article

Inflammatory processes play essential roles in the pathogenesis of tendinitis and tendinopathy. These events are accompanied by catabolic processes initiated by pro-inflammatory cytokines such as interleukin-1? (IL-1?) and tumor necrosis factor-? (TN... Read More about Curcumin modulates nuclear factor kB (NF-KB)-mediated inflammation in human tenocytes in vitro: Role of the PHOSPHATIDYLINOSITOL 3-KINASE/Akt PATHWAY.

Single-Molecule AFM Characterization of Individual Chemically Tagged DNA Tetrahedra (2011)
Journal Article

Single-molecule characterization is essential for ascertaining the structural and functional properties of bottom-up DNA nanostructures. Here we enlist three atomic force microscopy (AFM) techniques to examine tetrahedron-shaped DNA nanostructures th... Read More about Single-Molecule AFM Characterization of Individual Chemically Tagged DNA Tetrahedra.