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All Outputs (242)

Differential Recognition of Staphylococcus aureus Quorum-Sensing Signals Depends on Both Extracellular Loops 1 and 2 of the Transmembrane Sensor AgrC (2008)
Journal Article
Jensen, R. O., Winzer, K., Clarke, S. R., Chan, W. C., & Williams, P. (2008). Differential Recognition of Staphylococcus aureus Quorum-Sensing Signals Depends on Both Extracellular Loops 1 and 2 of the Transmembrane Sensor AgrC. Journal of Molecular Biology, 381(2), 300-309. https://doi.org/10.1016/j.jmb.2008.06.018

Virulence in Staphylococcus aureus is regulated via agr-dependent quorum sensing in which an autoinducing peptide (AIP) activates AgrC, a histidine protein kinase. AIPs are usually thiolactones containing seven to nine amino acid residues in which th... Read More about Differential Recognition of Staphylococcus aureus Quorum-Sensing Signals Depends on Both Extracellular Loops 1 and 2 of the Transmembrane Sensor AgrC.

Early life programming of hemispheric lateralization and synchronization in the adult medial prefrontal cortex (2008)
Journal Article
Stevenson, C. W., Halliday, D. M., Marsden, C. A., & Mason, R. (2008). Early life programming of hemispheric lateralization and synchronization in the adult medial prefrontal cortex. Neuroscience, 155(3), 852-863. https://doi.org/10.1016/j.neuroscience.2008.06.013

Neonatal maternal separation (MS) in the rat increases the vulnerability to stressors later in life. In contrast, brief handling (H) in early life confers resilience to stressors in adulthood. Early life programming of stress reactivity may involve t... Read More about Early life programming of hemispheric lateralization and synchronization in the adult medial prefrontal cortex.

Adaptive and assortative mating scheme for evolutionary multi-objective algorithms (2008)
Book Chapter
Le, K., & Landa-Silva, D. (2008). Adaptive and assortative mating scheme for evolutionary multi-objective algorithms. In Artificial Evolution: 8th International Conference, Evolution Artificielle, EA 2007, Tours, France, October 29-31, 2007, Revised Selected Papers (172-183). Springer Verlag. https://doi.org/10.1007/978-3-540-79305-2_15

We are interested in the role of restricted mating schemes in the context of evolutionary multi-objective algorithms. In this paper, we propose an adaptive assortative mating scheme that uses similarity in the decision space (genotypic assortative ma... Read More about Adaptive and assortative mating scheme for evolutionary multi-objective algorithms.

Exploring the communication of social support within virtual communities: A content analysis of messages posted to an online HIV/AIDS support group (2008)
Journal Article
Mo, P. K., & Coulson, N. S. (2008). Exploring the communication of social support within virtual communities: A content analysis of messages posted to an online HIV/AIDS support group. Cyberpsychology and Behavior, 11(3), 371-374. https://doi.org/10.1089/cpb.2007.0118

The present study examined the nature of social support exchanged within an online HIV/AIDS support group. Content analysis was conducted with reference to five types of social support (information support, tangible assistance, esteem support, networ... Read More about Exploring the communication of social support within virtual communities: A content analysis of messages posted to an online HIV/AIDS support group.

A Note on Palindromic δ -Vectors for Certain Rational Polytopes (2008)
Journal Article
Fiset, M., & Kasprzyk, A. M. (2008). A Note on Palindromic δ -Vectors for Certain Rational Polytopes. Electronic Journal of Combinatorics, 15, Article N18. https://doi.org/10.37236/893

Let P be a convex polytope containing the origin, whose dual is a lattice polytope. Hibi's Palindromic Theorem tells us that if P is also a lattice polytope then the Ehrhart δ-vector of P is palindromic. Perhaps less well-known is that a similar resu... Read More about A Note on Palindromic δ -Vectors for Certain Rational Polytopes.

Optimizing Automated AFLP Scoring Parameters to Improve Phylogenetic Resolution (2008)
Journal Article
Holland, B. R., Clarke, A. C., & Meudt, H. M. (2008). Optimizing Automated AFLP Scoring Parameters to Improve Phylogenetic Resolution. Systematic Biology, 57(3), 347-366. https://doi.org/10.1080/10635150802044037

The amplified fragment length polymorphism (AFLP) technique is an increasingly popular component of the phylogenetic toolbox, particularly for plant species. Technological advances in capillary electrophoresis now allow very precise estimates of DNA... Read More about Optimizing Automated AFLP Scoring Parameters to Improve Phylogenetic Resolution.

Care planning systems in care homes for older people (2008)
Journal Article
Worden, A., & Challis, D. (2008). Care planning systems in care homes for older people. Quality in Ageing and Older Adults, 9(2), 28-38. https://doi.org/10.1108/14717794200800012

Care planning is important in the provision of good-quality care and serves a variety of functions, including acting as a communication tool. An accessible format for care plans is therefore important. The National Minimum Care Standards in England n... Read More about Care planning systems in care homes for older people.

Loss of prokineticin receptor 2 signaling predisposes mice to torpor (2008)
Journal Article
Jethwa, P. H., I'Anson, H., Warner, A., Prosser, H. M., Hastings, M. H., Maywood, E. S., & Ebling, F. J. (2008). Loss of prokineticin receptor 2 signaling predisposes mice to torpor. AJP - Regulatory, Integrative and Comparative Physiology, 294(6), R1968-R1979. https://doi.org/10.1152/ajpregu.00778.2007

The genes encoding prokineticin 2 polypeptide (Prok2) and its cognate receptor (Prokr2/Gpcr73l1) are widely expressed in both the suprachiasmatic nucleus and its hypothalamic targets, and this signaling pathway has been implicated in the circadian re... Read More about Loss of prokineticin receptor 2 signaling predisposes mice to torpor.

Effect of timing of fungicide application on the development of fusarium head blight and the accumulation of deoxynivalenol (DON) in winter wheat grain (2008)
Journal Article
Pirgozliev, S. R., Ray, R. V., Edwards, S. G., Hare, M. C., & Jenkinson, P. (2008). Effect of timing of fungicide application on the development of fusarium head blight and the accumulation of deoxynivalenol (DON) in winter wheat grain. Cereal Research Communications, 36(2), 289-299. https://doi.org/10.1556/CRC.36.2008.2.9

The effect of different timings of fungicide applications on Fusarium head blight severity and mycotoxin accumulation in wheat grain was investigated in two field experiments. The fungicides metconazole, tebuconazole, azoxystrobin and mixtures of met... Read More about Effect of timing of fungicide application on the development of fusarium head blight and the accumulation of deoxynivalenol (DON) in winter wheat grain.

Albumin binding as a potential biomarker of exposure to moderately low levels of organophosphorus pesticides (2008)
Journal Article
Tarhoni, M. H., Lister, T., Ray, D. E., & Carter, W. G. (2008). Albumin binding as a potential biomarker of exposure to moderately low levels of organophosphorus pesticides. Biomarkers, 13(4), https://doi.org/10.1080/13547500801973563

We have evaluated the potential of plasma albumin to provide a sensitive biomarker of exposure to commonly used organophosphorus pesticides in order to complement the widely used measure of acetylcholinesterase (AChE) inhibition. Rat or human plasma... Read More about Albumin binding as a potential biomarker of exposure to moderately low levels of organophosphorus pesticides.

Configuring an open pipeline fulfilment system - a simulation study in an automotive context (2008)
Presentation / Conference Contribution
Brabazon, P. G., Woodcock, A., & MacCarthy, B. L. (2008). Configuring an open pipeline fulfilment system - a simulation study in an automotive context.

Automotive producers are adopting multi-modal fulfillment models in which customers can be fulfilled by products from stock, by allocating as yet unmade products that are in the planning pipeline, or by building a product to order. This study explore... Read More about Configuring an open pipeline fulfilment system - a simulation study in an automotive context.

Structure in parasite component communities in wild rodents: predictability, stability, associations and interactions or pure randomness? (2008)
Journal Article
Behnke, J. (2008). Structure in parasite component communities in wild rodents: predictability, stability, associations and interactions or pure randomness?. Parasitology, 135(7), https://doi.org/10.1017/S0031182008000334

Experimental data establish that interactions exist between species of intestinal helminths during concurrent infections in rodents, the strongest effects being mediated through the host’s immune responses. Detecting immune-mediated relationships in... Read More about Structure in parasite component communities in wild rodents: predictability, stability, associations and interactions or pure randomness?.

The papillomavirus E2 DNA binding domain (2008)
Journal Article
de Prat-Gay, G., Gaston, K., & Cicero, D. O. (2008). The papillomavirus E2 DNA binding domain. Frontiers in Bioscience, 13, 6006-6021. https://doi.org/10.2741/3132

The DNA binding domain of the E2 master regulator from papillomaviruses is the primary effector for most the essential activities controlled by this protein. In this review we focus on the properties of the DNA binding domain of human papillomavirus... Read More about The papillomavirus E2 DNA binding domain.

Balancing food risks and food benefits: the coverage of probiotics in the UK national press (2008)
Journal Article
Nerlich, B., & Koteyko, N. (2008). Balancing food risks and food benefits: the coverage of probiotics in the UK national press. Sociological Research Online, 13(3), https://doi.org/10.5153/sro.1692

The 1980s and 1990s were marked by a series of food crises, environmental disasters and the emergence of so-called 'superbugs'. At the same time, social scientists, such as Ulrich Beck, began to study the rise of a modern 'risk society'. The late 199... Read More about Balancing food risks and food benefits: the coverage of probiotics in the UK national press.

Resistance to FLT3 inhibition in an in vitro model of primary AML cells with a stem cell phenotype in a defined microenvironment (2008)
Journal Article
(2008). Resistance to FLT3 inhibition in an in vitro model of primary AML cells with a stem cell phenotype in a defined microenvironment. Leukemia, 22, 1395-1401. https://doi.org/10.1038/leu.2008.125

Relapse in acute myeloid leukaemia (AML) is mediated by survival of leukaemic stem cells following remission-induction chemotherapy. It would therefore be useful to identify therapeutic agents that target leukaemic stem cells. We devised a flow cytom... Read More about Resistance to FLT3 inhibition in an in vitro model of primary AML cells with a stem cell phenotype in a defined microenvironment.

Molecular and functional mapping of regional differences in P2Y receptor expression in the rat lens (2008)
Journal Article
Hu, R. G., Suzuki-Kerr, H., Webb, K. F., Rhodes, J. D., Collison, D. J., Duncan, G., & Donaldson, P. J. (2008). Molecular and functional mapping of regional differences in P2Y receptor expression in the rat lens. Experimental Eye Research, 87(2), 137-146. https://doi.org/10.1016/j.exer.2008.05.008

Extracellular ATP has been shown to mobilize intracellular Ca2+ in cultured ovine lens epithelial cells and in human lens epithelium, suggesting a role for purines in the modulation of lens transparency. In this study, we characterized the expression... Read More about Molecular and functional mapping of regional differences in P2Y receptor expression in the rat lens.

Neither Hide Nor Hair: The Difficulty of Identifying Useful Disease Biomarkers (2008)
Journal Article
Huett, A., & Xavier, R. J. (2008). Neither Hide Nor Hair: The Difficulty of Identifying Useful Disease Biomarkers. Gastroenterology, 134(7), 2164-2168. https://doi.org/10.1053/j.gastro.2008.04.013

Robert Koch was the first to propose a series of definitive tests to determine the agents of infectious disease. Koch's postulates, first published in 1890, were subsequently updated for the molecular era in 1988 by Stanley Falkow1 and continue to fo... Read More about Neither Hide Nor Hair: The Difficulty of Identifying Useful Disease Biomarkers.