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All Outputs (233)

Understanding Retail Productivity by Simulating Management Practices (2007)
Presentation / Conference Contribution
Siebers, P.-O., Aickelin, U., Celia, H., & Clegg, C. (2007). Understanding Retail Productivity by Simulating Management Practices.

Intelligent agents offer a new and exciting way of understanding the world of work. In this paper we apply agent-based modeling and simulation to investigate a set of problems in a retail context. Specifically, we are working to understand the relati... Read More about Understanding Retail Productivity by Simulating Management Practices.

DLG1 is an anchor for the E3 ligase MARCH2 at sites of cell-cell contact (2007)
Journal Article
Cao, Z., Huett, A., Kuballa, P., Giallourakis, C., & Xavier, R. J. (2008). DLG1 is an anchor for the E3 ligase MARCH2 at sites of cell-cell contact. Cellular Signalling, 20(1), 73-82. https://doi.org/10.1016/j.cellsig.2007.08.019

PDZ domain containing molecular scaffolds plays a central role in organizing synaptic junctions. Observations in Drosophila and mammalian cells have implicated that ubiquitination and endosomal trafficking, of molecular scaffolds are critical to the... Read More about DLG1 is an anchor for the E3 ligase MARCH2 at sites of cell-cell contact.

A bidomain threshold model of propagating calcium waves (2007)
Journal Article
Thul, R., Smith, G., & Coombes, S. (2008). A bidomain threshold model of propagating calcium waves. Journal of Mathematical Biology, 56(4), https://doi.org/10.1007/s00285-007-0123-5

We present a bidomain fire-diffuse-fire model that facilitates mathematical analysis of propagating waves of elevated intracellular calcium (Ca) in living cells. Modelling Ca release as a threshold process allows the explicit construction of travell... Read More about A bidomain threshold model of propagating calcium waves.

The anthelmintic efficacy of plant-derived cysteine proteinases against the rodent gastrointestinal nematode, Heligmosomoides polygyrus, in vivo (2007)
Journal Article
Stepek, G., Lowe, A., Buttle, D. J., Duce, I., & Behnke, J. M. (2007). The anthelmintic efficacy of plant-derived cysteine proteinases against the rodent gastrointestinal nematode, Heligmosomoides polygyrus, in vivo. Parasitology, 134(10), https://doi.org/10.1017/S0031182007002867

Gastrointestinal (GI) nematodes are important disease-causing organisms, controlled primarily through treatment with synthetic drugs, but the efficacy of these drugs has declined due to widespread resistance, and hence new drugs, with different modes... Read More about The anthelmintic efficacy of plant-derived cysteine proteinases against the rodent gastrointestinal nematode, Heligmosomoides polygyrus, in vivo.

Controlling Pattern Formation in Nanoparticle Assemblies via Directed Solvent Dewetting (2007)
Journal Article
Martin, C., Blunt, M., Pauliac-Vaujour, E., Stannard, A., Moriarty, P., Vancea, I., & Thiele, U. (2007). Controlling Pattern Formation in Nanoparticle Assemblies via Directed Solvent Dewetting. Physical Review Letters, 99,

We have achieved highly localised control of pattern formation in two dimensional nanoparticle assemblies by direct modification of solvent dewetting dynamics. A striking dependence of nanoparticle organisation on the size of atomic force microscope-... Read More about Controlling Pattern Formation in Nanoparticle Assemblies via Directed Solvent Dewetting.

Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the developing male Wistar(Han) rat I: no decrease in epididymal sperm count after a single acute dose (2007)
Journal Article
Bell, D. R., Clode, S., Fan, M., Fernandes, A., Foster, P. M. D., Jiang, T., …White, S. (2007). Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the developing male Wistar(Han) rat I: no decrease in epididymal sperm count after a single acute dose. Toxicological Sciences, 99(1),

It has been reported that fetal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes defects in the male reproductive system of the rat. We set out to replicate and extend these effects using a robust experimental design. Groups of 75 (contr... Read More about Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the developing male Wistar(Han) rat I: no decrease in epididymal sperm count after a single acute dose.

New Ways of Working in Acute Care: A Case for Change (2007)
Journal Article
Baguley, I., Alexander, J., Middleton, H., & Hope, R. (2007). New Ways of Working in Acute Care: A Case for Change. Journal of Mental Health Training, Education and Practice, 2,

This position paper focuses on the current tensions and challenges of aligning inpatient care with innovations in mental health services. It argues that a cultural shift is required within inpatient services. Obstacles to change including traditional... Read More about New Ways of Working in Acute Care: A Case for Change.

DLGH1 is a negative regulator of T-lymphocyte proliferation (2007)
Journal Article
Stephenson, L. M., Sammut, B., Graham, D. B., Chan-Wang, J., Brim, K. L., Huett, A. S., …Swat, W. (2007). DLGH1 is a negative regulator of T-lymphocyte proliferation. Molecular and Cellular Biology, 27(21), 7574-7581. https://doi.org/10.1128/MCB.00439-07

Discs large homolog 1 (DLGH1), a founding member of the membrane-associated guanylate kinase family of proteins containing Postsynaptic Density-95/Discs large/Zona Occludens-1 domains, is an ortholog of the Drosophila tumor suppressor gene Discs larg... Read More about DLGH1 is a negative regulator of T-lymphocyte proliferation.

Particle transfer in braneworld collisions (2007)
Journal Article
Saffin, P. M., & Tranberg, A. (2007). Particle transfer in braneworld collisions. Journal of High Energy Physics, 2007(8), https://doi.org/10.1088/1126-6708/2007/08/072

We study the behaviour of fermions localized on moving kinks as these collide with either antikinks or spacetime boundaries. We numerically solve for the evolution of the scalar kinks and the bound (i.e. localized) fermion modes, and calculate the nu... Read More about Particle transfer in braneworld collisions.

Rice pseudomolecule-anchored cross-species DNA sequence alignments indicate regional genomic variation in expressed sequence conservation (2007)
Journal Article
Armstead, I., Huang, L., King, J., Ougham, H., Thomas, H., & King, I. (2007). Rice pseudomolecule-anchored cross-species DNA sequence alignments indicate regional genomic variation in expressed sequence conservation. BMC Genomics, 8(1), Article 283. https://doi.org/10.1186/1471-2164-8-283

Background
Various methods have been developed to explore inter-genomic relationships among plant species. Here, we present a sequence similarity analysis based upon comparison of transcript-assembly and methylation-filtered databases from five plan... Read More about Rice pseudomolecule-anchored cross-species DNA sequence alignments indicate regional genomic variation in expressed sequence conservation.

Encountering competitors reduces clutch size and increases offspring size in a parasitoid with female–female fighting (2007)
Journal Article
Goubault, M., Mack, A. F., & Hardy, I. C. (2007). Encountering competitors reduces clutch size and increases offspring size in a parasitoid with female–female fighting. Proceedings of the Royal Society B: Biological Sciences, 274(1625), 2571-2577. https://doi.org/10.1098/rspb.2007.0867

Understanding the size of clutches produced by only one parent may require a game-theoretic approach: clutch size may affect offspring fitness in terms of future competitive ability. If larger clutches generate smaller offspring and larger adults are... Read More about Encountering competitors reduces clutch size and increases offspring size in a parasitoid with female–female fighting.

Influence of ursodeoxycholic acid on the mortality and malignancy associated with primary biliary cirrhosis: A population-based cohort study (2007)
Journal Article
Jackson, H., Solaymani-Dodaran, M., Card, T. R., Aithal, G. P., Logan, R., & West, J. (2007). Influence of ursodeoxycholic acid on the mortality and malignancy associated with primary biliary cirrhosis: A population-based cohort study. Hepatology, 46(4), 1131-1137. https://doi.org/10.1002/hep.21795

There is debate over the mortality and malignancy risk in people with primary biliary cirrhosis (PBC) and whether this risk is reduced by use of ursodeoxycholic acid. To investigate this issue, we identified 930 people with PBC and 9,202 control subj... Read More about Influence of ursodeoxycholic acid on the mortality and malignancy associated with primary biliary cirrhosis: A population-based cohort study.

MobGeoSen: facilitating personal geosensor data collection and visualization using mobile phones (2007)
Journal Article
Kanjo, E., Benford, S., Paxton, M., Chamberlain, A., Stanton Fraser, D., Woodgate, D., Crellin, D., & Woolard, A. (2008). MobGeoSen: facilitating personal geosensor data collection and visualization using mobile phones. Personal and Ubiquitous Computing, 12, 599-607. https://doi.org/10.1007/s00779-007-0180-1

Mobile sensing and mapping applications are becoming more prevalent because sensing hardware is becoming more portable and more affordable. However, most of the hardware uses small numbers of fixed sensors that report and share multiple sets of envir... Read More about MobGeoSen: facilitating personal geosensor data collection and visualization using mobile phones.

Novel pharmacological applications of G-protein-coupled receptor-G protein fusions (2007)
Journal Article
Milligan, G., Parenty, G., Stoddart, L. A., & Lane, J. R. (2007). Novel pharmacological applications of G-protein-coupled receptor-G protein fusions. Current Opinion in Pharmacology, 7(5), 521-526. https://doi.org/10.1016/j.coph.2007.06.007

Single, bi-functional polypeptides consisting of a G-protein-coupled receptor (GPCR) linked directly to a G protein alpha subunit have been employed for a number of years to study many aspects of signal initiation, including the roles of post-transla... Read More about Novel pharmacological applications of G-protein-coupled receptor-G protein fusions.

NF-κB activity in distinct neural subtypes of the rat hippocampus: Influence of time and GABA antagonism in acute slice preparations (2007)
Journal Article
Sheridan, G. K., Pickering, M., Twomey, C., Moynagh, P. N., O'Connor, J. J., & Murphy, K. J. (2007). NF-κB activity in distinct neural subtypes of the rat hippocampus: Influence of time and GABA antagonism in acute slice preparations. Learning and Memory, 14(8), 525-532. https://doi.org/10.1101/lm.590007

Hippocampal memory-associated synaptic plasticity is driven by a cascade of transcription and new protein synthesis. In vitro electrophysiological studies on acute hippocampal slices have elucidated much of what we know about this molecular cascade.... Read More about NF-κB activity in distinct neural subtypes of the rat hippocampus: Influence of time and GABA antagonism in acute slice preparations.

Effect of maternal undernutrition on ruminant carcass and meat quality (2007)
Journal Article
Zoe, D., Brameld, J., Scollan, N., & Buttery, P. (2007). Effect of maternal undernutrition on ruminant carcass and meat quality. Archives Animal Breeding, 50(SPEC. ISS.), 22-23

We have previously shown that, in sheep, the majority of muscle differentiation and fibre formation takes place around d85 of gestation, with myoblast proliferation occurring before this time (FAHEY et al., 2005a). In a second study (FAHEY et al., 20... Read More about Effect of maternal undernutrition on ruminant carcass and meat quality.

Just choices: Representations of choice and coercion in sex work in Cambodia (2007)
Journal Article
Sandy, L. (2007). Just choices: Representations of choice and coercion in sex work in Cambodia. Australian Journal of Anthropology, 18(2), 194-206. https://doi.org/10.1111/j.1835-9310.2007.tb00088.x

In global discourses about sex work, the image of the 'sex slave' has been influential in constructing the view of women working in the sex industry in developing countries as 'victims'. This paper examines the perpetuation of such discourses through... Read More about Just choices: Representations of choice and coercion in sex work in Cambodia.

Fetal exposure to a maternal low-protein diet during mid-gestation results in muscle-specific effects on fibre type composition in young rats (2007)
Journal Article
Mallinson, J. E., Sculley, D. V., Craigon, J., Plant, R., Langley-Evans, S. C., & Brameld, J. M. (2007). Fetal exposure to a maternal low-protein diet during mid-gestation results in muscle-specific effects on fibre type composition in young rats. British Journal of Nutrition, 98(2), 292-299. https://doi.org/10.1017/S0007114507701678

This study assessed the impact of reduced dietary protein during specific periods of fetal life upon muscle fibre development in young rats. Pregnant rats were fed a control or low-protein (LP) diet at early (days 0-7 gestation, LPEarly), mid (days 8... Read More about Fetal exposure to a maternal low-protein diet during mid-gestation results in muscle-specific effects on fibre type composition in young rats.

Hypothalamic thyroid hormone catabolism acts as a gatekeeper for the seasonal control of body weight and reproduction (2007)
Journal Article
Barrett, P., Ebling, F. J., Schuhler, S., Wilson, D., Ross, A. W., Warner, A., …Morgan, P. J. (2007). Hypothalamic thyroid hormone catabolism acts as a gatekeeper for the seasonal control of body weight and reproduction. Endocrinology, 148(8), 3608-3617. https://doi.org/10.1210/en.2007-0316

Seasonal adaptations in physiology exhibited by many animals involve an interface between biological timing and specific neuroendocrine systems, but the molecular basis of this interface is unknown. In this study of Siberian hamsters, we show that th... Read More about Hypothalamic thyroid hormone catabolism acts as a gatekeeper for the seasonal control of body weight and reproduction.