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Mutations of the TGF-β type II receptor BMPR2 in pulmonary arterial hypertension (2006)
Journal Article
Machado, R. D., Aldred, M. A., James, V., Harrison, R. E., Patel, B., Schwalbe, E. C., …Trembath, R. C. (2006). Mutations of the TGF-β type II receptor BMPR2 in pulmonary arterial hypertension. Human Mutation, 27(2), 121-132. https://doi.org/10.1002/humu.20285

Pulmonary arterial hypertension (PAH) is clinically characterized by a sustained elevation in mean pulmonary artery pressure leading to significant morbidity and mortality. The disorder is typically sporadic, and in such cases the term idiopathic PAH... Read More about Mutations of the TGF-β type II receptor BMPR2 in pulmonary arterial hypertension.

Genetic mapping of a major gene affecting onion bulb fructan content (2006)
Journal Article
McCallum, J., Clarke, A., Pither-Joyce, M., Shaw, M., Butler, R., Brash, D., …Havey, M. J. (2006). Genetic mapping of a major gene affecting onion bulb fructan content. TAG Theoretical and Applied Genetics, 112(5), 958-967. https://doi.org/10.1007/s00122-005-0199-5

The non-structural dry matter content of onion bulbs consists principally of fructose, glucose, sucrose and fructans. The objective of this study was to understand the genetic basis for the wide variation observed in the relative amounts of these car... Read More about Genetic mapping of a major gene affecting onion bulb fructan content.

Reconstructing the Origins and Dispersal of the Polynesian Bottle Gourd (Lagenaria siceraria) (2006)
Journal Article
Clarke, A. C., Burtenshaw, M. K., McLenachan, P. A., Erickson, D. L., & Penny, D. (2006). Reconstructing the Origins and Dispersal of the Polynesian Bottle Gourd (Lagenaria siceraria). Molecular Biology and Evolution, 23(5), 893-900. https://doi.org/10.1093/molbev/msj092

The origin of the Polynesian bottle gourd (Lagenaria siceraria), an important crop species in prehistoric Polynesia, has remained elusive. Most recently, a South American origin has been favored as the bottle gourd could have been introduced from thi... Read More about Reconstructing the Origins and Dispersal of the Polynesian Bottle Gourd (Lagenaria siceraria).

Relaxin Signaling from Natural Receptors (2006)
Presentation / Conference Contribution
Ivell, R., Anand-Ivell, R., & Bartsch, O. (2004, September). Relaxin Signaling from Natural Receptors. Presented at Relaxin 2004, Fourth International Conference on Relaxin and Related Peptides, Wyoming, USA

The heterodimeric peptide hormone relaxin in most cells appears to signal through a G-protein-coupled receptor, LGR7. Whereas in artificial cell systems, made by transfection of receptor-expressing gene constructs into cells normally not presenting t... Read More about Relaxin Signaling from Natural Receptors.

Asymmetric reduction of α, β-unsaturated ketone to (R) allylic alcohol by Candida chilensis (2006)
Journal Article
Pollard, D. J., Telari, K., Lane, J., Humphrey, G., McWilliams, C., Nidositko, S., Salmon, P., & Moore, J. (2006). Asymmetric reduction of α, β-unsaturated ketone to (R) allylic alcohol by Candida chilensis. Biotechnology and Bioengineering, 93(4), 674-686. https://doi.org/10.1002/bit.20751

A pilot scale whole cell process was developed for the enantioselective 1,2‐reduction of prochiral α,β‐unsaturated ketone to (R) allylic alcohol using Candida chilensis. Initial development showed high enantiomeric excess (EE > 95%) but low product y... Read More about Asymmetric reduction of α, β-unsaturated ketone to (R) allylic alcohol by Candida chilensis.

A discourse-based approach to human-computer communication (2006)
Journal Article
H Connolly, J., Chamberlain, A., & W Phillips, I. (2006). A discourse-based approach to human-computer communication. Semiotica, 2006(160), Article 203-217. https://doi.org/10.1515/sem.2006.046

The term ‘dialogue’ has its origin in the study of human language, where it is regarded primarily as a form of discourse, and hence as a pragmatic-level phenomenon. However, ‘dialogue’ is nowadays also used to denote human- computer interaction; and... Read More about A discourse-based approach to human-computer communication.

Effects of the A2A adenosine receptor antagonist KW6002 in the nucleus accumbens in vitro and in vivo (2006)
Journal Article
Harper, L. K., Beckett, S. R., Marsden, C. A., McCreary, A. C., & Alexander, S. P. (2006). Effects of the A2A adenosine receptor antagonist KW6002 in the nucleus accumbens in vitro and in vivo. Pharmacology Biochemistry and Behavior, 83(1), 114-121. https://doi.org/10.1016/j.pbb.2005.12.014

In this study, we have used the selective A2A adenosine receptor antagonist KW6002 to investigate the function of A2A receptors in the Lister hooded rat nucleus accumbens in vitro and in vivo. Radioligand binding studies confirmed a greater than 50-f... Read More about Effects of the A2A adenosine receptor antagonist KW6002 in the nucleus accumbens in vitro and in vivo.

How epidemiology has challenged 3 prevailing concepts about atopic dermatitis (2006)
Journal Article
Williams, H., & Flohr, C. (2006). How epidemiology has challenged 3 prevailing concepts about atopic dermatitis. Journal of Allergy and Clinical Immunology, 118,

We challenge 3 prevailing concepts in understanding atopic
dermatitis using data from epidemiologic studies. First, we
show that although atopy is associated with atopic dermatitis to
some degree, its importance is not likely to be a simple causea... Read More about How epidemiology has challenged 3 prevailing concepts about atopic dermatitis.

Reduced models of chemical reaction in chaotic flows (2006)
Journal Article
Vikhansky, A., & Cox, S. M. (2006). Reduced models of chemical reaction in chaotic flows. Physics of Fluids, 18(3), https://doi.org/10.1063/1.2182373

We describe and evaluate two reduced models for nonlinear chemical reactions in a chaotic laminar flow. Each model involves two separate steps to compute the chemical composition at a given location and time. The “manifold tracking model” first track... Read More about Reduced models of chemical reaction in chaotic flows.

Effectiveness and cost-effectiveness of salicylic acid and cryotherapy for cutaneous warts: an economic decision model (2006)
Book
Thomas, K., Keogh-Brown, M., Chalmers, J., Fordham, R., Holland, R., Armstrong, S., Bachmann, M., Howe, A., Rodgers, S., Avery, A., Harvey, I., & Williams, H. (2006). Effectiveness and cost-effectiveness of salicylic acid and cryotherapy for cutaneous warts: an economic decision model. NHS R&D HTA Programme. https://doi.org/10.3310/hta10250

Objectives: To estimate the costs of commonly used treatments for cutaneous warts, as well as their health benefits and risk. To create an economic decision model to evaluate the cost-effectiveness of these treatments, and, as a result, assess whethe... Read More about Effectiveness and cost-effectiveness of salicylic acid and cryotherapy for cutaneous warts: an economic decision model.

Data Reduction in Intrusion Alert Correlation (2006)
Journal Article
Tedesco, G., & Aickelin, U. (2006). Data Reduction in Intrusion Alert Correlation. WSEAS Transactions on Computers,

Network intrusion detection sensors are usually built around low level models of network traffic. This means that their output is of a similarly low level and as a consequence, is difficult to analyze. Intrusion alert correlation is the task of autom... Read More about Data Reduction in Intrusion Alert Correlation.

An immune inspired Network Intrusion Detection System utilising correlation (2006)
Book Chapter
Tedesco, G., & Aickelin, U. (2006). An immune inspired Network Intrusion Detection System utilising correlation. In T. Kovacs, & J. A. Marshall (Eds.), AISB '06: adaptation in artificial and biological systems. Society for the Study of Artificial Intelligence and the Simulation of Behaviour

Network Intrusion Detection Systems (NIDS) are computer systems which monitor a network with the aim of discerning malicious from benign activity on that network. While a wide range of approaches have met varying levels of success, most IDSs rely on... Read More about An immune inspired Network Intrusion Detection System utilising correlation.

Diatom D18O evidence for the development of the modern halocline system in the subarctic northwest Pacific at the onset of major Northern Hemisphere glaciation (2006)
Journal Article
Swann, G. E., Maslin, M. A., Leng, M. J., Sloane, H. J., & Haug, G. H. (2006). Diatom D18O evidence for the development of the modern halocline system in the subarctic northwest Pacific at the onset of major Northern Hemisphere glaciation. Paleoceanography, 21(PA1009), https://doi.org/10.1029/2005PA001147

Establishing a time frame for the development of the modern halocline and stratified water column in the subarctic North Pacific has significant paleoclimatic implications. Here we present a d18O(diatom) record consisting of only two species that rep... Read More about Diatom D18O evidence for the development of the modern halocline system in the subarctic northwest Pacific at the onset of major Northern Hemisphere glaciation.

Potential limitations of biogenic silica as an indicator of abrupt climate change in Lake Baikal, Russia (2006)
Journal Article
Swann, G. E., & Mackay, A. W. (2006). Potential limitations of biogenic silica as an indicator of abrupt climate change in Lake Baikal, Russia. Journal of Paleolimnology, 36(1), https://doi.org/10.1007/s10933-006-0005-7

Biogenic Silica (BSi) has been one of the most important proxies for determining the palaeoclimate from Lake Baikal over glacial-interglacial cycles. Concentrations (calculated through a 1% Na2CO3 wet-alkaline digestion) at a site in the north basin,... Read More about Potential limitations of biogenic silica as an indicator of abrupt climate change in Lake Baikal, Russia.

European Cosmopolitan Solidarity (2006)
Journal Article
Stevenson, N. (2006). European Cosmopolitan Solidarity. European Journal of Social Theory, 9(4),

The idea of a cosmopolitan Europe continues to be central to contemporary debates within post-national citizenship. However, much of the writing in this area remains disconnected from the need to reinvent European social
democracy that questions the... Read More about European Cosmopolitan Solidarity.