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All Outputs (229)

Whole blood-based measurement of SARS-CoV-2-specific T cell responses reveals asymptomatic infection and vaccine efficacy in healthy subjects and patients with solid organ cancers (2021)
Preprint / Working Paper
Scurr, M. J., Zelek, W. M., Lippiatt, G., Somerville, M., Burnell, S. E. A., Capitani, L., …Godkin, A. Whole blood-based measurement of SARS-CoV-2-specific T cell responses reveals asymptomatic infection and vaccine efficacy in healthy subjects and patients with solid organ cancers

Accurate assessment of SARS-CoV-2 immunity in the population is critical to evaluating vaccine efficacy and devising public health policies. Whilst the exact nature of effective immunity remains incompletely defined, SARS-CoV-2-specific T cell respon... Read More about Whole blood-based measurement of SARS-CoV-2-specific T cell responses reveals asymptomatic infection and vaccine efficacy in healthy subjects and patients with solid organ cancers.

Hippocampal disinhibition reduces contextual and elemental fear conditioning while sparing the acquisition of latent inhibition (2021)
Preprint / Working Paper
Williams, S. A., Gwilt, M., Hock, R., Taylor, C., Loayza, J., Stevenson, C. W., …Bast, T. Hippocampal disinhibition reduces contextual and elemental fear conditioning while sparing the acquisition of latent inhibition

Hippocampal neural disinhibition, i.e. reduced GABAergic inhibition, is a key feature of schizophrenia pathophysiology. The hippocampus is an important part of the neural circuitry that controls fear conditioning and can also modulate prefrontal and... Read More about Hippocampal disinhibition reduces contextual and elemental fear conditioning while sparing the acquisition of latent inhibition.

A validation study of the identification of haemophagocytic lymphohistiocytosis in England using population-based health data (2021)
Preprint / Working Paper
Bishton, M., Stilwell, P., Card, T. R., Lanyon, P., Ban, L., Elliss-Brookes, L., …Bythell, M. A validation study of the identification of haemophagocytic lymphohistiocytosis in England using population-based health data

We assessed the validity of coded health care data to identify cases of haemophagocytic lymphohistiocytosis (HLH). Hospital Episode Statistics (HES) identified 127 cases within five hospital Trusts 2013-2018 using ICD-10 codes D76.1, D76.2 and D76.3.... Read More about A validation study of the identification of haemophagocytic lymphohistiocytosis in England using population-based health data.

The Effectiveness of Mobile Phone Messaging–Based Interventions to Promote Physical Activity in Type 2 Diabetes Mellitus: Systematic Review and Meta-analysis (Preprint) (2021)
Preprint / Working Paper
Alsahli, M., Abd-Alrazaq, A., Househ, M., Konstantinidis, S., & Blake, H. The Effectiveness of Mobile Phone Messaging–Based Interventions to Promote Physical Activity in Type 2 Diabetes Mellitus: Systematic Review and Meta-analysis (Preprint)

Background: Type 2 diabetes mellitus (T2DM) is increasing in prevalence worldwide. Physical activity (PA) is an important aspect of self-care and first-line management for T2DM. Mobile text messages (SMS) can be used to support self-management in pe... Read More about The Effectiveness of Mobile Phone Messaging–Based Interventions to Promote Physical Activity in Type 2 Diabetes Mellitus: Systematic Review and Meta-analysis (Preprint).

Public Adoption of and Trust in the NHS COVID-19 Contact Tracing App in the United Kingdom: Quantitative Online Survey Study (2021)
Preprint / Working Paper
Dowthwaite, L., Fischer, J., Perez Vallejos, E., Portillo, V., Nichele, E., Goulden, M., & McAuley, D. Public Adoption of and Trust in the NHS COVID-19 Contact Tracing App in the United Kingdom: Quantitative Online Survey Study

Background: Digital contact tracing is employed to monitor and manage the spread of COVID-19. However, to be effective the system must be adopted by a substantial proportion of the population. Studies of mostly hypothetical contact tracing apps show... Read More about Public Adoption of and Trust in the NHS COVID-19 Contact Tracing App in the United Kingdom: Quantitative Online Survey Study.

Redesigning a web-based stakeholder consensus meeting about core outcomes for clinical trials: Formative feedback study (2021)
Preprint / Working Paper
Katiri, R., Hall, D. A., Hoare, D. J., Fackrell, K., Horobin, A., Buggy, N., …Core Rehabilitation Outcome Set For Single-Sided Deafness (CROSSSD) Initiative, . Redesigning a web-based stakeholder consensus meeting about core outcomes for clinical trials: Formative feedback study

Background: Clinical trials that assess the benefits and harms of an intervention do so by measuring and reporting outcomes. Inconsistent selection and diversity in the choice of outcomes makes it challenging to directly compare interventions. To... Read More about Redesigning a web-based stakeholder consensus meeting about core outcomes for clinical trials: Formative feedback study.

PROTOCOL: A cohort study examining the association between mirtazapine and mortality risk in adults with a diagnosis of depression (2021)
Preprint / Working Paper
Joseph, R. M., Jack, R. H., Morriss, R., Knaggs, R. D., Hollis, C., Hippisley-Cox, J., & Coupland, C. PROTOCOL: A cohort study examining the association between mirtazapine and mortality risk in adults with a diagnosis of depression

This protocol describes a cohort study comparing the risks of mortality and serious self-harm (suicide or near-fatal deliberate self-harm) between adults with depression prescribed mirtazapine, a selective serotonin reuptake inhibitor (SSRI), amitrip... Read More about PROTOCOL: A cohort study examining the association between mirtazapine and mortality risk in adults with a diagnosis of depression.

Do online support groups help individuals affected by HIV/AIDS?: A systematic review of the quantitative and qualitative literature (2021)
Preprint / Working Paper
Coulson, N. S., & Buchanan, H. Do online support groups help individuals affected by HIV/AIDS?: A systematic review of the quantitative and qualitative literature

Background: Online support groups provide opportunities for individuals affected by HIV/AIDS to seek information, advice and support from peers. However, if and how engagement with online support groups helps individuals affected by HIV/AIDS remains... Read More about Do online support groups help individuals affected by HIV/AIDS?: A systematic review of the quantitative and qualitative literature.

Students’ Views Towards SARS-CoV-2 Mass Asymptomatic Testing, Social Distancing and Self-Isolation in a University Setting during the COVID-19 Pandemic: A Qualitative Study (2021)
Preprint / Working Paper
Blake, H., Knight, H., Jia, R., Corner, J., Morling, J. R., Denning, C., …Vedhara, K. Students’ Views Towards SARS-CoV-2 Mass Asymptomatic Testing, Social Distancing and Self-Isolation in a University Setting during the COVID-19 Pandemic: A Qualitative Study

We aimed to explore university students’ perceptions and experiences of SARS-CoV-2 mass asymptomatic testing, social distancing and self-isolation during the COVID-19 pandemic. This qualitative study comprised of four rapid online focus groups conduc... Read More about Students’ Views Towards SARS-CoV-2 Mass Asymptomatic Testing, Social Distancing and Self-Isolation in a University Setting during the COVID-19 Pandemic: A Qualitative Study.

A systematic review and meta-analysis of Anakinra, Sarilumab, Siltuximab and Tocilizumab for Covid-19 (2021)
Preprint / Working Paper
Khan, F., Fabbri, L., Stewart, I., Robinson A., K., Smyth, A. R., & Jenkins, G. A systematic review and meta-analysis of Anakinra, Sarilumab, Siltuximab and Tocilizumab for Covid-19

Background There is accumulating evidence for an overly activated immune response in severe Covid-19, with several studies exploring the therapeutic role of immunomodulation. Through systematic review and meta-analysis, we assess the effectiveness of... Read More about A systematic review and meta-analysis of Anakinra, Sarilumab, Siltuximab and Tocilizumab for Covid-19.

Understanding each other's models: a standard representation of global water models to support improvement, intercomparison, and communication (2021)
Preprint / Working Paper
Telteu, C., Müller Schmied, H., Thiery, W., Leng, G., Burek, P., Liu, X., …Herz, F. Understanding each other's models: a standard representation of global water models to support improvement, intercomparison, and communication

Global water models (GWMs) simulate the terrestrial water cycle, on the global scale, and are used to assess the impacts of climate change on freshwater systems. GWMs are developed within different modeling frameworks and consider different underlyin... Read More about Understanding each other's models: a standard representation of global water models to support improvement, intercomparison, and communication.

The Functional Threshold: Direct International Legal Regulation of Collective Nonstate Entities and the Law of International Peace and Security (2020)
Preprint / Working Paper
Van der Ploeg, K. P. The Functional Threshold: Direct International Legal Regulation of Collective Nonstate Entities and the Law of International Peace and Security

This article explores transformations in international law with respect to collective nonstate entities, challenging the mainstream view that international law stipulates rights and obligations directly binding on such entities only on an exceptional... Read More about The Functional Threshold: Direct International Legal Regulation of Collective Nonstate Entities and the Law of International Peace and Security.

Experiences of the COVID-19 pandemic: cross-sectional analysis of risk perceptions and mental health in a student cohort (2020)
Preprint / Working Paper
Jia, R., Knight, H., Blake, H., Corner, J., Denning, C., Ball, J., …Vedhara, K. Experiences of the COVID-19 pandemic: cross-sectional analysis of risk perceptions and mental health in a student cohort

Objective: This study examined the COVID-19 risk perceptions and mental health of university students on returning to campus in the midst of the COVID-19 pandemic. Methods: An online survey was completed during the first four weeks of the academic... Read More about Experiences of the COVID-19 pandemic: cross-sectional analysis of risk perceptions and mental health in a student cohort.

The influence of surface charge on the coalescence of ice and dust particles in the mesosphere (2020)
Preprint / Working Paper
Baptiste, J., Williamson, C., Fox, J., Stace, A. J., Hassan, M., Braun, S., …Besley, E. The influence of surface charge on the coalescence of ice and dust particles in the mesosphere

Agglomeration of charged ice and dust particles in the mesosphere is studied using a classical electrostatic approach, which is extended to capture the induced polarisation of surface charge. Collision outcomes are predicted whilst varying particle s... Read More about The influence of surface charge on the coalescence of ice and dust particles in the mesosphere.

Comparing short and long batteries to assess deficits and their neural bases in stroke aphasia (2020)
Preprint / Working Paper
Halai, A. D., De Dios Perez, B., Stefaniak, J. D., & Lambon Ralph, M. A. Comparing short and long batteries to assess deficits and their neural bases in stroke aphasia

Multiple language assessments are necessary for diagnosing, characterising and quantifying the multifaceted deficits observed in many patients’ post-stroke. Current language batteries, however, tend to be an imperfect trade-off between time and sensi... Read More about Comparing short and long batteries to assess deficits and their neural bases in stroke aphasia.