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Diffusible VP22-E2 protein kills bystander cells and offers a route for cervical cancer gene therapy (2006)
Journal Article
Green, K. L., Southgate, T. D., Mulryan, K., Fairbairn, L. J., Stern, P. L., & Gaston, K. (2006). Diffusible VP22-E2 protein kills bystander cells and offers a route for cervical cancer gene therapy. Human Gene Therapy, 17(2), 147-157. https://doi.org/10.1089/hum.2006.17.147

Human papillomaviruses (HPVs) are a causative agent of cervical cancer and are implicated in several other types of malignant disease including cancer of the vulva, oral cancer, and skin cancer. In HPV-transformed cells, expression of the viral E6 an... Read More about Diffusible VP22-E2 protein kills bystander cells and offers a route for cervical cancer gene therapy.

Oligomerisation of the developmental regulator proline rich homeodomain (PRH/Hex) is mediated by a novel proline-rich dimerisation domain (2006)
Journal Article
Soufi, A., Smith, C., Clarke, A. R., Gaston, K., & Jayaraman, P. (2006). Oligomerisation of the developmental regulator proline rich homeodomain (PRH/Hex) is mediated by a novel proline-rich dimerisation domain. Journal of Molecular Biology, 358(4), 943-962. https://doi.org/10.1016/j.jmb.2006.02.020

Homeodomain proteins regulate multiple developmental pathways by altering gene expression temporally and in a tissue-specific fashion. The Proline Rich Homeodomain protein (PRH/Hex) is a transcription factor and an essential regulator of embryonic de... Read More about Oligomerisation of the developmental regulator proline rich homeodomain (PRH/Hex) is mediated by a novel proline-rich dimerisation domain.

Multifactorial day hospital intervention to reduce falls in high risk older people in primary care: a multi-centre randomised controlled trial [ISRCTN46584556] (2006)
Journal Article
Masud, T., Coupland, C., Drummond, A. E., Gladman, J. R., Kendrick, D., Sach, T., Harwood, R. H., Kumar, P., Morris, R., Taylor, R., Youde, J., & Conroy, S. (2006). Multifactorial day hospital intervention to reduce falls in high risk older people in primary care: a multi-centre randomised controlled trial [ISRCTN46584556]. Trials, 7(1), Article 10. https://doi.org/10.1186/1745-6215-7-5

Falls in older people are a major public health concern in terms of morbidity, mortality and cost. Previous studies suggest that multifactorial interventions can reduce falls, and many geriatric day hospitals are now offering falls intervention progr... Read More about Multifactorial day hospital intervention to reduce falls in high risk older people in primary care: a multi-centre randomised controlled trial [ISRCTN46584556].

Characterization of the hepatitis C virus E2 epitope defined by the broadly neutralizing monoclonal antibody AP33 (2006)
Journal Article
Tarr, A. W., Owsianka, A. M., Timms, J. M., McClure, C. P., Brown, R. J., Hickling, T. P., …Ball, J. K. (2006). Characterization of the hepatitis C virus E2 epitope defined by the broadly neutralizing monoclonal antibody AP33. Hepatology, 43(3), 592-601. https://doi.org/10.1002/hep.21088

The mouse monoclonal antibody (MAb) AP33, recognizing a 12 amino acid linear epitope in the hepatitis C virus (HCV) E2 glycoprotein, potently neutralizes retroviral pseudoparticles (HCVpp) carrying genetically diverse HCV envelope glycoproteins. Cons... Read More about Characterization of the hepatitis C virus E2 epitope defined by the broadly neutralizing monoclonal antibody AP33.

Purification and characterisation of the PRH homeodomain: removal of the N-terminal domain of PRH increases the PRH homeodomain-DNA interaction (2006)
Journal Article
Soufi, A., Gaston, K., & Jayaraman, P. (2006). Purification and characterisation of the PRH homeodomain: removal of the N-terminal domain of PRH increases the PRH homeodomain-DNA interaction. International Journal of Biological Macromolecules, 39(1-3), 45-50. https://doi.org/10.1016/j.ijbiomac.2006.01.004

The Proline-Rich Homeodomain (PRH) protein is a regulator of transcription and translation and plays a key role in the control of cell proliferation and cell differentiation. PRH contains an N-terminal proline-rich domain that can repress transcripti... Read More about Purification and characterisation of the PRH homeodomain: removal of the N-terminal domain of PRH increases the PRH homeodomain-DNA interaction.

Multiple-retrieval case-based reasoning for course timetabling problems (2006)
Journal Article
Burke, E., MacCarthy, B. L., Petrovic, S., & Qu, R. (2006). Multiple-retrieval case-based reasoning for course timetabling problems. Journal of the Operational Research Society, 57(2),

The structured representation of cases by attribute graphs in a Case-Based Reasoning (CBR) system for course timetabling has been the subject of previous research by the authors. In that system, the case base is organised as a decision tree and the r... Read More about Multiple-retrieval case-based reasoning for course timetabling problems.

A small temperature rise may contribute towards the apparent induction by microwaves of heatshock gene expression in the nematode Caenorhabditis elegans (2006)
Journal Article
Dawe, A. S., Smith, B., Thomas, D. W., Greedy, S., Vasic, N., Gregory, A., …de Pomerai, D. I. (2006). A small temperature rise may contribute towards the apparent induction by microwaves of heatshock gene expression in the nematode Caenorhabditis elegans. Bioelectromagnetics, 27(2), https://doi.org/10.1002/bem.20192

We have previously reported that low-intensity microwave exposure (0.75-1.0 GHz CW at 0.5 W; SAR 4-40 mW kg-1) can induce an apparently non-thermal heat-shock response in Caenorhabditis elegans worms carrying hsp16-1::reporter genes. Using matched co... Read More about A small temperature rise may contribute towards the apparent induction by microwaves of heatshock gene expression in the nematode Caenorhabditis elegans.

A classification of tasks for the systematic study of immune response using functional genomics data (2006)
Journal Article
Hedeler, C., Paton, N., Behnke, J. M., Bradley, J. E., Hamshere, M., & Else, K. (2006). A classification of tasks for the systematic study of immune response using functional genomics data. Parasitology, 132(2), https://doi.org/10.1017/S0031182005008796

A full understanding of the immune system and its responses to infection by different pathogens is important for the
development of anti-parasitic vaccines. A growing number of large-scale experimental techniques, such as microarrays, are being used... Read More about A classification of tasks for the systematic study of immune response using functional genomics data.

Effort-reward imbalance at work and the co-occurrence of lifestyle risk factors: cross-sectional survey in a sample of 36,127 public sector employees (2006)
Journal Article
Kouvonen, A., Kivimäki, M., Virtanen, M., Heponiemi, T., Elovainio, M., Pentti, J., …Vahtera, J. (2006). Effort-reward imbalance at work and the co-occurrence of lifestyle risk factors: cross-sectional survey in a sample of 36,127 public sector employees. BMC Public Health, 6,

Background
In occupational life, a mismatch between high expenditure of effort and receiving few rewards may promote the co-occurrence of lifestyle risk factors, however, there is insufficient evidence to support or refute this hypothesis. The aim o... Read More about Effort-reward imbalance at work and the co-occurrence of lifestyle risk factors: cross-sectional survey in a sample of 36,127 public sector employees.

Seismic retrofit schemes for RC structures and local-global consequences (2006)
Journal Article
Thermou, G., & Elnashai, A. (2006). Seismic retrofit schemes for RC structures and local-global consequences. Progress in Structural Engineering and Materials, 8(1), 1-15. https://doi.org/10.1002/pse.208

A review of repair schemes for reinforced concrete frame buildings is presented in this paper, within the context of global objectives of the intervention process. Local as well as global intervention measures are discussed and their technological ap... Read More about Seismic retrofit schemes for RC structures and local-global consequences.

Mutations of the TGF-β type II receptor BMPR2 in pulmonary arterial hypertension (2006)
Journal Article
Machado, R. D., Aldred, M. A., James, V., Harrison, R. E., Patel, B., Schwalbe, E. C., …Trembath, R. C. (2006). Mutations of the TGF-β type II receptor BMPR2 in pulmonary arterial hypertension. Human Mutation, 27(2), 121-132. https://doi.org/10.1002/humu.20285

Pulmonary arterial hypertension (PAH) is clinically characterized by a sustained elevation in mean pulmonary artery pressure leading to significant morbidity and mortality. The disorder is typically sporadic, and in such cases the term idiopathic PAH... Read More about Mutations of the TGF-β type II receptor BMPR2 in pulmonary arterial hypertension.

Genetic mapping of a major gene affecting onion bulb fructan content (2006)
Journal Article
McCallum, J., Clarke, A., Pither-Joyce, M., Shaw, M., Butler, R., Brash, D., …Havey, M. J. (2006). Genetic mapping of a major gene affecting onion bulb fructan content. TAG Theoretical and Applied Genetics, 112(5), 958-967. https://doi.org/10.1007/s00122-005-0199-5

The non-structural dry matter content of onion bulbs consists principally of fructose, glucose, sucrose and fructans. The objective of this study was to understand the genetic basis for the wide variation observed in the relative amounts of these car... Read More about Genetic mapping of a major gene affecting onion bulb fructan content.

Reconstructing the Origins and Dispersal of the Polynesian Bottle Gourd (Lagenaria siceraria) (2006)
Journal Article
Clarke, A. C., Burtenshaw, M. K., McLenachan, P. A., Erickson, D. L., & Penny, D. (2006). Reconstructing the Origins and Dispersal of the Polynesian Bottle Gourd (Lagenaria siceraria). Molecular Biology and Evolution, 23(5), 893-900. https://doi.org/10.1093/molbev/msj092

The origin of the Polynesian bottle gourd (Lagenaria siceraria), an important crop species in prehistoric Polynesia, has remained elusive. Most recently, a South American origin has been favored as the bottle gourd could have been introduced from thi... Read More about Reconstructing the Origins and Dispersal of the Polynesian Bottle Gourd (Lagenaria siceraria).

Asymmetric reduction of α, β-unsaturated ketone to (R) allylic alcohol by Candida chilensis (2006)
Journal Article
Pollard, D. J., Telari, K., Lane, J., Humphrey, G., McWilliams, C., Nidositko, S., Salmon, P., & Moore, J. (2006). Asymmetric reduction of α, β-unsaturated ketone to (R) allylic alcohol by Candida chilensis. Biotechnology and Bioengineering, 93(4), 674-686. https://doi.org/10.1002/bit.20751

A pilot scale whole cell process was developed for the enantioselective 1,2‐reduction of prochiral α,β‐unsaturated ketone to (R) allylic alcohol using Candida chilensis. Initial development showed high enantiomeric excess (EE > 95%) but low product y... Read More about Asymmetric reduction of α, β-unsaturated ketone to (R) allylic alcohol by Candida chilensis.

The effect of the hookworm Ancylostoma ceylanicum on the mucosal architecture of the small intestine in hamsters (2006)
Journal Article
Alkazmi, L., Dehlawi, M., & Behnke, J. (2006). The effect of the hookworm Ancylostoma ceylanicum on the mucosal architecture of the small intestine in hamsters. Journal of Helminthology, 80(4), https://doi.org/10.1017/JOH2006372

Hookworms are known to cause marked changes to the intestinal mucosa, especially in relation to erosion of the villi. However, since the development of enteropathy has not been examined thoroughly through quantitative experiments on infected animals,... Read More about The effect of the hookworm Ancylostoma ceylanicum on the mucosal architecture of the small intestine in hamsters.

Psychiatric treatment: in the absence of law?: R (on the application of B) v. Ashworth Hospital Authority and another, [2005] U.K.H.L. 20 (2006)
Journal Article
Bartlett, P. (2006). Psychiatric treatment: in the absence of law?: R (on the application of B) v. Ashworth Hospital Authority and another, [2005] U.K.H.L. 20. Medical Law Review, 15(1), https://doi.org/10.1093/medlaw/fwi037

This case concerns the scope of the compulsory treatment provisions of the Mental Health Act 1983. In particular, it determines whether persons confined under that Act may be compulsorily treated for any mental disorder or only for the form of mental... Read More about Psychiatric treatment: in the absence of law?: R (on the application of B) v. Ashworth Hospital Authority and another, [2005] U.K.H.L. 20.

Molecular evidence that Heligmosomoides polygyrus from laboratory mice and wood mice are separate species (2006)
Journal Article
Cable, J., Harris, P., Lewis, J., & Behnke, J. (2006). Molecular evidence that Heligmosomoides polygyrus from laboratory mice and wood mice are separate species. Parasitology, 133(1), https://doi.org/10.1017/S0031182006000047

The gastro-intestinal (GI) nematode Heligmosomoides polygyrus is an important experimental model in laboratory mice and a well-studied parasite of wood mice in the field. Despite an extensive literature, the taxonomy of this parasite in different hos... Read More about Molecular evidence that Heligmosomoides polygyrus from laboratory mice and wood mice are separate species.