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Occupational support following arthroplasty of the lower limb (OPAL): trial protocol for a UK-wide phase III randomised controlled trial (2024)
Journal Article
Sheehan, L., Woodward, A., Adamson, J., Archer, M., Drummond, A., Hewison, A., Jordan, C., Keding, A., Kottam, L., Madan, I., Martland, M., McDaid, C., McDonald, D. A., Parkinson, G., Reed, M., Sinclair, L., Smith, T. O., Thomson, L., Watkins, L., Wu, Q., & Baker, P. (2024). Occupational support following arthroplasty of the lower limb (OPAL): trial protocol for a UK-wide phase III randomised controlled trial. BMJ Open, 14(9), Article e085962. https://doi.org/10.1136/bmjopen-2024-085962

Background: In the UK, one in four patients are in work at the time of their hip or knee replacement surgery. These patients receive little support about their return to work (RTW). There is a need for an occupational support intervention that encour... Read More about Occupational support following arthroplasty of the lower limb (OPAL): trial protocol for a UK-wide phase III randomised controlled trial.

The effects of modal value and imperative mood on self-predicted compliance to health guidance: the case of COVID-19 (2024)
Journal Article
Vilar-Lluch, S., McClaughlin, E., Adolphs, S., Knight, D., & Nichele, E. (2024). The effects of modal value and imperative mood on self-predicted compliance to health guidance: the case of COVID-19. Text and Talk - An Interdisciplinary Journal of Language, Discourse and Communication Studies, https://doi.org/10.1515/text-2023-0125

Health messaging is effective if it is to achieve audience adherence to guidance. Through the lens of Systemic Functional Linguistics, we examine the expression of obligation in poster-based health campaigns (4 posters) employed during the COVID-19 p... Read More about The effects of modal value and imperative mood on self-predicted compliance to health guidance: the case of COVID-19.

Diatom silicon isotope ratios in Quaternary research: Where do we stand? (2024)
Journal Article
Frings, P. J., Panizzo, V. N., Sutton, J. N., & Ehlert, C. (2024). Diatom silicon isotope ratios in Quaternary research: Where do we stand?. Quaternary Science Reviews, 344, Article 108966. https://doi.org/10.1016/j.quascirev.2024.108966

Silicon stable isotope ratios (expressed as δ30Si) in biogenic silica have been widely used as a proxy for past and present biogeochemical cycling in both marine and lacustrine settings, in particular for nutrient utilization reconstructions. Yet an... Read More about Diatom silicon isotope ratios in Quaternary research: Where do we stand?.

Short-term risk of cardiovascular events in people newly diagnosed with gout (2024)
Journal Article
Cipolletta, E., Nakafero, G., Richette, P., Avery, A. J., Mamas, M. A., Tata, L. J., & Abhishek, A. (2024). Short-term risk of cardiovascular events in people newly diagnosed with gout. Arthritis and Rheumatology, https://doi.org/10.1002/art.42986

Objectives
To investigate the temporal association between first diagnosis of gout and cardiovascular events in the short-term.

Methods
We performed a self-controlled case series analysis and a cohort study using data from linked primary care, h... Read More about Short-term risk of cardiovascular events in people newly diagnosed with gout.

Structuring white rice with gellan gum reduces the glycemic response in healthy humans (2024)
Journal Article
Alshammari, N. A., Riches, K., Muttakin, S., Hoad, C. L., Strkalj, L., Gouseti, O., Bakalis, S., Lovegrove, A., Spiller, R. C., Gowland, P. A., Aithal, G. P., Yakubov, G. E., Taylor, M. A., & Marciani, L. (2024). Structuring white rice with gellan gum reduces the glycemic response in healthy humans. Food Research International, 196, Article 115090. https://doi.org/10.1016/j.foodres.2024.115090

White rice has a high glycemic index and its consumption has been linked to an increased risk of developing type-2 diabetes mellitus, increased diabetes associated complications and obesity. In recent in vitro studies we have shown that addition of f... Read More about Structuring white rice with gellan gum reduces the glycemic response in healthy humans.

Comparative judgement modeling to map forced marriage at local levels (2024)
Journal Article
Seymour, R., Nyarko-Agyei, A., Mccabe, H., Severn, K., Sirl, D., Kypraios, T., & Taylor, A. (in press). Comparative judgement modeling to map forced marriage at local levels. Annals of Applied Statistics,

Forcing someone into marriage against their will is a violation of their human rights. In 2021, the county of Nottinghamshire, UK, launched a strategy to tackle forced marriage and violence against women and girls. We set out to map the risk of force... Read More about Comparative judgement modeling to map forced marriage at local levels.

A novel small molecule ZYZ384 targeting SMYD3 for hepatocellular carcinoma via reducing H3K4 trimethylation of the Rac1 promoter (2024)
Journal Article
Ding, Q., Cai, J., Jin, L., Hu, W., Song, W., Rose, P., Tang, Z., Zhan, Y., Bao, L., Lei, W., & Zhu, Y. Z. (2024). A novel small molecule ZYZ384 targeting SMYD3 for hepatocellular carcinoma via reducing H3K4 trimethylation of the Rac1 promoter. MedComm, 5(10), Article e711. https://doi.org/10.1002/mco2.711

SMYD3 (SET and MYND domain-containing 3) is a histone lysine methyltransferase highly expressed in different types of cancer(s) and is a promising epigenetic target for developing novel antitumor therapeutics. No selective inhibitors for this protein... Read More about A novel small molecule ZYZ384 targeting SMYD3 for hepatocellular carcinoma via reducing H3K4 trimethylation of the Rac1 promoter.

High-temperature Brown-Zak oscillations in graphene/hBN moiré field effect transistor fabricated using molecular beam epitaxy (2024)
Journal Article
Makarovsky, O., Hill, R. J. A., Cheng, T. S., Summerfield, A., Taniguchi, T., Watanabe, K., Mellor, C. J., Patanè, A., Eaves, L., Novikov, S. V., & Beton, P. H. (2024). High-temperature Brown-Zak oscillations in graphene/hBN moiré field effect transistor fabricated using molecular beam epitaxy. Communications Materials, 5, Article 189. https://doi.org/10.1038/s43246-024-00633-x

High-temperature Brown-Zak oscillations in graphene/hBN moiré field effect transistor fabricated using molecular beam epitaxy Graphene placed on hexagonal boron nitride (hBN) has received significant interest due to its excellent electrical performan... Read More about High-temperature Brown-Zak oscillations in graphene/hBN moiré field effect transistor fabricated using molecular beam epitaxy.

Microplastics pollution in sediments of the Thames and Medway estuaries, UK: Organic matter associations and predominance of polyethylene (2024)
Journal Article
Trusler, M. M., Moss-Hayes, V. L., Cook, S., Lomax, B. H., & Vane, C. H. (2024). Microplastics pollution in sediments of the Thames and Medway estuaries, UK: Organic matter associations and predominance of polyethylene. Marine Pollution Bulletin, 208, Article 116971. https://doi.org/10.1016/j.marpolbul.2024.116971

Microplastics at 10 sites along a 77 km transect of the river Thames estuary (UK) and 5 sites along 29 km of the Medway estuary were separated from sediment and analysed by ATR-FTIR spectroscopy. Microplastics were observed at all sites. Highest Tham... Read More about Microplastics pollution in sediments of the Thames and Medway estuaries, UK: Organic matter associations and predominance of polyethylene.

The effect of cosmic web filaments on galaxy evolution (2024)
Journal Article
O'Kane, C. J., Kuchner, U., Gray, M. E., & Aragón-Salamanca, A. (2024). The effect of cosmic web filaments on galaxy evolution. Monthly Notices of the Royal Astronomical Society, https://doi.org/10.1093/mnras/stae2142

Galaxy properties are known to be affected by their environment. This is well established for the extremes of the density scales, between the high-density cluster environment and the low-density field. It is however not fully understood how the inter... Read More about The effect of cosmic web filaments on galaxy evolution.

Duration of Benefit and Risk of Dual Antiplatelet Therapy up to 72 Hours After Mild Ischemic Stroke and Transient Ischemic Attack (2024)
Journal Article
Guan, L., Han, S., Johnston, S. C., Bath, P. M., Amarenco, P., Yang, Y., Wang, T., Jing, J., Wang, C., Gao, Y., Chen, W., Yan, H., Wang, X., Wang, Y., Wang, Y., & Pan, Y. (2024). Duration of Benefit and Risk of Dual Antiplatelet Therapy up to 72 Hours After Mild Ischemic Stroke and Transient Ischemic Attack. Neurology, 103(7), https://doi.org/10.1212/wnl.0000000000209845

Background and Objectives
Clopidogrel-aspirin initiated within 72 hours of symptom onset is effective in patients with mild ischemic stroke or transient ischemic attack (TIA) in the Intensive Statin and Antiplatelet Therapy for Acute High-risk Intra... Read More about Duration of Benefit and Risk of Dual Antiplatelet Therapy up to 72 Hours After Mild Ischemic Stroke and Transient Ischemic Attack.

Is there a cost when predictions are not met? A VWP study investigating L1 and L2 speakers (2024)
Journal Article
Fernandez, L. B., Hadley, L. V., Koç, A., Gamboa, J. C., & Allen, S. E. (2024). Is there a cost when predictions are not met? A VWP study investigating L1 and L2 speakers. Quarterly Journal of Experimental Psychology, https://doi.org/10.1177/17470218241270200

Research has found that both L1 and L2 speakers make predictions about upcoming linguistic information, with predictive behavior being impacted by individual differences and methodological factors. However, it is not clear if a cost is incurred when... Read More about Is there a cost when predictions are not met? A VWP study investigating L1 and L2 speakers.

The Discovery of Substituted 5-(2-Hydroxybenzoyl)-2-Pyridone Analogues as Inhibitors of the Human Caf1/CNOT7 Ribonuclease (2024)
Journal Article
Kaur, I., Jadhav, G. P., Fischer, P. M., & Winkler, G. S. (2024). The Discovery of Substituted 5-(2-Hydroxybenzoyl)-2-Pyridone Analogues as Inhibitors of the Human Caf1/CNOT7 Ribonuclease. Molecules, 29(18), Article 4351. https://doi.org/10.3390/molecules29184351

The Caf1/CNOT7 nuclease is a catalytic component of the Ccr4-Not deadenylase complex, which is a key regulator of post-transcriptional gene regulation. In addition to providing catalytic activity, Caf1/CNOT7 and its paralogue Caf1/CNOT8 also contribu... Read More about The Discovery of Substituted 5-(2-Hydroxybenzoyl)-2-Pyridone Analogues as Inhibitors of the Human Caf1/CNOT7 Ribonuclease.

The Structure of Massive Star-Forming Galaxies from JWST and ALMA: Dusty, High Redshift Disk Galaxies (2024)
Journal Article
Gillman, S., Smail, I., Gullberg, B., Swinbank, A., Vijayan, A. P., Lee, M., Brammer, G., Dudzeviciute, U., Greve, T. R., Almaini, O., Brinch, M., Chapman, S. C., Chen, C.-C., Ikarashi, S., Matsuda, Y., Wang, W.-H., Walter, F., & van der Werf, P. P. (in press). The Structure of Massive Star-Forming Galaxies from JWST and ALMA: Dusty, High Redshift Disk Galaxies. Astronomy and Astrophysics,

We present an analysis of the JWST NIRCam and MIRI morphological and structural properties of 80 massive (log10(M∗[M]) = 11.2 ± 0.1) dusty star-forming galaxies at z = 2.7+1.2 −0.7 , identified as sub-millimetre galaxies (SMGs) by ALMA, that have bee... Read More about The Structure of Massive Star-Forming Galaxies from JWST and ALMA: Dusty, High Redshift Disk Galaxies.

Unleashing supply chain agility: Leveraging data network effects for digital transformation (2024)
Journal Article
Wu, L., Huang, J., Wang, M., & Kumar, A. (2024). Unleashing supply chain agility: Leveraging data network effects for digital transformation. International Journal of Production Economics, 277, Article 109402. https://doi.org/10.1016/j.ijpe.2024.109402

The global manufacturing supply chain is undergoing a digital transformation (DT) powered by various digital technologies. In both stable and turbulent environments, DT helps safeguard supply chain performance by enhancing supply chain agility. While... Read More about Unleashing supply chain agility: Leveraging data network effects for digital transformation.

Quantum Chemical Characterization of Rotamerism in Thio-Michael Additions for Targeted Covalent Inhibitors (2024)
Journal Article
Chaudhuri, S., M. Rogers, D., J. Hayes, C., Inzani, K., & D. Hirst, J. (2024). Quantum Chemical Characterization of Rotamerism in Thio-Michael Additions for Targeted Covalent Inhibitors. Journal of Chemical Information and Modeling, https://doi.org/10.1021/acs.jcim.4c01379

Myotonic dystrophy type I (DM1) is the most common form of adult muscular dystrophy and is a severe condition with no treatment currently available. Recently, small-molecule ligands have been developed as targeted covalent inhibitors that have some s... Read More about Quantum Chemical Characterization of Rotamerism in Thio-Michael Additions for Targeted Covalent Inhibitors.

Measuring fidelity to manualised peer support for people with severe mental health conditions: development and psychometric evaluation of the UPSIDES Fidelity Scale (2024)
Journal Article
Hiltensperger, R., Kotera, Y., Wolf, P., Nixdorf, R., Charles, A., Farkas, M., Grayzman, A., Kalha, J., Korde, P., Mahlke, C., Moran, G., Mpango, R., Mtei, R., Ryan, G., Shamba, D., Wenzel, L., Slade, M., & Puschner, B. (in press). Measuring fidelity to manualised peer support for people with severe mental health conditions: development and psychometric evaluation of the UPSIDES Fidelity Scale. BMC Psychiatry,

Background. Peer support workers provide support for people experiencing mental health conditions based on their own lived experience of mental health problems. Assessing fidelity to core ingredients of peer support is vital for successful implementa... Read More about Measuring fidelity to manualised peer support for people with severe mental health conditions: development and psychometric evaluation of the UPSIDES Fidelity Scale.

Beyond the bedside: A scoping review of the experiences of non‐practising health care professionals in Health Professions Education (2024)
Journal Article
Church, H. R., Brown, M. E. L., Brown, M. E., Govender, L., & Clark, D. (2024). Beyond the bedside: A scoping review of the experiences of non‐practising health care professionals in Health Professions Education. Medical Education, https://doi.org/10.1111/medu.15529

AbstractIntroductionThe shortage of educators within Health Professions Education (HPE) threatens the optimal training of the future health care workforce. Furthermore, without recruitment of diverse and skilled faculty, targets to expand the workfor... Read More about Beyond the bedside: A scoping review of the experiences of non‐practising health care professionals in Health Professions Education.