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All Outputs (1429)

Ligand-Directed Labeling of the Adenosine A1 Receptor in Living Cells (2024)
Journal Article
Comeo, E., Goulding, J., Lin, C.-Y., Groenen, M., Woolard, J., Kindon, N. D., Harwood, C. R., Platt, S., Briddon, S. J., Kilpatrick, L. E., Scammells, P. J., Hill, S. J., & Kellam, B. (2024). Ligand-Directed Labeling of the Adenosine A1 Receptor in Living Cells. Journal of Medicinal Chemistry, https://doi.org/10.1021/acs.jmedchem.4c00835

The study of protein function and dynamics in their native cellular environment is essential for progressing fundamental science. To overcome the requirement of genetic modification of the protein or the limitations of dissociable fluorescent ligands... Read More about Ligand-Directed Labeling of the Adenosine A1 Receptor in Living Cells.

Japanese martial arts (JMA) practice is an effective wellbeing strategy in post-COVID: a qualitative appraisal (2024)
Journal Article
Veasey, C. M., Lieu, J., Aledeh, M., Lawson, A., & Kotera, Y. (2024). Japanese martial arts (JMA) practice is an effective wellbeing strategy in post-COVID: a qualitative appraisal. International Journal of Spa and Wellness, https://doi.org/10.1080/24721735.2024.2374525

This study aimed to examine the experiences of Japanese martial arts (JMA) practitioners during the COVID-19 to understand how JMA impacted on their mental wellbeing. Using online semi-structured interviews and thematic analysis, we explored the firs... Read More about Japanese martial arts (JMA) practice is an effective wellbeing strategy in post-COVID: a qualitative appraisal.

A scoping review on intraoperative and postoperative surgical castration complications in domesticated equids (2024)
Journal Article
Rodden, E. B., Suthers, J. M., Busschers, E., Burford, J. H., & Freeman, S. L. (2024). A scoping review on intraoperative and postoperative surgical castration complications in domesticated equids. Equine Veterinary Journal, https://doi.org/10.1111/evj.14122

Background: Castration is the most common surgical procedure in domesticated equids; surgical techniques used and perioperative management vary considerably. Objectives: To identify and chart the current evidence on perioperative complications associ... Read More about A scoping review on intraoperative and postoperative surgical castration complications in domesticated equids.

Implementing responsible innovation: the role of the meso-level(s) between project and organisation (2024)
Journal Article
Stahl, B. C., Portillo, V., Wagner, H., Craigon, P. J., Darzentas, D., De Ossorno Garcia, S., Dowthwaite, L., Greenhalgh, C., Middleton, S. E., Nichele, E., Wagner, C., & Webb, H. (2024). Implementing responsible innovation: the role of the meso-level(s) between project and organisation. Journal of Responsible Innovation, 11(1), Article 2370934. https://doi.org/10.1080/23299460.2024.2370934

Much of academic discussion of responsible innovation (RI) has focused on RI integration into research projects. In addition, significant attention has also been paid to RI structures and policies at the research policy and institutional level. This... Read More about Implementing responsible innovation: the role of the meso-level(s) between project and organisation.

Interval Type-2 Fuzzy Logic Control of Linear Stages in Feedback-Error-Learning Structure Using Laser Interferometer (2024)
Journal Article
Khanesar, M. A., Yan, M., Karaca, A., Isa, M., Piano, S., & Branson, D. (2024). Interval Type-2 Fuzzy Logic Control of Linear Stages in Feedback-Error-Learning Structure Using Laser Interferometer. Energies, 17(14), Article 3434. https://doi.org/10.3390/en17143434

The output processer of interval type-2 fuzzy logic systems (IT2FLSs) is a complex operator which performs type-reduction plus defuzzification (TR+D) tasks. In this paper, a complexity-reduced yet high-performance TR+D for IT2FLSs based on Maclaurin... Read More about Interval Type-2 Fuzzy Logic Control of Linear Stages in Feedback-Error-Learning Structure Using Laser Interferometer.

LIGHTS. Survey Overview and a Search for Low Surface Brightness Satellite Galaxies (2024)
Journal Article
Zaritsky, D., Golini, G., Donnerstein, R., Trujillo, I., Akhlaghi, M., Chamba, N., D’Onofrio, M., Eskandarlou, S., Hosseini-ShahiSavandi, S. Z., Infante-Sainz, R., Martin, G., Montes, M., Román, J., Sedighi, N., & Sharbaf, Z. (2024). LIGHTS. Survey Overview and a Search for Low Surface Brightness Satellite Galaxies. Astronomical Journal, 168(2), Article 69. https://doi.org/10.3847/1538-3881/ad543f

We present an overview of the LBT Imaging of Galactic Halos and Tidal Structures survey, which currently includes 25 nearby galaxies that are on average ∼1 mag fainter than the Milky Way, and a catalog of 54 low central surface brightness (24 < μ 0,g... Read More about LIGHTS. Survey Overview and a Search for Low Surface Brightness Satellite Galaxies.

Metabolomic and Proteomic Analysis of ApoE4-Carrying H4 Neuroglioma Cells in Alzheimer’s Disease Using OrbiSIMS and LC-MS/MS (2024)
Journal Article
Lu, L., Kotowska, A. M., Kern, S., Fang, M., Rudd, T. R., Alexander, M. R., Scurr, D. J., & Zhu, Z. (2024). Metabolomic and Proteomic Analysis of ApoE4-Carrying H4 Neuroglioma Cells in Alzheimer’s Disease Using OrbiSIMS and LC-MS/MS. Analytical Chemistry, https://doi.org/10.1021/acs.analchem.4c01201

Growing clinical evidence reveals that systematic molecular alterations in the brain occur 20 years before the onset of AD pathological features. Apolipoprotein E4 (ApoE4) is one of the most significant genetic risk factors for Alzheimer’s disease (A... Read More about Metabolomic and Proteomic Analysis of ApoE4-Carrying H4 Neuroglioma Cells in Alzheimer’s Disease Using OrbiSIMS and LC-MS/MS.

Maternal selenium deficiency was positively associated with the risk of selenium deficiency in children aged 6–59 months in rural Zimbabwe (2024)
Journal Article
Mutonhodza, B., Manzeke-Kangara, M. G., Bailey, E. H., Matsungo, T. M., & Chopera, P. (2024). Maternal selenium deficiency was positively associated with the risk of selenium deficiency in children aged 6–59 months in rural Zimbabwe. PLOS Global Public Health, 4(7), Article e0003376. https://doi.org/10.1371/journal.pgph.0003376

There is growing evidence showing the existence of selenium (Se) deficiency among women and children in sub-Saharan Africa. Unfortunately, the key drivers of Se deficiency are not clearly understood. This study assessed the determinants of Se deficie... Read More about Maternal selenium deficiency was positively associated with the risk of selenium deficiency in children aged 6–59 months in rural Zimbabwe.

Guidelines Peri-operative pain management in adults: a multidisciplinary consensus statement from the Association of Anaesthetists and the British Pain Society (2024)
Journal Article
El-Boghdadly, K., Levy, N. A., Fawcett, W. J., Knaggs, R. D., Laycock, H., Baird, E., …Lobo, D. N. (in press). Guidelines Peri-operative pain management in adults: a multidisciplinary consensus statement from the Association of Anaesthetists and the British Pain Society. Anaesthesia,

This is a consensus document produced by expert members of a Working Party established by the Association of Anaesthetists and the British Pain Society. It has been seen and approved by their Committee and Board respectively. It is supported by the E... Read More about Guidelines Peri-operative pain management in adults: a multidisciplinary consensus statement from the Association of Anaesthetists and the British Pain Society.

Phase and amplitude responses for delay equations using harmonic balance (2024)
Journal Article
Nicks, R., Allen, R., & Coombes, S. (2024). Phase and amplitude responses for delay equations using harmonic balance. Physical Review E, 110(1), Article L012202. https://doi.org/10.1103/PhysRevE.110.L012202

Robust delay induced oscillations, common in nature, are often modeled by delay-differential equations (DDEs). Motivated by the success of phase-amplitude reductions for ordinary differential equations with limit cycle oscillations, there is now a gr... Read More about Phase and amplitude responses for delay equations using harmonic balance.

Loan guarantees and SMEs' investments under asymmetric information and Bayesian learning (2024)
Journal Article
Luo, P., Wang, H., & Yang, Z. (2024). Loan guarantees and SMEs' investments under asymmetric information and Bayesian learning. Journal of Risk and Insurance, https://doi.org/10.1111/jori.12485

We develop a dynamic investment model with loan guarantees wherein insurers face information disadvantages and learn about borrower quality. Borrowers signal their qualities through investment timing, which is characterized by the investment threshol... Read More about Loan guarantees and SMEs' investments under asymmetric information and Bayesian learning.

Work-related smartphone use during off-job hours and work-life conflict: a scoping review (2024)
Journal Article
Blake, H., Hassard, J., Singh, J., & Teoh, K. (in press). Work-related smartphone use during off-job hours and work-life conflict: a scoping review. PLOS Digital Health,

Over recent decades the use of smartphones for work purposes has burgeoned both within and beyond working hours. The aim of the study was to conduct a scoping review to explore the association between the use of smartphone technology for work purpose... Read More about Work-related smartphone use during off-job hours and work-life conflict: a scoping review.

Line manager training and organisational approaches to supporting wellbeing (2024)
Journal Article
Dulal-Arthur, T., Hassard, J., Bourke, J., Roper, S., Wishart, M., Belt, V., Bartle, C., Leka, S., Pahl, N., Thomson, L., & Blake, H. (2024). Line manager training and organisational approaches to supporting wellbeing. Occupational Medicine, https://doi.org/10.1093/occmed/kqae051

Background Employee mental health and well-being (MH&WB) is critical to the productivity and success of organizations. Training line managers (LMs) in mental health plays an important role in protecting and enhancing employee well-being, but its rel... Read More about Line manager training and organisational approaches to supporting wellbeing.

Self-similarity and limit spaces of substitution tiling semigroups (2024)
Journal Article
Walton, J., & Whittaker, M. F. (2024). Self-similarity and limit spaces of substitution tiling semigroups. Groups, Geometry, and Dynamics, https://doi.org/10.4171/GGD/807

We show that Kellendonk's tiling semigroup of an FLC substitution tiling is self-similar, in the sense of Bartholdi, Grigorchuk and Nekrashevych. We extend the notion of the limit space of a self-similar group to the setting of self-similar semigroup... Read More about Self-similarity and limit spaces of substitution tiling semigroups.

The Lyman-limit photon mean free path at the end of late reionization in the Sherwood–Relics simulations (2024)
Journal Article
Feron, J., Conaboy, L., Bolton, J. S., Chapman, E., Haehnelt, M. G., Keating, L. C., Kulkarni, G., & Puchwein, E. (2024). The Lyman-limit photon mean free path at the end of late reionization in the Sherwood–Relics simulations. Monthly Notices of the Royal Astronomical Society, 532(2), 2401-2417. https://doi.org/10.1093/mnras/stae1636

Recent evidence supporting reionization ending at redshift z ≲ 6 includes the rapid redshift evolution of the mean free path, λmfp , for Lyman-limit photons through the intergalactic medium (IGM) at 5 < z < 6. Here, we investigate λmfp predicted by t... Read More about The Lyman-limit photon mean free path at the end of late reionization in the Sherwood–Relics simulations.

Assessing correlations between two linear amplitude sweep (LAS) standards for evaluating the fatigue properties of aged bitumen (2024)
Journal Article
Hu, Y., Sreeram, A., Bahia, H. U., Airey, G. D., Si, W., Li, B., & Xu, X. (2024). Assessing correlations between two linear amplitude sweep (LAS) standards for evaluating the fatigue properties of aged bitumen. International Journal of Pavement Engineering, 25(1), Article 2375419. https://doi.org/10.1080/10298436.2024.2375419

Linear amplitude sweep (LAS) is an accelerated and well-established testing method to evaluate bitumen fatigue. However, there are different versions of LAS procedures employed. Significant differences in loading modes, damage failure criteria and ca... Read More about Assessing correlations between two linear amplitude sweep (LAS) standards for evaluating the fatigue properties of aged bitumen.

Identification of Predictive Biomarkers of Lameness in Transition Dairy Cows (2024)
Journal Article
Cardoso, A. S., Whitby, A., Green, M. J., Kim, D.-H., & Randall, L. V. (2024). Identification of Predictive Biomarkers of Lameness in Transition Dairy Cows. Animals, 14(14), Article 2030. https://doi.org/10.3390/ani14142030

The aim of this study was to identify with a high level of confidence metabolites previously identified as predictors of lameness and understand their biological relevance by carrying out pathway analyses. For the dairy cattle sector, lameness is a m... Read More about Identification of Predictive Biomarkers of Lameness in Transition Dairy Cows.

A Review of Thermochemical Energy Storage Systems for District Heating in the UK (2024)
Journal Article
Roger-Lund, S., Darkwa, J., Worall, M., Calautit, J., & Boukhanouf, R. (2024). A Review of Thermochemical Energy Storage Systems for District Heating in the UK. Energies, 17(14), Article 3389. https://doi.org/10.3390/en17143389

Thermochemical energy storage (TCES) presents a promising method for energy storage due to its high storage density and capacity for long-term storage. A combination of TCES and district heating networks exhibits an appealing alternative to natural g... Read More about A Review of Thermochemical Energy Storage Systems for District Heating in the UK.

Classification of osteoarthritic and healthy cartilage using deep learning with Raman spectra (2024)
Journal Article
Kok, Y. E., Crisford, A., Parkes, A., Venkateswaran, S., Oreffo, R., Mahajan, S., & Pound, M. (2024). Classification of osteoarthritic and healthy cartilage using deep learning with Raman spectra. Scientific Reports, 14(1), Article 15902. https://doi.org/10.1038/s41598-024-66857-6

Raman spectroscopy is a rapid method for analysing the molecular composition of biological material. However, noise contamination in the spectral data necessitates careful pre-processing prior to analysis. Here we propose an end-to-end Convolutional... Read More about Classification of osteoarthritic and healthy cartilage using deep learning with Raman spectra.