All Outputs (1392)

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial (2024)
Journal Article
RECOVERY Collaborative Group, Sandercock, P., Darbyshire, J., DeMets, D., Fowler, R., Lalloo, D., …Local Clinical Centre staff (for the RECOVERY Collaborative Group). (in press). Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. Nature Communications, 15, Article 924. https://doi.org/10.1038/s41467-023-43644-x

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOV... Read More about Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.

Glutaredoxin regulation of primary root growth is associated with early drought stress tolerance in pearl millet (2024)
Journal Article
de la Fuente, C., Grondin, A., Sine, B., Debieu, M., Belin, C., Hajjarpoor, A., …Laplaze, L. (2024). Glutaredoxin regulation of primary root growth is associated with early drought stress tolerance in pearl millet. eLife, 12, Article RP86169. https://doi.org/10.7554/elife.86169.3

Seedling root traits impact plant establishment under challenging environments. Pearl millet is one of the most heat and drought tolerant cereal crops that provides a vital food source across the sub-Saharan Sahel region. Pearl millet’s early root sy... Read More about Glutaredoxin regulation of primary root growth is associated with early drought stress tolerance in pearl millet.

Relativistic Perturbation Theory for Black-Hole Boson Clouds (2024)
Journal Article
Cannizzaro, E., Sberna, L., Green, S. R., & Hollands, S. (2024). Relativistic Perturbation Theory for Black-Hole Boson Clouds. Physical Review Letters, 132(5), Article 051401. https://doi.org/10.1103/PhysRevLett.132.051401

We develop a relativistic perturbation theory for scalar clouds around rotating black holes. We first introduce a relativistic product and corresponding orthogonality relation between modes, extending a recent result for gravitational perturbations.... Read More about Relativistic Perturbation Theory for Black-Hole Boson Clouds.

Lack of detection of SARS-CoV-2 in wildlife from Kerala, India in 2020–21 (2024)
Journal Article
Zachariah, A., Krishnankutty, S. P., Manazhi, J., Omanakuttan, V., Santosh, S., Blanchard, A., & Tarlinton, R. (2024). Lack of detection of SARS-CoV-2 in wildlife from Kerala, India in 2020–21. Access Microbiology, 6(1), Article 000686. https://doi.org/10.1099/acmi.0.000686.v3

Spillover of SARS-CoV-2 into a variety of wild and domestic animals has been an ongoing feature of the human pandemic. The establishment of a new reservoir in white-tailed deer in North America and increasing divergence of the viruses circulating in... Read More about Lack of detection of SARS-CoV-2 in wildlife from Kerala, India in 2020–21.

The effectiveness and safety of proton beam radiation therapy in children and young adults with Central Nervous System (CNS) tumours: a systematic review (2024)
Journal Article
Wilson, J. S., Main, C., Thorp, N., Taylor, R. E., Majothi, S., Kearns, P. R., …Pizer, B. (2024). The effectiveness and safety of proton beam radiation therapy in children and young adults with Central Nervous System (CNS) tumours: a systematic review. Journal of Neuro-Oncology, 167(1), 1-34. https://doi.org/10.1007/s11060-023-04510-4

Background Central nervous system (CNS) tumours account for around 25% of childhood neoplasms. With multi-modal therapy, 5-year survival is at around 75% in the UK. Conventional photon radiotherapy has made significant contributions to survival, but... Read More about The effectiveness and safety of proton beam radiation therapy in children and young adults with Central Nervous System (CNS) tumours: a systematic review.

Smoking is a risk factor for autoimmune hepatitis: An English registry-based case-control study (2024)
Journal Article
Grønbæk, L., Omeife, H., Ban, L., Crooks, C. J., Card, T. R., Jepsen, P., & West, J. (2024). Smoking is a risk factor for autoimmune hepatitis: An English registry-based case-control study. Clinical Epidemiology, 16, 23-30. https://doi.org/10.2147/CLEP.S439219

Purpose: Smoking is a risk factor for some autoimmune diseases, but its association with autoimmune hepatitis remains unknown. We conducted a population-based matched case–control study to examine the association between tobacco smoking and the risk... Read More about Smoking is a risk factor for autoimmune hepatitis: An English registry-based case-control study.

A phase 1 trial of human telomerase reverse transcriptase (hTERT) vaccination combined with therapeutic strategies to control immune-suppressor mechanisms (2024)
Journal Article
Zareian, N., Eremin, O., Pandha, H., Baird, R., Kwatra, V., Funingana, G., …Spicer, J. (2024). A phase 1 trial of human telomerase reverse transcriptase (hTERT) vaccination combined with therapeutic strategies to control immune-suppressor mechanisms. Experimental Biology and Medicine, 249(1), https://doi.org/10.3389/ebm.2024.10021

The presence of inhibitory immune cells and difficulty in generating activated effector T cells remain obstacles to development of effective cancer vaccines. We designed a vaccine regimen combining human telomerase reverse transcriptase (hTERT) pepti... Read More about A phase 1 trial of human telomerase reverse transcriptase (hTERT) vaccination combined with therapeutic strategies to control immune-suppressor mechanisms.

Using theory from the Global South: from social cohesion and collective efficacy to ubuntu (2024)
Journal Article
Dixon, B. (2024). Using theory from the Global South: from social cohesion and collective efficacy to ubuntu. Theoretical Criminology, https://doi.org/10.1177/13624806231221744

Criminologists adopting a southern or decolonial perspective bemoan the failure to use theories from the Global South in making sense of crime and responses to it. This article takes the African philosophy and ethics of ubuntu and demonstrates how th... Read More about Using theory from the Global South: from social cohesion and collective efficacy to ubuntu.

Waiting-list interventions for children and young people using child and adolescent mental health services: a systematic review (2024)
Journal Article
Valentine, A. Z., Hall, S. S., Sayal, K., & Hall, C. L. (2024). Waiting-list interventions for children and young people using child and adolescent mental health services: a systematic review. BMJ Mental Health, 27(1), 1-6. https://doi.org/10.1136/bmjment-2023-300844

Question Children and young people experience delays in assessment and/or treatment within mental health services. The objective of this systematic review, funded by the Emerging Minds Network, was to explore the current evidence base for mental heal... Read More about Waiting-list interventions for children and young people using child and adolescent mental health services: a systematic review.

Designing a Library of Lived Experience for Mental Health: integrated realist synthesis and experience-based co-design study in UK mental health services (2024)
Journal Article
Marshall, P., Barbrook, J., Collins, G., Foster, S., Glossop, Z., Inkster, C., …Lobban, F. (2024). Designing a Library of Lived Experience for Mental Health: integrated realist synthesis and experience-based co-design study in UK mental health services. BMJ Open, 14(1), Article e081188. https://doi.org/10.1136/bmjopen-2023-081188

ObjectiveLiving Library events involve people being trained as living 'Books', who then discuss aspects of their personal experiences in direct conversation with attendees, referred to as 'Readers'. This study sought to generate a realist programme t... Read More about Designing a Library of Lived Experience for Mental Health: integrated realist synthesis and experience-based co-design study in UK mental health services.

Glutaredoxin regulation of primary root growth is associated with early drought stress tolerance in pearl millet (2024)
Journal Article
de la Fuente, C., Grondin, A., Sine, B., Debieu, M., Belin, C., Hajjarpoor, A., …Laplaze, L. (2024). Glutaredoxin regulation of primary root growth is associated with early drought stress tolerance in pearl millet. eLife, https://doi.org/10.7554/eLife.86169

Seedling root traits impact plant establishment under challenging environments. Pearl millet is one of the most heat and drought tolerant cereal crops that provides a vital food source across the sub-Saharan Sahel region. Pearl millet’s early root sy... Read More about Glutaredoxin regulation of primary root growth is associated with early drought stress tolerance in pearl millet.

Review of the globally invasive freshwater mussels in the genus Sinanodonta Modell, 1945 (2024)
Journal Article
Douda, K., Zieritz, A., Vodáková, B., Urbańska, M., Bolotov, I. N., Marková, J., …Lopes-Lima, M. (2024). Review of the globally invasive freshwater mussels in the genus Sinanodonta Modell, 1945. Hydrobiologia, https://doi.org/10.1007/s10750-023-05457-3

In this review, we synthesize the current knowledge of the biology, ecology, and impact of Sinanodonta freshwater mussels (Bivalvia, Unionidae), native to East Asia, that have successfully invaded Europe, Central America, North Africa, and several As... Read More about Review of the globally invasive freshwater mussels in the genus Sinanodonta Modell, 1945.

SLAMB&MAI: a comprehensive methodology for SLAM benchmark and map accuracy improvement (2024)
Journal Article
Liu, S., Sun, E., & Dong, X. (2024). SLAMB&MAI: a comprehensive methodology for SLAM benchmark and map accuracy improvement. Robotica, https://doi.org/10.1017/S0263574724000079

SLAM Benchmark plays a pivotal role in the field by providing a common ground for performance evaluation. In this paper, a novel methodology of simultaneous localization and mapping benchmark and map accuracy improvement (SLAMB&MAI) is introduced. It... Read More about SLAMB&MAI: a comprehensive methodology for SLAM benchmark and map accuracy improvement.

Mental Health Staff Perspectives on Personal Recovery: A Narrative Study on Positive Professional Impact of Recovery-Oriented Care (2024)
Journal Article
Kirkegaard Thomsen, D., Østergaard Christensen, T., Tranberg Hansen, M., & Slade, M. (2024). Mental Health Staff Perspectives on Personal Recovery: A Narrative Study on Positive Professional Impact of Recovery-Oriented Care. Journal of Recovery in Mental Health, 7(1), 12-30. https://doi.org/10.33137/jrmh.v7i1.40671

Objectives Mental health staff play an important role in facilitating personal recovery. We examined how mental health staff perceived personal recovery and the impact of their experience with supporting personal recovery. Research Design and M... Read More about Mental Health Staff Perspectives on Personal Recovery: A Narrative Study on Positive Professional Impact of Recovery-Oriented Care.

First archaeological evidence for ginger consumption as a potential medicinal ingredient in a late medieval leprosarium at St Leonard, Peterborough, England (2024)
Journal Article
Fiorin, E., Roberts, C. A., Baldoni, M., Connelly, E., Lee, C., Ottoni, C., & Cristiani, E. (2024). First archaeological evidence for ginger consumption as a potential medicinal ingredient in a late medieval leprosarium at St Leonard, Peterborough, England. Scientific Reports, 14(1), Article 2452. https://doi.org/10.1038/s41598-024-52422-8

Leprosy was one of the most outwardly visible diseases in the European Middle Ages, a period during which leprosaria were founded to provide space for the sick. The extant documentary evidence for leprosy hospitals, especially in relation to diet, th... Read More about First archaeological evidence for ginger consumption as a potential medicinal ingredient in a late medieval leprosarium at St Leonard, Peterborough, England.

A fast ceramic mixed OH−/H+ ionic conductor for low temperature fuel cells (2024)
Journal Article
Zou, P., Iuga, D., Ling, S., Brown, A. J., Chen, S., Zhang, M., …Tao, S. (2024). A fast ceramic mixed OH−/H+ ionic conductor for low temperature fuel cells. Nature Communications, 15(1), Article 909. https://doi.org/10.1038/s41467-024-45060-1

Low temperature ionic conducting materials such as OH− and H+ ionic conductors are important electrolytes for electrochemical devices. Here we show the discovery of mixed OH−/H+ conduction in ceramic materials. SrZr0.8Y0.2O3-δ exhibits a high ionic c... Read More about A fast ceramic mixed OH−/H+ ionic conductor for low temperature fuel cells.

Conformational activation and inhibition of von Willebrand factor by targeting its autoinhibitory module (2024)
Journal Article
Arce, N. A., Markham-Lee, Z., Liang, Q., Najmudin, S., Legan, E. R., Dean, G., …Li, R. (2024). Conformational activation and inhibition of von Willebrand factor by targeting its autoinhibitory module. Blood, 143(19), 1992-2004. https://doi.org/10.1182/blood.2023022038

Activation of von Willebrand factor (VWF) is a tightly controlled process governed primarily by local elements around its A1 domain. Recent studies suggest that the O-glycosylated sequences flanking the A1 domain constitute a discontinuous and force-... Read More about Conformational activation and inhibition of von Willebrand factor by targeting its autoinhibitory module.

Continuous Sensing and Parameter Estimation with the Boundary Time Crystal (2024)
Journal Article
Cabot, A., Carollo, F., & Lesanovsky, I. (2024). Continuous Sensing and Parameter Estimation with the Boundary Time Crystal. Physical Review Letters, 132(5), Article 050801. https://doi.org/10.1103/physrevlett.132.050801

A boundary time crystal is a quantum many-body system whose dynamics is governed by the competition between coherent driving and collective dissipation. It is composed of N two-level systems and features a transition between a stationary phase and an... Read More about Continuous Sensing and Parameter Estimation with the Boundary Time Crystal.

Feasibility, validity and reliability of the Dutch translation of INCRESE (INCRESE-NL) inventory to characterize mental health recovery narratives (2024)
Journal Article
Lases, M. N., Bruins, J., Ng, F., Rennick-Egglestone, S., Llewellyn-Beardsley, J., Slade, M., …Castelein, S. (2024). Feasibility, validity and reliability of the Dutch translation of INCRESE (INCRESE-NL) inventory to characterize mental health recovery narratives. Journal of Recovery in Mental Health, 7(1), 31-49. https://doi.org/10.33137/jrmh.v7i1.39398

Objective: Methods for characterizing mental health recovery narratives are needed to enable the selection of helpful narratives which can support the recovery processes of other people. The Inventory of Characteristics of Recovery Stories (INCRESE)... Read More about Feasibility, validity and reliability of the Dutch translation of INCRESE (INCRESE-NL) inventory to characterize mental health recovery narratives.

Ciprofloxacin poly(β-amino ester) conjugates enhance antibiofilm activity and slow the development of resistance (2024)
Journal Article
Kasza, K., Richards, B., Jones, S., Romero, M., Robertson, S. N., Hardie, K. R., …Alexander, C. (2024). Ciprofloxacin poly(β-amino ester) conjugates enhance antibiofilm activity and slow the development of resistance. ACS Applied Materials and Interfaces, 16(5), 5412-5425. https://doi.org/10.1021/acsami.3c14357

To tackle the emerging antibiotic resistance crisis, novel antimicrobial approaches are urgently needed. Bacterial biofilms are a particular concern in this context as they are responsible for over 80% of bacterial infections and are inherently more... Read More about Ciprofloxacin poly(β-amino ester) conjugates enhance antibiofilm activity and slow the development of resistance.