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All Outputs (119)

Exploring the provision of social support within a computer-mediated huntington's disease support network (2004)
Presentation / Conference Contribution
Coulson, N., Aubeeluck, A., Buchanan, H., Semper, H., & Rooney, E. Exploring the provision of social support within a computer-mediated huntington's disease support network. Presented at 18th Annual Conference of the European Health Psychology Society, Helsinki, Finland

Objectives: The unique constraints placed upon the Huntington's Disease [HD] carer, and the lack of time and social support identified by this group may make computer-mediated support groups a unique channel of social support for these individuals. T... Read More about Exploring the provision of social support within a computer-mediated huntington's disease support network.

Virtual-Build-to-Order as a Mass Customization Order Fulfilment Model (2004)
Journal Article
Brabazon, P. G., & MacCarthy, B. L. (2004). Virtual-Build-to-Order as a Mass Customization Order Fulfilment Model

Virtual-build-to-order (VBTO) is a form of order fulfilment system in which the producer has the ability to search across the entire pipeline of finished stock, products in production and those in the production plan, in order to find the best produc... Read More about Virtual-Build-to-Order as a Mass Customization Order Fulfilment Model.

DnaG interacts with a linker region that joins the N- and C-domains of DnaB and induces the formation of 3-fold symmetric rings (2004)
Journal Article
Thirlway, J., Turner, I. J., Gibson, C. T., Gardiner, L., Brady, K., Allen, S., Roberts, C. J., & Soultanas, P. (2004). DnaG interacts with a linker region that joins the N- and C-domains of DnaB and induces the formation of 3-fold symmetric rings. Nucleic Acids Research, 32(10),

Loading of the replicative ring helicase onto the origin of replication (oriC) is the final outcome of a well coordinated series of events that collectively constitute a primosomal cascade. Once the ring helicase is loaded, it recruits the primase an... Read More about DnaG interacts with a linker region that joins the N- and C-domains of DnaB and induces the formation of 3-fold symmetric rings.

Clonal haemopoiesis may occur after conventional chemotherapy and is associated with accelerated telomere shortening and defects in the NQO1 pathway; possible mechanisms leading to an increased risk of t-AML/MDS (2004)
Journal Article
Fern, L., Pallis, M., Carter, G. I., Seedhouse, C., Russell, N., & Byrne, J. (2004). Clonal haemopoiesis may occur after conventional chemotherapy and is associated with accelerated telomere shortening and defects in the NQO1 pathway; possible mechanisms leading to an increased risk of t-AML/MDS. British Journal of Haematology, 126(1), 63-71. https://doi.org/10.1111/j.1365-2141.2004.05006.x

The molecular pathogenesis of therapy-related acute myeloid leukaemia/myelodysplastic syndrome (t-AML/MDS) remains uncertain. However, clonal haemopoiesis may develop following stem cell transplantation and precede the development of t-AML/MDS. Moreo... Read More about Clonal haemopoiesis may occur after conventional chemotherapy and is associated with accelerated telomere shortening and defects in the NQO1 pathway; possible mechanisms leading to an increased risk of t-AML/MDS.

A randomised controlled trial of a care home rehabilitation service to reduce long-term institutionalisation for elderly people (2004)
Journal Article
Fleming, S. A., Blake, H., Gladman, J. R., Hart, E., Lymbery, M., Dewey, M. E., McCloughry, H., Walker, M. F., & Miller, P. (in press). A randomised controlled trial of a care home rehabilitation service to reduce long-term institutionalisation for elderly people. Age and Ageing, 33(4), https://doi.org/10.1093/ageing/afh126

Objectives: to evaluate the effect of a care home rehabilitation service on institutionalisation, health outcomes and service use.

Design: randomised controlled trial, stratified by Barthel ADL index, social service sector and whether living alone... Read More about A randomised controlled trial of a care home rehabilitation service to reduce long-term institutionalisation for elderly people.

Molecular evidence links cryptic diversification in polar planktonic protists to Quaternary climate dynamics (2004)
Journal Article
Darling, K. F., Kucera, M., Pudsey, C. J., & Wade, C. M. (2004). Molecular evidence links cryptic diversification in polar planktonic protists to Quaternary climate dynamics. Proceedings of the National Academy of Sciences, 101(20), 7657-7662. https://doi.org/10.1073/pnas.0402401101

It is unknown how pelagic marine protists undergo diversification and speciation. Superficially, the open ocean appears homogeneous, with few clear barriers to gene flow, allowing extensive, even global, dispersal. Yet, despite the apparent lack of o... Read More about Molecular evidence links cryptic diversification in polar planktonic protists to Quaternary climate dynamics.

Expression of calpastatin isoforms in muscle and functionality of multiple calpastatin promoters (2004)
Journal Article
Parr, T., Jewell, K. K., Sensky, P. L., Brameld, J. M., Bardsley, R. G., & Buttery, P. J. (2004). Expression of calpastatin isoforms in muscle and functionality of multiple calpastatin promoters. Archives of Biochemistry and Biophysics, 427(1), 8-15. https://doi.org/10.1016/j.abb.2004.04.001

Calpastatin is the specific endogenous inhibitor of calpain proteinase that is encoded by a single gene. Transient transfection assays in both a non-fusing skeletal muscle and non-muscle cell-line demonstrated that the putative porcine calpastatin pr... Read More about Expression of calpastatin isoforms in muscle and functionality of multiple calpastatin promoters.

Vitamin A regulation of stearoyl-CoA desaturase mRNA levels and fatty acid composition in sheep tissues (2004)
Journal Article
Daniel, Z. C., Salter, A. M., & Buttery, P. J. (2004). Vitamin A regulation of stearoyl-CoA desaturase mRNA levels and fatty acid composition in sheep tissues. Animal Science, 78(2), 237-243. https://doi.org/10.1017/s1357729800054023

The effect of vitamin A (retinol) on ovine stearoyl-CoA desaturase (SCD) mRNA levels and fatty acid composition was investigated. Sheep adipose tissue explants were maintained in culture for 24 h in the presence of all-trans retinoic acid (RA). Tissu... Read More about Vitamin A regulation of stearoyl-CoA desaturase mRNA levels and fatty acid composition in sheep tissues.

Polymorphisms in Genes Involved in Homologous Recombination Repair Interact to Increase the Risk of Developing Acute Myeloid Leukemia (2004)
Journal Article
Seedhouse, C., Faulkner, R., Ashraf, N., Das-Gupta, E., & Russell, N. (2004). Polymorphisms in Genes Involved in Homologous Recombination Repair Interact to Increase the Risk of Developing Acute Myeloid Leukemia. Clinical Cancer Research, 10(8), 2675–2680. https://doi.org/10.1158/1078-0432.CCR-03-0372

Purpose: Double-strand break repair via homologous recombination is essential in maintaining genetic integrity. RAD51 and XRCC3 are involved in the repair of DNA by this pathway, and polymorphisms have been identified in both the RAD51 (RAD51-G135C)... Read More about Polymorphisms in Genes Involved in Homologous Recombination Repair Interact to Increase the Risk of Developing Acute Myeloid Leukemia.

Uranyl acetate speciation in aqueous solutions-An XAS study between 25°C and 250°C (2004)
Journal Article
Bailey, E. H., Mosselmans, J. F., & Schofield, P. F. (2004). Uranyl acetate speciation in aqueous solutions-An XAS study between 25°C and 250°C. Geochimica et Cosmochimica Acta, 68(8), 1711-1722. https://doi.org/10.1016/j.gca.2003.08.024

Speciation of uranium (VI) in acetate solutions between 25 and 250°C, at pH values between 1.8 and 3.8 and acetate/uranium (Ac/U) ratios of 0.5 to 100 has been investigated using uranium LIII-edge X-ray absorption spectroscopy. With increasing pH the... Read More about Uranyl acetate speciation in aqueous solutions-An XAS study between 25°C and 250°C.

Uranium biosorption by the lichen trapelia involuta at a uranium mine (2004)
Journal Article
Purvis, O. W., Bailey, E. H., McLean, J., Kasama, T., & Williamson, B. J. (2004). Uranium biosorption by the lichen trapelia involuta at a uranium mine. Geomicrobiology Journal, 21(3), 159-167. https://doi.org/10.1080/01490450490275398

Metal localisation was investigated in the lichenised ascomycete Trapelia involuta growing on a range of uraniferous minerals including metazeunerite [Cu(UO2)2(AsO42·8H2O], metatorbernite [Cu(UO22(PO4)2·8H2O], autunite [Ca(UO2)2(PO42·10H2O] and urani... Read More about Uranium biosorption by the lichen trapelia involuta at a uranium mine.

Democracy in South Asia: Getting beyond the Structure-Agency Dichotomy (2004)
Journal Article
(2004). Democracy in South Asia: Getting beyond the Structure-Agency Dichotomy. Political Studies, 52(1), 1 - 8. https://doi.org/10.1111/j.1467-9248.2004.00461.x

With reference to South Asia, we argue that recourse to the conventional structuralist and transition accounts of democratisation sustains an unhelpful dichotomy. Those approaches tend towards either determinism or agent-driven contingency. In contra... Read More about Democracy in South Asia: Getting beyond the Structure-Agency Dichotomy.

Radiative transfer through the intergalactic medium (2004)
Journal Article
Bolton, J., Meiksin, A., & White, M. (2004). Radiative transfer through the intergalactic medium. Monthly Notices of the Royal Astronomical Society, 348(3), L43-L48. https://doi.org/10.1111/j.1365-2966.2004.07567.x

We use a probabilistic method to compute the propagation of an ionization front corresponding to the reionization of the intergalactic medium in a Λ-cold dark matter (ΛCDM) cosmology, including both hydrogen and helium. The effects of radiative trans... Read More about Radiative transfer through the intergalactic medium.

Does the abundance of hoverfly mimics (Syrphidae) depend on the numbers of their hymenopteran models ? (2004)
Journal Article
Howarth, B., Edmunds, M., & Gilbert, F. (2004). Does the abundance of hoverfly mimics (Syrphidae) depend on the numbers of their hymenopteran models ?. Evolution, 58(2), 367-375. https://doi.org/10.1111/j.0014-3820.2004.tb01652.x

We tested the prediction that, if hoverflies are Batesian mimics, this may extend to behavioral mimicry such that their numerical abundance at each hour of the day (the daily activity pattern) is related to the numbers of their hymenopteran models. A... Read More about Does the abundance of hoverfly mimics (Syrphidae) depend on the numbers of their hymenopteran models ?.

The Ubiquitin Ligase SCF Fbw7 Antagonizes Apoptotic JNK Signaling (2004)
Journal Article
Nateri, A. S., Riera-Sans, L., Da Costa, C., & Behrens, A. (2004). The Ubiquitin Ligase SCF Fbw7 Antagonizes Apoptotic JNK Signaling. Science, 303(5662), 1374-1378. https://doi.org/10.1126/science.1092880

Jun N-terminal kinases (JNKs) are essential for neuronal microtubute assembly and apoptosis. Phosphorylation of the activating protein 1 (AP1) transcription factor c-Jun, at multiple sites within its transactivation domain, is required for JNK-induce... Read More about The Ubiquitin Ligase SCF Fbw7 Antagonizes Apoptotic JNK Signaling.

Galanin-Like Peptide Stimulates the Release of Gonadotropin-Releasing Hormone in Vitro and May Mediate the Effects of Leptin on the Hypothalamo-Pituitary-Gonadal Axis (2004)
Journal Article
Seth, A., Stanley, S., Jethwa, P., Gardiner, J., Ghatei, M., & Bloom, S. (2004). Galanin-Like Peptide Stimulates the Release of Gonadotropin-Releasing Hormone in Vitro and May Mediate the Effects of Leptin on the Hypothalamo-Pituitary-Gonadal Axis. Endocrinology, 145(2), 743-750. https://doi.org/10.1210/en.2003-0873

Leptin regulates the hypothalamo-pituitary-gonadal axis in relation to nutritional status. The mechanism through which leptin mediates its effects on neuroendocrine reproductive circuits remains unclear. Galanin-like peptide (GALP) is a recently iden... Read More about Galanin-Like Peptide Stimulates the Release of Gonadotropin-Releasing Hormone in Vitro and May Mediate the Effects of Leptin on the Hypothalamo-Pituitary-Gonadal Axis.