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Enhancing Health Outcomes through Optimized Body Composition in Prehabilitation (2025)
Journal Article
Kutnik, P., Da Silva, B. R., Shoemaker, M. E., Barbosa-Silva, T. G., Gonzalez, M. C., Lobo, D. N., & Prado, C. M. (2025). Enhancing Health Outcomes through Optimized Body Composition in Prehabilitation. Annals of Nutrition and Metabolism, 81(3), 180-190. https://doi.org/10.1159/000545026

Background: Prehabilitation, the process of optimizing a patient's physical and nutritional status before surgery, has gained increasing attention for its potential to improve outcomes by enhancing physiological reserves and functional capacity. Whil... Read More about Enhancing Health Outcomes through Optimized Body Composition in Prehabilitation.

Small bowel motility quantified by cine MRI to predict longer term response in patients with Crohn’s disease commencing biological therapy: The Motility study (2025)
Journal Article
Plumb, A. A., Moran, G., Chowdhury, K., Ahmed, N., Philpott, S., Ahmad, T., Bloom, S., Hart, A., Jacobs, I., Menys, A., Mooney, P., Tolan, D., Travis, S., Bhagwanani, A., Bhatnagar, G., Boone, D., Franklin, J., Gangi-Burton, A., Hameed, M., Helbren, E., …Taylor, S. A. (in press). Small bowel motility quantified by cine MRI to predict longer term response in patients with Crohn’s disease commencing biological therapy: The Motility study. Inflammatory Bowel Diseases, https://doi.org/10.1093/ibd/izaf023

Background:
Small bowel Crohn’s Disease (SBCD) is increasingly treated with biological therapies. Predicting response or remission (RoR) for individual patients is difficult and complicates treatment strategy. We aimed to determine if motility magne... Read More about Small bowel motility quantified by cine MRI to predict longer term response in patients with Crohn’s disease commencing biological therapy: The Motility study.

Developing an adaptive platform trial for evaluation of medical treatments for Crohn’s disease (2025)
Journal Article
Noor, N. M., Radford, S. J., Choodari-Oskooei, B., Gordon, M., Hart, A. L., Hepburn, T., Juszczak, E., Lindsay, J. O., Kennedy, N. A., Parmar, M. K. B., Jairath, V., & Moran, G. W. (2025). Developing an adaptive platform trial for evaluation of medical treatments for Crohn’s disease. Nature Reviews Gastroenterology and Hepatology, 22, 364-366. https://doi.org/10.1038/s41575-025-01052-0

There is emerging interest in adaptive platform trials for inflammatory bowel disease. In this Comment, we present the results of a workshop that was convened to consider the opportunities and challenges of developing a platform trial in Crohn’s dise... Read More about Developing an adaptive platform trial for evaluation of medical treatments for Crohn’s disease.

Purpose and Providence in Evolutionary Perspective: Considerations for Theological Anthropology in Light of Biocultural Evolution and Genetic Engineering (2025)
Journal Article
Burdett, M., & Jackson, A. (in press). Purpose and Providence in Evolutionary Perspective: Considerations for Theological Anthropology in Light of Biocultural Evolution and Genetic Engineering. The Heythrop Journal, 66(2), 157-173. https://doi.org/10.1111/heyj.14399

We argue here that bringing insights from evolution and bioengineering to bear on traditional accounts of divine providence helps to illustrate just how complex providence is and how difficult it is to achieve. While other non‐human animals might exh... Read More about Purpose and Providence in Evolutionary Perspective: Considerations for Theological Anthropology in Light of Biocultural Evolution and Genetic Engineering.

CF Tummy Tracker: A Cystic Fibrosis–Specific Patient-Reported Outcome Measure for Daily Gastrointestinal Symptom Burden (2025)
Journal Article
Calthorpe, R. J., Saumtally, H. A., Howells, L. M., Goodchild, N. J., Evans, B. C., Elliott, Z., Hayee, B. H., Carr, S. B., Elston, C. M., Horsley, A. A., Peckham, D. G., Barr, H. L., Major, G. A., Stewart, I. D., Thomas, K. S., & Smyth, A. R. (2025). CF Tummy Tracker: A Cystic Fibrosis–Specific Patient-Reported Outcome Measure for Daily Gastrointestinal Symptom Burden. Mayo Clinic Proceedings: Digital Health, 3(2), Article 100203. https://doi.org/10.1016/j.mcpdig.2025.100203

Objective
To develop a cystic fibrosis (CF)–specific patient-reported outcome measure (PROM) to measure the daily burden of gastrointestinal symptoms for people with cystic fibrosis (pwCF) aged 12 years and older and address the lack of validated ou... Read More about CF Tummy Tracker: A Cystic Fibrosis–Specific Patient-Reported Outcome Measure for Daily Gastrointestinal Symptom Burden.

Clinical Characteristics and Outcomes of Patients With Rome IV Functional Dyspepsia Who Consume Opioids: A Real‐World Study (2025)
Journal Article
Butt, M. F., Isherwood, G., Lewis‐Lawson, T., Sbarigia, C., Lambiase, C., Aburumman, R. N. M., Dhali, A., Bush, D., Card, T., & Corsetti, M. (2025). Clinical Characteristics and Outcomes of Patients With Rome IV Functional Dyspepsia Who Consume Opioids: A Real‐World Study. Neurogastroenterology and Motility, 37(7), Article e15019. https://doi.org/10.1111/nmo.15019

Introduction
The prevalence of opioid use and its impact on healthcare outcomes among patients with Rome IV functional dyspepsia (FD) has not been reported in real-world clinical practice in the United Kingdom (UK). The primary aim of this study was... Read More about Clinical Characteristics and Outcomes of Patients With Rome IV Functional Dyspepsia Who Consume Opioids: A Real‐World Study.

Impact of Opioid and Cannabis Use on Low-Dose Amitriptyline Efficacy in Cyclical Vomiting Syndrome: A Real-World Study in the United Kingdom (2025)
Journal Article
Butt, M. F., Cefalo, F., Sbarigia, C., Dhali, A., & Corsetti, M. (2025). Impact of Opioid and Cannabis Use on Low-Dose Amitriptyline Efficacy in Cyclical Vomiting Syndrome: A Real-World Study in the United Kingdom. Neurogastroenterology and Motility, Article e70007. https://doi.org/10.1111/nmo.70007

Background: Central neuromodulators, specifically tricyclic antidepressants (TCAs), are prescribed as prophylactic treatment for cyclical vomiting syndrome (CVS). It is unclear whether opioids and/or cannabis affect the treatment response to neuromod... Read More about Impact of Opioid and Cannabis Use on Low-Dose Amitriptyline Efficacy in Cyclical Vomiting Syndrome: A Real-World Study in the United Kingdom.

The challenge of assessing impaired awareness of hypoglycaemia in diabetes in the era of continuous glucose monitoring: A narrative review of evidence and translation into clinical practice (2025)
Journal Article
Berry, S. A., Liarakos, A. L., Koutroukas, V., Choudhary, P., Wilmot, E. G., & Iqbal, A. (2025). The challenge of assessing impaired awareness of hypoglycaemia in diabetes in the era of continuous glucose monitoring: A narrative review of evidence and translation into clinical practice. Diabetes, Obesity and Metabolism, 27(5), 2363-2376. https://doi.org/10.1111/dom.16284

Iatrogenic hypoglycaemia remains a major barrier in diabetes care. Over time, and with repeated hypoglycaemic episodes, the physiological responses to hypoglycaemia can become blunted, resulting in impaired awareness of hypoglycaemia (IAH). In IAH, t... Read More about The challenge of assessing impaired awareness of hypoglycaemia in diabetes in the era of continuous glucose monitoring: A narrative review of evidence and translation into clinical practice.

Wet spinning of sodium carboxymethyl cellulose-sodium caseinate hydrogel fibres: relationship between rheology and spinnability (2025)
Journal Article
Vaniyan, L., Borah, P. K., Pavlovskaya, G. E., Terrill, N., Reid, J. E., Boehm, M., Prochasson, P., Nicholson, R. A., Baier, S., & Yakubov, G. E. (2025). Wet spinning of sodium carboxymethyl cellulose-sodium caseinate hydrogel fibres: relationship between rheology and spinnability. Soft Matter, 21(20), 3946-3956. https://doi.org/10.1039/d4sm00705k

Mimicking the fibrous structures of meat is a significant challenge as natural plant protein assemblies lack the fibrous organisation ubiquitous in mammalian muscle tissues. In this work, wet-spun hydrogel fibres resembling the anisotropic fibrous mi... Read More about Wet spinning of sodium carboxymethyl cellulose-sodium caseinate hydrogel fibres: relationship between rheology and spinnability.

The Linear Association of Chest Radiograph Opacification With Both Respiratory Physiology and Systemic Inflammation in Hospital In-Patients With Covid-19 Infection (2025)
Journal Article
Crooks, C., Shaw, D., Card, T., Au-Yong, I., Higashi, Y., Giannotti, E., & Fogarty, A. (2025). The Linear Association of Chest Radiograph Opacification With Both Respiratory Physiology and Systemic Inflammation in Hospital In-Patients With Covid-19 Infection. Clinical Respiratory Journal, 19(2), Article e70056. https://doi.org/10.1111/crj.70056

Background: Chest radiographs are generally used for diagnostic purposes. They also have potential to quantify disease severity. This analysis tested the hypothesis that there was an association between chest radiograph opacification and measures of... Read More about The Linear Association of Chest Radiograph Opacification With Both Respiratory Physiology and Systemic Inflammation in Hospital In-Patients With Covid-19 Infection.

Gastroenterology Training and Career in Women: Challenges and Opportunities (2025)
Journal Article
Manthopoulou, E., Catalan‐Serra, I., Corsetti, M., Nowak, A., Perugorria, M. J., Simsek, C., & Ciacci, C. (2025). Gastroenterology Training and Career in Women: Challenges and Opportunities. United European Gastroenterology Journal, 13(4), 650-655. https://doi.org/10.1002/ueg2.12764

This review highlights gender gaps in training, career, and work-life balance in gastroenterology. Stereotypes and biases toward women’s abilities and commitment to their careers can influence evaluations, advancement in gastroenterology training, an... Read More about Gastroenterology Training and Career in Women: Challenges and Opportunities.

Oral hyoscine butylbromide exerts spasmolytic effects in both gastrointestinal and urogenital tissues in rats (2025)
Journal Article
Traserra, S., Appelqvist, T., Lange, R., Corsetti, M., & Jimenez, M. (2025). Oral hyoscine butylbromide exerts spasmolytic effects in both gastrointestinal and urogenital tissues in rats. British Journal of Pharmacology, 182(11), 2487-2502. https://doi.org/10.1111/bph.17474

Background and Purpose
Hyoscine butylbromide (HBB) has a low oral (PO) bioavailability. Further, limited data on its activity on non-gastrointestinal (GI) smooth muscle spasms after oral dosing are available, causing its effects beyond the GI tract... Read More about Oral hyoscine butylbromide exerts spasmolytic effects in both gastrointestinal and urogenital tissues in rats.

Oral Hyoscine butylbromide exerts spasmolytic effects both in gastrointestinal and urogenital tissues in rats (2025)
Journal Article
Traserra, S., Appelqvist, T., Lange, R., Corsetti, M., & Jimenez, M. (2025). Oral Hyoscine butylbromide exerts spasmolytic effects both in gastrointestinal and urogenital tissues in rats. British Journal of Pharmacology, 182(11), 2487-2502. https://doi.org/10.1111/bph.17474

Background and Purpose: Hyoscine butylbromide (HBB) has a low oral (PO) bioavailability. Further, limited data on its activity on non-gastrointestinal (GI) smooth muscle spasms after oral dosing are available, meaning its effect outside the GI tract... Read More about Oral Hyoscine butylbromide exerts spasmolytic effects both in gastrointestinal and urogenital tissues in rats.

Cognitive Outcomes in Children Treated for Ependymoma Diagnosed Under 36 Months: A Systematic Review (2025)
Journal Article
Thomas, S., Morley, E., Ritzmann, T., Clayton, C., Powers, K., Airdrie, J., Robinson, L., Fifield, K., Packham, A., Oprandi, M. C., Lui, J., Whitfield, G., Thorp, N., Limond, J., & Grundy, R. (in press). Cognitive Outcomes in Children Treated for Ependymoma Diagnosed Under 36 Months: A Systematic Review. Pediatric Blood and Cancer, Article e31588. https://doi.org/10.1002/pbc.31588

It is crucial to understand the morbidity associated with treatments for young children with ependymoma given this is a high incidence age group also known to be at risk of poorer cognitive outcomes. This review aimed to identify the quality of exist... Read More about Cognitive Outcomes in Children Treated for Ependymoma Diagnosed Under 36 Months: A Systematic Review.

Influence of Baseline Kidney Function on Patient and Kidney Outcomes in Patients with COVID-19: A Multi-National Observational Study (2025)
Journal Article
Rhee, H., Macedo, E., Cutter, G., Judd, E., Parameswaran, S., Maccariello, E., Liu, W.-J., Selby, N. M., Bouchard, J., Garcia-Garcia, G., Neyra, J. A., Manjusha, Y., Abraham, J., Doi, K., Villamizar, G., Hurtado, A., & Mehta, R. L. (2025). Influence of Baseline Kidney Function on Patient and Kidney Outcomes in Patients with COVID-19: A Multi-National Observational Study. Journal of Clinical Medicine, 14(4), Article 1212. https://doi.org/10.3390/jcm14041212

Background/Objectives: Acute kidney injury (AKI) is a common complication of coronavirus disease-19 (COVID-19), but the impact of baseline kidney function and care processes on outcomes is not well understood. We hypothesized that baseline kidney hea... Read More about Influence of Baseline Kidney Function on Patient and Kidney Outcomes in Patients with COVID-19: A Multi-National Observational Study.

Digital physical activity intervention via the Kidney BEAM platform in patients with polycystic kidney disease: a randomised controlled trial (2025)
Journal Article
Briggs, J., Ralston, E., Wilkinson, T. J., Walklin, C., Mangahis, E., ML Young, H., Castle, E. M., Billany, R. E., Asgari, E., Bhandari, S., Bramham10, K., Burton, J. O., Campbell, J., Chilcot, J., Deelchand, V., Hamilton, A., Jesky, M., Kalra, P. A., McCafferty, K., Nixon, A. C., …Greenwood, S. A. (2025). Digital physical activity intervention via the Kidney BEAM platform in patients with polycystic kidney disease: a randomised controlled trial. Clinical Kidney Journal, 18(3), Article sfaf041. https://doi.org/10.1093/ckj/sfaf041

Background
In people living with polycystic kidney disease (PKD), physical inactivity may contribute to poor health-related quality of life (HRQoL). To date, no research has elucidated the impact of a PKD-specific physical activity programme on HRQo... Read More about Digital physical activity intervention via the Kidney BEAM platform in patients with polycystic kidney disease: a randomised controlled trial.

Fucoxanthin mitigates mercury-induced mitochondrial toxicity in the human ovarian granulosa cell line (2025)
Journal Article
Elmorsy, E. M., Al Doghaither, H. A., Al-Ghafari, A. B., Amer, S., Fawzy, M. S., & Toraih, E. A. (2025). Fucoxanthin mitigates mercury-induced mitochondrial toxicity in the human ovarian granulosa cell line. Reproductive Toxicology, 132, Article 108855. https://doi.org/10.1016/j.reprotox.2025.108855

Mercury (Hg) is known to be a hazardous toxin with a significant negative impact on female reproduction through mechanisms that remain unclear. The carotenoid fucoxanthin (FX) is an antioxidant with several positive effects on human health. This stud... Read More about Fucoxanthin mitigates mercury-induced mitochondrial toxicity in the human ovarian granulosa cell line.