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Sex-specific attenuation of constant light-induced memory impairment and Clock gene expression in brain in hepatic Npas2 knockout mice (2025)
Journal Article
CHRISP, R., MASTERSON, M., POPE, R., ROBERTS, C. J., COLLINS, H. M., WATSON, D. J. G., O'NEIL, D., AAGAARD, K. M., GIBSON, C. L., HEERY, D. M., & MORAN, P. M. (2025). Sex-specific attenuation of constant light-induced memory impairment and Clock gene expression in brain in hepatic Npas2 knockout mice. Scientific Reports, 15, Article 8347. https://doi.org/10.1038/s41598-025-92938-1

NPAS2 (Neuronal PAS Domain Protein 2) is a component of the core circadian clock and the coordinated activity between central brain and peripheral liver clock proteins postulated to be instrumental for linking behaviour and metabolism. We investigate... Read More about Sex-specific attenuation of constant light-induced memory impairment and Clock gene expression in brain in hepatic Npas2 knockout mice.

Programming of pluripotency and the germline co-evolved from a Nanog ancestor (2025)
Journal Article
Crowley, D., Simpson, L., Chatfield, J., Forey, T., Allegrucci, C., Sang, F., Holmes, N., Genikhovich, G., Technau, U., Cunningham, D., Silva, E., Mullin, N., Dixon, J. E., Loose, M., Alberio, R., & Johnson, A. D. (2025). Programming of pluripotency and the germline co-evolved from a Nanog ancestor. Cell Reports, 44(3), Article 115396. https://doi.org/10.1016/j.celrep.2025.115396

Francois Jacob proposed that evolutionary novelty arises through incremental tinkering with pre-existing genetic mechanisms. Vertebrate evolution was predicated on pluripotency—the ability of embryonic cells to form somatic germ-layers and primordial... Read More about Programming of pluripotency and the germline co-evolved from a Nanog ancestor.

Wearable devices for exercise prescription and physical activity monitoring in patients with various cardiovascular conditions (2025)
Journal Article
Terada, T., Hausen, M., Way, K. L., O’Neill, C. D., Marçal, I. R., Dorian, P., & Reed, J. L. (2025). Wearable devices for exercise prescription and physical activity monitoring in patients with various cardiovascular conditions. CJC Open, https://doi.org/10.1016/j.cjco.2025.02.017

As wearable technologies have become increasingly affordable, accessible, and practical, an increasing number of people with cardiovascular disease (CVD) are beginning to use consumer-grade devices. Common health and wellness metrics reported by wear... Read More about Wearable devices for exercise prescription and physical activity monitoring in patients with various cardiovascular conditions.

High fat diet induces differential age- and gender-dependent changes in neuronal function in Drosophila linked to redox stress (2025)
Journal Article
de Lange, M., Yarosh, V., Farell, K., McDonnell, C., Patil, R., Hawthorn, I., Jung, M.-M., Wenje, S., & Steinert, J. R. (2025). High fat diet induces differential age- and gender-dependent changes in neuronal function in Drosophila linked to redox stress. Behavioural Brain Research, 484, Article 115510. https://doi.org/10.1016/j.bbr.2025.115510

The prevalence of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, is steadily increasing, thus posing significant challenges to global healthcare systems. Emerging evidence suggests that dietary habits, particularly consumpti... Read More about High fat diet induces differential age- and gender-dependent changes in neuronal function in Drosophila linked to redox stress.

Enhanced localized pressure-mediated non-viral gene delivery (2025)
Journal Article
Dixon, J. E., Wellington, V., Elnima, A., Savers, A., Ferreras, B., Jalal, A. R., & Eltaher, H. M. (in press). Enhanced localized pressure-mediated non-viral gene delivery. Drug Delivery and Translational Research,

A rapid genome-proteome approach to identify rate-limiting steps in the butyrate production pathway in probiotic Clostridium butyricum, CBM588 (2025)
Journal Article
Wood, L., Omorotionmwan, B. B., Blanchard, A. M., Dowle, A., Tooth, D., Bailey, T. S., & Griffin, R. (2025). A rapid genome-proteome approach to identify rate-limiting steps in the butyrate production pathway in probiotic Clostridium butyricum, CBM588. Anaerobe, 92, Article 102940. https://doi.org/10.1016/j.anaerobe.2025.102940

Objectives: Clostridium butyricum ferments non-digested dietary fibre in the colon to produce butyric acid. Butyrate is a four-carbon, short-chain fatty acid (SCFA) which has multiple health benefits. Many microbial products of pharmaceutical or indu... Read More about A rapid genome-proteome approach to identify rate-limiting steps in the butyrate production pathway in probiotic Clostridium butyricum, CBM588.

Novel drugs approved by the EMA, the FDA and the MHRA in 2024: A year in review (2025)
Journal Article
Topouzis, S., Papapetropoulos, A., Alexander, S. P., Cortese-Krott, M., Kendall, D. A., Martemyanov, K., Mauro, C., Nagercoil, N., Panettieri, R. A., Patel, H. H., Schulz, R., Stefanska, B., Stephens, G. J., Teixeira, M. M., Vergnolle, N., Wang, X., & Ferdinandy, P. (2025). Novel drugs approved by the EMA, the FDA and the MHRA in 2024: A year in review. British Journal of Pharmacology, 182(7), 1416-1445. https://doi.org/10.1111/bph.17458

In the past year, the European Medicines Agency (EMA), the Food and Drug Administration (FDA) and the Medicines and Healthcare Products Regulatory Agency (MHRA) authorised 53 novel drugs. While the 2024 harvest is not as rich as in 2023, when 70 new... Read More about Novel drugs approved by the EMA, the FDA and the MHRA in 2024: A year in review.

The human HELQ helicase and XRN2 exoribonuclease cooperate in R-loop resolution (2025)
Journal Article
Pan, J. M., Betts, H., Cubbon, A., Bolt, E. L., Soultanas, P., & He, L. (2025). The human HELQ helicase and XRN2 exoribonuclease cooperate in R-loop resolution. Open Biology, 15(2), https://doi.org/10.1098/rsob.240112

The human HELQ helicase is a superfamily 2, 3’-5’ helicase homologous to POLQ and RNA helicases of the Ski2-like subfamily. It is involved in diverse aspects of DNA repair and is an emerging prognosis biomarker and novel drug-target for cancer therap... Read More about The human HELQ helicase and XRN2 exoribonuclease cooperate in R-loop resolution.

Acute vascular and cardiac effects of lenvatinib in mice (2025)
Journal Article
Krüger, D. N., Pannucci, P., Wesley, C. D., Neutel, C. H. G., Martinet, W., De Meyer, G. R. Y., Hill, S. J., Woolard, J., Franssen, C., & Guns, P.-J. (2025). Acute vascular and cardiac effects of lenvatinib in mice. Cardio-Oncology, 11(1), Article 14. https://doi.org/10.1186/s40959-025-00307-8

Abstract
Background Tyrosine kinase inhibitors (TKIs) targeting vascular endothelial growth factor (VEGF) receptor signalling
are used in cancer therapy to inhibit angiogenesis. Unfortunately, VEGF inhibitors are known to induce severe hypertension... Read More about Acute vascular and cardiac effects of lenvatinib in mice.

Quantitative analysis of human umbilical vein endothelial cell morphology and tubulogenesis (2025)
Journal Article
Mignone, V., Arruda, M., Kilpatrick, L., Moore, B., Woolard, J., Hill, S., & Goulding, J. (in press). Quantitative analysis of human umbilical vein endothelial cell morphology and tubulogenesis. Journal of Microscopy,

Primary human umbilical vein endothelial cells can grow as both a monolayer in culture and also as a capillary-like network making them an ideal model system in order to study vascular remodelling. Image-based analysis can allow assessment of cell mo... Read More about Quantitative analysis of human umbilical vein endothelial cell morphology and tubulogenesis.

The development of a food-group, tree classification method and its use in exploring dietary associations with Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) and other health-related outcomes in a UK Population (2025)
Journal Article
Alawadi, A. A., Vijay, A., Grove, J. I., Taylor, M. A., & Aithal, G. P. (2025). The development of a food-group, tree classification method and its use in exploring dietary associations with Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) and other health-related outcomes in a UK Population. Metabolism Open, 100351. https://doi.org/10.1016/j.metop.2025.100351

Background
Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) affects up to one in five people in the UK, with persistent overeating and a sedentary lifestyle being significant risk factors. Exploring dietary patterns at a food level i... Read More about The development of a food-group, tree classification method and its use in exploring dietary associations with Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) and other health-related outcomes in a UK Population.

Monocyte eukaryotic initiation factor 2 (EIF2) signalling differentiates 17-hydroxy-docosahexaenoic acid levels and pain (2025)
Journal Article
Gowler, P. R., Arendt-Tranholm, A., Turnbull, J., Jha, R. R., Onion, D., Kelly, T., Kouraki, A., Millns, P., Gohir, S., Franks, S., Barrett, D. A., Valdes, A. M., & Chapman, V. (2025). Monocyte eukaryotic initiation factor 2 (EIF2) signalling differentiates 17-hydroxy-docosahexaenoic acid levels and pain. iScience, 28(2), Article 111862. https://doi.org/10.1016/j.isci.2025.111862

Our goal was to probe the potential transcriptomic basis for the relationship between plasma levels of the specialized pro-resolving precursor, 17-hydroxy-docosahexaenoic acid (17-HDHA) and chronic pain. Participants with osteoarthritis (average age... Read More about Monocyte eukaryotic initiation factor 2 (EIF2) signalling differentiates 17-hydroxy-docosahexaenoic acid levels and pain.

Comparative genomics of Aspergillus nidulans and section Nidulantes (2025)
Journal Article
Theobald, S., Vesth, T., Nybo, J. L., Frisvad, J. C., Kjærbølling, I., Mondo, S., LaButti, K., Haridas, S., Riley, R., Kuo, A. A., Salamov, A. A., Pangilinan, J., Lipzen, A., Koriabine, M., Yan, M., Barry, K., Clum, A., Lyhne, E. K., Drula, E., Wiebenga, A., …Andersen, M. R. (2025). Comparative genomics of Aspergillus nidulans and section Nidulantes. Current Research in Microbial Sciences, 8, Article 100342. https://doi.org/10.1016/j.crmicr.2025.100342

Aspergillus nidulans is an important model organism for eukaryotic biology and the reference for the section Nidulantes in comparative studies. In this study, we de novo sequenced the genomes of 25 species of this section. Whole-genome phylogeny of 3... Read More about Comparative genomics of Aspergillus nidulans and section Nidulantes.

Chlorpyrifos Acts as a Positive Modulator and an Agonist of N-Methyl-d-Aspartate (NMDA) Receptors: A Novel Mechanism of Chlorpyrifos-Induced Neurotoxicity (2025)
Journal Article
Sherif, M. A., Carter, W. G., & Mellor, I. R. (2025). Chlorpyrifos Acts as a Positive Modulator and an Agonist of N-Methyl-d-Aspartate (NMDA) Receptors: A Novel Mechanism of Chlorpyrifos-Induced Neurotoxicity. Journal of Xenobiotics, 15(1), Article 12. https://doi.org/10.3390/jox15010012

Chlorpyrifos (CPF) is a broad-spectrum organophosphate insecticide. Long-term exposure to low levels of CPF is associated with neurodevelopmental and neurodegenerative disorders. The mechanisms leading to these effects are still not fully understood... Read More about Chlorpyrifos Acts as a Positive Modulator and an Agonist of N-Methyl-d-Aspartate (NMDA) Receptors: A Novel Mechanism of Chlorpyrifos-Induced Neurotoxicity.

In vivo calcium imaging reveals directional sensitivity of C-low threshold mechanoreceptors (2025)
Journal Article
Semizoglou, E., Lo Re, L., Middleton, S. J., Perez‐Sanchez, J., Tufarelli, T., Bennett, D. L., & Chisholm, K. I. (2025). In vivo calcium imaging reveals directional sensitivity of C-low threshold mechanoreceptors. Journal of Physiology, 603(4), 895-908. https://doi.org/10.1113/jp286631

C-low threshold mechanoreceptors (C-LTMRs) in animals (termed C-tactile (CT) fibres in humans) are a subgroup of C-fibre primary afferents, which innervate hairy skin and respond to low-threshold punctate indentations and brush stimuli. These afferen... Read More about In vivo calcium imaging reveals directional sensitivity of C-low threshold mechanoreceptors.

Enhancing nanopore adaptive sampling for PromethION using readfish at scale (2025)
Journal Article
Munro, R., Payne, A., Holmes, N., Moore, C., Cahyani, I., & Loose, M. (in press). Enhancing nanopore adaptive sampling for PromethION using readfish at scale. Genome Research, https://doi.org/10.1101/gr.279329.124

A unique feature of Oxford Nanopore Technologies sequencers, adaptive sampling, allows precise DNA molecule selection from sequencing libraries. Here we present enhancements to our tool, readfish, enabling all features for the industrial scale Promet... Read More about Enhancing nanopore adaptive sampling for PromethION using readfish at scale.

Deconditioning in quiescent Crohn’s Disease patients with heightened fatigue perception (2025)
Journal Article
McGing, J. J., Serres, S., Nicholas, R., Gupta, A., Radford, S. J., Nixon, A. V., Mallinson, J., Bradley, C., Bawden, S., Francis, S. T., Greenhaff, P. L., & Moran, G. W. (2025). Deconditioning in quiescent Crohn’s Disease patients with heightened fatigue perception. Journal of Crohn's and Colitis, 19(1), Article jjae194. https://doi.org/10.1093/ecco-jcc/

Background & Objective

IBD fatigue aetiology is poorly understood. This study quantified body composition and physical function alongside proton magnetic resonance imaging (1H MRI) and spectroscopy (31P MRS) measures of organ structure and functio... Read More about Deconditioning in quiescent Crohn’s Disease patients with heightened fatigue perception.

Five year mortality in an RCT of a lung cancer biomarker to select people for low dose CT screening (2025)
Journal Article
Sullivan, F. M., Mair, F. S., Anderson, W., Chew, C., Dorward, A., Haughney, J., Hogarth, F., Kendrick, D., Littleford, R., McConnachie, A., McCowan, C., McMeekin, N., Patel, M., Rauchhaus, P., Daly, F., Ritchie, L., Robertson, J., Sarvesvaran, J., Sewell, H., Taylor, T., …Schembri, S. (2025). Five year mortality in an RCT of a lung cancer biomarker to select people for low dose CT screening. PLoS ONE, 20(1), Article e0306163. https://doi.org/10.1371/journal.pone.0306163

The role of biomarkers in risk-based early detection of lung cancer may enable screening to become cost effective and widely accessible. EarlyCDT-Lung is an example of such a blood-based autoantibody biomarker which may improve accessibility to Low d... Read More about Five year mortality in an RCT of a lung cancer biomarker to select people for low dose CT screening.