All Outputs (259)

Varadia, a new helicarionoidean semi-slug genus from India's Western Ghats (Stylommatophora: Helicarionoidea) (2021)
Preprint / Working Paper
Varadia, a new helicarionoidean semi-slug genus from India's Western Ghats (Stylommatophora: Helicarionoidea)

We here describe a new Indian helicarionoidean genus, Varadia Bhosale & Raheem gen. nov., containing the single species Varadia amboliensis Bhosale, Thackeray, Muley & Raheem gen. et sp. nov. This new semi-slug is endemic to the northern and central... Read More about Varadia, a new helicarionoidean semi-slug genus from India's Western Ghats (Stylommatophora: Helicarionoidea).

Varadia, a new helicarionoidean semi-slug genus from India's Western Ghats (Stylommatophora: Helicarionoidea) (2021)
Preprint / Working Paper
Bhosale, A. R., Saadi, A. J., Wade, C. M., Thackeray, T., Tamboli, A. S., Kadam, S. K., Muley, D. V., & Raheem, D. C. (2021). Varadia, a new helicarionoidean semi-slug genus from India's Western Ghats (Stylommatophora: Helicarionoidea)

We here describe a new Indian helicarionoidean genus, Varadia Bhosale & Raheem gen. nov., containing the single species Varadia amboliensis Bhosale, Thackeray, Muley & Raheem gen. et sp. nov. This new semi-slug is endemic to the northern and central... Read More about Varadia, a new helicarionoidean semi-slug genus from India's Western Ghats (Stylommatophora: Helicarionoidea).

Governing plant-centred eating at the urban scale in the UK: The Sustainable Food Cities network and the reframing of dietary biopower (2021)
Journal Article
Morris, C., Kaljonen, M., & Hadley Kershaw, E. (2021). Governing plant-centred eating at the urban scale in the UK: The Sustainable Food Cities network and the reframing of dietary biopower. Geographical Journal, 188(3), Article 358-369. https://doi.org/10.1111/geoj.12388

Recent years have seen an increase in actions to address a key feature of food in the Anthropocene: the over-production and consumption of animal-based foods or “animalisation” of diets. However, it is unclear whether such efforts can be understood a... Read More about Governing plant-centred eating at the urban scale in the UK: The Sustainable Food Cities network and the reframing of dietary biopower.

Protein phosphatase 1 regulates atypical mitotic and meiotic division in Plasmodium sexual stages (2021)
Journal Article
Zeeshan, M., Pandey, R., Subudhi, A. K., Ferguson, D. J., Kaur, G., Rashpa, R., Nugmanova, R., Brady, D., Bottrill, A. R., Vaughan, S., Brochet, M., Bollen, M., Pain, A., Holder, A. A., Guttery, D. S., & Tewari, R. (2021). Protein phosphatase 1 regulates atypical mitotic and meiotic division in Plasmodium sexual stages. Communications Biology, 4(1), Article 760. https://doi.org/10.1038/s42003-021-02273-0

PP1 is a conserved eukaryotic serine/threonine phosphatase that regulates many aspects of mitosis and meiosis, often working in concert with other phosphatases, such as CDC14 and CDC25. The proliferative stages of the malaria parasite life cycle incl... Read More about Protein phosphatase 1 regulates atypical mitotic and meiotic division in Plasmodium sexual stages.

Fluorescent nanosensors reveal dynamic pH gradients during biofilm formation (2021)
Journal Article
Hollmann, B., Perkins, M., Chauhan, V. M., Aylott, J. W., & Hardie, K. R. (2021). Fluorescent nanosensors reveal dynamic pH gradients during biofilm formation. npj Biofilms and Microbiomes, 7(1), Article 50. https://doi.org/10.1038/s41522-021-00221-8

Understanding the dynamic environmental microniches of biofilms will permit us to detect, manage and exploit these communities. The components and architecture of biofilms have been interrogated in depth; however, little is known about the environmen... Read More about Fluorescent nanosensors reveal dynamic pH gradients during biofilm formation.

Large-scale genomic analysis reveals the genetic cost of chicken domestication (2021)
Journal Article
Wang, M. S., Zhang, J. J., Guo, X., Li, M., Meyer, R., Ashari, H., Zheng, Z. Q., Wang, S., Peng, M. S., Jiang, Y., Thakur, M., Suwannapoom, C., Esmailizadeh, A., Hirimuthugoda, N. Y., Zein, M. S. A., Kusza, S., Kharrati-Koopaee, H., Zeng, L., Wang, Y. M., Yin, T. T., …Zhang, Y. P. (2021). Large-scale genomic analysis reveals the genetic cost of chicken domestication. BMC Biology, 19(1), Article 118. https://doi.org/10.1186/s12915-021-01052-x

Background: Species domestication is generally characterized by the exploitation of high-impact mutations through processes that involve complex shifting demographics of domesticated species. These include not only inbreeding and artificial selection... Read More about Large-scale genomic analysis reveals the genetic cost of chicken domestication.

A randomized controlled trial to isolate the effects of fasting and energy restriction on weight loss and metabolic health in lean adults (2021)
Journal Article
Templeman, I., Smith, H. A., Chowdhury, E., Chen, Y. C., Carroll, H., Johnson-Bonson, D., Hengist, A., Smith, R., Creighton, J., Clayton, D., Varley, I., Karagounis, L. G., Wilhelmsen, A., Tsintzas, K., Reeves, S., Walhin, J. P., Gonzalez, J. T., Thompson, D., & Betts, J. A. (2021). A randomized controlled trial to isolate the effects of fasting and energy restriction on weight loss and metabolic health in lean adults. Science Translational Medicine, 13(598), Article 00. https://doi.org/10.1126/scitranslmed.abd8034

Intermittent fasting may impart metabolic benefits independent of energy balance by initiating fasting-mediated mechanisms. This randomized controlled trial examined 24-hour fasting with 150% energy intake on alternate days for 3 weeks in lean, healt... Read More about A randomized controlled trial to isolate the effects of fasting and energy restriction on weight loss and metabolic health in lean adults.

Meta-analysis of epigenome-wide association studies in Alzheimer's disease highlights novel differentially methylated loci across cortex (2021)
Journal Article
Shireby, G., Smith, R. G., Pishva, E., Smith, A. R., Roubroeks, J. A. Y., Hannon, E., Wheildon, G., Mastroeni, D., Gasparoni, G., Giese, A., Riemenschneider, M., Sharp, A. J., Schalkwyk, L., Haroutunian, V., Viechtbauer, W., Van Den Hove, D. L. A., Weedon, M., Brokaw, D., Francis, P. T., Thomas, A. J., …Lunnon, K. (2021). Meta-analysis of epigenome-wide association studies in Alzheimer's disease highlights novel differentially methylated loci across cortex. Nature Communications, 12, Article 3517. https://doi.org/10.1038/s41467-021-23243-4

Epigenome-wide association studies of Alzheimer’s disease have highlighted neuropathology-associated DNA methylation differences, although existing studies have been limited in sample size and utilized different brain regions. Here, we combine data f... Read More about Meta-analysis of epigenome-wide association studies in Alzheimer's disease highlights novel differentially methylated loci across cortex.

Sex and Age Differences in Anxiety and Depression Levels Before and After Aerobic Interval Training in Cardiac Rehabilitation (2021)
Journal Article
O'Neill, C. D., Vidal-Almela, S., Terada, T., Kamiya, K., Tulloch, H. E., Pipe, A. L., & Reed, J. L. (2022). Sex and Age Differences in Anxiety and Depression Levels Before and After Aerobic Interval Training in Cardiac Rehabilitation. Journal of Cardiopulmonary Rehabilitation and Prevention, 42(1), 15-21. https://doi.org/10.1097/hcr.0000000000000617

Purpose:

The objective of this study was to investigate sex and age differences in anxiety and depression among patients with cardiovascular disease at baseline and following aerobic interval training (AIT)-based cardiac rehabilitation (CR) and s... Read More about Sex and Age Differences in Anxiety and Depression Levels Before and After Aerobic Interval Training in Cardiac Rehabilitation.

Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores (2021)
Journal Article
de Rojas, I., Moreno-Grau, S., Tesi, N., Grenier-Boley, B., Andrade, V., Jansen, I. E., Pedersen, N. L., Stringa, N., Zettergren, A., Hernández, I., Montrreal, L., Antúnez, C., Antonell, A., Tankard, R. M., Bis, J. C., Sims, R., Bellenguez, C., Quintela, I., González-Perez, A., Calero, M., …PGC-ALZ consortia. (2021). Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores. Nature Communications, 12(1), Article 3417. https://doi.org/10.1038/s41467-021-22491-8

Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a l... Read More about Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores.

LINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames (2021)
Journal Article
Blythe, M. J., Kocer, A., Rubio-Roldan, A., Giles, T., Abakir, A., Ialy-Radio, C., Wheldon, L. M., Bereshchenko, O., Bruscoli, S., Kondrashov, A., Drevet, J. R., Emes, R. D., Johnson, A. D., McCarrey, J. R., Gackowski, D., Olinski, R., Cocquet, J., Garcia-Perez, J. L., & Ruzov, A. (2021). LINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames. Communications Biology, 4, Article 691. https://doi.org/10.1038/s42003-021-02217-8

Chromatin of male and female gametes undergoes a number of reprogramming events during the transition from germ cell to embryonic developmental programs. Although the rearrangement of DNA methylation patterns occurring in the zygote has been extensiv... Read More about LINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames.

Biogeographic distribution of three phylotypes (T1, T2 and T6) of ammonia (foraminifera, Rhizaria) around Great Britain: new insights from combined molecular and morphological recognition (2021)
Journal Article
Richirt, J., Schweizer, M., Mouret, A., Quinchard, S., Saad, S. A., Bouchet, V. M. P., Wade, C. M., & Jorissen, F. J. (2021). Biogeographic distribution of three phylotypes (T1, T2 and T6) of ammonia (foraminifera, Rhizaria) around Great Britain: new insights from combined molecular and morphological recognition. Journal of Micropalaeontology, 40(1), 61-74. https://doi.org/10.5194/jm-40-61-2021

Ammonia is one of the most widespread foraminiferal genera worldwide. Three phylotypes (Ammonia sp. T1, T2 and T6), commonly encountered in the northeast Atlantic, are usually associated with the morphospecies Ammonia tepida. The biogeographic distri... Read More about Biogeographic distribution of three phylotypes (T1, T2 and T6) of ammonia (foraminifera, Rhizaria) around Great Britain: new insights from combined molecular and morphological recognition.

Modification of small ubiquitin-related modifier 2 (SUMO2) by phosphoubiquitin in HEK293T cells (2021)
Journal Article
Dongdem, J. T., Dawson, S. P., & Layfield, R. (2021). Modification of small ubiquitin-related modifier 2 (SUMO2) by phosphoubiquitin in HEK293T cells. Proteomics, 21(15), Article 2000234. https://doi.org/10.1002/pmic.202000234

Additional complexity in the post-translational modification of proteins by ubiquitin is achieved by ubiquitin phosphorylation, for example within PINK1-parkin mediated mitophagy. We performed a preliminary proteomic analysis to identify proteins dif... Read More about Modification of small ubiquitin-related modifier 2 (SUMO2) by phosphoubiquitin in HEK293T cells.

Dopaminergic neuromodulation of prefrontal cortex activity requires the NMDA receptor coagonist D-serine (2021)
Journal Article
Dallérac, G., Li, X., Lecouflet, P., Morisot, N., Sacchi, S., Asselot, R., Pham, T. H., Potier, B., Watson, D. J. G., Schmidt, S., Levasseur, G., Fossat, P., Besedin, A., Rivet, J. M., Coyle, J. T., Collo, G., Pollegioni, L., Kehr, J., Galante, M., Fone, K. C., …Mothet, J. P. (2021). Dopaminergic neuromodulation of prefrontal cortex activity requires the NMDA receptor coagonist D-serine. Proceedings of the National Academy of Sciences, 118(23), Article e2023750118. https://doi.org/10.1073/pnas.2023750118

Prefrontal control of cognitive functions critically depends upon glutamatergic transmission and N-methyl D-aspartate (NMDA) receptors, the activity of which is regulated by dopamine. Yet whether the NMDA receptor coagonist D-serine is implicated in... Read More about Dopaminergic neuromodulation of prefrontal cortex activity requires the NMDA receptor coagonist D-serine.

Whole blood-based measurement of SARS-CoV-2-specific T cell responses reveals asymptomatic infection and vaccine efficacy in healthy subjects and patients with solid organ cancers (2021)
Preprint / Working Paper
Scurr, M. J., Zelek, W. M., Lippiatt, G., Somerville, M., Burnell, S. E. A., Capitani, L., Davies, K., Lawton, H., Tozer, T., Rees, T., Roberts, K., Evans, M., Jackson, A., Young, C., Fairclough, L., Wills, M., Westwell, A. D., Morgan, B. P., Gallimore, A., & Godkin, A. Whole blood-based measurement of SARS-CoV-2-specific T cell responses reveals asymptomatic infection and vaccine efficacy in healthy subjects and patients with solid organ cancers

Accurate assessment of SARS-CoV-2 immunity in the population is critical to evaluating vaccine efficacy and devising public health policies. Whilst the exact nature of effective immunity remains incompletely defined, SARS-CoV-2-specific T cell respon... Read More about Whole blood-based measurement of SARS-CoV-2-specific T cell responses reveals asymptomatic infection and vaccine efficacy in healthy subjects and patients with solid organ cancers.

p62 overexpression induces TDP-43 cytoplasmic mislocalisation, aggregation and cleavage and neuronal death (2021)
Journal Article
Foster, A. D., Flynn, L. L., Cluning, C., Cheng, F., Davidson, J. M., Lee, A., Polain, N., Mejzini, R., Farrawell, N., Yerbury, J. J., Layfield, R., Akkari, P. A., & Rea, S. L. (2021). p62 overexpression induces TDP-43 cytoplasmic mislocalisation, aggregation and cleavage and neuronal death. Scientific Reports, 11(1), Article 11474. https://doi.org/10.1038/s41598-021-90822-2

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) that exist on a spectrum of neurodegenerative disease. A hallmark of pathology is cytoplasmic TDP-43 aggregates within neurons, observed in 97% of ALS cases and ~ 50% of... Read More about p62 overexpression induces TDP-43 cytoplasmic mislocalisation, aggregation and cleavage and neuronal death.

A High-Protein, Low Glycemic Index Diet Suppresses Hunger but Not Weight Regain After Weight Loss: Results From a Large, 3-Years Randomized Trial (PREVIEW) (2021)
Journal Article
Zhu, R., Fogelholm, M., Larsen, T. M., Poppitt, S. D., Silvestre, M. P., Vestentoft, P. S., Jalo, E., Navas-Carretero, S., Huttunen-Lenz, M., Taylor, M. A., Stratton, G., Swindell, N., Kaartinen, N. E., Lam, T., Handjieva-Darlenska, T., Handjiev, S., Schlicht, W., Martinez, J. A., Seimon, R. V., Sainsbury, A., …Raben, A. (2021). A High-Protein, Low Glycemic Index Diet Suppresses Hunger but Not Weight Regain After Weight Loss: Results From a Large, 3-Years Randomized Trial (PREVIEW). Frontiers in Nutrition, 8, https://doi.org/10.3389/fnut.2021.685648

Background: Previous studies have shown an increase in hunger during weight-loss maintenance (WLM) after diet-induced weight loss. Whether a combination of a higher protein, lower glycemic index (GI) diet and physical activity (PA) can counteract thi... Read More about A High-Protein, Low Glycemic Index Diet Suppresses Hunger but Not Weight Regain After Weight Loss: Results From a Large, 3-Years Randomized Trial (PREVIEW).

Erratum: “Human lung-on-chips: Advanced systems for respiratory virus models and assessment of immune response” [Biomicrofluidics 15, 021501 (2021)] (2021)
Journal Article
Saygili, E., Yildiz-Ozturk, E., Green, M. J., Ghaemmaghami, A. M., & Yesil-Celiktas, O. (2021). Erratum: “Human lung-on-chips: Advanced systems for respiratory virus models and assessment of immune response” [Biomicrofluidics 15, 021501 (2021)]. Biomicrofluidics, 15(3), Article 039901. https://doi.org/10.1063/5.0056623

It has been drawn to the authors’ attention that our original article1 did not appropriately attribute portions of a figure that we had reused from Ref. 2. The figure caption as it should have appeared follows. FIG. 2. (a) Schematic depicting human l... Read More about Erratum: “Human lung-on-chips: Advanced systems for respiratory virus models and assessment of immune response” [Biomicrofluidics 15, 021501 (2021)].

Domestic chicken diversity: Origin, distribution, and adaptation (2021)
Journal Article
Lawal, R. A., & Hanotte, O. (2021). Domestic chicken diversity: Origin, distribution, and adaptation. Animal Genetics, 52(4), 385-394. https://doi.org/10.1111/age.13091

Chicken is the most numerous among the domesticated livestock species. Across cultures, religions, and societies, chicken is widely accepted with little or no taboo compared to other domestic animals. Its adaptability to diverse environmental conditi... Read More about Domestic chicken diversity: Origin, distribution, and adaptation.

The physiological impact of high‐intensity interval training in octogenarians with comorbidities (2021)
Journal Article
Blackwell, J. E., Gharahdaghi, N., Brook, M. S., Watanabe, S., Boereboom, C. L., Doleman, B., Lund, J. N., Wilkinson, D. J., Smith, K., Atherton, P. J., Williams, J. P., & Phillips, B. E. (2021). The physiological impact of high‐intensity interval training in octogenarians with comorbidities. Journal of Cachexia, Sarcopenia and Muscle, 12(4), 866-879. https://doi.org/10.1002/jcsm.12724

Background
Declines in cardiorespiratory fitness (CRF) and fat-free mass (FFM) with age are linked to mortality, morbidity and poor quality of life. High-intensity interval training (HIIT) has been shown to improve CRF and FFM in many groups, but it... Read More about The physiological impact of high‐intensity interval training in octogenarians with comorbidities.