All Outputs (315)

Exploratory factor analysis and Rasch analysis to assess the structural validity of the Adult Social Care Outcomes Toolkit Proxy version (ASCOT-Proxy) completed by care home staff (2024)
Journal Article
Rand, S., Towers, A.-M., Allan, S., Webster, L., Palmer, S., Carroll, R., Gordon, A., Akdur, G., & Goodman, C. (2024). Exploratory factor analysis and Rasch analysis to assess the structural validity of the Adult Social Care Outcomes Toolkit Proxy version (ASCOT-Proxy) completed by care home staff. Quality of Life Research, 33, 1555-1567. https://doi.org/10.1007/s11136-024-03631-1

Purpose.

Rasch analysis and exploratory factor analysis (EFA) were used to evaluate the structural validity of the ASCOT-Proxy measures completed by staff on behalf of older adults resident in care homes, by comparison to the ASCOT-SCT4, the meas... Read More about Exploratory factor analysis and Rasch analysis to assess the structural validity of the Adult Social Care Outcomes Toolkit Proxy version (ASCOT-Proxy) completed by care home staff.

Associations between zinc deficiency, taste changes and salivary flow rate following gastric bypass and sleeve gastrectomy surgeries (2024)
Journal Article
Mozaffar, B., Mozaffar, H., Alkharaiji, M., Elbahrawy, A., & Idris, I. (2024). Associations between zinc deficiency, taste changes and salivary flow rate following gastric bypass and sleeve gastrectomy surgeries. Journal of Nutrition and Metabolism, 2024, Article 1197571. https://doi.org/10.1155/2024/1197571

Background. The prevalence of taste change (hypogeusia) and its association with zinc deficiency is unclear due to differences in methods of assessment. We investigate the prevalence of hypogeusia using mixed methods and link it with changes in zinc... Read More about Associations between zinc deficiency, taste changes and salivary flow rate following gastric bypass and sleeve gastrectomy surgeries.

Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases (2024)
Journal Article
Fuller, A., Hancox, J., Williams, H. C., Card, T., Taal, M. W., Aithal, G. P., Fox, C. P., Mallen, C. D., Maxwell, J. R., Bingham, S., Vedhara, K., & Abhishek, A. (2025). Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases. Rheumatology, 64(3), 969-975. https://doi.org/10.1093/rheumatology/keae175

Objective
To explore the acceptability of an individualized risk-stratified approach to monitoring for target-organ toxicity in adult patients with immune-mediated inflammatory diseases established on immune-suppressing treatment(s).

Methods
Ad... Read More about Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases.

Uptake and safety of pneumococcal vaccination in adults with immune-mediated inflammatory diseases: a UK wide observational study (2024)
Journal Article
Nakafero, G., Grainge, M. J., Card, T., Mallen, C. D., Nguyen Van-Tam, J. S., Abhishek, A., & . (2025). Uptake and safety of pneumococcal vaccination in adults with immune-mediated inflammatory diseases: a UK wide observational study. Rheumatology, 64(3), 962-968. https://doi.org/10.1093/rheumatology/keae160

Objective The uptake and safety of pneumococcal vaccination in people with immune mediated inflammatory diseases (IMIDs) is poorly understood. We investigated the UK wide pneumococcal vaccine uptake in adults with IMIDs and explored the association b... Read More about Uptake and safety of pneumococcal vaccination in adults with immune-mediated inflammatory diseases: a UK wide observational study.

Getting the message across: a realist study of the role of communication and information exchange processes in delivering Stroke Early Supported Discharge services in England (2024)
Journal Article
Chouliara, N., Cameron, T., Byrne, A., & Fisher, R. (2024). Getting the message across: a realist study of the role of communication and information exchange processes in delivering Stroke Early Supported Discharge services in England. PLoS ONE, 19(3), Article e0298140. https://doi.org/10.1371/journal.pone.0298140

Background
Stroke early supported discharge (ESD) involves the co-ordinated transfer of care from hospital to home. The quality of communication processes between professionals delivering ESD and external stakeholders may have a role to play in stre... Read More about Getting the message across: a realist study of the role of communication and information exchange processes in delivering Stroke Early Supported Discharge services in England.

Getting the message across; a realist study of the role of communication and information exchange processes in delivering stroke Early Supported Discharge services in England (2024)
Journal Article
Chouliara, N., Cameron, T., Byrne, A., & Fisher, R. (2024). Getting the message across; a realist study of the role of communication and information exchange processes in delivering stroke Early Supported Discharge services in England. PLoS ONE, 19(3), Article e0298140. https://doi.org/10.1371/journal.pone.0298140

Background: Stroke early supported discharge (ESD) involves the co-ordinated transfer of care from hospital to home. The quality of communication processes between professionals delivering ESD and external stakeholders may have a role to play in stre... Read More about Getting the message across; a realist study of the role of communication and information exchange processes in delivering stroke Early Supported Discharge services in England.

Development of a Job Retention Vocational Rehabilitation Intervention for People with Multiple Sclerosis Following the Person-Based Approach (2024)
Journal Article
De Dios Pérez, B., das Nair, R., & Radford, K. (2024). Development of a Job Retention Vocational Rehabilitation Intervention for People with Multiple Sclerosis Following the Person-Based Approach. Clinical Rehabilitation, 38(7), 965-978. https://doi.org/10.1177/02692155241235956

Objective
To describe the process of developing a job retention vocational rehabilitation intervention for people with multiple sclerosis.

Design
We used the person-based approach, to develop interventions through an iterative process incorporat... Read More about Development of a Job Retention Vocational Rehabilitation Intervention for People with Multiple Sclerosis Following the Person-Based Approach.

The Effect of Acute Knee Injuries and Related Knee Surgery on Serum Levels of Pro- and Anti-inflammatory Lipid Mediators and Their Associations With Knee Symptoms. (2024)
Journal Article
Turnbull, J., Jha, R. R., Barrett, D. A., Valdes, A. M., Alderson, J., Williams, A., Vincent, T. L., Watt, F. E., & Chapman, V. (2024). The Effect of Acute Knee Injuries and Related Knee Surgery on Serum Levels of Pro- and Anti-inflammatory Lipid Mediators and Their Associations With Knee Symptoms. American Journal of Sports Medicine, 52(4), 987-997. https://doi.org/10.1177/03635465241228209

Despite an acute knee injury being a major risk factor for osteoarthritis, the factors that initiate and maintain this risk of longer-term knee symptoms are poorly understood. Bioactive lipids derived from omega-3 and -6 polyunsaturated fatty acids h... Read More about The Effect of Acute Knee Injuries and Related Knee Surgery on Serum Levels of Pro- and Anti-inflammatory Lipid Mediators and Their Associations With Knee Symptoms..

Understanding barriers and facilitators to long-term participation needs in children and young people following acquired brain injuries: a qualitative multi-stakeholder study (2024)
Journal Article
Keetley, R., Manning, J. C., Williams, J., Bennett, E., Westlake, M., & Radford, K. (2024). Understanding barriers and facilitators to long-term participation needs in children and young people following acquired brain injuries: a qualitative multi-stakeholder study. Brain Impairment, 25(1), Article IB23100. https://doi.org/10.1071/IB23100

Background This study focused on exploring the longer-term participation needs of children and young people with acquired brain injury (CYP-ABI) and their families in one region of the UK and identifying the barriers and facilitators of their partici... Read More about Understanding barriers and facilitators to long-term participation needs in children and young people following acquired brain injuries: a qualitative multi-stakeholder study.

The association of painful and non-painful morbidities with frailty: a cross sectional analysis of a cohort of community dwelling older people in England (2024)
Journal Article
Chaplin, W. J., Lewis, H. R., Shahtaheri, S. M., Millar, B. S., McWilliams, D. F., Gladman, J. R. F., & Walsh, D. A. (2024). The association of painful and non-painful morbidities with frailty: a cross sectional analysis of a cohort of community dwelling older people in England. BMC Geriatrics, 24, Article 158. https://doi.org/10.1186/s12877-023-04602-w

Introduction
The association between chronic pain and frailty might indicate that pain is an independent driver of frailty but might alternatively be explained by inclusion within frailty identification tools of morbidities that commonly lead to chr... Read More about The association of painful and non-painful morbidities with frailty: a cross sectional analysis of a cohort of community dwelling older people in England.

Melatonin is a potential novel analgesic agent for osteoarthritis: Evidence from cohort studies in humans and preclinical research in rats (2024)
Journal Article
Li, H., Zhou, B., Wu, J., Zhang, Y., Zhang, W., Doherty, M., Deng, X., Wang, N., Xie, D., Wang, Y., Xie, H., Li, C., Wei, J., Lei, G., & Zeng, C. (2024). Melatonin is a potential novel analgesic agent for osteoarthritis: Evidence from cohort studies in humans and preclinical research in rats. Journal of Pineal Research, 76(2), Article e12945. https://doi.org/10.1111/jpi.12945

Melatonin exhibits potential for pain relief and long-term safety profile. We examined the analgesic effects of oral melatonin on osteoarthritis (OA) and investigated the underlying mechanism. Using data from a UK primary care database, we conducted... Read More about Melatonin is a potential novel analgesic agent for osteoarthritis: Evidence from cohort studies in humans and preclinical research in rats.

Bed‐rest and exercise remobilization: Concurrent adaptations in muscle glucose and protein metabolism (2024)
Journal Article
Shur, N. F., Simpson, E. J., Crossland, H., Constantin, D., Cordon, S. M., Constantin-Teodosiu, D., Stephens, F. B., Brook, M. S., Atherton, P. J., Smith, K., Wilkinson, D. J., Mougin, O. E., Bradley, C., Macdonald, I. A., & Greenhaff, P. L. (2024). Bed‐rest and exercise remobilization: Concurrent adaptations in muscle glucose and protein metabolism. Journal of Cachexia, Sarcopenia and Muscle, 15(2), 603-614. https://doi.org/10.1002/jcsm.13431

Background
Bed-rest (BR) of only a few days duration reduces muscle protein synthesis and induces skeletal muscle atrophy and insulin resistance, but the scale and juxtaposition of these events have not been investigated concurrently in the same ind... Read More about Bed‐rest and exercise remobilization: Concurrent adaptations in muscle glucose and protein metabolism.

Effects of colour-coded compartmentalised syringe trays on anaesthetic drug error detection under cognitive load (2024)
Journal Article
Laxton, V., Maratos, F. A., Hewson, D. W., Baird, A., Archer, S., & Stupple, E. J. N. (2024). Effects of colour-coded compartmentalised syringe trays on anaesthetic drug error detection under cognitive load. British Journal of Anaesthesia, 132(5), 911-917. https://doi.org/10.1016/j.bja.2023.12.033

Background
Anaesthetic drug administration is complex, and typical clinical environments can entail significant cognitive load. Colour-coded anaesthetic drug trays have shown promising results for error identification and reducing cognitive load.... Read More about Effects of colour-coded compartmentalised syringe trays on anaesthetic drug error detection under cognitive load.

Peer mentoring for people with acquired brain injury – a systematic review (2024)
Journal Article
De Dios Perez, B., Morris, R. P., Craven, K., & Radford, K. A. (2024). Peer mentoring for people with acquired brain injury – a systematic review. Brain Injury, 38(4), 316-329. https://doi.org/10.1080/02699052.2024.2310779

Introduction: Over 100 million people worldwide live with disabilities resulting from an acquired brain injury (ABI). ABI survivors experience cognitive and physical problems and require support to resume an active life. They can benefit from support... Read More about Peer mentoring for people with acquired brain injury – a systematic review.

2023 EULAR recommendations on imaging in diagnosis and management of crystal-induced arthropathies in clinical practice (2024)
Journal Article
Mandl, P., D'Agostino, M. A., Navarro-Compán, V., Geßl, I., Sakellariou, G., Abhishek, A., Becce, F., Dalbeth, N., Ea, H.-K., Filippucci, E., Hammer, H. B., Iagnocco, A., de Thurah, A., Naredo, E., Ottaviani, S., Pascart, T., Pérez-Ruiz, F., Pitsillidou, I. A., Proft, F., Rech, J., …Filippou, G. (2024). 2023 EULAR recommendations on imaging in diagnosis and management of crystal-induced arthropathies in clinical practice. Annals of the Rheumatic Diseases, 83, 752-759. https://doi.org/10.1136/ard-2023-224771

Objective: To formulate evidence-based recommendations and overarching principles on the use of imaging in the clinical management of crystal-induced arthropathies (CiAs). Methods: An international task force of 25 rheumatologists, radiologists, meth... Read More about 2023 EULAR recommendations on imaging in diagnosis and management of crystal-induced arthropathies in clinical practice.

Bacteriophages, gut bacteria, and microbial pathways interplay in cardiometabolic health (2024)
Journal Article
Kirk, D., Costeira, R., Visconti, A., Khan Mirzaei, M., Deng, L., Valdes, A. M., & Menni, C. (2024). Bacteriophages, gut bacteria, and microbial pathways interplay in cardiometabolic health. Cell Reports, 43(2), Article 113728. https://doi.org/10.1016/j.celrep.2024.113728

Cardiometabolic diseases are leading causes of mortality in Western countries. Well-established risk factors include host genetics, lifestyle, diet, and the gut microbiome. Moreover, gut bacterial communities and their activities can be altered by ba... Read More about Bacteriophages, gut bacteria, and microbial pathways interplay in cardiometabolic health.

Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation (2024)
Journal Article
Abhishek, A., Grainge, M., Card, T., Williams, H. C., Taal, M. W., Aithal, G. P., Fox, C. P., Mallen, C. D., Stevenson, M. D., Nakafero, G., & Riley, R. (2024). Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation. RMD Open, 10(1), Article e003980. https://doi.org/10.1136/rmdopen-2023-003980

Background Sulfasalazine-induced cytopenia, nephrotoxicity and hepatotoxicity is uncommon during long-term treatment. Some guidelines recommend 3 monthly monitoring blood tests indefinitely during long-term treatment while others recommend stopping m... Read More about Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation.

Using healthcare systems data for outcomes in clinical trials: issues to consider at the design stage (2024)
Journal Article
Toader, A.-M., Campbell, M. K., Quint, J. K., Robling, M., Sydes, M. R., Thorn, J., Wright-Hughes, A., Yu, L.-M., Abbott, T. E. F., Bond, S., Caskey, F. J., Clout, M., Collinson, M., Copsey, B., Davies, G., Driscoll, T., Gamble, C., Griffin, X. L., Hamborg, T., Harris, J., …Williamson, P. (2024). Using healthcare systems data for outcomes in clinical trials: issues to consider at the design stage. Trials, 25(1), Article 94. https://doi.org/10.1186/s13063-024-07926-z

Background: Healthcare system data (HSD) are increasingly used in clinical trials, augmenting or replacing traditional methods of collecting outcome data. This study, PRIMORANT, set out to identify, in the UK context, issues to be considered before t... Read More about Using healthcare systems data for outcomes in clinical trials: issues to consider at the design stage.

Sodium-glucose cotransporter-2 inhibitors (SGLT2) in frail or older people with type 2 diabetes and heart failure: a systematic review and meta-analysis (2024)
Journal Article
Aldafas, R., Crabtree, T., Alkharaiji, M., Vinogradova, Y., & Idris, I. (2024). Sodium-glucose cotransporter-2 inhibitors (SGLT2) in frail or older people with type 2 diabetes and heart failure: a systematic review and meta-analysis. Age and Ageing, 53(1), Article afad254. https://doi.org/10.1093/ageing/afad254

Objective: Sodium-glucose cotransporter-2 inhibitors (SGLT2Is) reduce cardio-metabolic and renal outcomes in patients with type 2 diabetes (T2D) but their efficacy and safety in older or frail individuals remains unclear. Methods: We searched PubMed,... Read More about Sodium-glucose cotransporter-2 inhibitors (SGLT2) in frail or older people with type 2 diabetes and heart failure: a systematic review and meta-analysis.

Feasibility of delivering a randomized controlled trial of weighted blanket intervention to help agitation and disturbed sleep after brain injury (2024)
Journal Article
Edwards, L. (2024). Feasibility of delivering a randomized controlled trial of weighted blanket intervention to help agitation and disturbed sleep after brain injury. Frontiers in Sleep, 3, Article 1325175. https://doi.org/10.3389/frsle.2024.1325175

Sleep disturbance and agitation are common after acquired brain injury (ABI). Weighted blankets may help these symptoms in other conditions, but have not been trialed in ABI. We aimed to determine acceptability and feasibility of weighted blankets to... Read More about Feasibility of delivering a randomized controlled trial of weighted blanket intervention to help agitation and disturbed sleep after brain injury.