All Outputs (42)

Competencies for Advanced Clinical Practice (ACP) Hand Therapists in First-Line Management of Closed Hand Fractures: Results of a United-Kingdom (UK) Stakeholder Consensus Study (2025)
Journal Article
Fournier, K., Li, L., Newington, L., Karantana, A., Bourke, G., Trickett, R., & Kennedy, D. (2025). Competencies for Advanced Clinical Practice (ACP) Hand Therapists in First-Line Management of Closed Hand Fractures: Results of a United-Kingdom (UK) Stakeholder Consensus Study. Hand Therapy, https://doi.org/10.1177/17589983251345406

Introduction
In the United Kingdom [UK], Advanced Clinical Practice (ACP) roles are being developed to improve access to high-quality patient care, where healthcare services are struggling to meet steadily increasing service demands. Increasingly, A... Read More about Competencies for Advanced Clinical Practice (ACP) Hand Therapists in First-Line Management of Closed Hand Fractures: Results of a United-Kingdom (UK) Stakeholder Consensus Study.

Negotiating Critical Tensions: Creating an Online Resource on Vaccine Hesitancy for Healthcare Professionals (2025)
Journal Article
Emerson, T., & Hobson-West, P. (in press). Negotiating Critical Tensions: Creating an Online Resource on Vaccine Hesitancy for Healthcare Professionals. Sociological Research Online,

Vaccine hesitancy is regarded as a priority for public health and has a long history of social science research. As part of a qualitative project on childhood vaccine hesitancy, a team of social scientists translated their empirical findings into an... Read More about Negotiating Critical Tensions: Creating an Online Resource on Vaccine Hesitancy for Healthcare Professionals.

The Legacy Effect of Early HbA1c Control on Microvascular Complications and Hospital Admissions in Type 2 Diabetes: 2 Findings from a Large UK Study (2025)
Journal Article
Aldafas, R., Vinogradova, Y., Crabtree, T. S. J., Gordon, J., & Idris, . I. (in press). The Legacy Effect of Early HbA1c Control on Microvascular Complications and Hospital Admissions in Type 2 Diabetes: 2 Findings from a Large UK Study. Therapeutic Advances in Endocrinology and Metabolism,

Introduction
There is conflicting evidence regarding optimal glycaemic targets to reflect the legacy effect of hyperglycaemia in people with type 2 diabetes (T2D). We examined the risks of microvascular complications and hospital admission with HbA... Read More about The Legacy Effect of Early HbA1c Control on Microvascular Complications and Hospital Admissions in Type 2 Diabetes: 2 Findings from a Large UK Study.

Healthcare Utilisation and Costs in Adults with Type 2 Diabetes Treated with First- or Second-Generation Basal Insulins in England (2025)
Journal Article
Holden, N., Diribe, O., Palmer, K., Puttanna, A., Mahieu, A., Nicholls, C., Li Marston, X., Denholm, N., Saberi Hosnijeh, F., & Idris, I. (2025). Healthcare Utilisation and Costs in Adults with Type 2 Diabetes Treated with First- or Second-Generation Basal Insulins in England. BMJ Open Diabetes Research and Care, 13(3), Article e005027. https://doi.org/10.1136/bmjdrc-2025-005027

Introduction: The prevalence of people with type 2 diabetes (T2D) on basal insulin (BI) is rising to improve glucose control and minimize minimise complications. However, limited evidence exists regarding the economic impact of second-generation BI a... Read More about Healthcare Utilisation and Costs in Adults with Type 2 Diabetes Treated with First- or Second-Generation Basal Insulins in England.

Developing a core outcome set for hand flexor tendon injuries: a systematic review of treatment outcomes (2025)
Journal Article
Deshmukh, S. R., Jerosch-Herold, C., Miller, . L., Fuller, A., See, A., Leighton, P., & Karantana, A. (2025). Developing a core outcome set for hand flexor tendon injuries: a systematic review of treatment outcomes. Journal of Hand Surgery (European Volume), https://doi.org/10.1177/17531934251342732

This study identifies the outcome domains used in recently published studies on the treatment of hand flexor tendon injuries in adults in order to inform the development of a core outcome set. Seven databases were searched from January 2013 to March... Read More about Developing a core outcome set for hand flexor tendon injuries: a systematic review of treatment outcomes.

Experiences and knowledge of nurses, occupational therapists, pharmacists and physiotherapists about certifying fit notes: a UK-wide survey (2025)
Journal Article
Kettlewell, J., Trusson, D., Powers, K., Drummond, A., Anderson, C., Phillips, G., Holmes, J., Radford, K., Pahl, N., Martin, S., Timmons, S., & Kendrick, D. (2025). Experiences and knowledge of nurses, occupational therapists, pharmacists and physiotherapists about certifying fit notes: a UK-wide survey. BMJ Open, 15(5), Article e092211. https://doi.org/10.1136/bmjopen-2024-092211

Objective To identify facilitators and barriers to fit note certification among nurses, occupational therapists, pharmacists and physiotherapists (NOPPs), and identify ongoing training needs.

Design An online survey informed by the Theoretical Dom... Read More about Experiences and knowledge of nurses, occupational therapists, pharmacists and physiotherapists about certifying fit notes: a UK-wide survey.

Bilateral neuromuscular adaptation to acute unilateral resistance exercise in healthy older adults (2025)
Journal Article
Gamage, N. N., Altheyab, A., Guo, Y., Phillips, B. E., Opie, G. M., Semmler, J. G., Atherton, P., & Piasecki, M. (2025). Bilateral neuromuscular adaptation to acute unilateral resistance exercise in healthy older adults. GeroScience, https://doi.org/10.1007/s11357-025-01693-8

Resistance exercise (RE) enhances functionality in older adults and has proven effective as a means of cross-education in scenarios of unilateral disuse. However, the extent to which older adults demonstrate cross-limb transfer at the motor unit (MU)... Read More about Bilateral neuromuscular adaptation to acute unilateral resistance exercise in healthy older adults.

Significant Heterogeneity in Pooled Patient Acceptable Symptom State (PASS) Threshold for Shoulder Pain: A Systematic Review and Meta-Analysis (2025)
Journal Article
Ozkutlu, O., Erekdag, A., Sirvan Tongar, S., Namlı Seker, A., Georgopoulos, V., & Celik, D. (2025). Significant Heterogeneity in Pooled Patient Acceptable Symptom State (PASS) Threshold for Shoulder Pain: A Systematic Review and Meta-Analysis. Arthroscopy: The Journal of Arthroscopy and Related Surgery, https://doi.org/10.1016/j.arthro.2025.04.050

Purpose
To identify studies reporting patient acceptable symptom state (PASS) thresholds in diverse shoulder pain populations and to investigate whether patient-reported outcome measurements measuring shoulder pain severity provide similar estimates... Read More about Significant Heterogeneity in Pooled Patient Acceptable Symptom State (PASS) Threshold for Shoulder Pain: A Systematic Review and Meta-Analysis.

Student perceptions of novel and traditional anatomy teaching tools in sport and exercise science (2025)
Journal Article
Noel-Barker, N. L., Billeter-Clark, R., Kluzek, S., Harlow, P., & Jacques, M. F. (2025). Student perceptions of novel and traditional anatomy teaching tools in sport and exercise science. Annals of Anatomy, 29(3), 401-412. https://doi.org/10.52083/GAMY1767

Anatomy teaching is considered a cornerstone of Sport and Exercise Science programmes, however has a wide array of teaching tools to consider. The present study has compared student perceptions of traditional anatomy teaching tools (cadaveric prosect... Read More about Student perceptions of novel and traditional anatomy teaching tools in sport and exercise science.

Central aspects of pain associated with physical activity: results from the Investigating Musculoskeletal Health and Wellbeing cohort (2025)
Journal Article
Smith, S., Habib, M., Chaplin, W., Millar, B., McWilliams, D., & Walsh, D. (2025). Central aspects of pain associated with physical activity: results from the Investigating Musculoskeletal Health and Wellbeing cohort. PAIN Reports, 10(3), Article e1268. https://doi.org/10.1097/PR9.0000000000001268

Background:
Knee pain reduces activity, while inactivity can increase pain. The central nervous system modulates both pain and activity. The 8-item Central Aspects of Pain (CAP) questionnaire measures self-reported symptoms associated with current a... Read More about Central aspects of pain associated with physical activity: results from the Investigating Musculoskeletal Health and Wellbeing cohort.

Temporary 2-week suspension of methotrexate treatment to enhance COVID-19 vaccine response in people with immune-mediated inflammatory diseases: the VROOM RCT (2025)
Journal Article
Abhishek, A., Peckham, N., Pade, C., Gibbons, J. M., Cureton, L., Reynolds, C. J., Francis, A., Barber, V., Williams, J., Appelbe, D., Eldridge, L., Julier, P., Altmann, D. M., Bluett, J., Brooks, T., Coates, L. C., Rombach, I., Semper, A., Otter, A., Valdes, A. M., …Cook, J. A. (2025). Temporary 2-week suspension of methotrexate treatment to enhance COVID-19 vaccine response in people with immune-mediated inflammatory diseases: the VROOM RCT. Efficacy and Mechanism Evaluation, 1-42. https://doi.org/10.3310/kytk6537

Objective
Methotrexate is first-line treatment for many immune-mediated inflammatory diseases. However, it inhibits vaccine-induced immunity – a major concern for this vulnerable group of patients. We evaluated if a 2-week interruption of methotrexa... Read More about Temporary 2-week suspension of methotrexate treatment to enhance COVID-19 vaccine response in people with immune-mediated inflammatory diseases: the VROOM RCT.

Theta-gamma transcranial alternating current stimulation enhances ballistic motor performance in healthy young and older adults (2025)
Journal Article
Gamage, N. N., Liao, W.-Y., Hand, B. J., Atherton, P. J., Piasecki, M., Opie, G. M., & Semmler, J. G. (2025). Theta-gamma transcranial alternating current stimulation enhances ballistic motor performance in healthy young and older adults. Neurobiology of Aging, 152, 1-12. https://doi.org/10.1101/2024.10.02.616370

Theta-gamma transcranial alternating current stimulation (TG tACS) over primary motor cortex (M1) can improve ballistic motor performance in young adults, but the effect on older adults is unknown. This study investigated the effects of TG tACS on mo... Read More about Theta-gamma transcranial alternating current stimulation enhances ballistic motor performance in healthy young and older adults.

Minimum Important Change for the Patient Evaluation Measure in patients with finger fractures and joint injuries (2025)
Journal Article
Mousoulis, C., Trickett, R. W., Thomas, K. S., Leighton, P., & Karantana, A. (2025). Minimum Important Change for the Patient Evaluation Measure in patients with finger fractures and joint injuries. Journal of Hand Surgery (European Volume), https://doi.org/10.1177/17531934251331727

The Minimum Important Change of the Patient Evaluation Measure for patients recovering from a finger fracture or joint injury was estimated to aid the design of future trials. Data from the Patient Outcomes for Finger Fractures and Joint Injuries pro... Read More about Minimum Important Change for the Patient Evaluation Measure in patients with finger fractures and joint injuries.

Key Outcomes for a Vocational Rehabilitation Intervention for People With Multiple Sclerosis: A Nominal Group Technique Study (2025)
Journal Article
De Dios Perez, B., Senior, C., Das Nair, R., Kendrick, D., Evangelou, N., Newsome, I., & Radford, K. (2025). Key Outcomes for a Vocational Rehabilitation Intervention for People With Multiple Sclerosis: A Nominal Group Technique Study. Health Expectations, 28(2), Article e70265. https://doi.org/10.1111/hex.70265

Background: Job retention vocational rehabilitation (VR) interventions for people with multiple sclerosis (MS) can positively impact a person's independence and directly influence health and employment outcomes. However, evaluating the effectiveness... Read More about Key Outcomes for a Vocational Rehabilitation Intervention for People With Multiple Sclerosis: A Nominal Group Technique Study.

Factors influencing fall prevention programmes across three regions of the UK: the challenge of implementing and spreading the Falls Management Exercise (FaME) programme in a complex landscape (2025)
Journal Article
Ventre, J. P., Manning, F., Mahmoud, A., Brough, G., Timmons, S., Hawley-Hague, H., Skelton, D. A., Goodwin, V. A., Todd, C. J., Kendrick, D., Logan, P., & Orton, E. (2025). Factors influencing fall prevention programmes across three regions of the UK: the challenge of implementing and spreading the Falls Management Exercise (FaME) programme in a complex landscape. Age and Ageing, 54(4), Article afaf083. https://doi.org/10.1093/ageing/afaf083

Background: The occurrence of falls in adults 65+ years remains a common and costly issue worldwide. There is current evidence to suggest that falls can be prevented using evidence-based strength and balance interventions, such as the 6-month Falls M... Read More about Factors influencing fall prevention programmes across three regions of the UK: the challenge of implementing and spreading the Falls Management Exercise (FaME) programme in a complex landscape.

Lessons from the PROTECT-CH COVID-19 platform trial in care homes (2025)
Journal Article
Bath, P. M., Ball, J., Boyd, M., Gage, H., Glover, M., Godfrey, M., Guthrie, B., Hewitt, J., Howard, R., Jaki, T., Juszczak, E., Lasserson, D., Leighton, P., Leyland, V., Shen Lim, W., Logan, P., Meakin, G., Montgomery, A., Ogollah, R., Passmore, P., …Gordon, A. L. (2025). Lessons from the PROTECT-CH COVID-19 platform trial in care homes. Health Technology Assessment, https://doi.org/10.3310/MTRS8833

Background
Coronavirus disease-2019 was associated with significant mortality and morbidity in care homes in 2020–1. Repurposed antiviral drugs might reduce morbidity and mortality through reducing viral transmission, infection, replication and infl... Read More about Lessons from the PROTECT-CH COVID-19 platform trial in care homes.

The meaning of “total pain” in the context of living and dying with dementia (2025)
Journal Article
Field-Richards, S. E., Bramley, L., Collins, J., Cowley, A., & Harwood, R. (2025). The meaning of “total pain” in the context of living and dying with dementia. Frontiers in Sociology, 9, Article 1412749. https://doi.org/10.3389/fsoc.2024.1412749

Background:

Globally, there are 55 million people living with dementia (PLWD). PLWD have an uncertain prognosis. Most are approaching the end of life but are not overtly or immediately dying. Contemporary approaches to dementia care therefore pro... Read More about The meaning of “total pain” in the context of living and dying with dementia.

Construct validity of measures of care home resident quality of life: cross-sectional analysis using data from a pilot minimum data set in England (2025)
Journal Article
Allan, S., Rand, S., Towers, A.-M., De Corte, K., Tracey, F., Crellin, E., Lloyd, T., Carroll, R. E., Palmer, S., Webster, L., Gordon, A., Smith, N., Akdur, G., Killett, A., Spilsbury, K., & Goodman, C. (2025). Construct validity of measures of care home resident quality of life: cross-sectional analysis using data from a pilot minimum data set in England. Health and Quality of Life Outcomes, 23(1), Article 33. https://doi.org/10.1186/s12955-025-02356-0

Background
To maintain good standards of care, evaluations of policy interventions or potential improvements to care are required. A number of quality of life (QoL) measures could be used but there is little evidence for England as to which measures... Read More about Construct validity of measures of care home resident quality of life: cross-sectional analysis using data from a pilot minimum data set in England.

Osteoarthritis treatment via the GLP-1–mediated gut-joint axis targets intestinal FXR signaling (2025)
Journal Article
Yang, Y., Hao, C., Jiao, T., Yang, Z., Li, H., Zhang, Y., Zhang, W., Doherty, M., Sun, C., Yang, T., Li, J., Wu, J., Zhang, M., Wang, Y., Xie, D., Wang, T., Wang, N., Huang, X., Li, C., Gonzalez, F. J., …Lei, G. (2025). Osteoarthritis treatment via the GLP-1–mediated gut-joint axis targets intestinal FXR signaling. Science, 388(6742), Article eadt0548. https://doi.org/10.1126/science.adt0548

Whether a gut-joint axis exists to regulate osteoarthritis is unknown. In two independent cohorts, we identified altered microbial bile acid metabolism with reduced glycoursodeoxycholic acid (GUDCA) in osteoarthritis. Suppressing farnesoid X receptor... Read More about Osteoarthritis treatment via the GLP-1–mediated gut-joint axis targets intestinal FXR signaling.

Accelerating the Delivery of Psychological Therapies After Stroke: A Feasibility Stepped-Wedge Cluster Randomised Controlled Trial (2025)
Journal Article
Lightbody, C. E., Patel, K., Holland, E.-J., Sutton, C. J., Brown, C., Tishkovskaya, S. V., Bowen, A., Read, J., Thomas, S., Roberts, T., & Watkins, C. L. (2025). Accelerating the Delivery of Psychological Therapies After Stroke: A Feasibility Stepped-Wedge Cluster Randomised Controlled Trial. Healthcare, 13(7), Article 824. https://doi.org/10.3390/healthcare13070824

Background:

Psychological problems post-stroke are common and debilitating, yet insufficient evidence-based psychological support exists for stroke survivors, either in stroke or general mental health services. Many stroke survivors with signific... Read More about Accelerating the Delivery of Psychological Therapies After Stroke: A Feasibility Stepped-Wedge Cluster Randomised Controlled Trial.