All Outputs (29)

Heterologous COVID-19 vaccine schedule with protein-based prime (NVX-CoV2373) and mRNA boost (BNT162b2) induces strong humoral responses: results from COV-BOOST trial (2025)
Journal Article
Janani, L., Munro, A. P. S., Wright, A., Aley, P. K., Babbage, G., Baxter, D., Bawa, T., Bibi, S., Bula, M., Cathie, K., Chatterjee, K., Cosgrove, C., Enever, Y., Galiza, E., Goodman, A. L., Green, C. A., Harris, M., Hicks, A., Jones, C. E., Kanji, N., …COV-BOOST study group. (2025). Heterologous COVID-19 vaccine schedule with protein-based prime (NVX-CoV2373) and mRNA boost (BNT162b2) induces strong humoral responses: results from COV-BOOST trial. Journal of Infection, https://doi.org/10.1016/j.jinf.2025.106576

Background
Heterologous schedules of booster vaccines for COVID-19 following initial doses of mRNA or adenoviral vector vaccines have been shown to be safe and immunogenic. There are few data on booster doses following initial doses of protein nanop... Read More about Heterologous COVID-19 vaccine schedule with protein-based prime (NVX-CoV2373) and mRNA boost (BNT162b2) induces strong humoral responses: results from COV-BOOST trial.

Sustainable and synthetic carbon polymers for safe and efficient H2 storage (2025)
Journal Article
Fernández-Lera, A., Álvarez-Rodríguez, M., Casal, M. D., Blankenship, L. S., Mokaya, R., Valdés-Solís, T., Arenillas, A., & Sevilla, M. (2025). Sustainable and synthetic carbon polymers for safe and efficient H2 storage. Journal of Energy Storage, 123, Article 116818. https://doi.org/10.1016/j.est.2025.116818

Highly porous carbon microspheres have been obtained by a sustainable and facile approach that combines a microwave-assisted sol-gel process with a physical activation process. This approach is based on the use of sustainable monomers, such as phloro... Read More about Sustainable and synthetic carbon polymers for safe and efficient H2 storage.

Tunnelling-induced wall damage: an appraisal of elastoplastic constitutive models for the masonry (2024)
Journal Article
Yu, Y., Franza, A., Ghiassi, B., Canhoto Neves, L., & Marshall, A. M. (2025). Tunnelling-induced wall damage: an appraisal of elastoplastic constitutive models for the masonry. Tunnelling and Underground Space Technology, 156, Article 106240. https://doi.org/10.1016/j.tust.2024.106240

This paper investigates the role of masonry elastoplastic constitutive models on tunnelling induced damage in buildings. A two-stage analysis method (TSAM) is adopted, incorporating input greenfield displacements, 3D masonry walls, and an elastic mod... Read More about Tunnelling-induced wall damage: an appraisal of elastoplastic constitutive models for the masonry.

Health outcomes 3 months and 6 months after molnupiravir treatment for COVID-19 for people at higher risk in the community (PANORAMIC): a randomised controlled trial (2024)
Journal Article
Harris, V., Holmes, J., Gbinigie, O., Rahman, N. M., Richards, D. B., Hayward, G., Dorward, J., Lowe, D. M., Standing, J. F., Breuer, J., Khoo, S., Petrou, S., Hood, K., Ahmed, H., Carson-Stevens, A., Nguyen-Van-Tam, J. S., Patel, M. G., Saville, B. R., Francis, N., Thomas, N. P. B., …Butler, C. C. (2025). Health outcomes 3 months and 6 months after molnupiravir treatment for COVID-19 for people at higher risk in the community (PANORAMIC): a randomised controlled trial. Lancet Infectious Diseases, 25(1), 68-79. https://doi.org/10.1016/s1473-3099%2824%2900431-6

Background
No randomised controlled trials have yet reported on the effectiveness of molnupiravir on longer term outcomes for COVID-19. The PANORAMIC trial found molnupiravir reduced time to recovery in acute COVID-19 over 28 days. We aimed to repor... Read More about Health outcomes 3 months and 6 months after molnupiravir treatment for COVID-19 for people at higher risk in the community (PANORAMIC): a randomised controlled trial.

Learnings from the vaccines taskforce: an apotheosis in mission, purpose and handling risk (2024)
Journal Article
Carroll, S. M., Van-Tam, J. N., Shaw, I., Todd, R., & Bell, E. (2024). Learnings from the vaccines taskforce: an apotheosis in mission, purpose and handling risk. Journal of Medical Economics (JME), 27(1), 1119-1123. https://doi.org/10.1080/13696998.2024.2395741

The Vaccines Task Force was established by the UK government in April 2020, with the objective of securing early access to effective COVID-19 vaccines for the UK population and internationally. The VTF was successful in securing the earliest access t... Read More about Learnings from the vaccines taskforce: an apotheosis in mission, purpose and handling risk.

Behaviour of Textile Reinforced Concrete panels under high-velocity impact loading (2024)
Journal Article
Esaker, M., Thermou, G. E., & Neves, L. (2024). Behaviour of Textile Reinforced Concrete panels under high-velocity impact loading. Construction and Building Materials, 445, Article 137806. https://doi.org/10.1016/j.conbuildmat.2024.137806

This study aims to experimentally investigate the impact resistance of Textile Reinforced Concrete (TRC) panels under high-velocity impact loading. 54 control and TRC panels were fabricated using a standard (29 MPa) and a high (101 MPa) compressive s... Read More about Behaviour of Textile Reinforced Concrete panels under high-velocity impact loading.

Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study (2024)
Journal Article
Nakafero, G., Grainge, M. J., Card, T., Mallen, C. D., Nguyen Van-Tam, J. S., & Abhishek, A. (2024). Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study. BMJ Open Gastroenterology, 11(1), Article e001370. https://doi.org/10.1136/bmjgast-2024-001370

Objective To investigate (1) the UK-wide inactivated influenza vaccine (IIV) uptake in adults with inflammatory bowel disease (IBD), (2) the association between vaccination against influenza and IBD flare and (3) the effectiveness of IIV in preventin... Read More about Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study.

Ultra-high surface area ionic-liquid-derived carbons that meet both gravimetric and volumetric methane storage targets (2024)
Journal Article
Albeladi, N., Blankenship, L. S., & Mokaya, R. (2024). Ultra-high surface area ionic-liquid-derived carbons that meet both gravimetric and volumetric methane storage targets. Energy and Environmental Science, https://doi.org/10.1039/d3ee03957a

The storage of methane, to enable vehicular use, may be achieved in porous solids, but to date, there is no material that meets the gravimetric and volumetric targets (for example those set by the US Department of Energy, DOE) for such use. Here, in... Read More about Ultra-high surface area ionic-liquid-derived carbons that meet both gravimetric and volumetric methane storage targets.

Uptake and safety of pneumococcal vaccination in adults with immune-mediated inflammatory diseases: a UK wide observational study (2024)
Journal Article
Nakafero, G., Grainge, M. J., Card, T., Mallen, C. D., Nguyen Van-Tam, J. S., Abhishek, A., & . (2025). Uptake and safety of pneumococcal vaccination in adults with immune-mediated inflammatory diseases: a UK wide observational study. Rheumatology, 64(3), 962-968. https://doi.org/10.1093/rheumatology/keae160

Objective The uptake and safety of pneumococcal vaccination in people with immune mediated inflammatory diseases (IMIDs) is poorly understood. We investigated the UK wide pneumococcal vaccine uptake in adults with IMIDs and explored the association b... Read More about Uptake and safety of pneumococcal vaccination in adults with immune-mediated inflammatory diseases: a UK wide observational study.

Randomized controlled trial of molnupiravir SARS-CoV-2 viral and antibody response in at-risk adult outpatients (2024)
Journal Article
Standing, J. F., Buggiotti, L., Guerra-Assunção, J. A., Woodall, M., Ellis, S., Agyeman, A. A., Miller, C., Okechukwu, M., Kirkpatrick, E., Jacobs, A. I., Williams, C. A., Roy, S., Martin-Bernal, L. M., Williams, R., Smith, C. M., Sanderson, T., Ashford, F., Emmanuel, B., Afzal, Z. M., Shields, A., …Breuer, J. (2024). Randomized controlled trial of molnupiravir SARS-CoV-2 viral and antibody response in at-risk adult outpatients. Nature Communications, 15, Article 1652. https://doi.org/10.1038/s41467-024-45641-0

Viral clearance, antibody response and the mutagenic effect of molnupiravir has not been elucidated in at-risk populations. Non-hospitalised participants within 5 days of SARS-CoV-2 symptoms randomised to receive molnupiravir (n=253) or Usual Care (n... Read More about Randomized controlled trial of molnupiravir SARS-CoV-2 viral and antibody response in at-risk adult outpatients.

Cost-utility analysis of molnupiravir for high-risk, community-based adults with COVID-19: an economic evaluation of the PANORAMIC trial (2024)
Journal Article
Png, M. E., Harris, V., Grabey, J., Hart, N. D., Jani, B. D., Butler, D., Carson-Stevens, A., Coates, M., Cureton, L., Dobson, M., Dorward, J., Evans, P., Francis, N., Gbinigie, O. A., Hayward, G., Holmes, J., Hood, K., Khoo, S., Ahmed, H., Lown, M., …Petrou, S. (2024). Cost-utility analysis of molnupiravir for high-risk, community-based adults with COVID-19: an economic evaluation of the PANORAMIC trial. British Journal of General Practice, 74(745), e570-e579. https://doi.org/10.3399/BJGP.2023.0444

Background The cost-effectiveness of molnupiravir, an oral antiviral for early treatment of SARS-CoV-2, has not been established in vaccinated populations.

Aim To evaluate the cost-effectiveness of molnupiravir relative to usual care alone among m... Read More about Cost-utility analysis of molnupiravir for high-risk, community-based adults with COVID-19: an economic evaluation of the PANORAMIC trial.

Two-week break in methotrexate treatment and COVID-19 vaccine response: a prospective, open label, two-arm parallel-group, multicentre, superiority, randomised controlled trial (2023)
Journal Article
Abhishek, A., Peckham, N., Pade, C., Gibbons, J. M., Cureton, L., Francis, A., Barber, V., Williams, J. A. E., Appelbe, D., Eldridge, L., Julier, P., Altmann, D. M., Bluett, J., Brooks, T., Coates, L. C., Rombach, I., Semper, A., Otter, A., Valdes, A. M., Nguyen-Van-Tam, J. S., …Study investigators, V. (2024). Two-week break in methotrexate treatment and COVID-19 vaccine response: a prospective, open label, two-arm parallel-group, multicentre, superiority, randomised controlled trial. The Lancet Rheumatology, 6(2), E92-E104. https://doi.org/10.1016/S2665-9913%2823%2900298-9

Background
Methotrexate is the first-line treatment for immune-mediated inflammatory diseases and reduces vaccine-induced immunity. We evaluated if a 2-week interruption of methotrexate treatment immediately after COVID-19 booster vaccination improv... Read More about Two-week break in methotrexate treatment and COVID-19 vaccine response: a prospective, open label, two-arm parallel-group, multicentre, superiority, randomised controlled trial.

Real world evidence for public health decision-making on vaccination policies: perspectives from an expert roundtable (2023)
Journal Article
de Waure, C., Gärtner, B. C., Lopalco, P. L., Puig-Barbera, J., & Nguyen-Van-Tam, J. S. (2024). Real world evidence for public health decision-making on vaccination policies: perspectives from an expert roundtable. Expert Review of Vaccines, 23(1), 27-38. https://doi.org/10.1080/14760584.2023.2290194

INTRODUCTION: Influenza causes significant morbidity and mortality, but influenza vaccine uptake remains below most countries' targets. Vaccine policy recommendations vary, as do procedures for reviewing and appraising the evidence. AREAS COVERED: Du... Read More about Real world evidence for public health decision-making on vaccination policies: perspectives from an expert roundtable.

Evaluation of pragmatic oxygenation measurement as a proxy for Covid-19 severity (2023)
Journal Article
Swets, M. C., Kerr, S., Scott-Brown, J., Brown, A. B., Gupta, R., Millar, J. E., Spata, E., McCurrach, F., Bretherick, A. D., Docherty, A., Harrison, D., Rowan, K., Young, N., Groeneveld, G. H., Dunning, J., Nguyen-Van-Tam, J. S., Openshaw, P., Horby, P. W., Harrison, E., Staplin, N., …ISARIC4C Investigators. (2023). Evaluation of pragmatic oxygenation measurement as a proxy for Covid-19 severity. Nature Communications, 14(1), Article 7374. https://doi.org/10.1038/s41467-023-42205-6

Choosing optimal outcome measures maximizes statistical power, accelerates discovery and improves reliability in early-phase trials. We devised and evaluated a modification to a pragmatic measure of oxygenation function, the S/F ratio. Because of the... Read More about Evaluation of pragmatic oxygenation measurement as a proxy for Covid-19 severity.

Synthesis and Characterization of Doped Magnesium Hydroxide for Medium Heat Storage Application (2023)
Journal Article
Albeladi, N., Kur, A., Mokaya, R., Darkwa, J., Roger-Lund, S., Worall, M., Calautit, J., & Boukhanouf, R. (2023). Synthesis and Characterization of Doped Magnesium Hydroxide for Medium Heat Storage Application. Materials, 16(18), Article 6296. https://doi.org/10.3390/ma16186296

The amount of waste heat generated annually in the UK exceeds the total annual electricity demand. Hence, it is crucial to effectively harness all available sources of waste heat based on their varying temperatures. Through suitable technologies, a s... Read More about Synthesis and Characterization of Doped Magnesium Hydroxide for Medium Heat Storage Application.

Platform adaptive trial of novel antivirals for early treatment of COVID-19 In the community (PANORAMIC): protocol for a randomised, controlled, open-label, adaptive platform trial of community novel antiviral treatment of COVID-19 in people at increased risk of more severe disease (2023)
Journal Article
Gbinigie, O., Ogburn, E., Allen, J., Dorward, J., Dobson, M., Madden, T.-A., Yu, L.-M., Lowe, D. M., Rahman, N., Petrou, S., Richards, D., Hood, K., Patel, M., Saville, B. R., Marion, J., Holmes, J., Png, M. E., Hayward, G., Lown, M., Harris, V., …Butler, C. C. (2023). Platform adaptive trial of novel antivirals for early treatment of COVID-19 In the community (PANORAMIC): protocol for a randomised, controlled, open-label, adaptive platform trial of community novel antiviral treatment of COVID-19 in people at increased risk of more severe disease. BMJ Open, 13(8), Article e069176. https://doi.org/10.1136/bmjopen-2022-069176

Introduction: There is an urgent need to determine the safety, effectiveness and cost-effectiveness of novel antiviral treatments for COVID-19 in vaccinated patients in the community at increased risk of morbidity and mortality from COVID-19.

Met... Read More about Platform adaptive trial of novel antivirals for early treatment of COVID-19 In the community (PANORAMIC): protocol for a randomised, controlled, open-label, adaptive platform trial of community novel antiviral treatment of COVID-19 in people at increased risk of more severe disease.

A simple, sustainable route to flexible microporous carbon cloth for energy storage applications (2023)
Journal Article
Alkhaldi, T., Blankenship, L. S., & Mokaya, R. (2023). A simple, sustainable route to flexible microporous carbon cloth for energy storage applications. Materials Advances, 4(16), 3559-3571. https://doi.org/10.1039/d3ma00157a

Activated carbon cloth (ACC) has the potential to be extremely useful in gas capture and storage applications as it combines high porosity, robustness, and flexibility with ease of handling. While it has been produced by a few researchers, the synthe... Read More about A simple, sustainable route to flexible microporous carbon cloth for energy storage applications.

Solvothermal synthesis of organoclay/Cu-MOF composite and its application in film modified GCE for simultaneous electrochemical detection of deoxyepinephrine, acetaminophen and tyrosine (2023)
Journal Article
Mouafo-Tchinda, E., Kemmegne-Mbouguen, J. C., Nanseu-Njiki, C. P., Langmi, H. W., Kowenje, C., Musyoka, N. M., & Mokaya, R. (2023). Solvothermal synthesis of organoclay/Cu-MOF composite and its application in film modified GCE for simultaneous electrochemical detection of deoxyepinephrine, acetaminophen and tyrosine. RSC Advances, 13(30), 20816-20829. https://doi.org/10.1039/d3ra03850e

An organoclay/copper-based metal-organic framework (MOF) composite was synthesized using a solvothermal method by growing a Cu-BTC (copper(ii) benzene-1,3,5-tricarboxylate) MOF from a mixture of the MOF precursor solution in which various amounts of... Read More about Solvothermal synthesis of organoclay/Cu-MOF composite and its application in film modified GCE for simultaneous electrochemical detection of deoxyepinephrine, acetaminophen and tyrosine.

Risk prediction of covid-19 related death or hospital admission in adults testing positive for SARS-CoV-2 infection during the omicron wave in England (QCOVID4): cohort study (2023)
Journal Article
Hippisley-Cox, J., Khunti, K., Sheikh, A., Nguyen-Van-Tam, J. S., & Coupland, C. A. (2023). Risk prediction of covid-19 related death or hospital admission in adults testing positive for SARS-CoV-2 infection during the omicron wave in England (QCOVID4): cohort study. British Medical Journal, 381, Article e072976. https://doi.org/10.1136/bmj-2022-072976

Objectives To derive and validate risk prediction algorithms (QCOVID4) to estimate the risk of covid-19 related death and hospital admission in people with a positive SARS-CoV-2 test result during the period when the omicron variant of the virus was... Read More about Risk prediction of covid-19 related death or hospital admission in adults testing positive for SARS-CoV-2 infection during the omicron wave in England (QCOVID4): cohort study.

Reactogenicity, immunogenicity and breakthrough infections following heterologous or fractional second dose COVID-19 vaccination in adolescents (Com-COV3): A randomised controlled trial (2023)
Journal Article
Kelly, E., Greenland, M., de Whalley, P. C., Aley, P. K., Plested, E. L., Singh, N., Koleva, S., Tonner, S., Macaulay, G. C., Read, R. C., Ramsay, M., Cameron, J. C., Turner, D. P., Heath, P. T., Bernatoniene, J., Connor, P., Cathie, K., Faust, S. N., Banerjee, I., Cantrell, L., …Com-COV3 Study Group, C.-C. S. G. (2023). Reactogenicity, immunogenicity and breakthrough infections following heterologous or fractional second dose COVID-19 vaccination in adolescents (Com-COV3): A randomised controlled trial. Journal of Infection, 87(3), 230-241. https://doi.org/10.1016/j.jinf.2023.06.007

Background: This was the first study to investigate the reactogenicity and immunogenicity of heterologous or fractional second dose COVID-19 vaccine regimens in adolescents. Methods: A phase II, single-blind, multi-centre, randomised-controlled trial... Read More about Reactogenicity, immunogenicity and breakthrough infections following heterologous or fractional second dose COVID-19 vaccination in adolescents (Com-COV3): A randomised controlled trial.