All Outputs (290)

First-trimester maternal folate and vitamin B12 concentrations and their associations with first-trimester placental growth: the Rotterdam Periconception Cohort (2025)
Journal Article
van Vliet, M. M., Schoenmakers, S., Willemsen, S. P., Sinclair, K. D., & Steegers-Theunissen, R. P. M. (2025). First-trimester maternal folate and vitamin B12 concentrations and their associations with first-trimester placental growth: the Rotterdam Periconception Cohort. Human Reproduction, https://doi.org/10.1093/humrep/deaf095

Study question: Are maternal folate and vitamin B12 concentrations associated with first-trimester placental growth?

Summary answer: Maternal folate concentrations and commencement of folic acid supplements prior to conception, as compared to foll... Read More about First-trimester maternal folate and vitamin B12 concentrations and their associations with first-trimester placental growth: the Rotterdam Periconception Cohort.

STAT3 signaling enhances tissue expansion during postimplantation mouse development (2025)
Journal Article
Azami, T., Theeuwes, B., Ton, M.-L. N., Mansfield, W., Harland, L., Kinoshita, M., Gottgens, B., & Nichols, J. (2025). STAT3 signaling enhances tissue expansion during postimplantation mouse development. Cell Reports, 44(4), Article 115506. https://doi.org/10.1016/j.celrep.2025.115506

Signal transducer and activator of transcription (STAT)3 signaling has been studied extensively using mouse embryonic stem cells. Zygotic deletion of Stat3 enables embryo implantation, but thereafter, mutants resemble non-affected littermates from th... Read More about STAT3 signaling enhances tissue expansion during postimplantation mouse development.

Programming of pluripotency and the germ line co-evolved from a Nanog ancestor (2025)
Journal Article
Crowley, D., Simpson, L., Chatfield, J., Forey, T., Allegrucci, C., Sang, F., Holmes, N., Genikhovich, G., Technau, U., Cunningham, D., Silva, E., Mullin, N., Dixon, J. E., Loose, M., Alberio, R., & Johnson, A. D. (2025). Programming of pluripotency and the germ line co-evolved from a Nanog ancestor. Cell Reports, 44(3), Article 115396. https://doi.org/10.1016/j.celrep.2025.115396

Francois Jacob proposed that evolutionary novelty arises through incremental tinkering with pre-existing genetic mechanisms. Vertebrate evolution was predicated on pluripotency, the ability of embryonic cells to form somatic germ layers and primordia... Read More about Programming of pluripotency and the germ line co-evolved from a Nanog ancestor.

Morphological and Chemical Changes in the Trophozoites and Cysts of Acanthamoeba Castellanii Induced by Camellia Sinensis Extracts (2025)
Journal Article
Fakae, L. B., Zhong, J., Chan, K. L. A., Mekapothula, S., Cave, G. W., Zhu, X.-Q., Stevenson, C. W., & Elsheikha, H. M. (2025). Morphological and Chemical Changes in the Trophozoites and Cysts of Acanthamoeba Castellanii Induced by Camellia Sinensis Extracts. Acta Parasitologica, 70(2), Article 63. https://doi.org/10.1007/s11686-024-00941-9

Purpose: Acanthamoeba castellanii is an important opportunistic human protozoal pathogen that can cause both skin, ocular and brain infections. Recent studies have established that brews and solvent extract (SE) of green tea (Camellia sinensis) can i... Read More about Morphological and Chemical Changes in the Trophozoites and Cysts of Acanthamoeba Castellanii Induced by Camellia Sinensis Extracts.

Too little and too much: medial prefrontal functional inhibition impairs early acquisition of operant reversal learning, whereas medial prefrontal disinhibition impairs established serial-reversal performance in rats (2025)
Preprint / Working Paper
Renstrom, J. G., Taylor, C. J. L., Grasmeder Allen, R., Loayza, J., O'Hara, L., von Heimendahl, M., Deiana, S., Moran, P. M., Stevenson, C. W., Maggi, S. G., & Bast, T. (2025). Too little and too much: medial prefrontal functional inhibition impairs early acquisition of operant reversal learning, whereas medial prefrontal disinhibition impairs established serial-reversal performance in rats

Schizophrenia has been linked to hypofrontality (reduced prefrontal activation) and neural disinhibition (reduced GABAergic inhibition) within the dorsolateral prefrontal cortex (dlPFC), as well as reversal learning deficits. Interestingly, whilst re... Read More about Too little and too much: medial prefrontal functional inhibition impairs early acquisition of operant reversal learning, whereas medial prefrontal disinhibition impairs established serial-reversal performance in rats.

Developmental programming: Sex-specific effects of prenatal exposure to a real-life mixture of environmental chemicals on liver function and transcriptome in sheep (2025)
Journal Article
Thangaraj, S. V., Bellingham, M., Lea, R., Evans, N., Sinclair, K., & Padmanabhan, V. (2025). Developmental programming: Sex-specific effects of prenatal exposure to a real-life mixture of environmental chemicals on liver function and transcriptome in sheep. Environmental Pollution, 367, Article 125630. https://doi.org/10.1016/j.envpol.2025.125630

Humans are chronically exposed to a mixture of environmental chemicals (ECs), many with metabolic and endocrine disrupting potential, contributing to non-communicable disease burden. Understanding the effects of chronic exposure to low-level mixtures... Read More about Developmental programming: Sex-specific effects of prenatal exposure to a real-life mixture of environmental chemicals on liver function and transcriptome in sheep.

Exploring aneuploidies in two-center isolated bovine embryonic stem cell lines: Implications for cultured meat production (2025)
Journal Article
Deelkens, C., De Vlieghere, E., Van Poucke, M., Kinoshita, M., Aalders, J., Thorrez, L., Devriendt, B., Van Soom, A., Peelman, L., Menten, B., De Schauwer, C., & van Hengel, J. (2025). Exploring aneuploidies in two-center isolated bovine embryonic stem cell lines: Implications for cultured meat production. Future Foods, 11, Article 100555. https://doi.org/10.1016/j.fufo.2025.100555

As the global population continues to grow, the demand for sustainable food production methods becomes increasingly critical. This study investigates the presence of chromosomal abnormalities in bovine embryonic stem cells (bESCs), which hold potenti... Read More about Exploring aneuploidies in two-center isolated bovine embryonic stem cell lines: Implications for cultured meat production.

Developmental epigenetics: Understanding genetic and sexually dimorphic responses to parental diet and outcomes following assisted reproduction (2024)
Journal Article
Sinclair, K. D. (2025). Developmental epigenetics: Understanding genetic and sexually dimorphic responses to parental diet and outcomes following assisted reproduction. Journal of Dairy Science, 108(7), 7723-7740. https://doi.org/10.3168/jds.2024-25811

The developmental integrity and wellbeing of offspring are influenced by events that occur in utero, particularly around the time of conception. While extraneous factors such as environmental temperature and exposure to environmental chemicals can ea... Read More about Developmental epigenetics: Understanding genetic and sexually dimorphic responses to parental diet and outcomes following assisted reproduction.

Association of childhood DHEAS concentration, pubertal development and DNA methylation at puberty-related genes (2024)
Journal Article
Sudman, M., Stöger, R., Bentley, G. R., & Melamed, P. (2024). Association of childhood DHEAS concentration, pubertal development and DNA methylation at puberty-related genes. European Journal of Endocrinology, 191(6), 623-635. https://doi.org/10.1093/ejendo/lvae156

Objective
High concentrations of dehydroepiandrosterone sulfate (DHEAS) often precede premature puberty and sometimes polycystic ovary syndrome (PCOS). We hypothesized that the underlying mechanisms might involve DNA methylation. As an indicator of... Read More about Association of childhood DHEAS concentration, pubertal development and DNA methylation at puberty-related genes.

Factors affecting first lactation milk yield and herd replacement rate and its effect on the economic and environmental cost of milk production (2024)
Presentation / Conference Contribution
Margerison, J. (2024, December). Factors affecting first lactation milk yield and herd replacement rate and its effect on the economic and environmental cost of milk production. Presented at 4th International Calf and Heifer Conference, Bejing, China

Peeking into the future: inferring mechanics in dynamical tissues (2024)
Journal Article
Borges, A., & Chara, O. (2024). Peeking into the future: inferring mechanics in dynamical tissues. Biochemical Society Transactions, 52(6), 2579-2592. https://doi.org/10.1042/BST20230225

Cells exert forces on each other and their environment, shaping the tissue. The resulting mechanical stresses can be determined experimentally or estimated computationally using stress inference methods. Over the years, mechanical stress inference ha... Read More about Peeking into the future: inferring mechanics in dynamical tissues.

Smarter Pregnancy Coaching and Maternal Blood Pressure (2024)
Journal Article
Hojeij, B., Schoenmakers, S., Van Mullem, I., Willemsen, S. P., Dinnyes, A., Sinclair, K. D., Rousian, M., & Steegers-Theunissen, R. P. (2025). Smarter Pregnancy Coaching and Maternal Blood Pressure. American Journal of Preventive Medicine, 68(3), 455-464. https://doi.org/10.1016/j.amepre.2024.11.007

Introduction
Maternal lifestyle behaviors can affect blood pressure with consequences for maternal and offspring health. The aim of this study was to investigate the effectiveness of the Smarter Pregnancy digital lifestyle coaching program on matern... Read More about Smarter Pregnancy Coaching and Maternal Blood Pressure.

Ovarian follicular flushing as a means of increasing oocyte yield and in vitro embryo production in cattle (2024)
Journal Article
Simmons, R. J., Tutt, D. A., Kwong, W. Y., Baroni, J. I., Lim, L. N., Cimpeanu, R., Castrejon-Pita, A. A., Vatish, M., Svensson, P., Piegsa, R., Hagby, U., Sinclair, K. D., Sinclair, K. D., & Georgiou, E. X. (2024). Ovarian follicular flushing as a means of increasing oocyte yield and in vitro embryo production in cattle. Reproduction, Fertility and Development, 36(17), Article RD24125. https://doi.org/10.1071/rd24125

Context The number of developmentally competent cumulus-oocyte complexes (COCs) retrieved during Ovum Pick-Up (OPU) determines success in both bovine and human assisted reproduction. Follicular flushing for COC retrieval is practicsed widely in human... Read More about Ovarian follicular flushing as a means of increasing oocyte yield and in vitro embryo production in cattle.

Developmental programming: preconceptional and gestational exposure of sheep to biosolids on offspring ovarian dynamics (2024)
Journal Article
Halloran, K. M., Zhou, Y., Bellingham, M., Lea, R. G., Evans, N. P., Sinclair, K. D., Smith, P., & Padmanabhan, V. (2025). Developmental programming: preconceptional and gestational exposure of sheep to biosolids on offspring ovarian dynamics. Biology of Reproduction, 112(2), 331-345. https://doi.org/10.1093/biolre/ioae166

Developmental exposure to environmental chemicals perturbs establishment and maintenance of the ovarian reserve across the reproductive lifetime, leading to premature follicle depletion and ovarian aging. Considering humans are exposed to a complex m... Read More about Developmental programming: preconceptional and gestational exposure of sheep to biosolids on offspring ovarian dynamics.

Reproductive and Metabolic Health Following Exposure to Environmental Chemicals: Mechanistic Insights from Mammalian Models (2024)
Journal Article
Bellingham, M., Evans, N. P., Lea, R. G., Padmanabhan, V., & Sinclair, K. D. (2025). Reproductive and Metabolic Health Following Exposure to Environmental Chemicals: Mechanistic Insights from Mammalian Models. Annual Review of Animal Biosciences, 13(1), 411-440. https://doi.org/10.1146/annurev-animal-111523-102259

The decline in human reproductive and metabolic health over the past 50 years is associated with exposure to complex mixtures of anthropogenic environmental chemicals (ECs). Real-life EC exposure has varied over time and differs across geographical l... Read More about Reproductive and Metabolic Health Following Exposure to Environmental Chemicals: Mechanistic Insights from Mammalian Models.

In-utero exposure to real-life environmental chemicals disrupts gene expression within the hypothalamo-pituitary-gonadal axis of prepubertal and adult rams (2024)
Journal Article
Ghasemzadeh Hasankolaei, M., Evans, N. P., Elcombe, C. S., Lea, R. G., Sinclair, K. D., Padmanabhan, V., & Bellingham, M. (2025). In-utero exposure to real-life environmental chemicals disrupts gene expression within the hypothalamo-pituitary-gonadal axis of prepubertal and adult rams. Environmental Research, 264, Article 120303. https://doi.org/10.1016/j.envres.2024.120303

Environmental chemicals (ECs) have been associated with a broad range of disorders and diseases. Daily exposure to various ECs in the environment, or real-life exposure, has raised significant public health concerns. Utilizing the biosolids-treated p... Read More about In-utero exposure to real-life environmental chemicals disrupts gene expression within the hypothalamo-pituitary-gonadal axis of prepubertal and adult rams.

Lineage tracing of Shh+ floor plate cells and dynamics of dorsal–ventral gene expression in the regenerating axolotl spinal cord (2024)
Journal Article
Arbanas, L. I., Cura Costa, E., Chara, O., Otsuki, L., & Tanaka, E. M. (2024). Lineage tracing of Shh+ floor plate cells and dynamics of dorsal–ventral gene expression in the regenerating axolotl spinal cord. Development, Growth and Differentiation, 66(8), 414-425. https://doi.org/10.1111/dgd.12945

Both development and regeneration depend on signaling centers, which are sources of locally secreted tissue-patterning molecules. As many signaling centers are decommissioned before the end of embryogenesis, a fundamental question is how signaling ce... Read More about Lineage tracing of Shh+ floor plate cells and dynamics of dorsal–ventral gene expression in the regenerating axolotl spinal cord.

Effects of manipulating prefrontal activity and dopamine D1 receptor signalling in an appetitive feature-negative discrimination learning task (2024)
Journal Article
Hock, R. M., Owusu-Amoah, N., Waite, L., Muir, C., Stevenson, C. W., Bonardi, C., & Cassaday, H. J. (2024). Effects of manipulating prefrontal activity and dopamine D1 receptor signalling in an appetitive feature-negative discrimination learning task. Behavioral Neuroscience, 138(6), 420-432. https://doi.org/10.1037/bne0000603

Healthy cognition requires inhibitory modulation of associative learning; conversely, impaired inhibitory discrimination is implicated in behavioral disorders. The medial prefrontal cortex (mPFC) and its dopamine innervation are key to understanding... Read More about Effects of manipulating prefrontal activity and dopamine D1 receptor signalling in an appetitive feature-negative discrimination learning task.

Nutritional analysis of commercially available, complete plant- and meat-based dry dog foods in the UK (2024)
Preprint / Working Paper
Brociek, R., Li, D., Broughton, R., & Gardner, D. Nutritional analysis of commercially available, complete plant- and meat-based dry dog foods in the UK

Background Adoption of a plant-based diet is a popular lifestyle choice for many owners of canine companion animals. Increasingly, owners would like to feed their canine companions a similar diet. A plant-based dietary pattern has been reported to be... Read More about Nutritional analysis of commercially available, complete plant- and meat-based dry dog foods in the UK.

Investigative power of Genomic Informational Field Theory (GIFT) relative to GWAS for genotype-phenotype mapping (2024)
Journal Article
Kyratzi, P., Matika, O., Brassington, A. H., Clare, C. E., Xu, J., Barrett, D. A., Emes, R. D., Archibald, A. L., Paldi, A., Sinclair, K. D., Wattis, J., & Rauch, C. (2024). Investigative power of Genomic Informational Field Theory (GIFT) relative to GWAS for genotype-phenotype mapping. Physiological Genomics, 56(11), 791-806. https://doi.org/10.1152/physiolgenomics.00049.2024

Identifying associations between phenotype and genotype is the fundamental basis of genetic analyses. Inspired by frequentist probability and the work of R.A. Fisher, genome-wide association studies (GWAS) extract information using averages and varia... Read More about Investigative power of Genomic Informational Field Theory (GIFT) relative to GWAS for genotype-phenotype mapping.