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UK research data resources based on primary care electronic health records: review and summary for potential users (2023)
Journal Article
Edwards, L., Pickett, J., Ashcroft, D. M., Dambha-Miller, H., Majeed, A., Mallen, C., …MacLeod, J. (2023). UK research data resources based on primary care electronic health records: review and summary for potential users. BJGP Open, 7(3), Article 0057. https://doi.org/10.3399/bjgpo.2023.0057

Objectives To describe the current landscape of UK electronic health record (EHR) databases and considerations of access and use of these resources relevant to researchers. Design & setting Narrative review Data sources Information was collecte... Read More about UK research data resources based on primary care electronic health records: review and summary for potential users.

Understanding colorectal cancer risk for symptomatic patients in primary care: A cohort study utilising faecal immunochemical tests and blood results in England (2023)
Journal Article
Crooks, C. J., Banerjea, A., Jones, J., Chapman, C., Oliver, S., West, J., & Humes, D. J. (2023). Understanding colorectal cancer risk for symptomatic patients in primary care: A cohort study utilising faecal immunochemical tests and blood results in England. Alimentary Pharmacology and Therapeutics, 58(4), 443-452. https://doi.org/10.1111/apt.17632

Background: A faecal immunochemical tests (FIT) cut-off of ≥10 μg Hb/g faeces is now recommended in the UK as a gateway to urgent (suspected cancer) investigation for colorectal cancer (CRC), based on an expected CRC risk threshold of 3%. Aims: To qu... Read More about Understanding colorectal cancer risk for symptomatic patients in primary care: A cohort study utilising faecal immunochemical tests and blood results in England.

Systematic review and meta-analysis investigating nicotine, cotinine and carbon monoxide exposures in people who both smoke and use nicotine replacement therapy (2023)
Journal Article
Podlasek, A., Clair, R., Campbell, K. A., Orton, S., Thomson, R., & Coleman, T. (2023). Systematic review and meta-analysis investigating nicotine, cotinine and carbon monoxide exposures in people who both smoke and use nicotine replacement therapy. Addiction, 118(11), 2076-2092. https://doi.org/10.1111/add.16279

Aims To determine effects of concurrent smoking and nicotine replacement therapy (NRT) use on reported heaviness of smoking, nicotine (cotinine) body fluid and exhaled air carbon monoxide (CO) concentrations. Methods Systematic review and meta-a... Read More about Systematic review and meta-analysis investigating nicotine, cotinine and carbon monoxide exposures in people who both smoke and use nicotine replacement therapy.

Systematic review and meta‐analysis investigating nicotine, cotinine and carbon monoxide exposures in people who both smoke and use nicotine replacement therapy (2023)
Journal Article
Podlasek, A., Claire, R., Campbell, K. A., Orton, S., Thomson, R., & Coleman, T. (2023). Systematic review and meta‐analysis investigating nicotine, cotinine and carbon monoxide exposures in people who both smoke and use nicotine replacement therapy. Addiction, 118(11), 2076-2092. https://doi.org/10.1111/add.16279

Aims: To determine effects of concurrent smoking and nicotine replacement therapy (NRT) use on reported heaviness of smoking, nicotine (cotinine) body fluid and exhaled air carbon monoxide (CO) concentrations. Methods: Systematic review and meta‐anal... Read More about Systematic review and meta‐analysis investigating nicotine, cotinine and carbon monoxide exposures in people who both smoke and use nicotine replacement therapy.

Respiratory rate responses to both hypercapnia and acidaemia are modified by age in patients with acidosis (2023)
Journal Article
Crooks, C. J., West, J., Morling, J. R., Simmonds, M., Juurlink, I., Briggs, S., …Fogarty, A. W. (2023). Respiratory rate responses to both hypercapnia and acidaemia are modified by age in patients with acidosis. Respiratory Physiology and Neurobiology, 315, Article 104098. https://doi.org/10.1016/j.resp.2023.104098

Objective To explore the associations between arterial pO2, pCO2 and pH and how these are modified by age. Methods An analysis of 2598 patients admitted with a diagnosis of Covid-19 infection to a large UK teaching hospital. Results There we... Read More about Respiratory rate responses to both hypercapnia and acidaemia are modified by age in patients with acidosis.

Does knowledge of liver fibrosis affect high-risk drinking behaviour (KLIFAD): an open-label pragmatic feasibility randomised controlled trial (2023)
Journal Article
Subhani, M., Enki, D. G., Knight, H., Jones, K. A., Sprange, K., Rennick-Egglestone, S., …Ryder, S. D. (2023). Does knowledge of liver fibrosis affect high-risk drinking behaviour (KLIFAD): an open-label pragmatic feasibility randomised controlled trial. eClinicalMedicine, 61, Article 102069. https://doi.org/10.1016/j.eclinm.2023.102069

Background: Early identification followed by effective behaviour interventions is pivotal to changing the natural history of alcohol-related liver disease. We examined the feasibility of using transient elastography based advice and alcohol recovery... Read More about Does knowledge of liver fibrosis affect high-risk drinking behaviour (KLIFAD): an open-label pragmatic feasibility randomised controlled trial.

Labels and descriptions of dental behaviour support techniques: A scoping review of clinical practice guidelines (2023)
Journal Article
Mac Giolla Phadraig, C., Kammer, P. V., Asimakopoulou, K., Healy, O., Fleischmann, I., Buchanan, H., …Nunn, J. (2023). Labels and descriptions of dental behaviour support techniques: A scoping review of clinical practice guidelines. Community Dentistry and Oral Epidemiology, 51(6), 1065-1077. https://doi.org/10.1111/cdoe.12890

Introduction: There is no agreed taxonomy of the techniques used to support patients to receive professional oral healthcare. This lack of specification leads to imprecision in describing, understanding, teaching and implementing behaviour support te... Read More about Labels and descriptions of dental behaviour support techniques: A scoping review of clinical practice guidelines.

Thinking outside the box: a review of gastrointestinal symptoms and complications in cystic fibrosis (2023)
Journal Article
Yule, A., Sills, D., Smith, S., Spiller, R., & Smyth, A. R. (2023). Thinking outside the box: a review of gastrointestinal symptoms and complications in cystic fibrosis. Expert Review of Respiratory Medicine, 17(7), 547-561. https://doi.org/10.1080/17476348.2023.2228194

Introduction Gastrointestinal (GI)-related symptoms, complications, and comorbidities in cystic fibrosis (CF) are common and research to reduce their burden is a priority for the CF community. To enable future research, this review aimed to summariz... Read More about Thinking outside the box: a review of gastrointestinal symptoms and complications in cystic fibrosis.

RF04 Oral spironolactone for adult female acne (SAFA): a multicentre, double-blind, randomized trial (2023)
Journal Article
Santer, M., Layton, A., Lau, E., Eminton, Z., Stuart, B., Sach, T., …Lawrence, M. (2023). RF04 Oral spironolactone for adult female acne (SAFA): a multicentre, double-blind, randomized trial. British Journal of Dermatology, 188(Supplement_4), Article ljad113.013. https://doi.org/10.1093/bjd/ljad113.013

Acne is common and results in significant burden and patients with acne frequently receive prolonged oral antibiotics leading to antimicrobial resistance. Oral spironolactone is prescribed for acne, although there is a paucity of evidence on its effe... Read More about RF04 Oral spironolactone for adult female acne (SAFA): a multicentre, double-blind, randomized trial.

Pathways to ethnic inequalities in COVID-19 health outcomes in the United Kingdom: A systematic map (2023)
Journal Article
Irizar, P., Kapadia, D., Amele, S., Bécares, L., Divall, P., Katikireddi, S. V., …Pareek, M. (2023). Pathways to ethnic inequalities in COVID-19 health outcomes in the United Kingdom: A systematic map. Social Science and Medicine, 329, Article 116044. https://doi.org/10.1016/j.socscimed.2023.116044

Background: Marked ethnic inequalities in COVID-19 infection and its consequences have been documented. The aim of this paper is to identify the range and nature of evidence on potential pathways which lead to ethnic inequalities in COVID-19 related... Read More about Pathways to ethnic inequalities in COVID-19 health outcomes in the United Kingdom: A systematic map.

Research priorities in the management of hidradenitis suppurativa (2023)
Journal Article
Leighton, P., Howells, L., Bates, J., Gibbons, A., Cannings-John, R., Collier, F., …Ingram, J. R. (2023). Research priorities in the management of hidradenitis suppurativa. British Journal of Dermatology, 189(3), 343–345. https://doi.org/10.1093/bjd/ljad152

There is a need for high-quality research to support the management of hidradenitis suppurativa. This letter offers suggestions for priority research topics derived from a stakeholder consensus meeting. Investigation of laser hair removal treatment,... Read More about Research priorities in the management of hidradenitis suppurativa.

Development of “Baby, Me, & NRT”: A Behavioral Intervention to Improve the Effectiveness of Nicotine Replacement Therapy in Pregnancy (2023)
Journal Article
McDaid, L., Emery, J., Thomson, R., Coleman, T., Cooper, S., Dickinson, A., …Naughton, F. (2023). Development of “Baby, Me, & NRT”: A Behavioral Intervention to Improve the Effectiveness of Nicotine Replacement Therapy in Pregnancy. Nicotine and Tobacco Research, 25(11), 1770-1780. https://doi.org/10.1093/ntr/ntad102

Background The effectiveness of Nicotine Replacement Therapy (NRT) for smoking cessation in pregnancy is limited by inconsistent and incorrect use. This paper describes the development process for “Baby, Me, & NRT”, a novel pregnancy-specific interv... Read More about Development of “Baby, Me, & NRT”: A Behavioral Intervention to Improve the Effectiveness of Nicotine Replacement Therapy in Pregnancy.

Stakeholder-identified barriers and enablers to ultrasound implementation in inflammatory bowel disease services in the UK: a qualitative interview study. (2023)
Journal Article
Radford, S., Leighton, P., Coad, J., & Moran, G. (2023). Stakeholder-identified barriers and enablers to ultrasound implementation in inflammatory bowel disease services in the UK: a qualitative interview study. BMJ Open, 13(6), Article e067528. https://doi.org/10.1136/bmjopen-2022-067528

The study sought to explore and better understand the perceptions and experiences of stakeholders in relation to the use of ultrasound for the assessment of inflammatory bowel disease (IBD) in adults in the UK. A qualitative semistructured interview... Read More about Stakeholder-identified barriers and enablers to ultrasound implementation in inflammatory bowel disease services in the UK: a qualitative interview study..

Risk prediction of covid-19 related death or hospital admission in adults testing positive for SARS-CoV-2 infection during the omicron wave in England (QCOVID4): cohort study (2023)
Journal Article
Hippisley-Cox, J., Khunti, K., Sheikh, A., Nguyen-Van-Tam, J. S., & Coupland, C. A. (2023). Risk prediction of covid-19 related death or hospital admission in adults testing positive for SARS-CoV-2 infection during the omicron wave in England (QCOVID4): cohort study. British Medical Journal, 381, Article e072976. https://doi.org/10.1136/bmj-2022-072976

Objectives To derive and validate risk prediction algorithms (QCOVID4) to estimate the risk of covid-19 related death and hospital admission in people with a positive SARS-CoV-2 test result during the period when the omicron variant of the virus was... Read More about Risk prediction of covid-19 related death or hospital admission in adults testing positive for SARS-CoV-2 infection during the omicron wave in England (QCOVID4): cohort study.

Association between antidepressants with pneumonia and exacerbation in patients with COPD: a self-controlled case series (SCCS) (2023)
Journal Article
Siraj, R. A., Bolton, C. E., & McKeever, T. M. (2023). Association between antidepressants with pneumonia and exacerbation in patients with COPD: a self-controlled case series (SCCS). Thorax, 79(1), 50-57. https://doi.org/10.1136/thorax-2022-219736

Objective: To assess whether antidepressant prescriptions are associated with an increased risk of pneumonia and chronic obstructive pulmonary disease (COPD) exacerbation. Methods: A self-controlled case series was performed to investigate the rates... Read More about Association between antidepressants with pneumonia and exacerbation in patients with COPD: a self-controlled case series (SCCS).

A content analysis of tobacco content in season 1 of ‘And Just Like That’ (2023)
Journal Article
Barker, A. B., Bal, J., & Murray, R. L. (2023). A content analysis of tobacco content in season 1 of ‘And Just Like That’. Journal of Public Health, https://doi.org/10.1007/s10389-023-01975-5

Aim ‘Sex and the City’ regularly featured smoking as a plot device, often linked with sexuality and female empowerment. Eighteen years later, the follow up ‘And Just Like That’ was released. The aim of this paper was to explore the amount of tobacco... Read More about A content analysis of tobacco content in season 1 of ‘And Just Like That’.

Adherence to limiting weight-bearing activity in patients with diabetic foot ulcers: A qualitative study (2023)
Journal Article
Hancox, J. E., Hilton, C., Gray, K., Game, F., & Vedhara, K. (2023). Adherence to limiting weight-bearing activity in patients with diabetic foot ulcers: A qualitative study. International Wound Journal, 20(10), 3945-3954. https://doi.org/10.1111/iwj.14282

Patients with diabetic foot ulcers are advised to limit weight-bearing activity for ulcers to heal. Patients often disregard this advice although the reasons are not yet fully understood. This study explored (1) patients' experiences of receiving the... Read More about Adherence to limiting weight-bearing activity in patients with diabetic foot ulcers: A qualitative study.

Prevalence of Non-alcoholic Fatty Liver Disease (NAFLD) in Saudi Arabia: Systematic Review and Meta-analysis (2023)
Journal Article
Alenezi, Y. . M., Harris, R., Morling, J., & Card, T. (2023). Prevalence of Non-alcoholic Fatty Liver Disease (NAFLD) in Saudi Arabia: Systematic Review and Meta-analysis. Cureus, 15(6), Article e40308. https://doi.org/10.7759/cureus.40308

Liver disease is fast emerging as a global health priority. Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in Western countries, with an increasing prevalence associated with the rising prevalence of diabetes mellitus and... Read More about Prevalence of Non-alcoholic Fatty Liver Disease (NAFLD) in Saudi Arabia: Systematic Review and Meta-analysis.