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All Outputs (151)

“Application of five different strategies to define a cohort of patients with knee osteoarthritis in a large primary care database” (2024)
Journal Article
Taqi, A., Gran, S., & Knaggs, R. D. (2024). “Application of five different strategies to define a cohort of patients with knee osteoarthritis in a large primary care database”. Journal of Evaluation in Clinical Practice, 30(7), 1429-1435. https://doi.org/10.1111/jep.14045

Background

Electronic health records (EHR) are frequently used for epidemiological research including drug utilisation studies in a defined population such as the population with knee osteoarthritis (KOA). We sought to describe the process of defi... Read More about “Application of five different strategies to define a cohort of patients with knee osteoarthritis in a large primary care database”.

DYNamic Assessment of Multi‐Organ level dysfunction in patients recovering from COVID‐19: DYNAMO COVID‐19 (2024)
Journal Article
Gupta, A., Nicholas, R., McGing, J. J., Nixon, A. V., Mallinson, J. E., McKeever, T. M., Bradley, C. R., Piasecki, M., Cox, E. F., Bonnington, J., Lord, J. M., Brightling, C. E., Evans, R. A., Hall, I. P., Francis, S. T., Greenhaff, P. L., & Bolton, C. E. (2024). DYNamic Assessment of Multi‐Organ level dysfunction in patients recovering from COVID‐19: DYNAMO COVID‐19. Experimental Physiology, 109(8), 1274-1291. https://doi.org/10.1113/ep091590

We evaluated the impacts of COVID-19 on multi-organ and metabolic function in patients following severe hospitalised infection compared to controls. Patients (n = 21) without previous diabetes, cardiovascular or cerebrovascular disease were recruited... Read More about DYNamic Assessment of Multi‐Organ level dysfunction in patients recovering from COVID‐19: DYNAMO COVID‐19.

Effectiveness and safety of self-management interventions for improving glycemic control and health-related quality-of-life among adults with type 2 diabetes mellitus in sub-Saharan Africa: a systematic review and meta-analysis (2024)
Journal Article
Carter, N., Nalbant, G., Chahal, P., & Chattopadhyay, K. (in press). Effectiveness and safety of self-management interventions for improving glycemic control and health-related quality-of-life among adults with type 2 diabetes mellitus in sub-Saharan Africa: a systematic review and meta-analysis. JBI Evidence Synthesis, 22(9), 1715-1788. https://doi.org/10.11124/JBIES-23-00273

Objective:

To assess and synthesize evidence on the effectiveness and safety of self- management interventions for improving glycemic control and health-related quality-of-life (HRQoL) among adults with type 2 diabetes mellitus (T2DM) in sub-Saha... Read More about Effectiveness and safety of self-management interventions for improving glycemic control and health-related quality-of-life among adults with type 2 diabetes mellitus in sub-Saharan Africa: a systematic review and meta-analysis.

Collagenase injection compared with limited fasciectomy for moderate Dupuytren's Contracture: the DISC non-inferiority Randomized Controlled Trial (2024)
Journal Article
Dias, J., Tharmanathan, P., Arundel, C., Welch, C., Math, M., Wu, Q., Leighton, P., Armaou, M., Johnson, N., James, S., Cooke, J., Bainbridge, L., Craigen, M., Warwick, D., Brady, S., Flett, L. G., Jones, J., Knowlson, C. N., Watson, M., Keding, A., …Torgerson, D. (in press). Collagenase injection compared with limited fasciectomy for moderate Dupuytren's Contracture: the DISC non-inferiority Randomized Controlled Trial. New England Journal of Medicine,

Prevalence and risk factors for milk allergy overdiagnosis in the BEEP trial cohort (2024)
Journal Article
Allen, H. I., Wing, O., Milkova, D., Jackson, E., Li, K., Bradshaw, L. E., Wyatt, L., Haines, R., Santer, M., Murphy, A. W., Brown, S. J., Kelleher, M., Perkin, M. R., Jay, N., Smith, T. D. H., Moriarty, F., Montgomery, A. A., Williams, H. C., & Boyle, R. J. (online). Prevalence and risk factors for milk allergy overdiagnosis in the BEEP trial cohort. Allergy, https://doi.org/10.1111/all.16203

Background: Cow's milk allergy (CMA) overdiagnosis in young children appears to be increasing and has not been well characterised. We used a clinical trial population to characterise CMA overdiagnosis and identify individual‐level and primary care pr... Read More about Prevalence and risk factors for milk allergy overdiagnosis in the BEEP trial cohort.

Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study (2024)
Journal Article
Nakafero, G., Grainge, M. J., Card, T., Mallen, C. D., Nguyen Van-Tam, J. S., & Abhishek, A. (2024). Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study. BMJ Open Gastroenterology, 11(1), Article e001370. https://doi.org/10.1136/bmjgast-2024-001370

Objective To investigate (1) the UK-wide inactivated influenza vaccine (IIV) uptake in adults with inflammatory bowel disease (IBD), (2) the association between vaccination against influenza and IBD flare and (3) the effectiveness of IIV in preventin... Read More about Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study.

Sub-optimal paternal diet at the time of mating disrupts maternal adaptations to pregnancy in the late gestation mouse (2024)
Journal Article
Khoshkerdar, A., Eid, N., Batra, V., Baker, N., Holmes, N., Henson, S., Sang, F., Wright, V., McLaren, J., Shakesheff, K., Woad, K. J., Morgan, H. L., & Watkins, A. J. (2024). Sub-optimal paternal diet at the time of mating disrupts maternal adaptations to pregnancy in the late gestation mouse. Nutrients, 16(12), Article 1879. https://doi.org/10.3390/nu16121879

Pregnancy represents a stage during which maternal physiology and homeostatic regulation undergo dramatic change and adaptation. The fundamental purpose of these adaptations is to ensure the survival of her offspring through adequate nutrient provisi... Read More about Sub-optimal paternal diet at the time of mating disrupts maternal adaptations to pregnancy in the late gestation mouse.

The acceptability of group B streptococcal bacteria (GBS) testing to women, including self-swabbing procedures: A qualitative study (2024)
Journal Article
Constantinou, G., Ayers, S., Mitchell, E. J., Moore, S., Jones, A.-M., Downe, S., Walker, K. F., & Daniels, J. (2024). The acceptability of group B streptococcal bacteria (GBS) testing to women, including self-swabbing procedures: A qualitative study. Midwifery, 135, Article 104063. https://doi.org/10.1016/j.midw.2024.104063

Background: Group B streptococcus (GBS) is a bacterium carried by 20–25 % of pregnant women in the UK, which can be transmitted from pregnant women to their babies at the time of birth. Women can be tested for GBS in pregnancy using a vaginal-rectal... Read More about The acceptability of group B streptococcal bacteria (GBS) testing to women, including self-swabbing procedures: A qualitative study.

Uptake, effectiveness and safety of COVID-19 vaccines in individuals at clinical risk due to immunosuppressive drug therapy or transplantation procedures: a population-based cohort study in England (2024)
Journal Article
Chen, D. T.-H., Copland, E., Hirst, J. A., Mi, E., Dixon, S., Coupland, C., & Hippisley-Cox, J. (2024). Uptake, effectiveness and safety of COVID-19 vaccines in individuals at clinical risk due to immunosuppressive drug therapy or transplantation procedures: a population-based cohort study in England. BMC Medicine, 22(1), Article 237. https://doi.org/10.1186/s12916-024-03457-1

Background: Immunocompromised individuals are at increased risk of severe COVID-19 outcomes, underscoring the importance of COVID-19 vaccination in this population. The lack of comprehensive real world data on vaccine uptake, effectiveness and safety... Read More about Uptake, effectiveness and safety of COVID-19 vaccines in individuals at clinical risk due to immunosuppressive drug therapy or transplantation procedures: a population-based cohort study in England.

Evaluation of the impact of the COVID-19 pandemic on a smoking cessation service in Derbyshire: An interrupted time series analysis (2024)
Journal Article
Gleeson, H., Earnshaw, J., Craig, C., Hodson, C., & Szatkowski, L. (2024). Evaluation of the impact of the COVID-19 pandemic on a smoking cessation service in Derbyshire: An interrupted time series analysis. PLoS ONE, 19(6), Article e0303876. https://doi.org/10.1371/journal.pone.0303876

Background
Data published early in the COVID-19 pandemic suggested that smokers infected with SARS-CoV-2 were more likely to need hospital treatment or die than non-smokers, and thus this was seen as a motivator to encourage smokers to make a quit a... Read More about Evaluation of the impact of the COVID-19 pandemic on a smoking cessation service in Derbyshire: An interrupted time series analysis.

Identifying neonatal transport research priorities: a modified Delphi consensus (2024)
Journal Article
Mistry, A., Leslie, A., Ojha, S., & Sharkey, D. (2024). Identifying neonatal transport research priorities: a modified Delphi consensus. Archives of Disease in Childhood. Fetal and Neonatal Edition, https://doi.org/10.1136/archdischild-2024-327213

Objectives: With increasing advances in neonatal transport, a focused research strategy is required to increase the evidence base towards providing optimal care. We aimed to identify the most important neonatal transport research questions as priorit... Read More about Identifying neonatal transport research priorities: a modified Delphi consensus.

Effects of implementation of a care bundle on rates of necrotising enterocolitis and own mother’s milk feeding in the East Midlands: protocol for a mixed methods impact and process evaluation study (2024)
Journal Article
Abramson, J., Szatkowski, L., Bains, M., Orton, E., Budge, H., Spruce, M., & Ojha, S. (2024). Effects of implementation of a care bundle on rates of necrotising enterocolitis and own mother’s milk feeding in the East Midlands: protocol for a mixed methods impact and process evaluation study. BMJ Open, 14(5), Article e078633. https://doi.org/10.1136/bmjopen-2023-078633

Introduction: Prevention of necrotising enterocolitis (NEC) is vital for improving neonatal outcomes. Feeding own mother’s milk helps prevent NEC. Rates of own mother’s milk feeding in the East Midlands are lower than the national average and the inc... Read More about Effects of implementation of a care bundle on rates of necrotising enterocolitis and own mother’s milk feeding in the East Midlands: protocol for a mixed methods impact and process evaluation study.

Psychological interventions for mood and cognition after stroke and transient ischaemic attack: A protocol for an umbrella review (2024)
Journal Article
Kontou, E., Shokraneh, F., das Nair, R., Quinn, T., Leonardi-Bee, J., Thorpe, N., …Drummond, A. (2024). Psychological interventions for mood and cognition after stroke and transient ischaemic attack: A protocol for an umbrella review. F1000Research, 13, 1-15. https://doi.org/10.12688/f1000research.146343.2

Background People who have had a stroke or a Transient Ischaemic Attack (TIA) can experience psychological and/or cognitive difficulties. The body of research for psychological and neuropsychological interventions after stroke is growing, however, pu... Read More about Psychological interventions for mood and cognition after stroke and transient ischaemic attack: A protocol for an umbrella review.

Smoking, nicotine and pregnancy 2 (SNAP2) trial: protocol for a randomised controlled trial of an intervention to improve adherence to nicotine replacement therapy in pregnancy (2024)
Journal Article
Clark, M., Cooper, S., Naughton, F., Ussher, M., Emery, J., Mcdaid, L., …Coleman, T. (2024). Smoking, nicotine and pregnancy 2 (SNAP2) trial: protocol for a randomised controlled trial of an intervention to improve adherence to nicotine replacement therapy in pregnancy. BMJ Open, 14(5), Article e087175. https://doi.org/10.1136/bmjopen-2024-087175

Introduction: Smoking in pregnancy is harmful for unborn babies, infants, and women. Nicotine replacement therapy (NRT) is offered as usual stop smoking support in the UK. However, this is often used in insufficient doses, intermittently, or for too... Read More about Smoking, nicotine and pregnancy 2 (SNAP2) trial: protocol for a randomised controlled trial of an intervention to improve adherence to nicotine replacement therapy in pregnancy.

Prospective study of exposure to smoking imagery in films and changes in susceptibility to smoking in a cohort of school students in Southern India (2024)
Journal Article
Kamath, V. G., Kulkarni, M. M., Kamath, A., Lewis, S., Bogdanovica, I., Bains, M., …Britton, J. (2024). Prospective study of exposure to smoking imagery in films and changes in susceptibility to smoking in a cohort of school students in Southern India. Tobacco Induced Diseases, 22(May), Article 88. https://doi.org/10.18332/tid/178442

INTRODUCTION India has unique tobacco-free film and TV rules designed to prevent tobacco uptake. In this study, we examined the potential influence of exposure to smoking imagery in regionally famous films, on susceptibility to smoke in teenagers enr... Read More about Prospective study of exposure to smoking imagery in films and changes in susceptibility to smoking in a cohort of school students in Southern India.

A SARS-CoV-2 minimum data standard to support national serology reporting (2024)
Journal Article
Urwin, E. N., Martin, J., Sebire, N., Harris, A., Johnson, J., Masood, E., …Jefferson, E. (2024). A SARS-CoV-2 minimum data standard to support national serology reporting. Annals of Clinical Biochemistry, https://doi.org/10.1177/00045632241261274

Background: Healthcare laboratory systems produce and capture a vast array of information, yet do not always report all of this to the national infrastructure within the United Kingdom. The global COVID-19 pandemic brought about a much greater need f... Read More about A SARS-CoV-2 minimum data standard to support national serology reporting.

Smoking, nicotine and pregnancy 2 (SNAP2) trial: protocol for a randomised controlled trial of an intervention to improve adherence to nicotine replacement therapy during pregnancy (2024)
Journal Article
Clark, M. M., Cooper, S., Naughton, F., Ussher, M., Emery, J., McDaid, L., Thomson, R., Phillips, L., Bauld, L., Aveyard, P., Torgerson, D., Berlin, I., Lewis, S., Parrott, S., Hewitt, C., Welch, C., Parkinson, G., Dickinson, A., Sutton, S., Brimicombe, J., …Coleman, T. (2024). Smoking, nicotine and pregnancy 2 (SNAP2) trial: protocol for a randomised controlled trial of an intervention to improve adherence to nicotine replacement therapy during pregnancy. BMJ Open, 14(5), Article e087175. https://doi.org/10.1136/bmjopen-2024-087175

IntroductionSmoking during pregnancy is harmful to unborn babies, infants and women. Nicotine replacement therapy (NRT) is offered as the usual stop-smoking support in the UK. However, this is often used in insufficient doses, intermittently or for t... Read More about Smoking, nicotine and pregnancy 2 (SNAP2) trial: protocol for a randomised controlled trial of an intervention to improve adherence to nicotine replacement therapy during pregnancy.

Safety outcomes following COVID-19 vaccination and infection in 5.1 million children in England (2024)
Journal Article
Copland, E., Patone, M., Saatci, D., Handunnetthi, L., Hirst, J., Hunt, D. P. J., …Hippisley-Cox, J. (2024). Safety outcomes following COVID-19 vaccination and infection in 5.1 million children in England. Nature Communications, 15(1), Article 3822. https://doi.org/10.1038/s41467-024-47745-z

The risk-benefit profile of COVID-19 vaccination in children remains uncertain. A self-controlled case-series study was conducted using linked data of 5.1 million children in England to compare risks of hospitalisation from vaccine safety outcomes af... Read More about Safety outcomes following COVID-19 vaccination and infection in 5.1 million children in England.

Impact of NICE clinical guidelines for prevention and treatment of neonatal infections on antibiotic use in very preterm infants in England and Wales: an interrupted time series analysis (2024)
Journal Article
Saunders, M., Ojha, S., & Szatkowski, L. (2024). Impact of NICE clinical guidelines for prevention and treatment of neonatal infections on antibiotic use in very preterm infants in England and Wales: an interrupted time series analysis. Archives of Disease in Childhood. Fetal and Neonatal Edition, https://doi.org/10.1136/archdischild-2024-326983

Objective: To assess the impact of publication of UK National Institute for Health and Care Excellence (NICE) guidelines on the prevention and treatment of early-onset infections (EOIs) in neonates (clinical guideline 149 (CG149), published in 2012,... Read More about Impact of NICE clinical guidelines for prevention and treatment of neonatal infections on antibiotic use in very preterm infants in England and Wales: an interrupted time series analysis.