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RAPID INTRAOPERATIVE GENETIC AUGMENTATION OF AUTOGRAFTS FOR RECONSTRUCTIVE SURGERY OF SEVERE TRAUMA (2022)
Presentation / Conference Contribution
Dixon, J., Thi Mai, T., McLaren, J., Ollivere, B., Scammell, B., & Eltaher, H. (2022). RAPID INTRAOPERATIVE GENETIC AUGMENTATION OF AUTOGRAFTS FOR RECONSTRUCTIVE SURGERY OF SEVERE TRAUMA. Tissue Engineering: Parts A, B, and C, 28(S1),

Survivors with severe tissue injury have unmet clinical needs for better bone and soft tissue regeneration. Specifically they have progressive tissue loss due to inflammation, necrosis, infection and the development of critical size bone defects is a... Read More about RAPID INTRAOPERATIVE GENETIC AUGMENTATION OF AUTOGRAFTS FOR RECONSTRUCTIVE SURGERY OF SEVERE TRAUMA.

Sustaining interventions in care homes initiated by quality improvement projects: a qualitative study (2022)
Journal Article
Devi, R., Martin, G. P., Banerjee, J., Gladman, J. R., Dening, T., Barat, A., & Gordon, A. L. (2022). Sustaining interventions in care homes initiated by quality improvement projects: a qualitative study. BMJ Quality and Safety, 32(11), 665-675. https://doi.org/10.1136/bmjqs-2021-014345

Introduction: Inadequate and varied quality of care in care homes has led to a proliferation of quality improvement (QI) projects. This study examined the sustainability of interventions initiated by such projects. Method: This qualitative study expl... Read More about Sustaining interventions in care homes initiated by quality improvement projects: a qualitative study.

A comparative analysis of multidimensional computerized adaptive testing for the DASH and QuickDASH scores in Dupuytren’s disease (2022)
Journal Article
Harrison, C., Clelland, A. D., Davis, T. R., Scammell, B. E., Zhang, W., Russell, P., …Rodrigues, J. (2022). A comparative analysis of multidimensional computerized adaptive testing for the DASH and QuickDASH scores in Dupuytren’s disease. Journal of Hand Surgery (European Volume), 47(7), 750-754. https://doi.org/10.1177/17531934221081803

The QuickDASH is a short-form version of the DASH questionnaire, the most widely used patient-reported outcome measure in hand surgery. Multidimensional computerized adaptive testing (MCAT) can produce shorter and more precise testing than static sho... Read More about A comparative analysis of multidimensional computerized adaptive testing for the DASH and QuickDASH scores in Dupuytren’s disease.

Clustering of comorbidities and associated outcomes in people with osteoarthritis - A UK Clinical Practice Research Datalink study (2022)
Journal Article
Swain, S., Coupland, C., Strauss, V., Mallen, C., Kuo, C. F., Sarmanova, A., …Zhang, W. (2022). Clustering of comorbidities and associated outcomes in people with osteoarthritis - A UK Clinical Practice Research Datalink study. Osteoarthritis and Cartilage, 30(5), 702-713. https://doi.org/10.1016/j.joca.2021.12.013

Objective: To examine the clusters of chronic conditions present in people with osteoarthritis and the associated risk factors and health outcomes. Methods: Clinical Practice Research Datalink (CPRD) GOLD was used to identify people diagnosed with in... Read More about Clustering of comorbidities and associated outcomes in people with osteoarthritis - A UK Clinical Practice Research Datalink study.

Serum levels of specialised pro-resolving molecule pathways are greatly increased in SARS-CoV-2 patients and correlate with markers of the adaptive immune response (2021)
Preprint / Working Paper
Turnbull, J., Jha, R., Ortori, C. A., Lunt, E., Tighe, P. J., Irving, W. L., Gohir, S. A., Kim, D.-H., Valdes, A. M., Tarr, A. W., Barrett, D. A., & Chapman, V. Serum levels of specialised pro-resolving molecule pathways are greatly increased in SARS-CoV-2 patients and correlate with markers of the adaptive immune response

Background Specialised pro-resolution molecules (SPMs) halt the transition to chronic pathogenic inflammation. We aimed to quantify serum levels of pro- and anti-inflammatory bioactive lipids in SARS-CoV-2 patients, and to identify potential relation... Read More about Serum levels of specialised pro-resolving molecule pathways are greatly increased in SARS-CoV-2 patients and correlate with markers of the adaptive immune response.

Association between serum urate and flares in people with gout and evidence for surrogate status: a secondary analysis of two randomised controlled trials (2021)
Journal Article
Stamp, L. K., Frampton, C., Morillon, M. B., Taylor, W. J., Dalbeth, N., Singh, J. A., …Christensen, R. (2022). Association between serum urate and flares in people with gout and evidence for surrogate status: a secondary analysis of two randomised controlled trials. The Lancet Rheumatology, 4(1), e53-e60. https://doi.org/10.1016/s2665-9913%2821%2900319-2

Background
Use of serum urate as a treatment target and outcome measure has become controversial in view of the 2017 American College of Physicians guidelines, which advocated a treat-to-symptom rather than a treat-to-target serum urate approach to... Read More about Association between serum urate and flares in people with gout and evidence for surrogate status: a secondary analysis of two randomised controlled trials.

Identifying multiple knee pain trajectories and the prediction of opioid and NSAID medication used: A latent class growth approach (2021)
Journal Article
Haybatollahi, S. M., James, R. J., Fernandes, G., Valdes, A., Doherty, M., Zhang, W., …Ferguson, E. (2022). Identifying multiple knee pain trajectories and the prediction of opioid and NSAID medication used: A latent class growth approach. Pain Practice, 22(2), 210-221. https://doi.org/10.1111/papr.13082

Background: Knee pain is a major source of distress and disability, with pain progression highly variable between individuals. Previous studies defining pain trajectories have all used a single measure of pain, and these differ across studies. Differ... Read More about Identifying multiple knee pain trajectories and the prediction of opioid and NSAID medication used: A latent class growth approach.

Efficacy of nonpharmacological interventions for individual features of fibromyalgia: a systematic review and meta-analysis of randomised controlled trials (2021)
Journal Article
Kundakci, B., Kaur, J., Goh, S. L., Hall, M., Doherty, M., Zhang, W., & Abhishek, A. (2022). Efficacy of nonpharmacological interventions for individual features of fibromyalgia: a systematic review and meta-analysis of randomised controlled trials. PAIN, 163(8), 1432-1445. https://doi.org/10.1097/j.pain.0000000000002500

Fibromyalgia is a highly heterogeneous condition, but the most common symptoms are widespread pain, fatigue, poor sleep, and low mood. Nonpharmacological interventions are recommended as first-line treatment of fibromyalgia. However which interventio... Read More about Efficacy of nonpharmacological interventions for individual features of fibromyalgia: a systematic review and meta-analysis of randomised controlled trials.

Identifying predictors of response to oral non-steroidal anti-inflammatory drugs and paracetamol in osteoarthritis: a hypothesis-driven protocol for an OA Trial Bank individual participant data meta-analysis (2021)
Journal Article
Xiong, Y., Zeng, C., Doherty, M., Persson, M. S., Wei, J., Van Middelkoop, M., …Zhang, W. (2023). Identifying predictors of response to oral non-steroidal anti-inflammatory drugs and paracetamol in osteoarthritis: a hypothesis-driven protocol for an OA Trial Bank individual participant data meta-analysis. BMJ Open, 11(8), Article e048652. https://doi.org/10.1136/bmjopen-2021-048652

Introduction Symptomatic treatments for osteoarthritis (OA) provide only small-to-moderate efficacy over placebo in randomised controlled trials (RCTs). Treatment guidelines therefore have emphasised the need to identify predictors of treatment respo... Read More about Identifying predictors of response to oral non-steroidal anti-inflammatory drugs and paracetamol in osteoarthritis: a hypothesis-driven protocol for an OA Trial Bank individual participant data meta-analysis.

Motor Unit Remodelling (2021)
Book Chapter
Kirk, B., & Piasecki, M. (2021). Motor Unit Remodelling. In A. J. Cruz-Jentoft, & J. E. Morley (Eds.), Sarcopenia (35-44). (Second Edition). Wiley

Reliability of detection of ultrasound and MRI features of hand osteoarthritis: a systematic review and meta-analysis (2021)
Journal Article
Obotiba, A. D., Swain, S., Kaur, J., Doherty, M., Zhang, W., & Abhishek, A. (2022). Reliability of detection of ultrasound and MRI features of hand osteoarthritis: a systematic review and meta-analysis. Rheumatology, 61(2), 542-553. https://doi.org/10.1093/rheumatology/keab470

OBJECTIVES: To systematically review the literature on inter- and intra-rater reliability of scoring US and MRI changes in hand OA. METHODS: MEDLINE, EMBASE, CINHAL, Web of Science and AMED were searched from inception to January 2020. Kappa (κ), wei... Read More about Reliability of detection of ultrasound and MRI features of hand osteoarthritis: a systematic review and meta-analysis.

Synovitis and bone marrow lesions associate with symptoms and radiographic progression in hand osteoarthritis: a systematic review and meta-analysis of observational studies (2021)
Journal Article
Obotiba, A. D., Swain, S., Kaur, J., Yaseen, K., Doherty, M., Zhang, W., & Abhishek, A. (2021). Synovitis and bone marrow lesions associate with symptoms and radiographic progression in hand osteoarthritis: a systematic review and meta-analysis of observational studies. Osteoarthritis and Cartilage, 29(7), 946-955. https://doi.org/10.1016/j.joca.2021.03.018

Aims: To systematically review observational studies for the association between features detected on ultrasound (US) and magnetic resonance imaging (MRI) and, symptoms, signs and radiographic progression of hand osteoarthritis (OA). Methods: Medline... Read More about Synovitis and bone marrow lesions associate with symptoms and radiographic progression in hand osteoarthritis: a systematic review and meta-analysis of observational studies.

Association Between Gut Microbiota and Symptomatic Hand Osteoarthritis: Data From the Xiangya Osteoarthritis Study (2021)
Journal Article
Wei, J., Zhang, C., Zhang, Y., Zhang, W., Doherty, M., Yang, T., …Lei, G. (2021). Association Between Gut Microbiota and Symptomatic Hand Osteoarthritis: Data From the Xiangya Osteoarthritis Study. Arthritis and Rheumatology, 73(9), 1656-1662. https://doi.org/10.1002/art.41729

Objective: Systemic inflammatory factors have been implicated in symptomatic hand osteoarthritis (OA). Gut microbiome dysbiosis promotes systemic inflammation. The aim of this study was to examine the association between the gut microbiome and the pr... Read More about Association Between Gut Microbiota and Symptomatic Hand Osteoarthritis: Data From the Xiangya Osteoarthritis Study.

Mixed-Methods Study on Caregiver Strain, Quality of Life, and Perceived Health (2021)
Journal Article
Di Lorito, C., Bosco, A., Godfrey, M., Dunlop, M., Lock, J., Pollock, K., Harwood, R. H., & van der Wardt, V. (2021). Mixed-Methods Study on Caregiver Strain, Quality of Life, and Perceived Health. Journal of Alzheimer's Disease, 80(2), 799-811. https://doi.org/10.3233/JAD-201257

Background:
Caring for someone with dementia is associated with negative and positive experiences. There is little evidence based on large datasets.

Objective:
To present data around the experience of caring for someone with dementia, to identif... Read More about Mixed-Methods Study on Caregiver Strain, Quality of Life, and Perceived Health.

Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting (2021)
Journal Article
Swain, S., Coupland, C., Mallen, C., Kuo, C. F., Sarmanova, A., Bierma-Zeinstra, S. M., …Zhang, W. (2021). Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting. Rheumatology, 60(9), 4327-4339. https://doi.org/10.1093/rheumatology/keab067

OBJECTIVE: To determine the burden of comorbidities in OA and their temporal relationships in the UK.

METHODS: The Clinical Practice Research Datalink (CPRD) GOLD was used to identify people with incident OA and age, gender and practice matched n... Read More about Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting.

Effects of bariatric surgery on serum uric acid in people with obesity with or without hyperuricaemia and gout: a retrospective analysis (2021)
Journal Article
Lu, J., Bai, Z., Chen, Y., Li, Y., Tang, M., Wang, N., …Zhang, W. (2021). Effects of bariatric surgery on serum uric acid in people with obesity with or without hyperuricaemia and gout: a retrospective analysis. Rheumatology, 60(8), 3628-3634. https://doi.org/10.1093/rheumatology/keaa822

Objectives: Weight reduction may reduce serum uric acid (SUA). This study aimed to examine the changes of SUA before and after bariatric surgery in patients with obesity with or without hyperuricaemia and gout. Methods: This is a retrospective analys... Read More about Effects of bariatric surgery on serum uric acid in people with obesity with or without hyperuricaemia and gout: a retrospective analysis.

Investigating the barriers and facilitators to implementing mental health first aid in the workplace: a qualitative study (2020)
Journal Article
Narayanasamy, M. J., THOMSON, L., Coole, C., Nouri, F., & Drummond, A. (2021). Investigating the barriers and facilitators to implementing mental health first aid in the workplace: a qualitative study. Journal of Mental Health Training, Education and Practice, 16(2), 164-178. https://doi.org/10.1108/JMHTEP-12-2019-0064

Purpose: There has been little research into the use and efficacy of Mental Health First Aid across UK workplaces. The present study investigated the implementation of MHFA across six UK organisations, identifying key barriers and facilitators.
Desi... Read More about Investigating the barriers and facilitators to implementing mental health first aid in the workplace: a qualitative study.

Level of physical activity among middle-aged and older Chinese people: evidence from the China health and retirement longitudinal study (2020)
Journal Article
Li, X., Zhang, W., Zhang, W., Tao, K., Ni, W., Wang, K., …Lin, J. (2020). Level of physical activity among middle-aged and older Chinese people: evidence from the China health and retirement longitudinal study. BMC Public Health, 20(1), Article 1682. https://doi.org/10.1186/s12889-020-09671-9

Background: With data from different regions accumulated, physical inactivity (PI) was found to be pandemic worldwide. Using China Health and Retirement Longitudinal Study (CHARLS), a nationwide longitudinal survey data, we aimed to delineate the pre... Read More about Level of physical activity among middle-aged and older Chinese people: evidence from the China health and retirement longitudinal study.