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All Outputs (217)

Effect of vitamin D supplementation on pain and physical function in patients with knee osteoarthritis (OA): an OA Trial Bank protocol for a systematic review and individual patient data (IPD) meta-analysis (2020)
Journal Article
Jin, X., Antony, B., Wang, X., Persson, M. S., McAlindon, T., Arden, N. K., …Ding, C. (2020). Effect of vitamin D supplementation on pain and physical function in patients with knee osteoarthritis (OA): an OA Trial Bank protocol for a systematic review and individual patient data (IPD) meta-analysis. BMJ Open, 10(4), Article e035302. https://doi.org/10.1136/bmjopen-2019-035302

Introduction: Observational data suggest that vitamin D deficiency is associated with the onset and progression of knee osteoarthritis (OA). However, randomised controlled trials (RCTs) to date investigating the efficacy of vitamin D supplementation... Read More about Effect of vitamin D supplementation on pain and physical function in patients with knee osteoarthritis (OA): an OA Trial Bank protocol for a systematic review and individual patient data (IPD) meta-analysis.

Anomia in people with rapidly evolving severe relapsing-remitting multiple sclerosis: both word retrieval inaccuracy and delay are common symptoms (2019)
Journal Article
De Dios Pérez, B., Cordova Luna, E., Cloutman, L., Rog, D., Preston, E., & Conroy, P. (2020). Anomia in people with rapidly evolving severe relapsing-remitting multiple sclerosis: both word retrieval inaccuracy and delay are common symptoms. Aphasiology, 34(2), 195-213. https://doi.org/10.1080/02687038.2019.1642999

Background: Multiple Sclerosis (MS) is a neurodegenerative disease that produces plaques throughout the central nervous system. MS can present in four different clinical courses. Of these, Relapsing-Remitting MS (RRMS) is the main clinical course, es... Read More about Anomia in people with rapidly evolving severe relapsing-remitting multiple sclerosis: both word retrieval inaccuracy and delay are common symptoms.

CGRP and painful pathologies other than headache (2019)
Book Chapter
Walsh, D. A., & McWilliams, D. F. (2019). CGRP and painful pathologies other than headache. In S. D. Brain, & P. Geppetti (Eds.), Calcitonin Gene-Related Peptide (CGRP) Mechanisms: Focus on Migraine (141-167). Springer. https://doi.org/10.1007/164_2019_242

© 2019, Springer Nature Switzerland AG. CGRP has long been suspected as a mediator of arthritis pain, although evidence that CGRP directly mediates human musculoskeletal pain remains circumstantial. This chapter describes in depth the evidence surrou... Read More about CGRP and painful pathologies other than headache.

Do maladaptive beliefs delay whiplash associated disorders (WAD): A systematic review (2018)
Journal Article
Gabriela Macias, E., Georgopoulos, V., & Taylor, A. (2018). Do maladaptive beliefs delay whiplash associated disorders (WAD): A systematic review. Edorium Journal of Disability and Rehabilitation, 4(1), 1-14. https://doi.org/10.5348/100040d05em2018ra

The purpose of the study is to try to establish if maladaptive beliefs effect recovery times and poor outcomes in whiplash associated disorders (WAD). In May 2017 the following databases were searched from their inception until June 2017: SPORT Discu... Read More about Do maladaptive beliefs delay whiplash associated disorders (WAD): A systematic review.

Clinical prediction rules in the prognosis of Whiplash Associated Disorder (WAD): A systematic review (2016)
Journal Article
Georgopoulos, V., & Taylor, A. (2016). Clinical prediction rules in the prognosis of Whiplash Associated Disorder (WAD): A systematic review. Pain and Rehabilitation, 2016(41), 5-16

Objectives: To identify, evaluate and ascertain the clinical readiness of prognostic Clinical Prediction Rules (CPRs) in the prognosis of Whiplash Associated Disorder (WAD).

Study design: Systematic review

Background: The scientific basis for m... Read More about Clinical prediction rules in the prognosis of Whiplash Associated Disorder (WAD): A systematic review.

Self-reported adult footwear and the risks of lower limb osteoarthritis: the GOAL case control study. (2014)
Journal Article
McWilliams, D. F., Muthuri, S., Muir, K. R., Maciewicz, R. A., Zhang, W., & Doherty, M. (2014). Self-reported adult footwear and the risks of lower limb osteoarthritis: the GOAL case control study. BMC Musculoskeletal Disorders, 15(1), https://doi.org/10.1186/1471-2474-15-308

Background: Biomechanical factors may play a role in osteoarthritis (OA) development and progression. Previous biomechanical studies have indicated that types of footwear may modulate forces across the knee joint, and high heeled womens' shoes in par... Read More about Self-reported adult footwear and the risks of lower limb osteoarthritis: the GOAL case control study..

Mechanisms, impact and management of pain in rheumatoid arthritis (2014)
Journal Article
Walsh, D. A., & McWilliams, D. F. (2014). Mechanisms, impact and management of pain in rheumatoid arthritis. Nature Reviews Rheumatology, 10(10), 581-592. https://doi.org/10.1038/nrrheum.2014.64

© 2014 Macmillan Publishers Limited. All rights reserved. People with rheumatoid arthritis (RA) identify pain as their most important symptom, one that often persists despite optimal control of inflammatory disease. RA pain arises from multiple mecha... Read More about Mechanisms, impact and management of pain in rheumatoid arthritis.

Pain in rheumatoid arthritis (2012)
Journal Article
Walsh, D. A., & McWilliams, D. F. (2012). Pain in rheumatoid arthritis. Current Pain and Headache Reports, 16(6), 509-517. https://doi.org/10.1007/s11916-012-0303-x

Rheumatoid arthritis (RA) is an inflammatory disease of synovial joints, and pain is the predominant problem for people with RA. Pain in RA is distressing in its own right and adversely affects disability and psychosocial outcomes. RA pain may be due... Read More about Pain in rheumatoid arthritis.

Lymphatic vessels in osteoarthritic human knees (2012)
Journal Article
Walsh, D. A., Verghese, P., Cook, G. J., McWilliams, D. F., Mapp, P. I., Ashraf, S., & Wilson, D. (2012). Lymphatic vessels in osteoarthritic human knees. Osteoarthritis and Cartilage, 20(5), 405-412. https://doi.org/10.1016/j.joca.2012.01.012

Objectives: The distribution and function of lymphatic vessels in normal and diseased human knees are understood incompletely. This study aimed to investigate whether lymphatic density is associated with clinical, histological or radiographic paramet... Read More about Lymphatic vessels in osteoarthritic human knees.

Acute medical unit comprehensive geriatric assessment intervention study (AMIGOS): Study protocol for a randomised controlled trial (2011)
Journal Article
Edmans, J., Conroy, S., Harwood, R., Lewis, S., Elliott, R. A., Logan, P., …Gladman, J. (2011). Acute medical unit comprehensive geriatric assessment intervention study (AMIGOS): Study protocol for a randomised controlled trial. Trials, 12, Article 200. https://doi.org/10.1186/1745-6215-12-200

Background
Many older people presenting to Acute Medical Units (AMU) are discharged after only a short stay (< 72 hours), yet many re-present to hospital or die within 1 year. Comprehensive Geriatric Assessment may improve patient outcomes for this... Read More about Acute medical unit comprehensive geriatric assessment intervention study (AMIGOS): Study protocol for a randomised controlled trial.

Inflammation and angiogenesis in osteoarthritis (2003)
Journal Article
Haywood, L., McWilliams, D. F., Pearson, C. I., Gill, S. E., Ganesan, A., Wilson, D., & Walsh, D. A. (2003). Inflammation and angiogenesis in osteoarthritis. Arthritis and Rheumatism, 48(8), 2173-2177. https://doi.org/10.1002/art.11094

Objective. To quantify the relationship between inflammation and angiogenesis in synovial tissue from patients with osteoarthritis (OA). Methods. Hematoxylin and eosin staining and histologic grading for inflammation were performed for 104 patients w... Read More about Inflammation and angiogenesis in osteoarthritis.

Antibodies raised against the extracellular tail of the CCKB/gastrin receptor inhibit gastrin-stimulated signalling (2001)
Journal Article
McWilliams, D. F., Grimes, S., & Watson, S. A. (2001). Antibodies raised against the extracellular tail of the CCKB/gastrin receptor inhibit gastrin-stimulated signalling. Regulatory Peptides, 99(2-3), 157-161. https://doi.org/10.1016/S0167-0115%2801%2900245-2

Introduction: Gastrin acts to stimulate gastric acid secretion and is an acknowledged growth factor for human gastrointestinal (GI) cancer. The identity of the exact receptor type mediating the growth promoting effects of gastrin in tumours is uncert... Read More about Antibodies raised against the extracellular tail of the CCKB/gastrin receptor inhibit gastrin-stimulated signalling.

Coexpression of gastrin and gastrin receptors (CCK-B and ΔCCK-B) in gastrointestinal tumour cell lines (1998)
Journal Article
McWilliams, D. F., Watson, S. A., Crosbee, D. M., Michaeli, D., & Seth, R. (1998). Coexpression of gastrin and gastrin receptors (CCK-B and ΔCCK-B) in gastrointestinal tumour cell lines. Gut, 42(6), 795-798. https://doi.org/10.1136/gut.42.6.795

Background - The peptide hormone gastrin is a recognised growth factor for gastrointestinal (GI) tumour cells. Carboxyamidated gastrins bind to the cell surface gastrin/cholecystokinin B (CCK-B) receptor which can be expressed as either a normal or a... Read More about Coexpression of gastrin and gastrin receptors (CCK-B and ΔCCK-B) in gastrointestinal tumour cell lines.

P073 Comparative effectiveness of different exercise interventions on central sensitisation indices in humans: A systematic review and network meta-analysis
Presentation / Conference Contribution
Abd Elkhabir, A. A., McWilliams, D. F., Smith, S., Chaplin, W., Salimian, M., Georgopoulos, V., Kouraki, A., & Walsh, D. A. (2023, April). P073 Comparative effectiveness of different exercise interventions on central sensitisation indices in humans: A systematic review and network meta-analysis. Presented at British Society for Rheumatology Annual Conference 2023, Manchester

Background/Aims

Exercise has shown a promising effect in reducing central sensitisation (CS), but it is unknown which exercise type is the most effective. This review aimed to rank and compare the effectiveness of different exercise interventions... Read More about P073 Comparative effectiveness of different exercise interventions on central sensitisation indices in humans: A systematic review and network meta-analysis.