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All Outputs (216)

Gut Microbiome Diversity and Composition Correlates With Time in the Therapeutic Range in Patients on Warfarin Treatment: A Pilot Study (2024)
Journal Article
Agosti, P., Kouraki, A., Dionisi, T., Addolorato, G., D’Innocenzo, L., Sorrentino, S., De Maio, F., De Candia, E., Blanco-Miguez, A., Bazzani, D., Bonadiman, A., Tonidandel, G., Bolzan, M., Gianniello, F., Passamonti, S. M., Abbattista, M., Valdes, A. M., Bucciarelli, P., Peyvandi, F., & Menni, C. (2024). Gut Microbiome Diversity and Composition Correlates With Time in the Therapeutic Range in Patients on Warfarin Treatment: A Pilot Study. Arteriosclerosis, Thrombosis, and Vascular Biology, https://doi.org/10.1161/ATVBAHA.124.321490

Implementing vocational rehabilitation for people with multiple sclerosis in the UK National Health Service: a mixed-methods feasibility study (2024)
Journal Article
De Dios Perez, B., Holmes, J., Elder, T., Lindley, R., Evangelou, N., das Nair, R., Senior, C., Booth, V., Hassard, J., Ford, H. L., Newsome, I., & Radford, K. (2024). Implementing vocational rehabilitation for people with multiple sclerosis in the UK National Health Service: a mixed-methods feasibility study. Disability and Rehabilitation, https://doi.org/10.1080/09638288.2024.2417031

Purpose
To implement a job retention vocational rehabilitation (VR) intervention (MSVR) for people with multiple sclerosis (MS) and their employers in the UK National Health Service (NHS).

Methods
Multicentre, single-arm feasibility study with p... Read More about Implementing vocational rehabilitation for people with multiple sclerosis in the UK National Health Service: a mixed-methods feasibility study.

Associations between biomarkers and skeletal muscle function in individuals with osteoarthritis: a systematic review and meta-analysis (2024)
Journal Article
Smith, S. L., Paul, L., Steultjens, M. P. M., & Jones, R. L. (in press). Associations between biomarkers and skeletal muscle function in individuals with osteoarthritis: a systematic review and meta-analysis. Arthritis Research and Therapy, https://doi.org/10.1186/s13075-024-03419-1

Objectives: Skeletal muscle dysfunction is the primary cause of functional limitations in osteoarthritis, associated biomarkers have the potential as targets for early disease identification, diagnosis, and prevention of osteoarthritis disability. Th... Read More about Associations between biomarkers and skeletal muscle function in individuals with osteoarthritis: a systematic review and meta-analysis.

Contribution of inflammation markers and quantitative sensory testing (QST) indices of central sensitisation to rheumatoid arthritis pain (2024)
Journal Article
Georgopoulos, V., Smith, S., McWilliams, D. F., Ferguson, E., Wakefield, R., Platts, D., Ledbury, S., Wilson, D., & Walsh, D. A. (2024). Contribution of inflammation markers and quantitative sensory testing (QST) indices of central sensitisation to rheumatoid arthritis pain. Arthritis Research and Therapy, 26(1), Article 175. https://doi.org/10.1186/s13075-024-03407-5

Background: Pain, the primary complaint in rheumatoid arthritis (RA), is multifaceted, and may be driven by inflammatory disease activity and central sensitisation. We aimed to ascertain what proportion of RA pain severity is explained by markers of... Read More about Contribution of inflammation markers and quantitative sensory testing (QST) indices of central sensitisation to rheumatoid arthritis pain.

Development of a Vocational Rehabilitation Intervention to support Return to Work and Wellbeing following Major Trauma: A Person-Based Approach (2024)
Journal Article
Radford, K., Kettlewell, J., das Nair, R., Morriss, R., Holmes, J., Kellezi, B., Timmons, S., Jones, T., Tressider, H., Andrews, I., Bridger, K., Patel, P., Lindley, R., De Dios Perez, B., Statham, A., Jones, T., Hoffman, K., James, M., Kendrick, D., & ROWTATE study team. (2024). Development of a Vocational Rehabilitation Intervention to support Return to Work and Wellbeing following Major Trauma: A Person-Based Approach. BMJ Open, 14(10), Article e085724. https://doi.org/10.1136/bmjopen-2024-085724+

Objectives: Major trauma centres save lives but rehabilitation to support return-to-work (RTW) is lacking. This paper describes development of a vocational rehabilitation intervention (the ROWTATE intervention) to support RTW following traumatic inju... Read More about Development of a Vocational Rehabilitation Intervention to support Return to Work and Wellbeing following Major Trauma: A Person-Based Approach.

What do employers need when supporting stroke survivors to return to work?: a mixed-methods study (2024)
Journal Article
Craven, K., Kettlewell, J., De Dios Péreza, B., Powers, K., Holmes, J., & Radford, K. A. (2024). What do employers need when supporting stroke survivors to return to work?: a mixed-methods study. Topics in Stroke Rehabilitation, https://doi.org/10.1080/10749357.2024.2409005

Background

Employers are key in supporting stroke survivors to return to work (RTW) but do not always have knowledge/skills or guidance to do so.

Objectives

To explore employers’ needs for provision of post-stroke RTW support.

Methods... Read More about What do employers need when supporting stroke survivors to return to work?: a mixed-methods study.

Short-term risk of cardiovascular events in people newly diagnosed with gout (2024)
Journal Article
Cipolletta, E., Nakafero, G., Richette, P., Avery, A. J., Mamas, M. A., Tata, L. J., & Abhishek, A. (2024). Short-term risk of cardiovascular events in people newly diagnosed with gout. Arthritis and Rheumatology, https://doi.org/10.1002/art.42986

Objectives
To investigate the temporal association between first diagnosis of gout and cardiovascular events in the short-term.

Methods
We performed a self-controlled case series analysis and a cohort study using data from linked primary care, h... Read More about Short-term risk of cardiovascular events in people newly diagnosed with gout.

Mechanisms of manipulation: a systematic review of the literature on immediate anatomical structural or positional changes in response to manually delivered high-velocity, low-amplitude spinal manipulation (2024)
Journal Article
Young, K. J., Leboeuf-Yde, C., Gorrell, L., Bergström, C., Evans, D. W., Axén, I., Chance-Larsen, K., Gagey, O., Georgopoulos, V., Goncalves, G., Harris, C., Harsted, S., Kerry, R., Lee, E., McCarthy, C., Nim, C., Nyirö, L., Schweinhardt, P., & Vogel, S. (2024). Mechanisms of manipulation: a systematic review of the literature on immediate anatomical structural or positional changes in response to manually delivered high-velocity, low-amplitude spinal manipulation. Chiropractic & Manual Therapies, 32(1), Article 28. https://doi.org/10.1186/s12998-024-00549-w

Background
Spinal manipulation (SM) has been claimed to change anatomy, either in structure or position, and that these changes may be the cause of clinical improvements. The aim of this systematic review was to evaluate and synthesise the peer-revi... Read More about Mechanisms of manipulation: a systematic review of the literature on immediate anatomical structural or positional changes in response to manually delivered high-velocity, low-amplitude spinal manipulation.

Quality of Life, Pain and Use of Analgesic, Anxiolytic and Antidepressant medication, in people living in care homes (2024)
Journal Article
Collins, J., Irvine, L., Logan, P., Robinson, K., Sims, E., & Gordon, A. (2024). Quality of Life, Pain and Use of Analgesic, Anxiolytic and Antidepressant medication, in people living in care homes. Age and Ageing, 53(9), Article afae196. https://doi.org/10.1093/ageing/afae196

Background
People living in care homes often have problems with pain, anxiety and depression. Whether being on analgesia, anxiolytics or antidepressants has any bearing on pain severity and quality of life (QoL) in this population, requires further... Read More about Quality of Life, Pain and Use of Analgesic, Anxiolytic and Antidepressant medication, in people living in care homes.

Provisions, Experiential Opportunities And Perceived Value Of Undergraduate Physiotherapy Clinical Placements Within Care Home Settings (2024)
Preprint / Working Paper
Cheng, K. S., Booth, V., Cowley, A., Robinson, K., & Logan, P. A. Provisions, Experiential Opportunities And Perceived Value Of Undergraduate Physiotherapy Clinical Placements Within Care Home Settings

Introduction
There is a growing ageing population who will live longer, but with a greater burden of comorbidity requiring care home placement. Despite evidence indicating that rehabilitation in long term care improves function and quality of life,... Read More about Provisions, Experiential Opportunities And Perceived Value Of Undergraduate Physiotherapy Clinical Placements Within Care Home Settings.

A qualitative study exploring how vocational rehabilitation for people with multiple sclerosis can be integrated within existing healthcare services in the United Kingdom (2024)
Journal Article
De Dios Perez, B., Booth, V., das Nair, R., Evangelou, N., Hassard, J., Ford, H. L., Newsome, I., & Radford, K. (2024). A qualitative study exploring how vocational rehabilitation for people with multiple sclerosis can be integrated within existing healthcare services in the United Kingdom. BMC Health Services Research, 24, Article 995. https://doi.org/10.1186/s12913-024-11424-y

Background
To explore how a vocational rehabilitation (VR) intervention can be integrated within existing healthcare services for people with multiple sclerosis (MS) in the United Kingdom (UK) National Health Service (NHS).

Methods
Data from 37... Read More about A qualitative study exploring how vocational rehabilitation for people with multiple sclerosis can be integrated within existing healthcare services in the United Kingdom.

Metagenomic changes in response to antibiotic treatment in severe orthopedic trauma patients (2024)
Journal Article
Kouraki, A., Zheng, A. S., Miller, S., Kelly, A., Ashraf, W., Bazzani, D., Bonadiman, A., Tonidandel, G., Bolzan, M., Vijay, A., Nightingale, J., Menni, C., Ollivere, B. J., & Valdes, A. M. (2024). Metagenomic changes in response to antibiotic treatment in severe orthopedic trauma patients. iScience, 27(9), Article 110783. https://doi.org/10.1016/j.isci.2024.110783

We investigated changes in microbiome composition and abundance of antimicrobial resistance (AMR) genes post-antibiotic treatment in severe trauma patients. Shotgun sequencing revealed beta diversity (Bray-Curtis) differences between 16 hospitalized... Read More about Metagenomic changes in response to antibiotic treatment in severe orthopedic trauma patients.

Vitamin A carotenoids, but not retinoids, mediate the impact of a healthy diet on gut microbial diversity (2024)
Journal Article
Valdes, A. M., Louca, P., Visconti, A., Asnicar, F., Bermingham, K., Nogal, A., Wong, K., Michelotti, G. A., Wolf, J., Segata, N., Spector, T. D., Berry, S. E., Falchi, M., & Menni, C. (2024). Vitamin A carotenoids, but not retinoids, mediate the impact of a healthy diet on gut microbial diversity. BMC Medicine, 22, Article 321. https://doi.org/10.1186/s12916-024-03543-4

: Background: Vitamin A is essential for physiological processes like vision and immunity. Vitamin A’s effect on gut microbiome composition, which affects absorption and metabolism of other vitamins, is still unknown. Here we examined the relationshi... Read More about Vitamin A carotenoids, but not retinoids, mediate the impact of a healthy diet on gut microbial diversity.

Association of serum biomarkers with radiographic knee osteoarthritis, knee pain and function in a young, male, trauma-exposed population – Findings from the ADVANCE study (2024)
Journal Article
O'Sullivan, O., Stocks, J., Schofield, S., Bilzon, J., Boos, C. J., Bull, A. M., Fear, N. T., Watt, F. E., Bennett, A. N., Kluzek, S., & Valdes, A. M. (2024). Association of serum biomarkers with radiographic knee osteoarthritis, knee pain and function in a young, male, trauma-exposed population – Findings from the ADVANCE study. Osteoarthritis and Cartilage, https://doi.org/10.1016/j.joca.2024.07.016

Objective: The ArmeD SerVices TrAuma RehabilitatioN OutComE (ADVANCE) study is investigating long-term combat-injury outcomes; this sub-study aims to understand the association of osteoarthritis (OA) biomarkers with knee radiographic OA (rOA), pain a... Read More about Association of serum biomarkers with radiographic knee osteoarthritis, knee pain and function in a young, male, trauma-exposed population – Findings from the ADVANCE study.

Impact of COVID-19 on home care provision: A qualitative study (2024)
Journal Article
Darby, J., Allen, F., Bennett, C., Logan, P., & Kasonde, C. (2024). Impact of COVID-19 on home care provision: A qualitative study. Journal of Social Work, 24(5), 645-663. https://doi.org/10.1177/14680173241258900

Summary The COVID-19 pandemic and subsequent public health restrictions caused an unprecedented impact on long-term care services in the United Kingdom (UK). A qualitative study was conducted in the East Midlands, UK, to explore how home care provisi... Read More about Impact of COVID-19 on home care provision: A qualitative study.

Social participation in the promoting activity, independence and stability in early dementia (PrAISED), a home-based therapy intervention for people living with dementia: a realist evaluation (2024)
Journal Article
Lorito, C. D., Pollock, K., Booth, V., Howe, L., Goldberg, S., Godfrey, M., Dunlop, M., Harwood, R. H., Van Der Wardt, V., & Lorito, C. D. (2024). Social participation in the promoting activity, independence and stability in early dementia (PrAISED), a home-based therapy intervention for people living with dementia: a realist evaluation. BMC Geriatrics, 24(1), Article 615. https://doi.org/10.1186/s12877-024-05086-y

Background: Interventions promoting social activity may reduce behavioural psychological symptoms and improve quality of life in people living with dementia. This study aimed to identify social benefits for participants living with dementia in the co... Read More about Social participation in the promoting activity, independence and stability in early dementia (PrAISED), a home-based therapy intervention for people living with dementia: a realist evaluation.

How does mentoring occupational therapists improve intervention fidelity in a randomised controlled trial? A realist evaluation (2024)
Journal Article
De Dios Pérez, B., Merchán-Baeza, J. A., Powers, K., Craven, K., Holmes, J., Phillips, J., Tyerman, R., & Radford, K. (2024). How does mentoring occupational therapists improve intervention fidelity in a randomised controlled trial? A realist evaluation. BMC Medical Research Methodology, 24(1), Article 142. https://doi.org/10.1186/s12874-024-02269-4

Background: Integrating complex interventions within healthcare settings can be challenging. Mentoring can be embedded within a randomised controlled trial (RCT) to upskill and support those delivering the intervention. This study aimed to understand... Read More about How does mentoring occupational therapists improve intervention fidelity in a randomised controlled trial? A realist evaluation.