All Outputs (92)

The interrater and test–retest reliability of 3 modalities of quantitative sensory testing in healthy adults and people with chronic low back pain or rheumatoid arthritis (2023)
Journal Article
Brady, S. M., Georgopoulos, V., Veldhuijzen van Zanten, J. J., Duda, J. L., Metsios, G. S., Kitas, G. D., …McWilliams, D. F. (2023). The interrater and test–retest reliability of 3 modalities of quantitative sensory testing in healthy adults and people with chronic low back pain or rheumatoid arthritis. PAIN Reports, 8(6), Article e1102. https://doi.org/10.1097/pr9.0000000000001102

Introduction:
Quantitative Sensory Testing (QST) modalities used to assess central pain mechanisms require different protocols in people with different musculoskeletal conditions.

Objectives:
We aimed to explore the possible effects of musculo... Read More about The interrater and test–retest reliability of 3 modalities of quantitative sensory testing in healthy adults and people with chronic low back pain or rheumatoid arthritis.

Chronic back pain prevalence at small area level in England - the design and validation of a 2-stage static spatial microsimulation model (2023)
Journal Article
Smalley, H., & Edwards, K. (2024). Chronic back pain prevalence at small area level in England - the design and validation of a 2-stage static spatial microsimulation model. Spatial and Spatio-temporal Epidemiology, 48, Article 100633. https://doi.org/10.1016/j.sste.2023.100633

Spatially disaggregated estimates provide valuable insights into the nature of a disease. They highlight inequalities, aid public health planning and identify avenues for further research. Spatial microsimulation is advantageous in that it can be use... Read More about Chronic back pain prevalence at small area level in England - the design and validation of a 2-stage static spatial microsimulation model.

COVID-19 in a Dutch Nursing Home: A Longitudinal Retrospective Care-Home-Level Case Study on Infection Rate, Survival Rate, and Daily Functioning (2023)
Journal Article
de Vries, D., Röhlinger, D., Everink, I., Winkens, B., Heffels, J., Gordon, A., & Schols, J. (2024). COVID-19 in a Dutch Nursing Home: A Longitudinal Retrospective Care-Home-Level Case Study on Infection Rate, Survival Rate, and Daily Functioning. Journal of Clinical Medicine, 13(1), Article 149. https://doi.org/10.3390/jcm13010149

During the pandemic, nursing homes in the Netherlands were heavily affected by COVID-19. This study assesses the impact of COVID-19 on infection rate, survival rate, and daily functioning over the course of two years among residents of a nursing home... Read More about COVID-19 in a Dutch Nursing Home: A Longitudinal Retrospective Care-Home-Level Case Study on Infection Rate, Survival Rate, and Daily Functioning.

Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation (2023)
Preprint / Working Paper
Abhishek, A., Grainge, M. J., Card, T., Williams, H. C., Taal, M. W., Aithal, G. P., Fox, C. P., Mallen, C. D., Stevenson, M. D., Nakafero, G., & Riley, R. D. Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation

Background Sulfasalazine induced cytopenia, nephrotoxicity, and hepatotoxicity is uncommon during long-term treatment. Some guidelines recommend three monthly monitoring blood-tests indefinitely while others recommend stopping monitoring after one ye... Read More about Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation.

Gut-joint axis in knee synovitis: gut fungal dysbiosis and altered fungi–bacteria correlation network identified in a community-based study (2023)
Journal Article
Jiang, T., Liu, K., Li, J., Zhang, Y., Zhang, W., Doherty, M., …Zeng, C. (2023). Gut-joint axis in knee synovitis: gut fungal dysbiosis and altered fungi–bacteria correlation network identified in a community-based study. RMD Open, 9(4), Article e003529. https://doi.org/10.1136/rmdopen-2023-003529

Objectives: Knee synovitis is a highly prevalent and potentially curable condition for knee pain; however, its pathogenesis remains unclear. We sought to assess the associations of the gut fungal microbiota and the fungi–bacteria correlation network... Read More about Gut-joint axis in knee synovitis: gut fungal dysbiosis and altered fungi–bacteria correlation network identified in a community-based study.

Influence of central aspects of pain on self-management in people with chronic low back pain (2023)
Journal Article
Georgopoulos, V., McWilliams, D. F., Hendrick, P., & Walsh, D. A. (2023). Influence of central aspects of pain on self-management in people with chronic low back pain. Patient Education and Counseling, 121, Article 108109. https://doi.org/10.1016/j.pec.2023.108109

Objective: This observational study investigated whether central aspects of pain are associated with self-management domains in individuals with chronic low back pain (CLBP) undertaking a pain management program. Methods: Individuals with CLBP provid... Read More about Influence of central aspects of pain on self-management in people with chronic low back pain.

Management of acute cervical spinal cord injury in the non‐specialist intensive care unit: a narrative review of current evidence (2023)
Journal Article
Wiles, M. D., Benson, I., Edwards, L., Miller, R., Tait, F., & Wynn-Hebden, A. (2024). Management of acute cervical spinal cord injury in the non‐specialist intensive care unit: a narrative review of current evidence. Anaesthesia, 79(2), 193-202. https://doi.org/10.1111/anae.16198

Each year approximately one million people suffer spinal cord injury, which has significant physical, psychosocial and economic impacts on patients and their families. Spinal cord rehabilitation centres are a well-established part of the care pathway... Read More about Management of acute cervical spinal cord injury in the non‐specialist intensive care unit: a narrative review of current evidence.

Association between quadriceps tendon elasticity and neuromuscular control in individuals with knee osteoarthritis. (2023)
Journal Article
Dickson, D. M., Smith, S. L., & Hendry, G. J. (2024). Association between quadriceps tendon elasticity and neuromuscular control in individuals with knee osteoarthritis. Clinical Biomechanics, 111, Article 106159. https://doi.org/10.1016/j.clinbiomech.2023.106159

Background: Knee osteoarthritis is a complex condition with established risk factors such as female sex, increasing age and body mass index, reduced quadriceps muscle strength and knee injury. Despite known associated risks, the role and behaviour of... Read More about Association between quadriceps tendon elasticity and neuromuscular control in individuals with knee osteoarthritis..

Effect of a 2-week interruption in methotrexate treatment on COVID-19 vaccine response in people with immune-mediated inflammatory diseases (VROOM study): a randomised, open label, superiority trial (2023)
Journal Article
Abhishek, A., Peckham, N., Pade, C., Gibbons, J. M., Cureton, L., Francis, A., …Cook, J. A. (2023). Effect of a 2-week interruption in methotrexate treatment on COVID-19 vaccine response in people with immune-mediated inflammatory diseases (VROOM study): a randomised, open label, superiority trial. The Lancet Rheumatology, 6(2), e92-e104. https://doi.org/10.1016/s2665-9913%2823%2900298-9

Background: Methotrexate is the first-line treatment for immune-mediated inflammatory diseases and reduces vaccine-induced immunity. We evaluated if a 2-week interruption of methotrexate treatment immediately after COVID-19 booster vaccination improv... Read More about Effect of a 2-week interruption in methotrexate treatment on COVID-19 vaccine response in people with immune-mediated inflammatory diseases (VROOM study): a randomised, open label, superiority trial.

Two-week break in methotrexate treatment and COVID-19 vaccine response: a prospective, open label, two-arm parallel-group, multicentre, superiority, randomised controlled trial (2023)
Journal Article
Abhishek, A., Peckham, N., Pade, C., Gibbons, J. M., Cureton, L., Francis, A., …Study investigators, V. (2024). Two-week break in methotrexate treatment and COVID-19 vaccine response: a prospective, open label, two-arm parallel-group, multicentre, superiority, randomised controlled trial. The Lancet Rheumatology, 6(2), E92-E104. https://doi.org/10.1016/S2665-9913%2823%2900298-9

Background
Methotrexate is the first-line treatment for immune-mediated inflammatory diseases and reduces vaccine-induced immunity. We evaluated if a 2-week interruption of methotrexate treatment immediately after COVID-19 booster vaccination improv... Read More about Two-week break in methotrexate treatment and COVID-19 vaccine response: a prospective, open label, two-arm parallel-group, multicentre, superiority, randomised controlled trial.

‘Smart’ BLE wearables for digital contact tracing in care homes during the COVID-19 pandemic—a process evaluation of the CONTACT feasibility study (2023)
Journal Article
Thompson, C. A., Daffu-O’Reilly, A., Willis, T., Gordon, A., Noakes, C., Khaliq, K., …Spilsbury, K. (2023). ‘Smart’ BLE wearables for digital contact tracing in care homes during the COVID-19 pandemic—a process evaluation of the CONTACT feasibility study. Implementation Science Communications, 4(1), Article 155. https://doi.org/10.1186/s43058-023-00533-0

Background: Rapid and mass transmission of the SARS-CoV-2 virus amongst vulnerable people led to devastating effects from COVID-19 in care homes. The CONTACT intervention introduced Bluetooth Low Energy ‘smart’ wearable devices (BLE wearables) as a b... Read More about ‘Smart’ BLE wearables for digital contact tracing in care homes during the COVID-19 pandemic—a process evaluation of the CONTACT feasibility study.

Developing a list of core competencies for medical aspects of healthcare delivery in care homes: scoping review and Delphi process (2023)
Journal Article
McCarthy, L., Borley, K., Ancelin, T., Carroll, R., Chadborn, N., Blundell, A. G., & Gordon, A. L. (2023). Developing a list of core competencies for medical aspects of healthcare delivery in care homes: scoping review and Delphi process. Age and Ageing, 52(12), Article afad237. https://doi.org/10.1093/ageing/afad237

BACKGROUND: Care home residents live with frailty and multiple long-term conditions. Their medical management is complex and specialised. We set out to develop a list of core competencies for doctors providing medical care in long-term care homes. ME... Read More about Developing a list of core competencies for medical aspects of healthcare delivery in care homes: scoping review and Delphi process.

Association between hyperuricaemia and hand osteoarthritis: data from the Xiangya Osteoarthritis Study (2023)
Journal Article
Zhu, Y., Li, J., Zhang, Y., Zhang, W., Doherty, M., Yang, Z., …Wei, J. (2023). Association between hyperuricaemia and hand osteoarthritis: data from the Xiangya Osteoarthritis Study. RMD Open, 9(4), Article e003683. https://doi.org/10.1136/rmdopen-2023-003683

Objective
The pathogenesis of hand osteoarthritis (OA) remains unknown. Hyperuricaemia, which is related to inflammation, may play a role in hand OA, but evidence is lacking. In a large population-based study, we examined the association between hyp... Read More about Association between hyperuricaemia and hand osteoarthritis: data from the Xiangya Osteoarthritis Study.

Spotlight on the academic multidisciplinary team: proposals from the 3rd NIHR Newcastle BRC Academic Geriatric Medicine Workshop (2023)
Journal Article
Witham, M. D., Bridges, J., Gladman, J., Gordon, A. L., Kay, S., Manthorpe, J., …Sayer, A. A. (2023). Spotlight on the academic multidisciplinary team: proposals from the 3rd NIHR Newcastle BRC Academic Geriatric Medicine Workshop. Clinical Medicine Journal, 23(6), 611-614. https://doi.org/10.7861/clinmed.2023-0389

High-quality care for older people is best delivered by multidisciplinary teams involving a range of professions. Similarly, if research evidence is to effectively inform practice, it needs to be designed and executed by teams that are both multidisc... Read More about Spotlight on the academic multidisciplinary team: proposals from the 3rd NIHR Newcastle BRC Academic Geriatric Medicine Workshop.

Long-term psychological outcomes following stroke: the OX-CHRONIC study (2023)
Journal Article
Kusec, A., Milosevich, E., Williams, O. A., Chiu, E. G., Watson, P., Carrick, C., …Demeyere, N. (2023). Long-term psychological outcomes following stroke: the OX-CHRONIC study. BMC Neurology, 23, Article 426. https://doi.org/10.1186/s12883-023-03463-5

Background

Stroke survivors rate longer-term (> 2 years) psychological recovery as their top priority, but data on how frequently psychological consequences occur is lacking. Prevalence of cognitive impairment, depression/anxiety, fatigue, apathy... Read More about Long-term psychological outcomes following stroke: the OX-CHRONIC study.

Liraglutide 3.0mg (Saxenda©) for weight loss and remission of pre-diabetes. Real- world clinical evaluation of effectiveness among patients awaiting bariatric surgery (2023)
Journal Article
Wilmington, R., Ardavani, A., Simenacz, A., Green, C., & Idris, I. (2024). Liraglutide 3.0mg (Saxenda©) for weight loss and remission of pre-diabetes. Real- world clinical evaluation of effectiveness among patients awaiting bariatric surgery. Obesity Surgery, 34, 286-289. https://doi.org/10.1007/s11695-023-06895-7

Objective
The effectiveness of liraglutide 3.0 mg (Saxenda) therapy to induce weight loss among obese patients prior to bariatric surgery remains uncertain.

Methods
Clinical data was retrospectively obtained from patients with prediabetes (HbA1c... Read More about Liraglutide 3.0mg (Saxenda©) for weight loss and remission of pre-diabetes. Real- world clinical evaluation of effectiveness among patients awaiting bariatric surgery.

Association between gut microbiome-related metabolites and symptomatic hand osteoarthritis in two independent cohorts (2023)
Journal Article
Wei, J., Yang, Z., Li, J., Zhang, Y., Zhang, W., Doherty, M., …Zeng, C. (2023). Association between gut microbiome-related metabolites and symptomatic hand osteoarthritis in two independent cohorts. EBioMedicine, 98, Article 104892. https://doi.org/10.1016/j.ebiom.2023.104892

Background: Since gut microbiome dysbiosis can cause inflammatory disorders by affecting host metabolism, we postulate that the gut microbiome and related metabolites could play a role in hand osteoarthritis. We characterised gut microbiome-related m... Read More about Association between gut microbiome-related metabolites and symptomatic hand osteoarthritis in two independent cohorts.

Osteoarthritis pain phenotypes: How best to cut the cake? (2023)
Journal Article
Smith, S. L., & Walsh, D. A. (2023). Osteoarthritis pain phenotypes: How best to cut the cake?. Osteoarthritis and Cartilage, Article S1063-4584(23)00986-X. https://doi.org/10.1016/j.joca.2023.11.008

Evaluation of a COVID‐19 fundamental nursing care guideline versus usual care: The COVID‐NURSE cluster randomized controlled trial (2023)
Journal Article
Richards, D. A., Bollen, J., Jones, B., Melendez-Torres, G. J., Hulme, C., Cockcroft, E., …Wootton, S. (2024). Evaluation of a COVID‐19 fundamental nursing care guideline versus usual care: The COVID‐NURSE cluster randomized controlled trial. Journal of Advanced Nursing, 80(5), 2137-2152. https://doi.org/10.1111/jan.15959

Aim: To evaluate the impact of usual care plus a fundamental nursing care guideline compared to usual care only for patients in hospital with COVID‐19 on patient experience, care quality, functional ability, treatment outcomes, nurses' moral distress... Read More about Evaluation of a COVID‐19 fundamental nursing care guideline versus usual care: The COVID‐NURSE cluster randomized controlled trial.

How do clinicians prescribe bridging glucocorticoids in people starting or escalating disease-modifying anti-rheumatic drugs for rheumatoid arthritis: a service evaluation survey (2023)
Journal Article
Prior, J. A., Roddy, E., Solis-Trapala, I., Cornwall, N., Jinks, C., Abhishek, A., …Hider, S. (2023). How do clinicians prescribe bridging glucocorticoids in people starting or escalating disease-modifying anti-rheumatic drugs for rheumatoid arthritis: a service evaluation survey. Rheumatology Advances in Practice, 7(3), Article rkad102. https://doi.org/10.1093/rap/rkad102