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MRI tagging of colonic chyme mixing in healthy subjects: Inter‐observer variability and reliability of the measurement with time (2023)
Journal Article
Alshammari, M. T., Alyami, A. S., Wilkinson-Smith, V., Spiller, R. C., Gowland, P., Marciani, L., …Hoad, C. L. (2023). MRI tagging of colonic chyme mixing in healthy subjects: Inter‐observer variability and reliability of the measurement with time. Neurogastroenterology and Motility, 35(8), Article e14610. https://doi.org/10.1111/nmo.14610

Background: Magnetic resonance imaging (MRI) tagging techniques have been applied to the GI tract to assess bowel contractions and content mixing. We aimed to evaluate the dependence of a tagging measurement (for assessing chyme mixing) on inter-obse... Read More about MRI tagging of colonic chyme mixing in healthy subjects: Inter‐observer variability and reliability of the measurement with time.

Application of a 3D hydrogel-based model to replace use of animals for passaging patient-derived xenografts (2023)
Journal Article
Jones, S., Ashworth, J. C., Meakin, M., Collier, P., Probert, C., Ritchie, A. A., Merry, C. L. R., & Grabowska, A. M. (2023). Application of a 3D hydrogel-based model to replace use of animals for passaging patient-derived xenografts. In Vitro Models, 2(3-4), 99-111. https://doi.org/10.1007/s44164-023-00048-x

Purpose
This 3D in vitro cancer model for propagation of patient-derived cells, using a synthetic self-assembling peptide gel, allows the formation of a fully characterised, tailorable tumour microenvironment. Unlike many existing 3D cancer models,... Read More about Application of a 3D hydrogel-based model to replace use of animals for passaging patient-derived xenografts.

Nomenclature, diagnosis and management of drug-induced autoimmune-like hepatitis (DI-ALH): An expert opinion meeting report (2023)
Journal Article
Andrade, R. J., Aithal, G. P., de Boer, Y. S., Liberal, R., Gerbes, A., Regev, A., …Björnsson, E. S. (2023). Nomenclature, diagnosis and management of drug-induced autoimmune-like hepatitis (DI-ALH): An expert opinion meeting report. Journal of Hepatology, https://doi.org/10.1016/j.jhep.2023.04.033

Drug-induced liver injury (DILI) can mimic almost all other liver disorders. A phenotype increasingly ascribed to drugs is autoimmune-like hepatitis (ALH). This article summarises the major topics discussed at a joint International Conference held be... Read More about Nomenclature, diagnosis and management of drug-induced autoimmune-like hepatitis (DI-ALH): An expert opinion meeting report.

The synergistic effect of Levilactobacillus breves IBRC-M10790 and vitamin D3 on Helicobacter pylori-induced inflammation (2023)
Journal Article
Nabavi-Rad, A., Jamshidizadeh, S., Azizi, M., Yadegar, A., Robinson, K., Monaghan, T. M., & Reza Zali, M. (2023). The synergistic effect of Levilactobacillus breves IBRC-M10790 and vitamin D3 on Helicobacter pylori-induced inflammation. Frontiers in Cellular and Infection Microbiology, 13, Article 1171469

Owing to the emergence and spread of multidrug resistance mechanisms in Helicobacter pylori, achieving a successful eradication has become exceedingly difficult. Thus, this study for the first time determines the effect of a combination of vitamin D3... Read More about The synergistic effect of Levilactobacillus breves IBRC-M10790 and vitamin D3 on Helicobacter pylori-induced inflammation.

Targeting DNA damage repair precision medicine strategies in cancer (2023)
Journal Article
Brownlie, J., Kulkarni, S., Algethami, M., Jeyapalan, J. N., Mongan, N. P., Rakha, E. A., & Madhusudan, S. (2023). Targeting DNA damage repair precision medicine strategies in cancer. Current Opinion in Pharmacology, 70, Article 102381. https://doi.org/10.1016/j.coph.2023.102381

DNA repair targeted therapeutics is a promising precision medicine strategy in cancer. The development and clinical use of PARP inhibitors has transformed lives for many patients with BRCA germline deficient breast and ovarian cancer as well as plati... Read More about Targeting DNA damage repair precision medicine strategies in cancer.

The effect of post-discharge oral nutritional supplements on outcomes after gastrointestinal surgery: A systematic review and meta-analysis (2023)
Journal Article
Rowley, A., Adiamah, A., Kushairi, A., Lewis, S. J., & Lobo, D. N. (2023). The effect of post-discharge oral nutritional supplements on outcomes after gastrointestinal surgery: A systematic review and meta-analysis. Clinical Nutrition, 42(7), 1189-1201. https://doi.org/10.1016/j.clnu.2023.04.028

Background
Malnutrition is a risk-factor for adverse postoperative outcomes. This systematic review and meta-analysis evaluated the impact of post-discharge oral nutritional supplements (ONS) on outcomes in patients undergoing gastrointestinal surge... Read More about The effect of post-discharge oral nutritional supplements on outcomes after gastrointestinal surgery: A systematic review and meta-analysis.

Potential clinical value of catheters impregnated with antimicrobials for the prevention of infections associated with peritoneal dialysis (2023)
Journal Article
Taal, M. W., Dukka, H., & Bayston, R. (2023). Potential clinical value of catheters impregnated with antimicrobials for the prevention of infections associated with peritoneal dialysis. Expert Review of Medical Devices, 20(6), 459-466. https://doi.org/10.1080/17434440.2023.2205587

Introduction
Peritoneal dialysis (PD) is a widely used dialysis modality, which offers the advantage of being a home therapy but is associated with a risk of potentially serious infections, including exit site infection, catheter tunnel infection, a... Read More about Potential clinical value of catheters impregnated with antimicrobials for the prevention of infections associated with peritoneal dialysis.

Defining the road map to a UK national lung cancer screening programme (2023)
Journal Article
O'Dowd, E. L., Lee, R. W., Akram, A. R., Bartlett, E. C., Bradley, S. H., Brain, K., …Crosbie, P. (2023). Defining the road map to a UK national lung cancer screening programme. Lancet Oncology, 24(5), e207-e218. https://doi.org/10.1016/S1470-2045%2823%2900104-3

Lung cancer screening with low-dose CT was recommended by the UK National Screening Committee (UKNSC) in September, 2022, on the basis of data from trials showing a reduction in lung cancer mortality. These trials provide sufficient evidence to show... Read More about Defining the road map to a UK national lung cancer screening programme.

Evaluation of Endothelial Progenitor Cell Characteristics as Clinical Biomarkers for Elderly Patients with Ischaemic Stroke (2023)
Journal Article
Rakkar, K., Othman, O. A., Sprigg, N., Bath, P. M., & Bayraktutan, U. (2023). Evaluation of Endothelial Progenitor Cell Characteristics as Clinical Biomarkers for Elderly Patients with Ischaemic Stroke. Stem Cell Reviews and Reports, 19(6), 1856-1869. https://doi.org/10.1007/s12015-023-10544-y

Ageing impairs endothelial function and predisposes the person to ischaemic stroke (IS). Endothelial progenitor cells (EPCs) repair endothelial damage and induce post-ischaemic neovascularisation. Given the prevalence of IS in older population, this... Read More about Evaluation of Endothelial Progenitor Cell Characteristics as Clinical Biomarkers for Elderly Patients with Ischaemic Stroke.

Extracellular Vesicles Potentiate Medulloblastoma Metastasis in an EMMPRIN and MMP-2 Dependent Manner (2023)
Journal Article
Jackson, H. K., Mitoko, C., Linke, F., Macarthur, D., Kerr, I. D., & Coyle, B. (2023). Extracellular Vesicles Potentiate Medulloblastoma Metastasis in an EMMPRIN and MMP-2 Dependent Manner. Cancers, 15(9), Article 2601. https://doi.org/10.3390/cancers15092601

Extracellular vesicles (EVs) have emerged as pivotal mediators of communication in the tumour microenvironment. More specifically, nanosized extracellular vesicles termed exosomes have been shown to contribute to the establishment of a premetastatic... Read More about Extracellular Vesicles Potentiate Medulloblastoma Metastasis in an EMMPRIN and MMP-2 Dependent Manner.

Health-related Quality of Life in Patients With Nonalcoholic Fatty Liver Disease: A Prospective Multi-center UK Study (2023)
Journal Article
Papatheodoridi, M., Pallini, G., Aithal, G., Lim, H. K., Cobbold, J., Plaz Torres, M. C., …Tsochatzis, E. A. (2023). Health-related Quality of Life in Patients With Nonalcoholic Fatty Liver Disease: A Prospective Multi-center UK Study. Clinical Gastroenterology and Hepatology, 21(12), 3107-3114.e3. https://doi.org/10.1016/j.cgh.2023.04.018

Background & Aims: It is unclear whether health-related quality of life (HRQoL) is impaired in patients with nonalcoholic fatty liver disease (NAFLD) without advanced fibrosis and how this compares with the general population. We aimed to assess HRQo... Read More about Health-related Quality of Life in Patients With Nonalcoholic Fatty Liver Disease: A Prospective Multi-center UK Study.

Outcomes of National Survey of the Practice of Hepatocellular Carcinoma Surveillance (2023)
Journal Article
Scott, R. A., Cross, T. J., Clarke, C., Khan, S. A., Ryder, S. D., Franklin, J., & Aravinthan, A. D. (2023). Outcomes of National Survey of the Practice of Hepatocellular Carcinoma Surveillance. Journal of Hepatocellular Carcinoma, 10, 725-731. https://doi.org/10.2147/JHC.S403702

Background & Aim:

HCC has significantly improved outcomes when detected early. Guidelines recommend biannual surveillance with ultrasound (US) and/or AFP in at-risk individuals. This survey aimed to describe HCC surveillance adherence/practices a... Read More about Outcomes of National Survey of the Practice of Hepatocellular Carcinoma Surveillance.

Disproportionate Expression of ATM in Cerebellar Cortex During Human Neurodevelopment (2023)
Journal Article
Deacon, S., Dalleywater, W., Peat, C., Paine, S. M., & Dineen, R. A. (2024). Disproportionate Expression of ATM in Cerebellar Cortex During Human Neurodevelopment. Cerebellum, 23(2), 502-511. https://doi.org/10.1007/s12311-023-01560-2

Cerebellar neurodegeneration is a classical feature of ataxia telangiectasia (A-T), an autosomal recessive condition caused by loss-of-function mutation of the ATM gene, a gene with multiple regulatory functions. The increased vulnerability of cerebe... Read More about Disproportionate Expression of ATM in Cerebellar Cortex During Human Neurodevelopment.

Targeting FGFRs Using PD173074 as a Novel Therapeutic Strategy in Cholangiocarcinoma (2023)
Journal Article
Balasubramanian, B., Yacqub-Usman, K., Venkatraman, S., Myint, K. Z., Juengsamarn, J., Sarkhampee, P., …Tohtong, R. (2023). Targeting FGFRs Using PD173074 as a Novel Therapeutic Strategy in Cholangiocarcinoma. Cancers, 15(9), Article 2528. https://doi.org/10.3390/cancers15092528

Cholangiocarcinoma (CCA) is an architecturally complex tumour with high heterogeneity. Discovery at later stages makes treatment challenging. However, the lack of early detection methodologies and the asymptomatic nature of CCA make early diagnosis m... Read More about Targeting FGFRs Using PD173074 as a Novel Therapeutic Strategy in Cholangiocarcinoma.

OptoRheo: Simultaneous in situ micro-mechanical sensing and imaging of live 3D biological systems (2023)
Journal Article
Mendonca, T., Lis-Slimak, K., Matheson, A. B., Smith, M. G., Anane-Adjei, A. B., Ashworth, J. C., …Wright, A. J. (2023). OptoRheo: Simultaneous in situ micro-mechanical sensing and imaging of live 3D biological systems. Communications Biology, 6, Article 463. https://doi.org/10.1038/s42003-023-04780-8

Biomechanical cues from the extracellular matrix (ECM) are essential for directing many cellular processes, from normal development and repair, to disease progression. To better understand cell-matrix interactions, we have developed a new instrument... Read More about OptoRheo: Simultaneous in situ micro-mechanical sensing and imaging of live 3D biological systems.

Assessment of the Androgen Receptor in Older Women with Primary Breast Cancer: Association with a Panel of Biomarkers and Breast Cancer Specific Survival (2023)
Journal Article
Kalvala, J., Parks, R. M., Abdi, J., Green, A. R., & Cheung, K. L. (2023). Assessment of the Androgen Receptor in Older Women with Primary Breast Cancer: Association with a Panel of Biomarkers and Breast Cancer Specific Survival. Advances in Therapy, https://doi.org/10.1007/s12325-023-02504-2

Introduction
Breast cancer in older women tends to have more favourable biology, compared to younger women. Androgen receptor (AR) is significant for breast tumour carcinogenesis; however, the role of AR in older women has not been fully explored.... Read More about Assessment of the Androgen Receptor in Older Women with Primary Breast Cancer: Association with a Panel of Biomarkers and Breast Cancer Specific Survival.

Identification and characterisation of a rare MTTP variant underlying hereditary non-alcoholic fatty liver disease (2023)
Journal Article
Grove, J. I., Lo, P. C., Shrine, N., Barwell, J., Wain, L. V., Tobin, M. D., …Aithal, G. P. (2023). Identification and characterisation of a rare MTTP variant underlying hereditary non-alcoholic fatty liver disease. JHEP Reports, 5(8), Article 100764. https://doi.org/10.1016/j.jhepr.2023.100764

Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is a complex trait with an estimated prevalence of 25% globally. We aimed to identify the genetic variant underlying a four-generation family with progressive NAFLD leading to cirrhosis, de... Read More about Identification and characterisation of a rare MTTP variant underlying hereditary non-alcoholic fatty liver disease.