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Radiogenomics as an Integrated Approach to Glioblastoma Precision Medicine (2024)
Journal Article
Sanchez, I., & Rahman, R. (2024). Radiogenomics as an Integrated Approach to Glioblastoma Precision Medicine. Current Oncology Reports, https://doi.org/10.1007/s11912-024-01580-z

Purpose of Review Isocitrate dehydrogenase wild-type glioblastoma is the most aggressive primary brain tumour in adults. Its infiltrative nature and heterogeneity confer a dismal prognosis, despite multimodal treatment. Precision medicine is increa... Read More about Radiogenomics as an Integrated Approach to Glioblastoma Precision Medicine.

Identification of Predictive Biomarkers of Lameness in Transition Dairy Cows (2024)
Journal Article
Cardoso, A. S., Whitby, A., Green, M. J., Kim, D.-H., & Randall, L. V. (2024). Identification of Predictive Biomarkers of Lameness in Transition Dairy Cows. Animals, 14(14), Article 2030. https://doi.org/10.3390/ani14142030

The aim of this study was to identify with a high level of confidence metabolites previously identified as predictors of lameness and understand their biological relevance by carrying out pathway analyses. For the dairy cattle sector, lameness is a m... Read More about Identification of Predictive Biomarkers of Lameness in Transition Dairy Cows.

Evaluation of the mechanism of action of paracetamol, drotaverine, and peppermint oil and their effects in combination with hyoscine butylbromide on colonic motility: Human ex-vivo study (2024)
Journal Article
Traserra, S., Barber, C., Gerardo Alcalá-González, L., Landolfi, S., Lange, R., Malagelada, C., …Jimenez, M. (2024). Evaluation of the mechanism of action of paracetamol, drotaverine, and peppermint oil and their effects in combination with hyoscine butylbromide on colonic motility: Human ex-vivo study. Frontiers in Pharmacology, 15, Article 1384070. https://doi.org/10.3389/fphar.2024.1384070

Introduction: Drotaverine, paracetamol, and peppermint oil are often prescribed for the treatment of gastrointestinal spasm and pain. This study aimed to evaluate the effect of these drugs alone and combined with the well-known antispasmodic hyoscine... Read More about Evaluation of the mechanism of action of paracetamol, drotaverine, and peppermint oil and their effects in combination with hyoscine butylbromide on colonic motility: Human ex-vivo study.

Presentation and Publication Skills: How to prepare a scientific poster (2024)
Journal Article
Davies, N. A., Deutz, N. E., Delzenne, N., & Lobo, D. N. (2024). Presentation and Publication Skills: How to prepare a scientific poster. Clinical Nutrition ESPEN, 63, 457-461. https://doi.org/10.1016/j.clnesp.2024.06.056

A good scientific poster should capture the interest and imagination of the viewer and the overall aim should be to make the target audience want to know more about the topic. A well prepared poster will speak for itself and significantly aid the pre... Read More about Presentation and Publication Skills: How to prepare a scientific poster.

An unusual variant of Type I common bile duct duplication associated with ampullary carcinoma (2024)
Journal Article
Bancu, A., Poundall, T., Santos, C., Higashi, Y., Zaitoun, A. M., & Lobo, D. N. (2024). An unusual variant of Type I common bile duct duplication associated with ampullary carcinoma. Archive of Clinical Cases, 11(2), 56-60. https://doi.org/10.22551/2024.43.1102.10289

Common bile duct duplications represent exceptionally rare congenital anomalies of the biliary tract. In this case report we document an unusual variant of common bile duct duplication in a 79-year-old man who underwent a pancreaticoduodenectomy for... Read More about An unusual variant of Type I common bile duct duplication associated with ampullary carcinoma.

A polygenic risk score for alcohol-related cirrhosis among heavy drinkers with European ancestry (2024)
Journal Article
Schwantes-An, T.-H., Whitfield, J., Aithal, G., Atkinson, S., Bataller, R., Botwin, G., …GenomALC Consortium, G. C. (2024). A polygenic risk score for alcohol-related cirrhosis among heavy drinkers with European ancestry. Hepatology Communications, 8(6), Article e0431. https://doi.org/10.1097/HC9.0000000000000431

Background & Aims: Polygenic Risk Scores (PRS) based on results from genome-wide association studies offer the prospect of risk stratification for many common and complex diseases. We developed a PRS for alcohol-related cirrhosis by comparing SNPs am... Read More about A polygenic risk score for alcohol-related cirrhosis among heavy drinkers with European ancestry.

A comparison of the top 500 papers in Clinical Nutrition ranked by citation and Altmetric Attention Scores (2024)
Journal Article
Lewis-Lloyd, C. A., & Lobo, D. N. (2024). A comparison of the top 500 papers in Clinical Nutrition ranked by citation and Altmetric Attention Scores. Clinical Nutrition, 43(8), 1790-1797. https://doi.org/10.1016/j.clnu.2024.06.021

Background and aims Citation scores (CS) have been traditionally used to measure the impact of scientific publications. Sourced from the Internet, Altmetric Attention Scores (AAS) are complementary metrics that assess how often publications are disc... Read More about A comparison of the top 500 papers in Clinical Nutrition ranked by citation and Altmetric Attention Scores.

Comparative cytotoxicity of Acanthamoeba castellanii-derived conditioned medium on human corneal epithelial and stromal cells (2024)
Journal Article
Alhazmi, A., Sidney, L. E., Hopkinson, A., & Elsheikha, H. M. (2024). Comparative cytotoxicity of Acanthamoeba castellanii-derived conditioned medium on human corneal epithelial and stromal cells. Acta Tropica, 257, Article 107288. https://doi.org/10.1016/j.actatropica.2024.107288

Soluble factors in the secretome of Acanthamoeba castellanii play crucial roles in the pathogenesis of Acanthamoeba keratitis (AK). Investigating the pathological effects of A. castellanii-derived conditioned medium (ACCM) on ocular cells can provide... Read More about Comparative cytotoxicity of Acanthamoeba castellanii-derived conditioned medium on human corneal epithelial and stromal cells.

ECCO Guidelines on Therapeutics in Crohn's Disease: Surgical Treatment (2024)
Journal Article
Adamina, M., Minozzi, S., Warusavitarne, J., Buskens, C., Chaparro, M., Verstockt, B., …Myrelid, P. (2024). ECCO Guidelines on Therapeutics in Crohn's Disease: Surgical Treatment. Journal of Crohn's and Colitis, https://doi.org/10.1093/ecco-jcc/jjae089

This article is the second in a series of two publications on the European Crohn’s and Colitis Organisation [ECCO] evidence-based consensus on the management of Crohn’s disease. The first article covers medical management; the present article address... Read More about ECCO Guidelines on Therapeutics in Crohn's Disease: Surgical Treatment.

Real-world clinical effectiveness of ustekinumab in the treatment of Crohn’s disease in the East Midlands UK (2024)
Journal Article
White, J. R., Ahmad, S., Ashraf, F., Foley, S., Din, S., Das, R. K., …Moran, G. (in press). Real-world clinical effectiveness of ustekinumab in the treatment of Crohn’s disease in the East Midlands UK. Frontline Gastroenterology, flgastro-2024-102718. https://doi.org/10.1136/flgastro-2024-102718

Objectives: To evaluate the effectiveness of ustekinumab in treating Crohn’s disease (CD) in a UK real-world setting. Design: This was a multicentre, retrospective observational study of patients (aged ≥18 years) with CD or inflammatory bowel dise... Read More about Real-world clinical effectiveness of ustekinumab in the treatment of Crohn’s disease in the East Midlands UK.

ATF4 as a Prognostic Marker and Modulator of Glutamine Metabolism in Estrogen Receptor Positive Breast Cancer (2024)
Journal Article
Patel, R., Alfarsi, L. H., El-Ansari, R., Masisi, B. K., Erkan, B., Fakroun, A., …Green, A. R. (in press). ATF4 as a Prognostic Marker and Modulator of Glutamine Metabolism in Estrogen Receptor Positive Breast Cancer. Pathobiology, https://doi.org/10.1159/000539564

Purpose: ATF4, a stress-responsive transcription factor that upregulates adaptive genes, is a potential prognostic marker and modulator of glutamine metabolism in breast cancer. However, its exact role remains to be elucidated. Methods: ATF4 expre... Read More about ATF4 as a Prognostic Marker and Modulator of Glutamine Metabolism in Estrogen Receptor Positive Breast Cancer.

The characteristics and prognostic significance of histone H1 expression in breast cancer (2024)
Journal Article
Lashen, A. G., Almalki, N., Toss, M., Mirza, S., Malki, M. I., Rutland, C. S., …Rakha, E. A. (2024). The characteristics and prognostic significance of histone H1 expression in breast cancer. Pathology, https://doi.org/10.1016/j.pathol.2024.03.012

Histone H1 (H.H1) is involved in chromatin organisation and gene regulation and is overexpressed in many malignant tumours, including breast cancer (BC). This study proposed and evaluated the prognostic role of H.H1 expression in BC. H.H1 mRNA exp... Read More about The characteristics and prognostic significance of histone H1 expression in breast cancer.

Sparsely PEGylated poly(beta-amino ester) polyplexes enhance antigen specific T-cell response of a bivalent SARS-CoV-2 DNA vaccine (2024)
Journal Article
Bayraktutan, H., Symonds, P., Brentville, V. A., Moloney, C., Galley, C., Bennett, C. L., …Gurnani, P. (2024). Sparsely PEGylated poly(beta-amino ester) polyplexes enhance antigen specific T-cell response of a bivalent SARS-CoV-2 DNA vaccine. Biomaterials, 311, Article 122647. https://doi.org/10.1016/j.biomaterials.2024.122647

DNA technology has emerged as a promising route to accelerated manufacture of sequence agnostic vaccines. For activity, DNA vaccines must be protected and delivered to the correct antigen presenting cells. However, the physicochemical properties of t... Read More about Sparsely PEGylated poly(beta-amino ester) polyplexes enhance antigen specific T-cell response of a bivalent SARS-CoV-2 DNA vaccine.

Neuroinflammation and Lysosomal Abnormalities Characterise the Essential Role for Oxidation Resistance 1 in the Developing and Adult Cerebellum (2024)
Journal Article
Bucknor, E. M. V., Johnson, E., Efthymiou, S., Alvi, J. R., Sultan, T., Houlden, H., …Oliver, P. L. (2024). Neuroinflammation and Lysosomal Abnormalities Characterise the Essential Role for Oxidation Resistance 1 in the Developing and Adult Cerebellum. Antioxidants, 13(6), Article 685. https://doi.org/10.3390/antiox13060685

Loss-of-function mutations in the TLDc family of proteins cause a range of severe childhood-onset neurological disorders with common clinical features that include cerebellar neurodegeneration, ataxia and epilepsy. Of these proteins, oxidation resist... Read More about Neuroinflammation and Lysosomal Abnormalities Characterise the Essential Role for Oxidation Resistance 1 in the Developing and Adult Cerebellum.

Protein Oxidative Modifications in Neurodegenerative Diseases: From Advances in Detection and Modelling to Their Use as Disease Biomarkers (2024)
Journal Article
Anjo, S. I., He, Z., Hussain, Z., Farooq, A., McIntyre, A., Laughton, C. A., …Finelli, M. J. (2024). Protein Oxidative Modifications in Neurodegenerative Diseases: From Advances in Detection and Modelling to Their Use as Disease Biomarkers. Antioxidants, 13(6), Article 681. https://doi.org/10.3390/antiox13060681

Oxidation–reduction post-translational modifications (redox-PTMs) are chemical alterations to amino acids of proteins. Redox-PTMs participate in the regulation of protein conformation, localization and function, acting as signalling effectors that im... Read More about Protein Oxidative Modifications in Neurodegenerative Diseases: From Advances in Detection and Modelling to Their Use as Disease Biomarkers.

Population infection estimation from wastewater surveillance for SARS-CoV-2 in Nagpur, India during the second pandemic wave (2024)
Journal Article
Acheampong, E., Husain, A. A., Dudani, H., Nayak, A. R., Nag, A., Meena, E., …Monaghan, T. M. (2024). Population infection estimation from wastewater surveillance for SARS-CoV-2 in Nagpur, India during the second pandemic wave. PLoS ONE, 19(5), Article e0303529. https://doi.org/10.1371/journal.pone.0303529

Wastewater-based epidemiology (WBE) has emerged as an effective environmental surveillance tool for predicting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease outbreaks in high-income countries (HICs) with centralized sewage infr... Read More about Population infection estimation from wastewater surveillance for SARS-CoV-2 in Nagpur, India during the second pandemic wave.

How Long Does It Take to Read a Mammogram? Investigating the Reading Time of Digital Breast Tomosynthesis and Digital Mammography (2024)
Journal Article
Partridge, G. J., Darker, I., James, J. J., Satchithananda, K., Sharma, N., Valencia, A., …Chen, Y. (2024). How Long Does It Take to Read a Mammogram? Investigating the Reading Time of Digital Breast Tomosynthesis and Digital Mammography. European Journal of Radiology, 177, Article 111535. https://doi.org/10.1016/j.ejrad.2024.111535

Purpose To analyse digital breast tomosynthesis (DBT) reading times in the screening setting, compared to 2D full-field digital mammography (FFDM), and investigate the impact of reader experience and professional group on interpretation times. Me... Read More about How Long Does It Take to Read a Mammogram? Investigating the Reading Time of Digital Breast Tomosynthesis and Digital Mammography.

A requirement for the use of supplementary oxygen to guide medical treatment decisions may introduce bias against non-white individuals (2024)
Journal Article
Crooks, C. J., West, J., Morling, J. R., Simmonds, M., Juurlink, I., Briggs, S., Cruickshank, S., Hammond-Pears, S., Shaw, D., Card, T. R., & Fogarty, A. W. (in press). A requirement for the use of supplementary oxygen to guide medical treatment decisions may introduce bias against non-white individuals. European Respiratory Journal, Article 2302320. https://doi.org/10.1183/13993003.02320-2023

Immunohistochemical inflammation in histologically normal gallbladders containing gallstones (2024)
Journal Article
Psaltis, E., Zaitoun, A. M., Neal, K. R., & Lobo, D. N. (2024). Immunohistochemical inflammation in histologically normal gallbladders containing gallstones. World Journal of Surgery, 48(7), 1662-1673. https://doi.org/10.1002/wjs.12219

Background: The aim of this study was to establish features of inflammation in histologically normal gallbladders with gallstones and compare the expression of inflammatory markers in acutely and chronically inflamed gallbladders. Methods: Immunohist... Read More about Immunohistochemical inflammation in histologically normal gallbladders containing gallstones.