All Outputs (242)

Plant-Derived Products with Therapeutic Potential against Gastrointestinal Bacteria (2023)
Journal Article
Qassadi, F. I., Zhu, Z., & Monaghan, T. M. (2023). Plant-Derived Products with Therapeutic Potential against Gastrointestinal Bacteria. Pathogens, 12(2), Article 333. https://doi.org/10.3390/pathogens12020333

The rising burden of antimicrobial resistance and increasing infectious disease outbreaks, including the recent COVID-19 pandemic, has led to a growing demand for the development of natural products as a valuable source of leading medicinal compounds... Read More about Plant-Derived Products with Therapeutic Potential against Gastrointestinal Bacteria.

Biomaterial-based platforms for tumour tissue engineering (2023)
Journal Article
Curvello, R., Kast, V., Ordóñez-Morán, P., Mata, A., & Loessner, D. (2023). Biomaterial-based platforms for tumour tissue engineering. Nature Reviews Materials, 8, 314–330. https://doi.org/10.1038/s41578-023-00535-3

Tissue engineering has produced innovative tools for cancer research. 3D cancer models based on molecularly designed biomaterials aim to harness the dimensionality and biomechanical and biochemical properties of tumour tissues. However, to date, desp... Read More about Biomaterial-based platforms for tumour tissue engineering.

BSG 2024 IBD guidelines protocol (standard operating procedures) (2023)
Journal Article
Darie, A.-M., Sinopoulou, V., Ajay, V., Bel Kok, K., Patel, K. V., Limdi, J., …Gordon, M. (2023). BSG 2024 IBD guidelines protocol (standard operating procedures). BMJ Open Gastroenterology, 10(1), Article e001067. https://doi.org/10.1136/bmjgast-2022-001067

Introduction In the past 5 years, there have been several advances in the management of inflammatory bowel disease (IBD). We aim for a new guideline to update the most recent guideline published in 2019. We present the prospective operating procedure... Read More about BSG 2024 IBD guidelines protocol (standard operating procedures).

Low-Density Lipoprotein Pathway Is a Ubiquitous Metabolic Vulnerability in High Grade Glioma Amenable for Nanotherapeutic Delivery (2023)
Journal Article
Adekeye, A. O., Needham, D., & Rahman, R. (2023). Low-Density Lipoprotein Pathway Is a Ubiquitous Metabolic Vulnerability in High Grade Glioma Amenable for Nanotherapeutic Delivery. Pharmaceutics, 15(2), Article 599. https://doi.org/10.3390/pharmaceutics15020599

Metabolic reprogramming, through increased uptake of cholesterol in the form of low-density lipoproteins (LDL), is one way by which cancer cells, including high grade gliomas (HGG), maintain their rapid growth. In this study, we determined LDL recept... Read More about Low-Density Lipoprotein Pathway Is a Ubiquitous Metabolic Vulnerability in High Grade Glioma Amenable for Nanotherapeutic Delivery.

Drug Resistance in Medulloblastoma Is Driven by YB-1, ABCB1 and a Seven-Gene Drug Signature (2023)
Journal Article
Taylor, L., Wade, P. K., Johnson, J. E. C., Aldighieri, M., Morlando, S., Di Leva, G., …Coyle, B. (2023). Drug Resistance in Medulloblastoma Is Driven by YB-1, ABCB1 and a Seven-Gene Drug Signature. Cancers, 15(4), Article 1086. https://doi.org/10.3390/cancers15041086

Therapy resistance represents an unmet challenge in the treatment of medulloblastoma. Accordingly, the identification of targets that mark drug-resistant cell populations, or drive the proliferation of resistant cells, may improve treatment strategie... Read More about Drug Resistance in Medulloblastoma Is Driven by YB-1, ABCB1 and a Seven-Gene Drug Signature.

Understanding Early Modern Beer: An Interdisciplinary Case-Study (2023)
Journal Article
Flavin, S., Meltonville, M., Taverner, C., Reid, J., Lawrence, S., Belloch-Molina, C., & Morrissey, J. (2023). Understanding Early Modern Beer: An Interdisciplinary Case-Study. Historical Journal, 66(3), 516-549. https://doi.org/10.1017/S0018246X23000043

Beer was a staple of early modern diets across northern Europe and the Atlantic World. While its profound social, economic, and cultural significance is well established, little is known about the nature and quality of the drink itself, particularly... Read More about Understanding Early Modern Beer: An Interdisciplinary Case-Study.

Use of a real-world synthetic control arm for direct comparison of lisocabtagene maraleucel and conventional therapy in relapsed/refractory large B-cell lymphoma (2023)
Journal Article
Van Le, H., Van Naarden Braun, K., Nowakowski, G. S., Sermer, D., Radford, J., Townsend, W., …Hasskarl, J. (2023). Use of a real-world synthetic control arm for direct comparison of lisocabtagene maraleucel and conventional therapy in relapsed/refractory large B-cell lymphoma. Leukemia & Lymphoma, 64(3), 573-585. https://doi.org/10.1080/10428194.2022.2160200

This study used a real-world population as a synthetic comparator for the single-arm TRANSCEND NHL 001 study (TRANSCEND; NCT02631044) to evaluate the efficacy of lisocabtagene maraleucel (liso-cel) compared with conventional (noncellular) therapies i... Read More about Use of a real-world synthetic control arm for direct comparison of lisocabtagene maraleucel and conventional therapy in relapsed/refractory large B-cell lymphoma.

Contrast‐enhanced ultrasound repeatability for the measurement of skeletal muscle microvascular blood flow (2023)
Journal Article
Jones, E. J., Atherton, P. J., Piasecki, M., & Phillips, B. E. (2023). Contrast‐enhanced ultrasound repeatability for the measurement of skeletal muscle microvascular blood flow. Experimental Physiology, 108(4), 549-553. https://doi.org/10.1113/ep091034

Contrast-enhanced ultrasound (CEUS) can be used to directly assess skeletal muscle perfusion. However, its repeatability over time has not yet been validated and therefore its use in longitudinal measures (i.e., exploring the impact of a chronic inte... Read More about Contrast‐enhanced ultrasound repeatability for the measurement of skeletal muscle microvascular blood flow.

Plasma Sphingoid Base Profiles of Patients Diagnosed with Intrinsic or Idiosyncratic Drug-induced Liver Injury (2023)
Journal Article
Gai, Z., Samodelov, S. L., Alecu, I., Hornemann, T., Grove, J. I., Aithal, G. P., …Kullak-Ublick, G. A. (2023). Plasma Sphingoid Base Profiles of Patients Diagnosed with Intrinsic or Idiosyncratic Drug-induced Liver Injury. International Journal of Molecular Sciences, 24(3), Article 3013. https://doi.org/10.3390/ijms24033013

Sphingolipids are exceptionally diverse, comprising hundreds of unique species. The bulk of circulating sphingolipids are synthesized in the liver, thereby plasma sphingolipid profiles represent reliable surrogates of hepatic sphingolipid metabolism... Read More about Plasma Sphingoid Base Profiles of Patients Diagnosed with Intrinsic or Idiosyncratic Drug-induced Liver Injury.

Hydrogel-Based Pre-Clinical Evaluation of Repurposed FDA-Approved Drugs for AML (2023)
Journal Article
James, J. R., Curd, J., Ashworth, J. C., Abuhantash, M., Grundy, M., Seedhouse, C. H., …Thompson, A. (2023). Hydrogel-Based Pre-Clinical Evaluation of Repurposed FDA-Approved Drugs for AML. International Journal of Molecular Sciences, 24(4), Article 4235. https://doi.org/10.3390/ijms24044235

In vivo models of acute myeloid leukemia (AML) are low throughput, and standard liquid culture models fail to recapitulate the mechanical and biochemical properties of the extracellular matrix-rich protective bone marrow niche that contributes to dru... Read More about Hydrogel-Based Pre-Clinical Evaluation of Repurposed FDA-Approved Drugs for AML.

Exploring Pharmacological Treatments for Chronic Idiopathic Constipation in Adults: A Look Back to the Future (2023)
Journal Article
Bassotti, G., Villanacci, V., & Corsetti, M. (2023). Exploring Pharmacological Treatments for Chronic Idiopathic Constipation in Adults: A Look Back to the Future. Journal of Clinical Medicine, 12(4), Article 1702. https://doi.org/10.3390/jcm12041702

Despite great progress in pharmaceutical research, the medical treatment of chronic idiopathic constipation is far from ideal. The aim of the present article was to review literature data, focusing on poorly studied or commercially unavailable/unappr... Read More about Exploring Pharmacological Treatments for Chronic Idiopathic Constipation in Adults: A Look Back to the Future.

Childhood Brain Tumors: A Review of Strategies to Translate CNS Drug Delivery to Clinical Trials (2023)
Journal Article
Rahman, R., Janowski, M., Killick-Cole, C. L., Singleton, W. G. B., Campbell, E., Walczak, P., …Walker, D. A. (2023). Childhood Brain Tumors: A Review of Strategies to Translate CNS Drug Delivery to Clinical Trials. Cancers, 15(3), Article 857. https://doi.org/10.3390/cancers15030857

Brain and spinal tumors affect 1 in 1000 people by 25 years of age, and have diverse histological, biological, anatomical and dissemination characteristics. A mortality of 30–40% means the majority are cured, although two-thirds have life-long disabi... Read More about Childhood Brain Tumors: A Review of Strategies to Translate CNS Drug Delivery to Clinical Trials.

Revisiting primary endocrine therapy versus surgery in older women with breast cancer: meta-analysis (2023)
Journal Article
Chan, K. S., Chong, M. T. H., Chia, C. L. K., & Cheung, K. L. (2023). Revisiting primary endocrine therapy versus surgery in older women with breast cancer: meta-analysis. British Journal of Surgery, 110(4), 420-431. https://doi.org/10.1093/bjs/znac435

Background Old age is associated with increased co-morbidities, resulting in reduced life expectancy. Primary endocrine therapy is an alternative to primary surgical therapy for patients with breast cancer and increased co-morbidities. The aim was to... Read More about Revisiting primary endocrine therapy versus surgery in older women with breast cancer: meta-analysis.

Inhibition of Intimal Thickening By PRH (Proline-Rich Homeodomain) in Mice (2023)
Journal Article
Reolizo, L. M., Williams, H., Wadey, K., Frankow, A., Li, Z., Gaston, K., …George, S. J. (2023). Inhibition of Intimal Thickening By PRH (Proline-Rich Homeodomain) in Mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 43(3), 456-473. https://doi.org/10.1161/ATVBAHA.122.318367

Background: Late vein graft failure is caused by intimal thickening resulting from endothelial cell (EC) damage and inflammation which promotes vascular smooth muscle cell (VSMC) dedifferentiation, migration, and proliferation. Nonphosphorylatable PR... Read More about Inhibition of Intimal Thickening By PRH (Proline-Rich Homeodomain) in Mice.

Extra‐hepatic Morbidity and Mortality in Alcohol‐related Liver Disease: Systematic Review and Meta‐analysis (2023)
Journal Article
Theodoreson, M. D., Aithal, G. P., Allison, M., Brahmania, M., Forrest, E., Hagström, H., …Parker, R. (2023). Extra‐hepatic Morbidity and Mortality in Alcohol‐related Liver Disease: Systematic Review and Meta‐analysis. Liver International, 43(4), 763-772. https://doi.org/10.1111/liv.15526

Background
Alcohol use increases the risk of many conditions in addition to liver disease; patients with alcohol-related liver disease (ALD) are therefore at risk from both extra-hepatic and hepatic disease.

Aims
This review synthesises informat... Read More about Extra‐hepatic Morbidity and Mortality in Alcohol‐related Liver Disease: Systematic Review and Meta‐analysis.

Risk of liver fibrosis associated with long-term methotrexate therapy may be overestimated (2023)
Journal Article
Atallah, E., Grove, J. I., Crooks, C., Burden-Teh, E., Abhishek, A., Moreea, S., …Aithal, G. P. (2023). Risk of liver fibrosis associated with long-term methotrexate therapy may be overestimated. Journal of Hepatology, 78(5), 989-997. https://doi.org/10.1016/j.jhep.2022.12.034

Background & Aims: The risk of significant liver fibrosis from prolonged methotrexate (MTX) exposure has been estimated at around 5%, prompting intensive monitoring strategies. However, the evidence is derived from retrospective studies that under-re... Read More about Risk of liver fibrosis associated with long-term methotrexate therapy may be overestimated.

Expression, assessment and significance of Ki67 expression in breast cancer: an update (2023)
Journal Article
Lashen, A. G., Toss, M. S., Ghannam, S. F., Makhlouf, S., Green, A., Mongan, N. P., & Rakha, E. (2023). Expression, assessment and significance of Ki67 expression in breast cancer: an update. Journal of Clinical Pathology, 76(6), Article 357-364. https://doi.org/10.1136/jcp-2022-208731

Ki67 expression is one of the most important and cost-effective surrogate markers to assess for tumour cell proliferation in breast cancer (BC). The Ki67 labelling index has prognostic and predictive value in patients with early-stage BC, particularl... Read More about Expression, assessment and significance of Ki67 expression in breast cancer: an update.

Activated tissue resident memory T-cells (CD8+CD103+CD39+) uniquely predict survival in left sided “immune-hot” colorectal cancers (2023)
Journal Article
Talhouni, S., Fadhil, W., Mongan, N. P., Field, L., Hunter, K., Makhsous, S., …Ramage, J. M. (2023). Activated tissue resident memory T-cells (CD8+CD103+CD39+) uniquely predict survival in left sided “immune-hot” colorectal cancers. Frontiers in Immunology, 14, Article 1057292. https://doi.org/10.3389/fimmu.2023.1057292

Introduction: Characterization of the tumour immune infiltrate (notably CD8+ T-cells) has strong predictive survival value for cancer patients. Quantification of CD8 T-cells alone cannot determine antigenic experience, as not all infiltrating T-cells... Read More about Activated tissue resident memory T-cells (CD8+CD103+CD39+) uniquely predict survival in left sided “immune-hot” colorectal cancers.

Clinically Translatable Transcrocetin Delivery Platform for Correction of Tumor Hypoxia and Enhancement of Radiation Therapy Effects (2023)
Journal Article
Diringer, M., Coliat, P., Mathieu, C., Laurent, N., Mura, C., Banerjee, M., …Detappe, A. (2023). Clinically Translatable Transcrocetin Delivery Platform for Correction of Tumor Hypoxia and Enhancement of Radiation Therapy Effects. Small, 19(12), Article 2205961. https://doi.org/10.1002/smll.202205961

Improving the tumor reoxygenation to sensitize the tumor to radiation therapy is a cornerstone in radiation oncology. Here, the pre‐clinical development of a clinically transferable liposomal formulation encapsulating trans sodium crocetinate (NP TSC... Read More about Clinically Translatable Transcrocetin Delivery Platform for Correction of Tumor Hypoxia and Enhancement of Radiation Therapy Effects.

HRT in Women Undergoing Pelvic Clearance for Endometriosis—A Case Report and a National Survey (2023)
Journal Article
Amer, S., & Bazmi, S. (2023). HRT in Women Undergoing Pelvic Clearance for Endometriosis—A Case Report and a National Survey. Journal of Clinical Medicine, 12(1), Article 336. https://doi.org/10.3390/jcm12010336

The optimal hormone replacement therapy (HRT) in women who have undergone pelvic clearance for endometriosis remains uncertain with insufficient evidence. The purpose of this case report and the national survey was to highlight the potential HRT-rela... Read More about HRT in Women Undergoing Pelvic Clearance for Endometriosis—A Case Report and a National Survey.