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Plant-Derived Products with Therapeutic Potential against Gastrointestinal Bacteria

Qassadi, Fatimah I.; Zhu, Zheying; Monaghan, Tanya M.

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Fatimah I. Qassadi

Associate Professor in International Pharmacy and Traditional Medicines

Clinical Associate Professor in Luminal Gastroenterology


The rising burden of antimicrobial resistance and increasing infectious disease outbreaks, including the recent COVID-19 pandemic, has led to a growing demand for the development of natural products as a valuable source of leading medicinal compounds. There is a wide variety of active constituents found in plants, making them an excellent source of antimicrobial agents with therapeutic potential as alternatives or potentiators of antibiotics. The structural diversity of phytochemicals enables them to act through a variety of mechanisms, targeting multiple biochemical pathways, in contrast to traditional antimicrobials. Moreover, the bioactivity of the herbal extracts can be explained by various metabolites working in synergism, where hundreds to thousands of metabolites make up the extract. Although a vast amount of literature is available regarding the use of these herbal extracts against bacterial and viral infections, critical assessments of their quality are lacking. This review aims to explore the efficacy and antimicrobial effects of herbal extracts against clinically relevant gastrointestinal infections including pathogenic Escherichia coli, toxigenic Clostridioides difficile, Campylobacter and Salmonella species. The review will discuss research gaps and propose future approaches to the translational development of plant-derived products for drug discovery purposes for the treatment and prevention of gastrointestinal infectious diseases.


Qassadi, F. I., Zhu, Z., & Monaghan, T. M. (2023). Plant-Derived Products with Therapeutic Potential against Gastrointestinal Bacteria. Pathogens, 12(2), Article 333.

Journal Article Type Review
Acceptance Date Feb 14, 2023
Online Publication Date Feb 15, 2023
Publication Date Feb 15, 2023
Deposit Date Feb 20, 2023
Publicly Available Date Feb 21, 2023
Journal Pathogens
Electronic ISSN 2076-0817
Publisher MDPI AG
Peer Reviewed Peer Reviewed
Volume 12
Issue 2
Article Number 333
Keywords Plant-derived products; antibiotic resistance; new drug targets; gastrointestinal infections; clinical trials
Public URL
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