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Hearing loss rehabilitation and higher-order auditory and cognitive processing (2023)
Book
Henshaw, H., Dawes, P., Naples, J. G., & Moberly, A. C. (Eds.). (2023). Hearing loss rehabilitation and higher-order auditory and cognitive processing. https://www.frontiersin.org/research-topics/32403/hearing-loss-rehabilitation-and-higher-order-auditory-and-cognitive-processing: Frontiers Media. https://doi.org/10.3389/9782832531945

The associations between hearing loss and cognition are complex. Over the last decade, our understanding of some of the underlying mechanisms that contribute to this association have emerged. Additionally, more recent research has focused on the role... Read More about Hearing loss rehabilitation and higher-order auditory and cognitive processing.

Characterisation of the treatment provided for children with unilateral hearing loss (2023)
Journal Article
Patel, R., Hoare, D. J., Willis, K. R., Tabraiz, S., Bateman, P. K., & Thornton, S. K. (2023). Characterisation of the treatment provided for children with unilateral hearing loss. Frontiers in Pediatrics, 11, Article 1197713. https://doi.org/10.3389/fped.2023.1197713

Background: Children with permanent unilateral hearing loss (UHL) are an understudied population, with limited data to inform the guidelines on clinical management. There is a funding gap in healthcare provision for the children with UHL in the Unite... Read More about Characterisation of the treatment provided for children with unilateral hearing loss.

Patients’ experience of accessing support for tics from primary care in the UK: an online mixed-methods survey (2023)
Journal Article
Marino, C., Khan, K., Groom, M. J., Hall, S. S., Anderson, S., Mcnally, E., …Hall, C. L. (2023). Patients’ experience of accessing support for tics from primary care in the UK: an online mixed-methods survey. BMC Health Services Research, 23, Article 788. https://doi.org/10.1186/s12913-023-09753-5

Background
Tics are common in children and young people and may persist into adulthood. Tics can cause challenges with social, occupational, physical, and academic functioning. The current study explores the perceptions of adults with tics and paren... Read More about Patients’ experience of accessing support for tics from primary care in the UK: an online mixed-methods survey.

Usability and feasibility of PreventS-MD webapp for stroke prevention (2023)
Journal Article
Feigin, V. L., Krishnamurthi, R., Medvedev, O., Merkin, A., Nair, B., Kravchenko, M., …Feigin, V. L. (2024). Usability and feasibility of PreventS-MD webapp for stroke prevention. International Journal of Stroke, 19(1), 94-104. https://doi.org/10.1177/17474930231190745

Background: Most strokes and cardiovascular diseases (CVDs) are potentially preventable if their risk factors are identified and well controlled. Digital platforms, such as the PreventS-MD webapp (PreventS-MD) may aid health care professionals (HCPs)... Read More about Usability and feasibility of PreventS-MD webapp for stroke prevention.

Early MRI Predictors of Relapse in Primary Central Nervous System Lymphoma Treated with MATRix Immunochemotherapy (2023)
Journal Article
Cornell, I., Al Busaidi, A., Wastling, S., Anjari, M., Cwynarski, K., Fox, C. P., Martinez-Calle, N., Poynton, E., Maynard, J., & Thust, S. C. (2023). Early MRI Predictors of Relapse in Primary Central Nervous System Lymphoma Treated with MATRix Immunochemotherapy. Journal of Personalized Medicine, 13(7), Article 1182. https://doi.org/10.3390/jpm13071182

Primary Central Nervous System Lymphoma (PCNSL) is a highly malignant brain tumour. We investigated dynamic changes in tumour volume and apparent diffusion coefficient (ADC) measurements for predicting outcome following treatment with MATRix chemothe... Read More about Early MRI Predictors of Relapse in Primary Central Nervous System Lymphoma Treated with MATRix Immunochemotherapy.

Bleeding with intensive versus guideline antiplatelet therapy in acute cerebral ischaemia (2023)
Journal Article
Woodhouse, L. J., Appleton, J. P., Christensen, H., Dineen, R. A., England, T. J., James, M., …Bath, P. M. (2023). Bleeding with intensive versus guideline antiplatelet therapy in acute cerebral ischaemia. Scientific Reports, 13, Article 11717. https://doi.org/10.1038/s41598-023-38474-2

Intensive antiplatelet therapy did not reduce recurrent stroke/transient ischaemic attack (TIA) events as compared with guideline treatment in the Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke (TARDIS) trial, but did increase th... Read More about Bleeding with intensive versus guideline antiplatelet therapy in acute cerebral ischaemia.

Remote ischemic conditioning for stroke: A critical systematic review (2023)
Journal Article
Keevil, H., Phillips, B. E., & England, T. J. (in press). Remote ischemic conditioning for stroke: A critical systematic review. International Journal of Stroke, 19(3), 271-279. https://doi.org/10.1177/17474930231191082

Remote ischemic conditioning (RIC) is the application of brief periods of ischemia to an organ or tissue with the aim of inducing protection from ischemia in a distant organ. It was first developed as a cardioprotective strategy but has been increasi... Read More about Remote ischemic conditioning for stroke: A critical systematic review.

The clinical utility of QbTest in supporting the assessment and monitoring of Attention-Deficit/Hyperactivity Disorder (ADHD): What do paediatricians need to know? (2023)
Journal Article
Hall, C. L., Bellato, A., Kirk, J. D., & Hollis, C. (2023). The clinical utility of QbTest in supporting the assessment and monitoring of Attention-Deficit/Hyperactivity Disorder (ADHD): What do paediatricians need to know?. Paediatrics and Child Health, 33(9), 259-264. https://doi.org/10.1016/j.paed.2023.06.006

The assessment of Attention-Deficit/Hyperactivity Disorder (ADHD) typically relies on subjective observer reports from parents, teachers, or the young person, combined with clinical observation and history. Children and young people often experience... Read More about The clinical utility of QbTest in supporting the assessment and monitoring of Attention-Deficit/Hyperactivity Disorder (ADHD): What do paediatricians need to know?.

Using mobile health technology to assess childhood autism in low-resource community settings in India: An innovation to address the detection gap (2023)
Journal Article
Dubey, I., Bishain, R., Dasgupta, J., Bhavnani, S., Belmonte, M. K., Gliga, T., …Chakrabarti, B. (2024). Using mobile health technology to assess childhood autism in low-resource community settings in India: An innovation to address the detection gap. Autism, 28(3), 755–769. https://doi.org/10.1177/13623613231182801

A diagnosis of autism typically depends on clinical assessments by highly trained professionals. This high resource demand poses a challenge in low-resource settings. Digital assessment of neurodevelopmental symptoms by non-specialists provides a pot... Read More about Using mobile health technology to assess childhood autism in low-resource community settings in India: An innovation to address the detection gap.

Relationship between autonomic arousal and attention orienting in children and adolescents with ADHD, autism and co-occurring ADHD and autism (2023)
Journal Article
Bellato, A., Arora, I., Kochhar, P., Ropar, D., Hollis, C., & Groom, M. J. (2023). Relationship between autonomic arousal and attention orienting in children and adolescents with ADHD, autism and co-occurring ADHD and autism. Cortex, 166, 306-321. https://doi.org/10.1016/j.cortex.2023.06.002

Introduction
Attention-Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) may be characterized by different profiles of visual attention orienting. However, there are also many inconsistent findings emerging from the literature... Read More about Relationship between autonomic arousal and attention orienting in children and adolescents with ADHD, autism and co-occurring ADHD and autism.

Listening efficiency in adult cochlear-implant users compared with normally-hearing controls at ecologically relevant signal-to-noise ratios (2023)
Journal Article
Perea Pérez, F., Hartley, D. E. H., Kitterick, P. T., Zekveld, A. A., Naylor, G., & Wiggins, I. M. (2023). Listening efficiency in adult cochlear-implant users compared with normally-hearing controls at ecologically relevant signal-to-noise ratios. Frontiers in Human Neuroscience, 17, Article 1214485. https://doi.org/10.3389/fnhum.2023.1214485

Introduction: Due to having to work with an impoverished auditory signal, cochlear-implant (CI) users may experience reduced speech intelligibility and/or increased listening effort in real-world listening situations, compared to their normally-heari... Read More about Listening efficiency in adult cochlear-implant users compared with normally-hearing controls at ecologically relevant signal-to-noise ratios.

TNF-α evokes blood-brain barrier dysfunction through activation of Rho-kinase and neurokinin 1 receptor (2023)
Journal Article
Gao, X., & Bayraktutan, U. (2023). TNF-α evokes blood-brain barrier dysfunction through activation of Rho-kinase and neurokinin 1 receptor. Immunobiology, 228(5), Article 152706. https://doi.org/10.1016/j.imbio.2023.152706

Ischaemic stroke, accompanied by neuroinflammation, impairs blood–brain barrier (BBB) integrity through a complex mechanism involving activation of both RhoA/Rho kinase/myosin light chain-2 and neurokinin 1 receptor (NK1R). Using an in vitro model of... Read More about TNF-α evokes blood-brain barrier dysfunction through activation of Rho-kinase and neurokinin 1 receptor.

Risk of COVID-19 in people with multiple sclerosis who are seronegative following vaccination (2023)
Journal Article
Zaloum, S. A., Wood, C. H., Tank, P., Upcott, M., Vickaryous, N., Anderson, V., …Tallantyre, E. C. (2023). Risk of COVID-19 in people with multiple sclerosis who are seronegative following vaccination. Multiple Sclerosis Journal, 29(8), 979-989. https://doi.org/10.1177/13524585231185247

Background:

People with multiple sclerosis (pwMS) treated with certain disease-modifying therapies (DMTs) have attenuated IgG response following COVID-19 vaccination; however, the clinical consequences remain unclear.

Objective:

To report CO... Read More about Risk of COVID-19 in people with multiple sclerosis who are seronegative following vaccination.

“It’s not just for the Past but it’s for the Here and Now”: Gift-Giver Perspectives on the Memory Machine to Gift Digital Memories (2023)
Presentation / Conference Contribution
Gibson, R., Babbage, C. M., Wagner, H. G., Price, D. J., Martindale, S., Chadborn, N. H., …Perez Vallejos, E. (2023). “It’s not just for the Past but it’s for the Here and Now”: Gift-Giver Perspectives on the Memory Machine to Gift Digital Memories. In DIS '23: Proceedings of the 2023 ACM Designing Interactive Systems Conference (987-1001). https://doi.org/10.1145/3563657.3595962

We present the design of the Memory Machine (MeMa), a technology probe that can store, contextualise, and document media to represent memories. We accumulate vast physical and digital possessions throughout our lives, making it difficult to distingui... Read More about “It’s not just for the Past but it’s for the Here and Now”: Gift-Giver Perspectives on the Memory Machine to Gift Digital Memories.

A systematic review of ambulance service-based randomised controlled trials in stroke (2023)
Journal Article
Dixon, M., Appleton, J. P., Siriwardena, A. N., Williams, J., & Bath, P. M. (2023). A systematic review of ambulance service-based randomised controlled trials in stroke. Neurological Sciences, 44(12), 4363-4378. https://doi.org/10.1007/s10072-023-06910-w

Background: Treatment for stroke is time-dependent, and ambulance services play a vital role in the early recognition, assessment and transportation of stroke patients. Innovations which begin in ambulance services to expedite delivery of treatments... Read More about A systematic review of ambulance service-based randomised controlled trials in stroke.

Optimising the analysis of vascular prevention trials: Re-Assessment of the TARDIS trial, the first prevention trial to adopt an ordinal primary outcome measure (2023)
Journal Article
Woodhouse, L. J., Montgomery, A. A., Pocock, S., James, M., Ranta, A., Bath, P. M., & TARDIS Investigators, T. I. (2023). Optimising the analysis of vascular prevention trials: Re-Assessment of the TARDIS trial, the first prevention trial to adopt an ordinal primary outcome measure. Contemporary Clinical Trials Communications, 35, Article 101186. https://doi.org/10.1016/j.conctc.2023.101186

Background: Ordinalised vascular outcomes incorporating event severity are more informative than binary outcomes that just include event numbers. The TARDIS trial was the first vascular prevention study to use an ordinalised vascular outcome as its p... Read More about Optimising the analysis of vascular prevention trials: Re-Assessment of the TARDIS trial, the first prevention trial to adopt an ordinal primary outcome measure.

Examining the Use of Autonomous Systems for Home Health Support using a Smart Mirror (2023)
Preprint / Working Paper
Dowthwaite, L., Reyez Cruz, G., Pena, A. R., Pepper, C., Jäger, N., Barnard, P., …Benford, S. Examining the Use of Autonomous Systems for Home Health Support using a Smart Mirror

The home is becoming a key location for healthcare delivery, including the use of technology driven by autonomous systems (AS) to monitor and support healthcare plans. Using the example of a smart mirror, this paper describes the outcomes of focus gr... Read More about Examining the Use of Autonomous Systems for Home Health Support using a Smart Mirror.

TrustScapes: A visualisation tool to capture stakeholders' concerns and recommendations about data protection, algorithmic bias, and online safety (2023)
Journal Article
Ito-Jaeger, S., Lane, G., Dowthwaite, L., Webb, H., Patel, M., Rawsthorne, M., …Perez Vallejos, E. (2023). TrustScapes: A visualisation tool to capture stakeholders' concerns and recommendations about data protection, algorithmic bias, and online safety. International Journal of Qualitative Methods, 22, 1-10. https://doi.org/10.1177/1609406923118696

This paper presents a new methodological approach, TrustScapes, an open access tool designed to identify and visualise stakeholders’ concerns and policy recommendations on data protection, algorithmic bias, and online safety for a fairer and more tru... Read More about TrustScapes: A visualisation tool to capture stakeholders' concerns and recommendations about data protection, algorithmic bias, and online safety.

TrustScapes: A Visualisation Tool to Capture Stakeholders’ Concerns and Recommendations About Data Protection, Algorithmic Bias, and Online Safety (2023)
Journal Article
Ito-Jaeger, S., Lane, G., Dowthwaite, L., Webb, H., Patel, M., Rawsthorne, M., …Perez Vallejos, E. (2023). TrustScapes: A Visualisation Tool to Capture Stakeholders’ Concerns and Recommendations About Data Protection, Algorithmic Bias, and Online Safety. International Journal of Qualitative Methods, 22, https://doi.org/10.1177/16094069231186965

This paper presents a new methodological approach, TrustScapes, an open access tool designed to identify and visualise stakeholders’ concerns and policy recommendations on data protection, algorithmic bias, and online safety for a fairer and more tru... Read More about TrustScapes: A Visualisation Tool to Capture Stakeholders’ Concerns and Recommendations About Data Protection, Algorithmic Bias, and Online Safety.