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All Outputs (17)

Establishing a Core Domain Set for early-phase clinical trials of electrical stimulation interventions for tinnitus in adults: protocol for an online Delphi study (2022)
Journal Article
Labree, B., Hoare, D. J., Fackrell, K., Hall, D. A., Gascoyne, L. E., & Sereda, M. (2022). Establishing a Core Domain Set for early-phase clinical trials of electrical stimulation interventions for tinnitus in adults: protocol for an online Delphi study. Trials, 23(1), Article 1039. https://doi.org/10.1186/s13063-022-07020-2

Background: Tinnitus is the awareness of a sound in the ear or head in the absence of an external source. It affects around 10–15% of people and current treatment options are limited. Experimental treatments include various forms of electrical stimul... Read More about Establishing a Core Domain Set for early-phase clinical trials of electrical stimulation interventions for tinnitus in adults: protocol for an online Delphi study.

Dementia and hearing-aid use: a two-way street (2022)
Journal Article
Naylor, G., Dillard, L., Orrell, M., Stephan, B. C. M., Zobay, O., & Saunders, G. H. (2022). Dementia and hearing-aid use: a two-way street. Age and Ageing, 51(12), Article afac266. https://doi.org/10.1093/ageing/afac266

Objectives
Hearing-aid use may reduce risk of dementia, but cognitive impairment makes use more challenging. An observed association between reduced hearing-aid use and incident dementia could reflect either or both of these causal paths. The object... Read More about Dementia and hearing-aid use: a two-way street.

Mental health in clinically referred children and young people before and during the Covid-19 pandemic (2022)
Journal Article
Sayal, K., Partlett, C., Bhardwaj, A., Dubicka, B., Marshall, T., Gledhill, J., …Montgomery, A. (2023). Mental health in clinically referred children and young people before and during the Covid-19 pandemic. European Child and Adolescent Psychiatry, 32(12), 2657–2666. https://doi.org/10.1007/s00787-022-02115-2

The Covid-19 pandemic and mitigation approaches, including lockdowns and school closures, are thought to have negatively impacted children and young people’s (CYP) mental health. However, the impact for clinically referred CYP is less clear. We inves... Read More about Mental health in clinically referred children and young people before and during the Covid-19 pandemic.

A cross sectional survey on UK older adult’s attitudes to ageing, dementia and positive psychology attributes (2022)
Journal Article
Thelu, M., Webster, B., Jones, K., & Orrell, M. (2022). A cross sectional survey on UK older adult’s attitudes to ageing, dementia and positive psychology attributes. BMC Geriatrics, 22, Article 837. https://doi.org/10.1186/s12877-022-03539-w

Background
With an increasingly ageing population worldwide, the predominant attitude towards ageing is still negative. Negative stereotypes have detrimental effects on individuals’ physical and mental health. Evidence is required about factors that... Read More about A cross sectional survey on UK older adult’s attitudes to ageing, dementia and positive psychology attributes.

Evolution of Type D Personality Traits After Cochlear Implantation in Severely Hearing Impaired Adults 55 Years and Older: An Exploratory Prospective, Longitudinal, Controlled, Multicenter Study (2022)
Journal Article
Andries, E., Bieńkowska, K., Świerniak, W., Skarżyński, P. H., Skarżyński, H., Calvino, M., …Mertens, G. (2022). Evolution of Type D Personality Traits After Cochlear Implantation in Severely Hearing Impaired Adults 55 Years and Older: An Exploratory Prospective, Longitudinal, Controlled, Multicenter Study. Otology and Neurotology, 43(8), e865-e871. https://doi.org/10.1097/MAO.0000000000003622

Purpose To study the evolution of type D personality traits in older adults after cochlear implantation compared with a control group of severely hearing impaired older adults who did not receive a cochlear implant (CI). The influence of COVID-19 on... Read More about Evolution of Type D Personality Traits After Cochlear Implantation in Severely Hearing Impaired Adults 55 Years and Older: An Exploratory Prospective, Longitudinal, Controlled, Multicenter Study.

Delay of endothelial cell senescence protects cerebral barrier against age-related dysfunction: role of senolytics and senomorphics (2022)
Journal Article
Ya, J., Reskiawan, R., Kadir, R. R. A., & Bayraktutan, U. (2023). Delay of endothelial cell senescence protects cerebral barrier against age-related dysfunction: role of senolytics and senomorphics. Tissue Barriers, 11(3), Article 2103353. https://doi.org/10.1080/21688370.2022.2103353

Accumulation of senescent cells in cerebrovasculature is thought to play an important role in age-related disruption of blood–brain barrier (BBB). Using an in vitro model of human BBB, composed of brain microvascular endothelial cells (BMECs), astroc... Read More about Delay of endothelial cell senescence protects cerebral barrier against age-related dysfunction: role of senolytics and senomorphics.

Systems and Processes that Enable Progress for Older Forensic Mental Health Patients (2022)
Journal Article
Walker, K., Furtado, V., Yates, J., Dening, T., Völlm, B., & Griffiths, C. (2023). Systems and Processes that Enable Progress for Older Forensic Mental Health Patients. International Journal of Forensic Mental Health, 22(2), 93-104. https://doi.org/10.1080/14999013.2022.2080304

Older forensic mental health patients have complex needs and requirements; service provision is required to address mental health, offending risk and issues associated with aging (geriatric care). This study aimed to identify the systems and processe... Read More about Systems and Processes that Enable Progress for Older Forensic Mental Health Patients.

Prevalence of Victimisation in Autistic Individuals: A Systematic Review and Meta-Analysis (2022)
Journal Article
Trundle, G., Jones, K. A., Ropar, D., & Egan, V. (2023). Prevalence of Victimisation in Autistic Individuals: A Systematic Review and Meta-Analysis. Trauma, Violence, and Abuse, 24(4), 2282-2296. https://doi.org/10.1177/15248380221093689

Autistic individuals are at an increased risk of experiencing victimisation. Previous reviews have focussed specific types of victimisation. Thus, a clearer picture considering the range of victimisation experiences autistic people face is required.... Read More about Prevalence of Victimisation in Autistic Individuals: A Systematic Review and Meta-Analysis.

Perfusion Imaging for Endovascular Thrombectomy in Acute Ischemic Stroke Is Associated With Improved Functional Outcomes in the Early and Late Time Windows (2022)
Journal Article
Dhillon, P. S., Butt, W., Podlasek, A., McConachie, N., Lenthall, R., Nair, S., …England, T. J. (2022). Perfusion Imaging for Endovascular Thrombectomy in Acute Ischemic Stroke Is Associated With Improved Functional Outcomes in the Early and Late Time Windows. Stroke, 53(9), 2770–2778. https://doi.org/10.1161/STROKEAHA.121.038010

Background: The impact on clinical outcomes of patient selection using perfusion imaging for endovascular thrombectomy (EVT) in patients with acute ischemic stroke presenting beyond 6 hours from onset remains undetermined in routine clinical practice... Read More about Perfusion Imaging for Endovascular Thrombectomy in Acute Ischemic Stroke Is Associated With Improved Functional Outcomes in the Early and Late Time Windows.

Association between anesthesia modality and clinical outcomes following endovascular stroke treatment in the extended time window (2022)
Journal Article
Dhillon, P. S., Butt, W., Podlasek, A., McConachie, N., Lenthall, R., Nair, S., …England, T. J. (2023). Association between anesthesia modality and clinical outcomes following endovascular stroke treatment in the extended time window. Journal of NeuroInterventional Surgery, 15(5), 478-482. https://doi.org/10.1136/neurintsurg-2022-018846

Background: There is a paucity of data on anesthesia-related outcomes for endovascular treatment (EVT) in the extended window (>6 hours from ischemic stroke onset). We compared functional and safety outcomes between local anesthesia (LA) without seda... Read More about Association between anesthesia modality and clinical outcomes following endovascular stroke treatment in the extended time window.

Sustaining interventions in care homes initiated by quality improvement projects: a qualitative study (2022)
Journal Article
Devi, R., Martin, G. P., Banerjee, J., Gladman, J. R., Dening, T., Barat, A., & Gordon, A. L. (2022). Sustaining interventions in care homes initiated by quality improvement projects: a qualitative study. BMJ Quality and Safety, 32(11), 665-675. https://doi.org/10.1136/bmjqs-2021-014345

Introduction: Inadequate and varied quality of care in care homes has led to a proliferation of quality improvement (QI) projects. This study examined the sustainability of interventions initiated by such projects. Method: This qualitative study expl... Read More about Sustaining interventions in care homes initiated by quality improvement projects: a qualitative study.

Dynamic susceptibility-contrast magnetic resonance imaging with contrast agent leakage correction aids in predicting grade in pediatric brain tumours: a multicenter study (2022)
Journal Article
Withey, S. B., MacPherson, L., Oates, A., Powell, S., Novak, J., Abernethy, L., Pizer, B., Grundy, R., Morgan, P. S., Bailey, S., Mitra, D., Arvanitis, T. N., Auer, D. P., Avula, S., & Peet, A. C. (2022). Dynamic susceptibility-contrast magnetic resonance imaging with contrast agent leakage correction aids in predicting grade in pediatric brain tumours: a multicenter study. Pediatric Radiology, 52(6), 1134-1149. https://doi.org/10.1007/s00247-021-05266-7

Background: Relative cerebral blood volume (rCBV) measured using dynamic susceptibility-contrast MRI can differentiate between low- and high-grade pediatric brain tumors. Multicenter studies are required for translation into clinical practice.

Ob... Read More about Dynamic susceptibility-contrast magnetic resonance imaging with contrast agent leakage correction aids in predicting grade in pediatric brain tumours: a multicenter study.

Psychological impact of lung cancer screening using a novel antibody blood test followed by imaging: the ECLS randomised controlled trial (2022)
Journal Article
Hancox, J., Ayling, K., Bedford, L., Vedhara, K., Robertson, J. F. R., Young, B., …Kendrick., D. (2023). Psychological impact of lung cancer screening using a novel antibody blood test followed by imaging: the ECLS randomised controlled trial. Journal of Public Health, 45(2), e275–e284. https://doi.org/10.1093/pubmed/fdac032

Background: The Early CDT®-Lung antibody blood test plus serial CT-scans for test-positives reduces late-stage lung cancer presentation. This study assessed psychological outcomes of this approach.

Methods: Randomised controlled trial (n=12,208) c... Read More about Psychological impact of lung cancer screening using a novel antibody blood test followed by imaging: the ECLS randomised controlled trial.

Systematic Evaluation of the T30 Neurostimulator Treatment for Tinnitus: A Double-Blind Randomised Placebo-Controlled Trial with Open-Label Extension (2022)
Journal Article
Hall, D. A., Pierzycki, R. H., Thomas, H., Greenberg, D., Sereda, M., & Hoare, D. J. (2022). Systematic Evaluation of the T30 Neurostimulator Treatment for Tinnitus: A Double-Blind Randomised Placebo-Controlled Trial with Open-Label Extension. Brain Sciences, 12(3), Article 317. https://doi.org/10.3390/brainsci12030317

Tinnitus is often triggered by cochlear damage and has been linked with aberrant patterns of neuronal activity. Acoustic Coordinated Reset (CR®) Neuromodulation is a sound therapy hypothesised to reduce tinnitus symptoms by desynchronising pathologic... Read More about Systematic Evaluation of the T30 Neurostimulator Treatment for Tinnitus: A Double-Blind Randomised Placebo-Controlled Trial with Open-Label Extension.