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All Outputs (584)

Genomic diversity of Helicobacter pylori populations from different regions of the human stomach (2022)
Journal Article
Wilkinson, D. J., Dickins, B., Robinson, K., & Winter, J. A. (2022). Genomic diversity of Helicobacter pylori populations from different regions of the human stomach. Gut Microbes, 14(1), Article 2152306. https://doi.org/10.1080/19490976.2022.2152306

Individuals infected with Helicobacter pylori harbor unique and diverse populations of quasispecies, but diversity between and within different regions of the human stomach and the process of bacterial adaptation to each location are not yet well und... Read More about Genomic diversity of Helicobacter pylori populations from different regions of the human stomach.

Digital Informed Consent: Modernising Information Sharing in Surgery to Empower Patients (2022)
Journal Article
Parsons, S. L., Daliya, P., Evans, P., & Lobo, D. N. (2023). Digital Informed Consent: Modernising Information Sharing in Surgery to Empower Patients. World Journal of Surgery, 47(3), 649-657. https://doi.org/10.1007/s00268-022-06846-w

Background Despite the 2015 Montgomery Ruling highlighting key requisites for informed consent, little has changed to modernise data-sharing and documentation of the consent process. It can be difficult to gauge patient understanding and address all... Read More about Digital Informed Consent: Modernising Information Sharing in Surgery to Empower Patients.

Temporal Trends in the Incidence of Hemophagocytic Lymphohistiocytosis: A Nationwide Cohort Study From England 2003–2018 (2022)
Journal Article
West, J., Stilwell, P., Liu, H., Ban, L., Bythell, M., Card, T. R., …Crooks, C. J. (2022). Temporal Trends in the Incidence of Hemophagocytic Lymphohistiocytosis: A Nationwide Cohort Study From England 2003–2018. HemaSphere, 6(11), Article e797. https://doi.org/10.1097/HS9.0000000000000797

Hemophagocytic lymphohistiocytosis (HLH) is rare, results in high mortality, and is increasingly being diagnosed. We aimed to quantify the incidence of diagnosed HLH and examine temporal trends in relation to age and associated diseases. Using nation... Read More about Temporal Trends in the Incidence of Hemophagocytic Lymphohistiocytosis: A Nationwide Cohort Study From England 2003–2018.

Diagnostic accuracy of serum ascites albumin gradient (SAAG) in a contemporary unselected medical cohort (2022)
Journal Article
Subhani, M., Sheth, A., Palaniyappan, N., Sugathan, P., Wilkes, E. A., & Aithal, G. P. (2022). Diagnostic accuracy of serum ascites albumin gradient (SAAG) in a contemporary unselected medical cohort. Journal of International Medical Research, 50(11), Article 030006052211403. https://doi.org/10.1177/03000605221140310

Abstract
Objectives
To describe the different aetiologies of ascites and test the validity of serum ascites albumin gradient (SAAG) and cytology in a contemporary unselected medical cohort.
Methods
All adult patients admitted to Nottingham Univer... Read More about Diagnostic accuracy of serum ascites albumin gradient (SAAG) in a contemporary unselected medical cohort.

The relationship between Central Nervous System morphometry changes and key symptoms in Crohn’s disease (2022)
Journal Article
Thapaliya, G., Eldeghaidy, S., Asghar, M., McGing, J., Radford, S., Francis, S., & Moran, G. W. (2022). The relationship between Central Nervous System morphometry changes and key symptoms in Crohn’s disease. Brain Imaging and Behavior, 17(2), 149–160. https://doi.org/10.1007/s11682-022-00742-6

Alterations in grey matter volume (GMV) and cortical thickness (CT) in Crohn’s disease (CD) patients has been previously documented. However, the findings are inconsistent, and not a true representation of CD burden, as only CD patients in remission... Read More about The relationship between Central Nervous System morphometry changes and key symptoms in Crohn’s disease.

Haemphagocytic Lymphohistiocytosis in an English Nationwide Cohort Confirms Increasing Incidence and Variation in Trigger Factors (2022)
Presentation / Conference Contribution
Bishton, M., Crooks, C., Liu, H., Ban, L., Bythell, M., Card, T., …West, J. (2022). Haemphagocytic Lymphohistiocytosis in an English Nationwide Cohort Confirms Increasing Incidence and Variation in Trigger Factors. Blood, 140(Supplement 1), 2599-2600. https://doi.org/10.1182/blood-2022-158999

Background: Haemophagocytic Lymphohistiocytosis (HLH) is a rare, life-threatening hyper-inflammatory syndrome triggered by constitutive and acquired risk factors including haematological malignancy, infection, auto-immunity and rheumatological diseas... Read More about Haemphagocytic Lymphohistiocytosis in an English Nationwide Cohort Confirms Increasing Incidence and Variation in Trigger Factors.

Helicobacter pylori eradication for primary prevention of peptic ulcer bleeding in older patients prescribed aspirin in primary care (HEAT): a randomised, double-blind, placebo-controlled trial (2022)
Journal Article
Hawkey, C., Avery, A., Coupland, C. A., Crooks, C., Dumbleton, J., Hobbs, F. D. R., …Hodgson, S. (2022). Helicobacter pylori eradication for primary prevention of peptic ulcer bleeding in older patients prescribed aspirin in primary care (HEAT): a randomised, double-blind, placebo-controlled trial. Lancet, 400(10363), 1597-1606. https://doi.org/10.1016/S0140-6736%2822%2901843-8

Background: Peptic ulcers in patients receiving aspirin are associated with Helicobacter pylori infection. We aimed to investigate whether H pylori eradication would protect against aspirin-associated ulcer bleeding. Methods: We conducted a randomise... Read More about Helicobacter pylori eradication for primary prevention of peptic ulcer bleeding in older patients prescribed aspirin in primary care (HEAT): a randomised, double-blind, placebo-controlled trial.

Post-inflammatory Polyp Burden as a Prognostic Marker of Disease-outcome in Patients with Inflammatory Bowel Disease (2022)
Journal Article
Ellul, P., Schembri, J., Vella Baldacchino, A., Molnár, T., Resal, T., Allocca, M. A., …Katsanos, K. (2023). Post-inflammatory Polyp Burden as a Prognostic Marker of Disease-outcome in Patients with Inflammatory Bowel Disease. Journal of Crohn's and Colitis, 17(4), 489-496. https://doi.org/10.1093/ecco-jcc/jjac169

BACKGROUND AND AIMS: Post-inflammatory polyps [PIPs] are considered as indicators of previous episodes of severe inflammation and mucosal ulceration. Inflammatory bowel disease [IBD], namely Crohn's disease [CD] and ulcerative colitis [UC], exhibit a... Read More about Post-inflammatory Polyp Burden as a Prognostic Marker of Disease-outcome in Patients with Inflammatory Bowel Disease.

Prehabilitation: high-quality evidence is still required (2022)
Journal Article
Lobo, D. N., Skořepa, P., Gomez, D., & Greenhaff, P. L. (2022). Prehabilitation: high-quality evidence is still required. British Journal of Anaesthesia, https://doi.org/10.1016/j.bja.2022.09.016

Prehabilitation comprises multidisciplinary healthcare interventions, including exercise, nutritional optimisation, and psychological preparation, which aim to dampen the metabolic response to surgery, shorten the period of recovery, reduce complicat... Read More about Prehabilitation: high-quality evidence is still required.

Identification of Surgeon Burnout via a Single-Item Measure (2022)
Journal Article
Houdmont, J., Daliya, P., Adiamah, A., Theophilidou, E., Hassard, J., Lobo, D. N., …Young, L. (2022). Identification of Surgeon Burnout via a Single-Item Measure. Occupational Medicine, 72(9), 641-643. https://doi.org/10.1093/occmed/kqac116

Background
Burnout is endemic in surgeons in the UK and linked with poor patient safety and quality of care, mental health problems, and workforce sustainability. Mechanisms are required to facilitate the efficient identification of burnout in this... Read More about Identification of Surgeon Burnout via a Single-Item Measure.

Standards of care for CFTR variant-specific therapy (including modulators) for people with cystic fibrosis (2022)
Journal Article
Southern, K. W., Castellani, C., Lammertyn, E., Smyth, A., VanDevanter, D., van Koningsbruggen-Rietschel, S., …Duff, A. (2023). Standards of care for CFTR variant-specific therapy (including modulators) for people with cystic fibrosis. Journal of Cystic Fibrosis, 22(1), 17-30. https://doi.org/10.1016/j.jcf.2022.10.002

Cystic fibrosis (CF) has entered the era of variant-specific therapy, tailored to the genetic variants in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene. CFTR modulators, the first variant-specific therapy available, have transfo... Read More about Standards of care for CFTR variant-specific therapy (including modulators) for people with cystic fibrosis.

Low Accuracy of FIB-4 and NAFLD Fibrosis Scores for Screening for Liver Fibrosis in the Population (2022)
Journal Article
Graupera, I., Thiele, M., Serra-Burriel, M., Caballeria, L., Roulot, D., Wong, G. L.-H., …Krag, A. (2022). Low Accuracy of FIB-4 and NAFLD Fibrosis Scores for Screening for Liver Fibrosis in the Population. Clinical Gastroenterology and Hepatology, 20(11), 2567-2576.e6. https://doi.org/10.1016/j.cgh.2021.12.034

Background & Aims

Fibrosis-4 (FIB-4) and the nonalcoholic fatty liver disease fibrosis score (NFS) are the 2 most popular noninvasive blood-based serum tests proposed for widespread fibrosis screening. We therefore aimed to describe the accuracy o... Read More about Low Accuracy of FIB-4 and NAFLD Fibrosis Scores for Screening for Liver Fibrosis in the Population.

Variability of noninvasive MRI and biological markers in compensated cirrhosis: insights for assessing disease progression (2022)
Journal Article
Bradley, C. R., Cox, E. F., Palaniyappan, N., Aithal, G. P., Francis, S. T., & Guha, I. N. (2022). Variability of noninvasive MRI and biological markers in compensated cirrhosis: insights for assessing disease progression. European Radiology Experimental, 6(1), Article 52. https://doi.org/10.1186/s41747-022-00303-y

Abstract: Background: We annually monitored stable compensated cirrhosis (CC) patients to evaluate serial variation in blood serum, liver stiffness, and multiparametric magnetic resonance imaging (mpMRI) measures to provide reference change values (R... Read More about Variability of noninvasive MRI and biological markers in compensated cirrhosis: insights for assessing disease progression.

M1 macrophages evoke an increase in polymeric immunoglobulin receptor (PIGR) expression in MDA-MB468 breast cancer cells through secretion of interleukin-1β (2022)
Journal Article
Asanprakit, W., Lobo, D. N., Eremin, O., & Bennett, A. J. (2022). M1 macrophages evoke an increase in polymeric immunoglobulin receptor (PIGR) expression in MDA-MB468 breast cancer cells through secretion of interleukin-1β. Scientific Reports, 12(1), Article 16842. https://doi.org/10.1038/s41598-022-20811-6

High expression of polymeric immunoglobulin receptor (PIGR) in breast cancer is associated with increased 5-year survival rate. However, the factors influencing PIGR expression in breast cancer have not been elucidated. The aim of this study was to d... Read More about M1 macrophages evoke an increase in polymeric immunoglobulin receptor (PIGR) expression in MDA-MB468 breast cancer cells through secretion of interleukin-1β.

Social support and risk of mortality in cirrhosis: A cohort study (2022)
Journal Article
Askgaard, G., Madsen, L. G., von Wowern, N., Winther-Jensen, M., Lau, C. J., Christensen, A. I., …Jepsen, P. (2023). Social support and risk of mortality in cirrhosis: A cohort study. JHEP Reports, 5(1), Article 100600. https://doi.org/10.1016/j.jhepr.2022.100600

Background & Aims
The function and structure of social relationships influence mortality in individuals within the general population. We compared aspects of social relationships in patients with cirrhosis and a matched comparison c... Read More about Social support and risk of mortality in cirrhosis: A cohort study.

Long-term adverse effects and healthcare burden of rectal cancer radiotherapy: systematic review and meta-analysis (2022)
Journal Article
Morton, A. J., Rashid, A., Shim, J. S., West, J., Humes, D. J., & Grainge, M. J. (2023). Long-term adverse effects and healthcare burden of rectal cancer radiotherapy: systematic review and meta-analysis. ANZ Journal of Surgery, 93(1-2), 42-53. https://doi.org/10.1111/ans.18059

Background: As rectal cancer survival increases, more patients survive with potentially severe, long-term gastrointestinal and genitourinary complications from radiotherapy. The burden of these complications for patients and healthcare services is un... Read More about Long-term adverse effects and healthcare burden of rectal cancer radiotherapy: systematic review and meta-analysis.

Postinfective bowel dysfunction following Campylobacter enteritis is characterised by reduced microbiota diversity and impaired microbiota recovery (2022)
Journal Article
Jalanka, J., Gunn, D., Singh, G., Krishnasamy, S., Lingaya, M., Crispie, F., …Spiller, R. C. (2022). Postinfective bowel dysfunction following Campylobacter enteritis is characterised by reduced microbiota diversity and impaired microbiota recovery. Gut, https://doi.org/10.1136/gutjnl-2021-326828

Objectives: Persistent bowel dysfunction following gastroenteritis (postinfectious (PI)-BD) is well recognised, but the associated changes in microbiota remain unclear. Our aim was to define these changes after gastroenteritis caused by a single orga... Read More about Postinfective bowel dysfunction following Campylobacter enteritis is characterised by reduced microbiota diversity and impaired microbiota recovery.

Liver blood marker testing in UK primary care: a UK wide cohort study, 2004-2016 (2022)
Journal Article
Scutt, P., Ban, L., Card, T., Crooks, C. J., Guha, N., West, J., & Morling, J. R. (2022). Liver blood marker testing in UK primary care: a UK wide cohort study, 2004-2016. BMJ Open, 12(9), e058967. https://doi.org/10.1136/bmjopen-2021-058967

OBJECTIVE: We aimed to determine (1) the temporal trends of liver enzyme testing in UK general practice and (2) how these vary among different subgroups at risk of chronic liver disease (CLD). DESIGN: Retrospective cohort study. SETTING: UK primary c... Read More about Liver blood marker testing in UK primary care: a UK wide cohort study, 2004-2016.