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All Outputs (82)

Barriers and facilitators to vaccination uptake against COVID-19, influenza, and pneumococcal pneumonia in immunosuppressed adults with immune-mediated inflammatory diseases: A qualitative interview study during the COVID-19 pandemic (2022)
Journal Article
Fuller, A., Hancox, J., Vedhara, K., Card, T., Mallen, C., Van-Tam, J. S. N., & Abhishek, A. (2022). Barriers and facilitators to vaccination uptake against COVID-19, influenza, and pneumococcal pneumonia in immunosuppressed adults with immune-mediated inflammatory diseases: A qualitative interview study during the COVID-19 pandemic. PLoS ONE, 17(9), Article e0267769. https://doi.org/10.1371/journal.pone.0267769

Objectives To explore barriers and facilitators to COVID-19, influenza, and pneumococcal vaccine uptake in immunosuppressed adults with immune-mediated inflammatory diseases (IMIDs). Methods Recruiting through national patient charities and a local h... Read More about Barriers and facilitators to vaccination uptake against COVID-19, influenza, and pneumococcal pneumonia in immunosuppressed adults with immune-mediated inflammatory diseases: A qualitative interview study during the COVID-19 pandemic.

Is routine laboratory testing in healthy young patients taking isotretinoin necessary – a critically appraised topic (2022)
Journal Article
Affleck, A., Jackson, D., Williams, H. C., Chavez, P., & Albrecht, J. (2022). Is routine laboratory testing in healthy young patients taking isotretinoin necessary – a critically appraised topic. British Journal of Dermatology, 187(6), 857-865. https://doi.org/10.1111/bjd.21840

Clinical question: Is monitoring of liver function, lipids and full blood count necessary in healthy people taking isotretinoin?

Background: Routine blood testing was recommended in the original licence for Roaccutane™ (isotretinoin) in 1983. In r... Read More about Is routine laboratory testing in healthy young patients taking isotretinoin necessary – a critically appraised topic.

Chronic postoperative pain after total knee arthroplasty: The potential contributions of synovitis, pain sensitization and pain catastrophizing—An explorative study (2022)
Journal Article
Kurien, T., Kerslake, R. W., Graven‐Nielsen, T., Arendt‐Nielsen, L., Auer, D. P., Edwards, K., …Petersen, K. K. (2022). Chronic postoperative pain after total knee arthroplasty: The potential contributions of synovitis, pain sensitization and pain catastrophizing—An explorative study. European Journal of Pain, 26(9), 1979-1989. https://doi.org/10.1002/ejp.2018

Background: A subset of osteoarthritis patients will experience chronic postoperative pain after total knee arthroplasty (TKA), but the source of pain is unclear. The aim of this exploratory study was to assess patients with and without postoperative... Read More about Chronic postoperative pain after total knee arthroplasty: The potential contributions of synovitis, pain sensitization and pain catastrophizing—An explorative study.

Biomarkers associated with lower limb muscle function in individuals with sarcopenia: a systematic review (2022)
Journal Article
Jones, R., Paul, L., Steultjens, M., & Smith, S. L. (2022). Biomarkers associated with lower limb muscle function in individuals with sarcopenia: a systematic review. Journal of Cachexia, Sarcopenia and Muscle, 13(6), 2791-2806. https://doi.org/10.1002/jcsm.13064

Lower limb muscle dysfunction is a key driver for impaired physical capacity and frailty status, both characteristics of sarcopenia. Sarcopenia is the key pathway between frailty and disability. Identifying biological markers for early diagnosis, tre... Read More about Biomarkers associated with lower limb muscle function in individuals with sarcopenia: a systematic review.

Strain sonoelastography in asymptomatic individuals and individuals with knee osteoarthritis: an evaluation of quadriceps and patellar tendon (2022)
Journal Article
Dickson, D. M., Smith, S. L., & Hendry, G. J. (2022). Strain sonoelastography in asymptomatic individuals and individuals with knee osteoarthritis: an evaluation of quadriceps and patellar tendon. Rheumatology International, 42(12), 2241-2251. https://doi.org/10.1007/s00296-022-05184-3

An advanced ultrasound imaging technique, sonoelastography (SE) is used to evaluate tissue elasticity. To determine SE potential to detect pathological-related changes, and characteristics related to tendon pathology we aimed to (1) compare quadricep... Read More about Strain sonoelastography in asymptomatic individuals and individuals with knee osteoarthritis: an evaluation of quadriceps and patellar tendon.

Association between Gout Flare and Subsequent Cardiovascular Events among Patients with Gout (2022)
Journal Article
Cipolletta, E., Tata, L. J., Nakafero, G., Avery, A. J., Mamas, M. A., & Abhishek, A. (2022). Association between Gout Flare and Subsequent Cardiovascular Events among Patients with Gout. Journal of the American Medical Association, 328(5), 440-450. https://doi.org/10.1001/jama.2022.11390

Importance: Gout is associated with cardiovascular diseases. The temporal association between gout flares and cardiovascular events has not been investigated. Objective: To investigate whether there is a transient increase in risk of cardiovascular e... Read More about Association between Gout Flare and Subsequent Cardiovascular Events among Patients with Gout.

Patient experiences of scaphoid waist fractures and their treatment a qualitative investigation (2022)
Journal Article
Leighton, P. A., Dias, J., & Brearley, S. (2022). Patient experiences of scaphoid waist fractures and their treatment a qualitative investigation. Bone & Joint Open, 3(8), 641-647. https://doi.org/10.1302/2633-1462.38.BJO-2022-0042.R1

Aims To explore individuals’ experience of a scaphoid waist fracture and its subsequent treatment. Methods A purposive sample was created, consisting of 49 participants in the Scaphoid Waist Internal Fixation for Fractures Trial of initial surgery co... Read More about Patient experiences of scaphoid waist fractures and their treatment a qualitative investigation.

Response to Comment on: “Black Box Prediction Methods in Sports Medicine Deserve a Red Card for Reckless Practice: A Change of Tactics is Needed to Advance Athlete Care” (2022)
Journal Article
Bullock, G. S., Hughes, T., Arundale, A. H., Ward, P., Collins, G. S., & Kluzek, S. (2022). Response to Comment on: “Black Box Prediction Methods in Sports Medicine Deserve a Red Card for Reckless Practice: A Change of Tactics is Needed to Advance Athlete Care”. Sports Medicine, 52, 2799-2801. https://doi.org/10.1007/s40279-022-01737-5

Content validity of the Recap of atopic eczema (RECAP) instrument in Dutch, English and German to measure eczema control in young people with atopic eczema: a cognitive interview study (2022)
Journal Article
Gabes, M., Ragamin, A., Baker, A., Kann, G., Donhauser, T., Gabes, D., …Apfelbacher, C. (2022). Content validity of the Recap of atopic eczema (RECAP) instrument in Dutch, English and German to measure eczema control in young people with atopic eczema: a cognitive interview study. British Journal of Dermatology, 187(6), 919-926. https://doi.org/10.1111/bjd.21767

Background: Recap of atopic eczema (RECAP) is a patient-reported outcome measure assessing eczema control. This instrument has been developed and validated in the UK. There are self-reported and proxy-reported versions in English, Dutch and German. H... Read More about Content validity of the Recap of atopic eczema (RECAP) instrument in Dutch, English and German to measure eczema control in young people with atopic eczema: a cognitive interview study.

Development of Food Group Tree-Based Analysis and Its Association with Non-Alcoholic Fatty Liver Disease (NAFLD) and Co-Morbidities in a South Indian Population: A Large Case-Control Study (2022)
Journal Article
Vijay, A., Al-Awadi, A., Chalmers, J., Balakumaran, L., Grove, J. I., Valdes, A. M., …Aithal, G. P. (2022). Development of Food Group Tree-Based Analysis and Its Association with Non-Alcoholic Fatty Liver Disease (NAFLD) and Co-Morbidities in a South Indian Population: A Large Case-Control Study. Nutrients, 14(14), Article 2808. https://doi.org/10.3390/nu14142808

Background: Non-alcoholic fatty liver disease (NAFLD) is a global problem growing in parallel to the epidemics of obesity and diabetes, with South Asians being particularly susceptible. Nutrition and behaviour are important modifiers of the disease,... Read More about Development of Food Group Tree-Based Analysis and Its Association with Non-Alcoholic Fatty Liver Disease (NAFLD) and Co-Morbidities in a South Indian Population: A Large Case-Control Study.

Serum urate outcomes of treat-to-target urate lowering treatment: results of a nationwide cohort study from 1997 to the COVID-19 pandemic using data from the Clinical Practice Research Datalink (2022)
Journal Article
Abhishek, A., Cipolletta, E., Nakafero, G., Avery, A. J., Mamas, M., & Tata, L. J. (2022). Serum urate outcomes of treat-to-target urate lowering treatment: results of a nationwide cohort study from 1997 to the COVID-19 pandemic using data from the Clinical Practice Research Datalink. Annals of the Rheumatic Diseases, 81(12), https://doi.org/10.1136/ard-2022-222668

Effect of a 2-week interruption in methotrexate treatment versus continued treatment on COVID-19 booster vaccine immunity in adults with inflammatory conditions (VROOM study): a randomised, open label, superiority trial (2022)
Journal Article
Abhishek, A., Boyton, R. J., Peckham, N., McKnight, Á., Coates, L. C., Bluett, J., …Cook, J. A. (2022). Effect of a 2-week interruption in methotrexate treatment versus continued treatment on COVID-19 booster vaccine immunity in adults with inflammatory conditions (VROOM study): a randomised, open label, superiority trial. Lancet Respiratory Medicine, 10(9), 840-850. https://doi.org/10.1016/S2213-2600%2822%2900186-2

Background: Immunosuppressive treatments inhibit vaccine-induced immunity against SARS-CoV-2. We evaluated whether a 2-week interruption of methotrexate treatment immediately after the COVID-19 vaccine booster improved antibody responses against the... Read More about Effect of a 2-week interruption in methotrexate treatment versus continued treatment on COVID-19 booster vaccine immunity in adults with inflammatory conditions (VROOM study): a randomised, open label, superiority trial.

Assessment of Fatigue and Recovery in Sport: Narrative Review (2022)
Journal Article
Bestwick-Stevenson, T., Toone, R., Neupert, E., Edwards, K., & Kluzek, S. (2022). Assessment of Fatigue and Recovery in Sport: Narrative Review. International Journal of Sports Medicine, 43(14), 1151-1162. https://doi.org/10.1055/a-1834-7177

Fatigue is a phenomenon associated with decreases in both physical and cognitive performances and increases in injury occurrence. Competitive athletes are required to complete demanding training programs with high workloads to elicit the physiologica... Read More about Assessment of Fatigue and Recovery in Sport: Narrative Review.

Where are we with developing diagnostic criteria for skin diseases? Mapping the evidence in 2021 (2022)
Journal Article
Luke, J., & Burden-Teh, E. (2022). Where are we with developing diagnostic criteria for skin diseases? Mapping the evidence in 2021. Clinical and Experimental Dermatology, 47(11), 2018-2021. https://doi.org/10.1111/ced.15297

The breadth and scope of dermatological diagnostic criteria is currently unknown. We created a map of diagnostic criteria to provide a panoramic view of past and ongoing research to develop dermatological diagnostic criteria. We analysed studies for... Read More about Where are we with developing diagnostic criteria for skin diseases? Mapping the evidence in 2021.

Neuropsychological evaluation and rehabilitation in multiple sclerosis (NEuRoMS): protocol for a mixed-methods, multicentre feasibility randomised controlled trial (2022)
Journal Article
Topcu, G., Smith, L., Mhizha-Murira, J. R., Goulden, N., Hoare, Z., Drummond, A., …On behalf of the NEuRoMS Collective. (2022). Neuropsychological evaluation and rehabilitation in multiple sclerosis (NEuRoMS): protocol for a mixed-methods, multicentre feasibility randomised controlled trial. Pilot and Feasibility Studies, 8(1), Article 123. https://doi.org/10.1186/s40814-022-01073-5

Background: Cognitive problems affect up to 70% of people with multiple sclerosis (MS), which can negatively impact mood, ability to work, and quality of life. Addressing cognitive problems is a top 10 research priority for people with MS. Our ongoin... Read More about Neuropsychological evaluation and rehabilitation in multiple sclerosis (NEuRoMS): protocol for a mixed-methods, multicentre feasibility randomised controlled trial.

A Hybrid Architecture (CO-CONNECT) to Facilitate Rapid Discovery and Access to Data Across the United Kingdom in Response to the COVID-19 Pandemic: Development Study (2022)
Journal Article
Jefferson, E., Cole, C., Mumtaz, S., Cox, S., Giles, T., Adejumo, S., …Quinlan, P. (2022). A Hybrid Architecture (CO-CONNECT) to Facilitate Rapid Discovery and Access to Data Across the United Kingdom in Response to the COVID-19 Pandemic: Development Study. Journal of Medical Internet Research, 24(12), Article e40035. https://doi.org/10.2196/40035

Background:
COVID-19 data have been generated across the United Kingdom as a by-product of clinical care and public health provision, as well as numerous bespoke and repurposed research endeavors. Analysis of these data has underpinned the United Ki... Read More about A Hybrid Architecture (CO-CONNECT) to Facilitate Rapid Discovery and Access to Data Across the United Kingdom in Response to the COVID-19 Pandemic: Development Study.

Prescribing and using vitiligo treatments: lessons from a nested process evaluation within the HI-Light vitiligo randomized controlled trial (2022)
Journal Article
Leighton, P., Chalmers, J. R., Batchelor, J., Rogers, A., Akram, P., Haines, R. H., …Thomas, K. S. (2022). Prescribing and using vitiligo treatments: lessons from a nested process evaluation within the HI-Light vitiligo randomized controlled trial. Clinical and Experimental Dermatology, 47(8), 1480-1489. https://doi.org/10.1111/ced.15193

Background: The HI-Light Trial demonstrated that for active, limited vitiligo, combination treatment with potent topical corticosteroid (TCS) and handheld narrowband ultraviolet B offers a better treatment response than potent TCS alone. However, it... Read More about Prescribing and using vitiligo treatments: lessons from a nested process evaluation within the HI-Light vitiligo randomized controlled trial.

Are polymorphisms affecting serum urate, renal urate handling and alcohol intake associated with co-morbidities in gout cases? A case–control study using data from the UK Biobank (2022)
Journal Article
Sandoval-Plata, G., Morgan, K., & Abhishek, A. (2022). Are polymorphisms affecting serum urate, renal urate handling and alcohol intake associated with co-morbidities in gout cases? A case–control study using data from the UK Biobank. Rheumatology International, 42, 1617-1622. https://doi.org/10.1007/s00296-022-05148-7

Objective: To examine the association between common comorbidities, eGFR and loci involved in the hyperuricaemia-gout transition.

Methods: This study was conducted in people with gout from the UK Biobank. Logistic regression was used to examine th... Read More about Are polymorphisms affecting serum urate, renal urate handling and alcohol intake associated with co-morbidities in gout cases? A case–control study using data from the UK Biobank.

On the definition of dermatological disease. Part 1: conceptual frameworks (2022)
Journal Article
Williams, H. C. (2022). On the definition of dermatological disease. Part 1: conceptual frameworks. Clinical and Experimental Dermatology, 47(10), 1805-1811. https://doi.org/10.1111/ced.15279

Little attention is paid to disease definition in dermatology and how such definitions come about, yet defining a disease is a fundamental step upon which all subsequent clinical management and prognostic judgements depend. Developing diagnostic crit... Read More about On the definition of dermatological disease. Part 1: conceptual frameworks.