All Outputs (961)

Safety and immunogenicity of concomitant administration of COVID-19 vaccines (ChAdOx1 or BNT162b2) with seasonal influenza vaccines in adults in the UK (ComFluCOV): a multicentre, randomised, controlled, phase 4 trial (2021)
Journal Article
Lazarus, R., Baos, S., Cappel-Porter, H., Carson-Stevens, A., Clout, M., Culliford, L., …and the ComfluCOV Trial Group. (2021). Safety and immunogenicity of concomitant administration of COVID-19 vaccines (ChAdOx1 or BNT162b2) with seasonal influenza vaccines in adults in the UK (ComFluCOV): a multicentre, randomised, controlled, phase 4 trial. Lancet, 398(10318), 2277-2287. https://doi.org/10.1016/s0140-6736%2821%2902329-1

Background: Concomitant administration of COVID-19 and influenza vaccines could reduce burden on health-care systems. We aimed to assess the safety of concomitant administration of ChAdOx1 or BNT162b2 plus an age-appropri... Read More about Safety and immunogenicity of concomitant administration of COVID-19 vaccines (ChAdOx1 or BNT162b2) with seasonal influenza vaccines in adults in the UK (ComFluCOV): a multicentre, randomised, controlled, phase 4 trial.

Does knowledge of liver fibrosis affect high-risk drinking behaviour (KLIFAD)? protocol for a feasibility randomised controlled trial (2021)
Journal Article
Subhani, M., Jones, K. A., Sprange, K., Rennick-Egglestone, S., Knight, H., Morling, J. R., …Ryder, S. D. (2021). Does knowledge of liver fibrosis affect high-risk drinking behaviour (KLIFAD)? protocol for a feasibility randomised controlled trial. BMJ Open, 11(11), Article e054954. https://doi.org/10.1136/bmjopen-2021-054954

Introduction Heavy drinkers in contact with alcohol services do not routinely have access to testing to establish the severity of potential liver disease. Transient elastography by FibroScan can provide this information. A recent systematic review su... Read More about Does knowledge of liver fibrosis affect high-risk drinking behaviour (KLIFAD)? protocol for a feasibility randomised controlled trial.

Anti-reflux medication use in preterm infants (2021)
Journal Article
Binti Abdul Hamid, H., Szatkowski, L., Budge, H., & Ojha, S. (2022). Anti-reflux medication use in preterm infants. Pediatric Research, 92, 520-525. https://doi.org/10.1038/s41390-021-01821-y

Background: Current recommendations do not support the use of anti-reflux medications to treat gastro-oesophageal reflux disease (GORD) among preterm infants. Objective: To describe the prevalence of GORD and the use of anti-reflux medications amongs... Read More about Anti-reflux medication use in preterm infants.

Selection of eligible participants for screening for lung cancer using primary care data (2021)
Journal Article
O’Dowd, E. L., Ten Haaf, K., Kaur, J., Duffy, S. W., Hamilton, W., Hubbard, R. B., …Baldwin, D. R. (2022). Selection of eligible participants for screening for lung cancer using primary care data. Thorax, 77(9), 882-890. https://doi.org/10.1136/thoraxjnl-2021-217142

Lung cancer screening is effective if offered to people at increased risk of the disease. Currently, direct contact with potential participants is required for evaluating risk. A way to reduce the number of ineligible people contacted might be to app... Read More about Selection of eligible participants for screening for lung cancer using primary care data.

Barriers and Facilitators to Staying Smoke-Free after Having a Baby, a Qualitative Study: Women’s Views on Support Needed to Prevent Returning to Smoking Postpartum (2021)
Journal Article
Phillips, L., Campbell, K. A., Coleman, T., Ussher, M., Cooper, S., Lewis, S., & Orton, S. (2021). Barriers and Facilitators to Staying Smoke-Free after Having a Baby, a Qualitative Study: Women’s Views on Support Needed to Prevent Returning to Smoking Postpartum. International Journal of Environmental Research and Public Health, 18(21), Article 11358. https://doi.org/10.3390/ijerph182111358

Background: Postpartum return to smoking (PPRS) is a common and important public health problem. Interventions to prevent PPRS have not been shown to be effective. We aimed to qualitatively explore the barriers and facilitators to staying smoke-free... Read More about Barriers and Facilitators to Staying Smoke-Free after Having a Baby, a Qualitative Study: Women’s Views on Support Needed to Prevent Returning to Smoking Postpartum.

School-based behaviour change intervention to increase physical activity levels among children: A feasibility cluster non-randomised controlled trial in Yangzhou, China (2021)
Journal Article
Wang, H., Blake, H., & Chattopadhyay, K. (2021). School-based behaviour change intervention to increase physical activity levels among children: A feasibility cluster non-randomised controlled trial in Yangzhou, China. BMJ Open, 11(10), Article e052659. https://doi.org/10.1136/bmjopen-2021-052659

Children in China have low levels of physical activity. We developed a school-based behaviour change intervention to increase their physical activity levels. The study aimed to determine the feasibility of undertaking a cluster randomised controlled... Read More about School-based behaviour change intervention to increase physical activity levels among children: A feasibility cluster non-randomised controlled trial in Yangzhou, China.

Development and validation of a prognostic model for leflunomide discontinuation with abnormal blood tests during long-term treatment: cohort study using data from the Clinical Practice Research Datalink Gold and Aurum (2021)
Journal Article
Nakafero, G., Grainge, M. J., Card, T., Taal, M. W., Aithal, G. P., Zhang, W., …Abhishek, A. (2022). Development and validation of a prognostic model for leflunomide discontinuation with abnormal blood tests during long-term treatment: cohort study using data from the Clinical Practice Research Datalink Gold and Aurum. Rheumatology, 61(7), 2783-2791. https://doi.org/10.1093/rheumatology/keab790

OBJECTIVE: To develop and validate a prognostic model for LEF discontinuation with abnormal blood test results. METHODS: Data from the Clinical Practice Research Datalink Gold and Aurum were used for model development and external validation, respect... Read More about Development and validation of a prognostic model for leflunomide discontinuation with abnormal blood tests during long-term treatment: cohort study using data from the Clinical Practice Research Datalink Gold and Aurum.

COVID-19 infection, admission and death among people with rare autoimmune rheumatic disease in England: results from the RECORDER project (2021)
Journal Article
Rutter, M., Lanyon, P. C., Grainge, M. J., Hubbard, R., Peach, E., Bythell, M., …Pearce, F. A. (2022). COVID-19 infection, admission and death among people with rare autoimmune rheumatic disease in England: results from the RECORDER project. Rheumatology, 61(8), 3161-3171. https://doi.org/10.1093/rheumatology/keab794

Objectives: To calculate the rates of COVID-19 infection and COVID-19-related death among people with rare autoimmune rheumatic diseases (RAIRD) during the first wave of the COVID-19 pandemic in England compared to the general population.

Methods... Read More about COVID-19 infection, admission and death among people with rare autoimmune rheumatic disease in England: results from the RECORDER project.

36-month evaluation of a weight management programme in Chinese overweight and obese adults (2021)
Journal Article
Yang, X., Chattopadhyay, K., Hubbard, R., Li, J.-L., Li, L., & Lin, Y. (2021). 36-month evaluation of a weight management programme in Chinese overweight and obese adults. Frontiers in Public Health, 9, Article 749302

Background: Few comprehensive lifestyle intervention programmes have been investigated on overweight and obese adults in China. This study was to evaluate the effect of a 36-month weight management programme on weight loss and its maintenance among o... Read More about 36-month evaluation of a weight management programme in Chinese overweight and obese adults.

Acute kidney injury in patients hospitalized with COVID-19 from the ISARIC WHO CCP-UK Study: A prospective, multicentre cohort study (2021)
Journal Article
Sullivan, M. K., Lees, J. S., Drake, T. M., Docherty, A. B., Oates, G., Hardwick, H. E., …Mark, P. B. (2022). Acute kidney injury in patients hospitalized with COVID-19 from the ISARIC WHO CCP-UK Study: A prospective, multicentre cohort study. Nephrology Dialysis Transplantation, 37(2), 271-284. https://doi.org/10.1093/ndt/gfab303

Background: Acute kidney injury (AKI) is common in coronavirus disease 2019 (COVID-19). This study investigated adults hospitalized with COVID-19 and hypothesized that risk factors for AKI would include comorbidities and non-White race. Methods: A pr... Read More about Acute kidney injury in patients hospitalized with COVID-19 from the ISARIC WHO CCP-UK Study: A prospective, multicentre cohort study.

Understanding and addressing vaccine hesitancy in the context of COVID-19: development of a digital intervention (2021)
Journal Article
Knight, H., Jia, R., Ayling, K., Bradbury, K., Baker, K., Chalder, T., …Vedhara, K. (2021). Understanding and addressing vaccine hesitancy in the context of COVID-19: development of a digital intervention. Public Health, 201, 98-107. https://doi.org/10.1016/j.puhe.2021.10.006

Objectives: Severe Acute Respiratory Coronavirus 2 (SARS-CoV-2) was identified in late 2019, spreading to over 200 countries and resulting in almost two million deaths worldwide. The emergence of safe and effective vaccines provides a route out of th... Read More about Understanding and addressing vaccine hesitancy in the context of COVID-19: development of a digital intervention.

Population‐based cohort study of the efficacy of brentuximab vedotin in relapsed systemic anaplastic large‐cell lymphoma using Public Health England data (2021)
Journal Article
Halligan, S. J., Grainge, M. J., Martinez-Calle, N., Fox, C. P., & Bishton, M. J. (2022). Population‐based cohort study of the efficacy of brentuximab vedotin in relapsed systemic anaplastic large‐cell lymphoma using Public Health England data. British Journal of Haematology, 196(4), 932-938. https://doi.org/10.1111/bjh.17896

Systemic anaplastic large cell lymphoma (sALCL) is a rare T-cell lymphoma associated with poor prognosis after relapse. The immuno-conjugate Brentuximab Vedotin (BV) first became available for relapsed sALCL in England in 2013, following the results... Read More about Population‐based cohort study of the efficacy of brentuximab vedotin in relapsed systemic anaplastic large‐cell lymphoma using Public Health England data.

Conduct and reporting of formula milk trials: systematic review (2021)
Journal Article
Helfer, B., Leonardi-Bee, J., Mundell, A., Parr, C., Ierodiakonou, D., Garcia-Larsen, V., …Boyle, R. J. (2021). Conduct and reporting of formula milk trials: systematic review. BMJ, 375, Article n2202. https://doi.org/10.1136/bmj.n2202

Importance: Formula milk is consumed by most infants in Europe and North America and global consumption is rising. New formula products need to be tested in clinical trials, but concerns have been raised that such trials are biased and may undermine... Read More about Conduct and reporting of formula milk trials: systematic review.

Risk of subtrochanteric and femoral shaft fractures due to bisphosphonate therapy in asthma: a population-based nested case–control study (2021)
Journal Article
Chalitsios, C. V., Shaw, D. E., & McKeever, T. M. (2021). Risk of subtrochanteric and femoral shaft fractures due to bisphosphonate therapy in asthma: a population-based nested case–control study. Osteoporosis International, https://doi.org/10.1007/s00198-021-06197-7

Summary: Concerns have been raised over the association between bisphosphonates and atypical fractures in subtrochanteric and femoral shaft regions, but the potential risk of these fractures due to bisphosphonate use in asthma has not been examined.... Read More about Risk of subtrochanteric and femoral shaft fractures due to bisphosphonate therapy in asthma: a population-based nested case–control study.

Comparing the performance of the novel FAMCAT algorithms and established case-finding criteria for familial hypercholesterolaemia in primary care (2021)
Journal Article
Qureshi, N., Akyea, R. K., Dutton, B., Leonardi-Bee, J., Humphries, S. E., Weng, S., & Kai, J. (2021). Comparing the performance of the novel FAMCAT algorithms and established case-finding criteria for familial hypercholesterolaemia in primary care. Open Heart, 8(2), Article e001752. https://doi.org/10.1136/openhrt-2021-001752

Objective Familial hypercholesterolaemia (FH) is a common inherited disorder causing premature coronary heart disease (CHD) and death. We have developed the novel Familial Hypercholesterolaemia Case Ascertainment Tool (FAMCAT 1) case-finding algorith... Read More about Comparing the performance of the novel FAMCAT algorithms and established case-finding criteria for familial hypercholesterolaemia in primary care.

Evaluating stroke early supported discharge using cost-consequence analysis (2021)
Journal Article
Byrne, A., Chouliara, N., Cameron, T., Geue, C., Lewis, S., Robinson, T., …Fisher, R. J. (2022). Evaluating stroke early supported discharge using cost-consequence analysis. Disability and Rehabilitation, 44(23), 7127-7133. https://doi.org/10.1080/09638288.2021.1983043

Purpose: To evaluate different stroke Early Supported Discharge (ESD) services in different geographical settings using cost-consequence analysis (CCA), which presents information about costs and outcomes in the form of a balance sheet. ESD is a mult... Read More about Evaluating stroke early supported discharge using cost-consequence analysis.

Strategies for screening for familial hypercholesterolaemia in primary care and other community settings (2021)
Journal Article
Qureshi, N., Da Silva, M. L. R., Abdul-Hamid, H., Weng, S. F., Kai, J., & Leonardi-Bee, J. (2021). Strategies for screening for familial hypercholesterolaemia in primary care and other community settings. Cochrane Database of Systematic Reviews, 2021(10), Article CD012985. https://doi.org/10.1002/14651858.cd012985.pub2

Background: Familial hypercholesterolaemia is a common inherited condition that is associated with premature cardiovascular disease. The increased cardiovascular morbidity and mortality, resulting from high levels of cholesterol since birth, can be p... Read More about Strategies for screening for familial hypercholesterolaemia in primary care and other community settings.

Motivation and willingness to increase physical activity for dementia risk reduction: Cross-Sectional UK survey with people aged 50 and over (2021)
Journal Article
Oliveira, D., Knight, H., Jones, K. A., Ogollah, R., & Orrell, M. (2022). Motivation and willingness to increase physical activity for dementia risk reduction: Cross-Sectional UK survey with people aged 50 and over. Aging and Mental Health, 26(9), 1899-1908. https://doi.org/10.1080/13607863.2021.1984393

Objective:Tackling modifiable risk factors such as physical inactivity currently represents the only way to reduce the increasing prevalence of dementia worldwide. This study aimed to investigate attitudes to increasing physical activity to reduce ri... Read More about Motivation and willingness to increase physical activity for dementia risk reduction: Cross-Sectional UK survey with people aged 50 and over.

Proportion of School Attending Adolescents Meeting the Recommended Moderate-to-Vigorous Physical Activity Level and Its Predictors in Lagos, Nigeria (2021)
Journal Article
Adebusoye, B., Leonardi-Bee, J., Phalkey, R., & Chattopadhyay, K. (2021). Proportion of School Attending Adolescents Meeting the Recommended Moderate-to-Vigorous Physical Activity Level and Its Predictors in Lagos, Nigeria. International Journal of Environmental Research and Public Health, 18(20), Article 10744. https://doi.org/10.3390/ijerph182010744

We aimed to assess the proportion of school attending adolescents who reached the recommended moderate-to-vigorous physical activity (MVPA) level in Lagos State, Nigeria as well as the predictors associated with it. A cross-sectional study was conduc... Read More about Proportion of School Attending Adolescents Meeting the Recommended Moderate-to-Vigorous Physical Activity Level and Its Predictors in Lagos, Nigeria.

Effectiveness of cascade testing strategies in relatives for familial hypercholesterolemia: A systematic review and meta-analysis (2021)
Journal Article
Leonardi-Bee, J., Boateng, C., Faria, R., Eliman, K., Young, B., & Qureshi, N. (2021). Effectiveness of cascade testing strategies in relatives for familial hypercholesterolemia: A systematic review and meta-analysis. Atherosclerosis, 338, 7-14. https://doi.org/10.1016/j.atherosclerosis.2021.09.014

Background and aims: Cascade testing in relatives of index cases is the most cost-effective approach to identifying people with familial hypercholesterolemia (FH); however, it is currently unclear which strategy to contact relatives would be the most... Read More about Effectiveness of cascade testing strategies in relatives for familial hypercholesterolemia: A systematic review and meta-analysis.