All Outputs (1126)

Evaluation of Host Defense Peptide (CaD23)-Antibiotic Interaction and Mechanism of Action: Insights From Experimental and Molecular Dynamics Simulations Studies (2021)
Journal Article
Ting, D. S. J., Li, J., Verma, C. S., Goh, E. T., Nubile, M., Mastropasqua, L., …Dua, H. S. (2021). Evaluation of Host Defense Peptide (CaD23)-Antibiotic Interaction and Mechanism of Action: Insights From Experimental and Molecular Dynamics Simulations Studies. Frontiers in Pharmacology, 12, Article 731499. https://doi.org/10.3389/fphar.2021.731499

Background/Aim: Host defense peptides (HDPs) have the potential to provide a novel solution to antimicrobial resistance (AMR) in view of their unique and broad-spectrum antimicrobial activities. We had recently developed a novel hybrid HDP based on L... Read More about Evaluation of Host Defense Peptide (CaD23)-Antibiotic Interaction and Mechanism of Action: Insights From Experimental and Molecular Dynamics Simulations Studies.

Synchrony as a measure of conversation difficulty: Movement coherence increases with background noise level and complexity in dyads and triads (2021)
Journal Article
Hadley, L. V., & Ward, J. A. (2021). Synchrony as a measure of conversation difficulty: Movement coherence increases with background noise level and complexity in dyads and triads. PLoS ONE, 16(10), Article e0258247. https://doi.org/10.1371/journal.pone.0258247

When people interact, they fall into synchrony. This synchrony has been demonstrated in a range of contexts, from walking or playing music together to holding a conversation, and has been linked to prosocial outcomes such as development of rapport an... Read More about Synchrony as a measure of conversation difficulty: Movement coherence increases with background noise level and complexity in dyads and triads.

Mild traumatic brain injury impairs the coordination of intrinsic and motor-related neural dynamics (2021)
Journal Article
Rier, L., Zamyadi, R., Zhang, J., Emami, Z., Seedat, Z. A., Mocanu, S., …Dunkley, B. T. (2021). Mild traumatic brain injury impairs the coordination of intrinsic and motor-related neural dynamics. NeuroImage: Clinical, 32, Article 102841. https://doi.org/10.1016/j.nicl.2021.102841

Mild traumatic brain injury (mTBI) poses a considerable burden on healthcare systems. Whilst most patients recover quickly, a significant number suffer from sequelae that are not accompanied by measurable structural damage. Understanding the neural u... Read More about Mild traumatic brain injury impairs the coordination of intrinsic and motor-related neural dynamics.

Auditory Tests for Characterizing Hearing Deficits in Listeners With Various Hearing Abilities: The BEAR Test Battery (2021)
Journal Article
Sanchez-Lopez, R., Nielsen, S. G., El-Haj-Ali, M., Bianchi, F., Fereczkowski, M., Cañete, O. M., …Santurette, S. (2021). Auditory Tests for Characterizing Hearing Deficits in Listeners With Various Hearing Abilities: The BEAR Test Battery. Frontiers in Neuroscience, 15, Article 724007. https://doi.org/10.3389/fnins.2021.724007

The Better hEAring Rehabilitation (BEAR) project aims to provide a new clinical profiling tool—a test battery—for hearing loss characterization. Although the loss of sensitivity can be efficiently measured using pure-tone audiometry, the assessment o... Read More about Auditory Tests for Characterizing Hearing Deficits in Listeners With Various Hearing Abilities: The BEAR Test Battery.

Investigating Cortical Responses to Noise-Vocoded Speech in Children with Normal Hearing Using Functional Near-Infrared Spectroscopy (fNIRS) (2021)
Journal Article
Mushtaq, F., Wiggins, I. M., Kitterick, P. T., Anderson, C. A., & Hartley, D. E. (2021). Investigating Cortical Responses to Noise-Vocoded Speech in Children with Normal Hearing Using Functional Near-Infrared Spectroscopy (fNIRS). Journal of the Association for Research in Otolaryngology, 22(6), 703-717. https://doi.org/10.1007/s10162-021-00817-z

Whilst functional neuroimaging has been used to investigate cortical processing of degraded speech in adults, much less is known about how these signals are processed in children. An enhanced understanding of cortical correlates of poor speech percep... Read More about Investigating Cortical Responses to Noise-Vocoded Speech in Children with Normal Hearing Using Functional Near-Infrared Spectroscopy (fNIRS).

Test@work: evaluation of workplace HIV testing for construction workers using the RE-AIM framework (2021)
Journal Article
Jones, W., Somerset, S., Evans, C., Whittingham, K., Middleton, M., & Blake, H. (2021). Test@work: evaluation of workplace HIV testing for construction workers using the RE-AIM framework. BMC Public Health, 21, Article 1737. https://doi.org/10.1186/s12889-021-11739-z

Background: Community testing for HIV can reach previously untested populations but is rarely offered in workplaces. Targeting the construction sector could reach workers from high risk populations. Methods: The RE-AIM framework was used to evaluate... Read More about Test@work: evaluation of workplace HIV testing for construction workers using the RE-AIM framework.

Clinical Considerations for Routine Auditory and Vestibular Monitoring in Patients With Cystic Fibrosis (2021)
Journal Article
Garinis, A. C., Poling, G. L., Rubenstein, R. C., Konrad-Martin, D., Hullar, T. E., Baguley, D. M., …Brewer, C. C. (2021). Clinical Considerations for Routine Auditory and Vestibular Monitoring in Patients With Cystic Fibrosis. American Journal of Audiology, 30(3S), 800-809. https://doi.org/10.1044/2021_aja-21-00031

Purpose Specific classes of antibiotics, such as aminoglycosides, have well-established adverse events producing permanent hearing loss, tinnitus, and balance and/or vestibular problems (i.e., ototoxicity). Although these antibiotics are frequently u... Read More about Clinical Considerations for Routine Auditory and Vestibular Monitoring in Patients With Cystic Fibrosis.

Managing post-stroke fatigue: A qualitative study to explore multifaceted clinical perspectives (2021)
Journal Article
Drummond, A., Nouri, F., Ablewhite, J., Condon, L., Das Nair, R., Jones, A., …Thomas, S. (2022). Managing post-stroke fatigue: A qualitative study to explore multifaceted clinical perspectives. British Journal of Occupational Therapy, 85(7), 505-512. https://doi.org/10.1177/03080226211042269

Introduction: Post-stroke fatigue (PSF) is common and debilitating. However, while its effective management is a priority for clinicians and stroke survivors, there remains little evidence to provide guidance or underpin practice. Our aim, therefore,... Read More about Managing post-stroke fatigue: A qualitative study to explore multifaceted clinical perspectives.

Hybrid derivative of cathelicidin and human beta defensin-2 against Gram-positive bacteria: A novel approach for the treatment of bacterial keratitis (2021)
Journal Article
Ting, D. S. J., Leng, E. T., Mayandi, V., Busoy, J. M. F., Aung, T. T., Periayah, M. H., …Dua, H. S. (2021). Hybrid derivative of cathelicidin and human beta defensin-2 against Gram-positive bacteria: A novel approach for the treatment of bacterial keratitis. Scientific Reports, 11, Article 18304. https://doi.org/10.1038/s41598-021-97821-3

Bacterial keratitis (BK) is a major cause of corneal blindness globally. This study aimed to develop a novel class of antimicrobial therapy, based on human-derived hybrid host defense peptides (HyHDPs), for treating BK. HyHDPs were rationally designe... Read More about Hybrid derivative of cathelicidin and human beta defensin-2 against Gram-positive bacteria: A novel approach for the treatment of bacterial keratitis.

Case-finding and genetic testing for familial hypercholesterolaemia in primary care (2021)
Journal Article
Qureshi, N., Akyea, R. K., Dutton, B., Leonardi-Bee, J., Humphries, S. E., Weng, S., & Kai, J. (2021). Case-finding and genetic testing for familial hypercholesterolaemia in primary care. Heart, 107(24), 1956-1961. https://doi.org/10.1136/heartjnl-2021-319742

Objective: Familial Hypercholesterolaemia (FH) is a common inherited disorder causing premature heart disease and death. We have developed novel case-finding algorithms (FAMCAT version 1 & 2) for application in primary care, to improve detection of... Read More about Case-finding and genetic testing for familial hypercholesterolaemia in primary care.

Neural fields with rebound currents: Novel routes to patterning (2021)
Journal Article
Modhara, S., Lai, Y. M., Thul, R., & Coombes, S. (2021). Neural fields with rebound currents: Novel routes to patterning. SIAM Journal on Applied Dynamical Systems, 20(3), 1596-1620. https://doi.org/10.1137/20M1364710

The understanding of how spatio-temporal patterns of neural activity may arise in the cortex of the brain has advanced with the development and analysis of neural field models. Replicating this success for subcortical tissues, such as the thalamus, r... Read More about Neural fields with rebound currents: Novel routes to patterning.

The Human Connectome Project: A retrospective (2021)
Journal Article
Elam, J. S., Glasser, M. F., Harms, M. P., Sotiropoulos, S. N., Andersson, J. L., Burgess, G. C., …Van Essen, D. C. (2021). The Human Connectome Project: A retrospective. NeuroImage, 244, Article 118543. https://doi.org/10.1016/j.neuroimage.2021.118543

The Human Connectome Project (HCP) was launched in 2010 as an ambitious effort to accelerate advances in human neuroimaging, particularly for measures of brain connectivity; apply these advances to study a large number of healthy young adults; and fr... Read More about The Human Connectome Project: A retrospective.

Surrounded by sound: The impact of tinnitus on musicians (2021)
Journal Article
Burns-O’Connell, G., Stockdale, D., Cassidy, O., Knowles, V., & Hoare, D. J. (2021). Surrounded by sound: The impact of tinnitus on musicians. International Journal of Environmental Research and Public Health, 18(17), Article 9036. https://doi.org/10.3390/ijerph18179036

AIM: To investigate the impact of tinnitus on professional musicians in the UK. BACKGROUND: Tinnitus is the experience of sound when an external source is absent, primarily associated with the ageing process, hearing loss, and noise exposure. Amongst... Read More about Surrounded by sound: The impact of tinnitus on musicians.

Tractography dissection variability: What happens when 42 groups dissect 14 white matter bundles on the same dataset? (2021)
Journal Article
Schilling, K. G., Rheault, F., Petit, L., Hansen, C. B., Nath, V., Yeh, F. C., …Descoteaux, M. (2021). Tractography dissection variability: What happens when 42 groups dissect 14 white matter bundles on the same dataset?. NeuroImage, 243, Article 118502. https://doi.org/10.1016/j.neuroimage.2021.118502

White matter bundle segmentation using diffusion MRI fiber tractography has become the method of choice to identify white matter fiber pathways in vivo in human brains. However, like other analyses of complex data, there is considerable variability i... Read More about Tractography dissection variability: What happens when 42 groups dissect 14 white matter bundles on the same dataset?.

Causal Relationship between the Right Auditory Cortex and Speech-Evoked Envelope-Following Response: Evidence from Combined Transcranial Stimulation and Electroencephalography (2021)
Journal Article
Mai, G., & Howell, P. (2022). Causal Relationship between the Right Auditory Cortex and Speech-Evoked Envelope-Following Response: Evidence from Combined Transcranial Stimulation and Electroencephalography. Cerebral Cortex, 32(7), 1437-1454. https://doi.org/10.1093/cercor/bhab298

Speech-evoked envelope-following response (EFR) reflects brain encoding of speech periodicity that serves as a biomarker for pitch and speech perception and various auditory and language disorders. Although EFR is thought to originate from the subcor... Read More about Causal Relationship between the Right Auditory Cortex and Speech-Evoked Envelope-Following Response: Evidence from Combined Transcranial Stimulation and Electroencephalography.

Redesigning a Web-Based Stakeholder Consensus Meeting About Core Outcomes for Clinical Trials: Formative Feedback Study (2021)
Journal Article
Katiri, R., Hall, D. A., Hoare, D. J., Fackrell, K., Horobin, A., Buggy, N., …Core Rehabilitation Outcome Set For Single-Sided Deafness (CROSSSD) Initiative. (2021). Redesigning a Web-Based Stakeholder Consensus Meeting About Core Outcomes for Clinical Trials: Formative Feedback Study. JMIR Formative Research, 5(8), Article e28878

Background: Clinical trials that assess the benefits and harms of an intervention do so by measuring and reporting outcomes. Inconsistent selection and diversity in the choice of outcomes makes it challenging to directly compare interventions. To ach... Read More about Redesigning a Web-Based Stakeholder Consensus Meeting About Core Outcomes for Clinical Trials: Formative Feedback Study.

Therapeutic hypothermia augments the restorative effects of PKC-β and Nox2 inhibition on an in vitro model of human blood–brain barrier (2021)
Journal Article
Kadir, R. R. A., Alwjwaj, M., McCarthy, Z., & Bayraktutan, U. (2021). Therapeutic hypothermia augments the restorative effects of PKC-β and Nox2 inhibition on an in vitro model of human blood–brain barrier. Metabolic Brain Disease, 36(7), 1817-1832. https://doi.org/10.1007/s11011-021-00810-8

To investigate whether therapeutic hypothermia augments the restorative impact of protein kinase C-β (PKC-β) and Nox2 inhibition on an in vitro model of human blood–brain barrier (BBB). Cells cultured in normoglycaemic (5.5mM) or hyperglycaemic (25mM... Read More about Therapeutic hypothermia augments the restorative effects of PKC-β and Nox2 inhibition on an in vitro model of human blood–brain barrier.

The impact of chemotherapy-induced inner ear damage on quality of life in cancer survivors: a qualitative study (2021)
Journal Article
Pearson, S. E., Caimino, C., Shabbir, M., & Baguley, D. M. (2022). The impact of chemotherapy-induced inner ear damage on quality of life in cancer survivors: a qualitative study. Journal of Cancer Survivorship, 16, 976-987. https://doi.org/10.1007/s11764-021-01089-5

Purpose: This study aimed to explore the burden of inner ear damage (ototoxicity) on adults living with and beyond cancer treated with chemotherapy and the impact on their quality of life (QoL). Furthermore, this study aimed to explore patient awaren... Read More about The impact of chemotherapy-induced inner ear damage on quality of life in cancer survivors: a qualitative study.

Validation of the estimation of the macrovascular contribution in multi‐timepoint arterial spin labeling MRI using a 2‐component kinetic model (2021)
Journal Article
Plas, M. C. E., Craig, M., Schmid, S., Chappell, M. A., & Osch, M. J. P. (2022). Validation of the estimation of the macrovascular contribution in multi‐timepoint arterial spin labeling MRI using a 2‐component kinetic model. Magnetic Resonance in Medicine, 87(1), 85-101. https://doi.org/10.1002/mrm.28960

Purpose In this paper, the ability to quantify cerebral blood flow by arterial spin labeling (ASL) was studied by investigating the separation of the macrovascular and tissue component using a 2-component model. Underlying assumptions of this model,... Read More about Validation of the estimation of the macrovascular contribution in multi‐timepoint arterial spin labeling MRI using a 2‐component kinetic model.

Risk Factors, Clinical Outcomes, and Prognostic Factors of Bacterial Keratitis: The Nottingham Infectious Keratitis Study (2021)
Journal Article
Ting, D. S. J., Cairns, J., Gopal, B. P., Shan Ho, C. S., Krstic, L., Elsahn, A., …Dua, H. S. (2021). Risk Factors, Clinical Outcomes, and Prognostic Factors of Bacterial Keratitis: The Nottingham Infectious Keratitis Study. Frontiers in Medicine, 8, Article 715118. https://doi.org/10.3389/fmed.2021.715118

Background/Aim: To examine the risk factors, clinical characteristics, outcomes, and prognostic factors of bacterial keratitis (BK) in Nottingham, UK. Methods: This was a retrospective study of patients who presented to the Queen's Medical Centre, No... Read More about Risk Factors, Clinical Outcomes, and Prognostic Factors of Bacterial Keratitis: The Nottingham Infectious Keratitis Study.