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Early results on the use of chitosan-N-acetylcysteine (Lacrimera®) in the management of dry eye disease of varied etiology (2018)
Journal Article
Messina, M., & Dua, H. S. (2019). Early results on the use of chitosan-N-acetylcysteine (Lacrimera®) in the management of dry eye disease of varied etiology. International Ophthalmology, 39(3), 693-696. https://doi.org/10.1007/s10792-018-0843-0

Purpose
To evaluate the effect of once daily administration of chitosan-N-acetylcysteine (Lacrimera®) in the management of dry eye disease (DED).

Methods
Eighteen patients (3 male, 15 female) aged 25–86 years (mean 61.1) and suffering from moder... Read More about Early results on the use of chitosan-N-acetylcysteine (Lacrimera®) in the management of dry eye disease of varied etiology.

The Physiological Bases of Hidden Noise-Induced Hearing Loss: Protocol for a Functional Neuroimaging Study (Preprint) (2018)
Other
Dewey, R. S., Hall, D. A., Guest, H., Prendergast, G., Plack, C. J., & Francis, S. T. (2018). The Physiological Bases of Hidden Noise-Induced Hearing Loss: Protocol for a Functional Neuroimaging Study (Preprint)

Background:

Rodent studies indicate that noise exposure can cause permanent damage to synapses between inner hair cells and high-threshold auditory nerve fibers, without permanently altering threshold sensitivity. These demonstrations of what is c... Read More about The Physiological Bases of Hidden Noise-Induced Hearing Loss: Protocol for a Functional Neuroimaging Study (Preprint).

The Physiological Bases of Hidden Noise-Induced Hearing Loss: Protocol for a Functional Neuroimaging Study (2018)
Journal Article
Dewey, R. S., Hall, D. A., Guest, H., Prendergast, G., Plack, C. J., & Francis, S. T. (2018). The Physiological Bases of Hidden Noise-Induced Hearing Loss: Protocol for a Functional Neuroimaging Study. JMIR Research Protocols, 7(3), Article e79. https://doi.org/10.2196/resprot.9095

Background: Rodent studies indicate that noise exposure can cause permanent damage to synapses between inner hair cells and high-threshold auditory nerve fibers, without permanently altering threshold sensitivity. These demonstrations of what is comm... Read More about The Physiological Bases of Hidden Noise-Induced Hearing Loss: Protocol for a Functional Neuroimaging Study.

Bayesian optimization of large-scale biophysical networks (2018)
Journal Article
Hadida, J., Sotiropoulos, S. N., Abeysuriya, R. G., Woolrich, M. W., & Jbabdi, S. (2018). Bayesian optimization of large-scale biophysical networks. NeuroImage, 174, https://doi.org/10.1016/j.neuroimage.2018.02.063

The relationship between structure and function in the human brain is well established, but not yet well characterised. Large-scale biophysical models allow us to investigate this relationship, by leveraging structural information (e.g. derived from... Read More about Bayesian optimization of large-scale biophysical networks.

The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: study protocol for a randomised controlled trial (2018)
Journal Article
Al-Shahi Salman, R., Dennis, M. S., Murray, G. D., Innes, K., Drever, J., Dinsmore, L., …Werring, D. J. (2018). The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: study protocol for a randomised controlled trial. Trials, 19(1), Article 162. https://doi.org/10.1186/s13063-018-2542-6

Background

For adults surviving stroke due to spontaneous (non-traumatic) intracerebral haemorrhage (ICH) who had taken an antithrombotic (i.e. anticoagulant or antiplatelet) drug for the prevention of vaso-occlusive disease before the ICH, it is... Read More about The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: study protocol for a randomised controlled trial.

Defining and evaluating novel procedures for involving patients in Core Outcome Set research: creating a meaningful long list of candidate outcome domains (2018)
Journal Article
Smith, H., Horobin, A. J., Fackrell, K., Colley, V., Thacker, B., & Hall, D. A. (2018). Defining and evaluating novel procedures for involving patients in Core Outcome Set research: creating a meaningful long list of candidate outcome domains. Research Involvement and Engagement, 4(8), https://doi.org/10.1186/s40900-018-0091-5

Background
Tinnitus is a complex audiological condition affecting many different domains of everyday life. Clinical trials of tinnitus interventions measure and report those outcome domains inconsistently and this hinders direct comparison between s... Read More about Defining and evaluating novel procedures for involving patients in Core Outcome Set research: creating a meaningful long list of candidate outcome domains.

Interpreting the Tinnitus Questionnaire (German version):what individual differences are clinically important? (2018)
Journal Article
Hall, D. A., Mehta, R., & Argstatter, H. (2018). Interpreting the Tinnitus Questionnaire (German version):what individual differences are clinically important?. International Journal of Audiology, 57(7), 553-557. https://doi.org/10.1080/14992027.2018.1442591

Objective: Reporting of clinical significance is recommended because findings can be statistically significant without being relevant to patients. For aiding clinical interpretation of the Tinnitus Questionnaire (TQ), many investigators use a 5-point... Read More about Interpreting the Tinnitus Questionnaire (German version):what individual differences are clinically important?.

The effectiveness and safety of antifibrinolytics in patients with acute intracranial haemorrhage: statistical analysis plan for an individual patient data meta-analysis [version 2; peer review: 2 approved] (2018)
Journal Article
Ker, K., Prieto-Merino, D., Sprigg, N., Mahmood, A., Bath, P. M., Kang Law, Z., …Roberts, I. (2018). The effectiveness and safety of antifibrinolytics in patients with acute intracranial haemorrhage: statistical analysis plan for an individual patient data meta-analysis [version 2; peer review: 2 approved]. Wellcome Open Research, Article 120. https://doi.org/10.12688/wellcomeopenres.13262.2

© 2018 Ker K et al. Introduction: The Antifibrinolytic Trialists Collaboration aims to increase knowledge about the effectiveness and safety of antifibrinolytic treatment by conducting individual patient data (IPD) meta-analyses of randomised trials.... Read More about The effectiveness and safety of antifibrinolytics in patients with acute intracranial haemorrhage: statistical analysis plan for an individual patient data meta-analysis [version 2; peer review: 2 approved].

Predicting 30-day mortality in patients with sepsis: an exploratory analysis of process of care and patient characteristics (2018)
Journal Article
Sanderson, M., Chikhani, M., Blyth, E., Wood, S., Moppett, I. K., McKeever, T., & Simmonds, M. J. (2018). Predicting 30-day mortality in patients with sepsis: an exploratory analysis of process of care and patient characteristics. Journal of the Intensive Care Society, 19(4), 299-304. https://doi.org/10.1177/1751143718758975

Background

Sepsis represents a significant public health burden, costing the NHS £2.5 billion annually, with 35% mortality in 2006. The aim of this exploratory study was to investigate risk factors predictive of 30-day mortality amongst patients w... Read More about Predicting 30-day mortality in patients with sepsis: an exploratory analysis of process of care and patient characteristics.

Barriers to voluntary participation in sport for children: a systematic review (2018)
Journal Article
Somerset, S., & Hoare, D. J. (2018). Barriers to voluntary participation in sport for children: a systematic review. BMC Pediatrics, 18(1), Article 47. https://doi.org/10.1186/s12887-018-1014-1

Background
Numerous studies have detailed the physical health benefits of children’s participation in sport and a growing body of research also highlights the benefits for mental health. Children who participate in sport have also been shown to be a... Read More about Barriers to voluntary participation in sport for children: a systematic review.

Hyperacusis: major research questions (2018)
Journal Article
Baguley, D. M., & Hoare, D. J. (2018). Hyperacusis: major research questions. HNO, 66(5), 358-363. https://doi.org/10.1007/s00106-017-0464-3

Background: Hyperacusis is a troublesome symptom that can have a marked negative impact on quality of life.
Objectives: To identify major research questions in hyperacusis.
Materials and methods: Review of gaps in knowledge regarding hyperacusis, a... Read More about Hyperacusis: major research questions.

Statistical analysis plan for the ‘Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2)’ (2018)
Journal Article
Scutt, P., Appleton, J. P., Dixon, M., Woodhouse, L. J., Sprigg, N., Wardlaw, J. M., …Bath, P. M. (2018). Statistical analysis plan for the ‘Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2)’. European Stroke Journal, 3(2), 193-196. https://doi.org/10.1177/2396987318756696

Rationale: Glyceryl trinitrate, a nitric oxide donor, is a candidate treatment for acute stroke; it lowers blood pressure, does not alter cerebral blood flow or platelet function and is neuroprotective in experimental stroke. The ongoing rapid interv... Read More about Statistical analysis plan for the ‘Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2)’.

Does tranexamic acid lead to changes in MRI-measures of brain tissue health in patients with spontaneous intracerebral haemorrhage? An MRI sub-study nested within the double-blind randomised controlled TICH-2 trial (2018)
Journal Article
Dineen, R. A., Pszczolkowski, S., Flaherty, K., Law, Z. K., Morgan, P. S., Roberts, I., …Sprigg, N. (in press). Does tranexamic acid lead to changes in MRI-measures of brain tissue health in patients with spontaneous intracerebral haemorrhage? An MRI sub-study nested within the double-blind randomised controlled TICH-2 trial. BMJ Open, 8(2), Article e019930. https://doi.org/10.1136/bmjopen-2017-019930

Objectives: To test whether administration of the antifibrinolytic drug tranexamic acid (TXA) in patients with spontaneous intracerebral haemorrhage (SICH) leads to increased prevalence of diffusion-weighted MRI defined hyperintense ischaemic lesions... Read More about Does tranexamic acid lead to changes in MRI-measures of brain tissue health in patients with spontaneous intracerebral haemorrhage? An MRI sub-study nested within the double-blind randomised controlled TICH-2 trial.

Cochrane Corner: Hearing aids for mild to moderate hearing loss in adults (2018)
Journal Article
Brennan-Jones, C. G., Weeda, E., & Ferguson, M. A. (in press). Cochrane Corner: Hearing aids for mild to moderate hearing loss in adults. International Journal of Audiology, https://doi.org/10.1080/14992027.2018.1432903

This Cochrane Corner features the review entitled “Hearing aids for mild to moderate hearing loss in adults” published in 2017. In their review, Ferguson et al. identified five randomised controlled trials (RCTs) involving 825 participants, with mode... Read More about Cochrane Corner: Hearing aids for mild to moderate hearing loss in adults.

The application of pupillometry in hearing science to assess listening effort (2018)
Journal Article
Naylor, G., Koelewijn, T., Zekveld, A. A., & Kramer, S. E. (2018). The application of pupillometry in hearing science to assess listening effort. Trends in Hearing, 22, 1-3. https://doi.org/10.1177/2331216518799437

In recent years, the fields of Audiology and Cognitive Sciences have seen a burgeoning of research focusing on the assessment of the effort required during listening. Among approaches to this question, the pupil dilation response has shown to be an i... Read More about The application of pupillometry in hearing science to assess listening effort.

“There are more important things to worry about”:attitudes and behaviours towards leisure noise and use ofhearing protection in young adults (2018)
Journal Article
Hunter, A. (2018). “There are more important things to worry about”:attitudes and behaviours towards leisure noise and use ofhearing protection in young adults. International Journal of Audiology, 57(6), 449-456. https://doi.org/10.1080/14992027.2018.1430383

Objective: Noise-induced hearing problems among young adults are increasing due to participation in activities where music is played at a loud volume. This study explored attitudes towards leisure noise, hearing protection, and perceived susceptibili... Read More about “There are more important things to worry about”:attitudes and behaviours towards leisure noise and use ofhearing protection in young adults.

Early time course of major bleeding on antiplatelet therapy after TIA or ischemic stroke (2018)
Journal Article
Hilkens, N. A., Algra, A., Kappelle, L. J., Bath, P. M., Csiba, L., Rothwell, P. M., & Greving, J. P. (2018). Early time course of major bleeding on antiplatelet therapy after TIA or ischemic stroke. Neurology, 90(8), Article e683-e689. https://doi.org/10.1212/WNL.0000000000004997

Objective: To study the early time course of major bleeding and its subtypes in patients with cerebral ischemia on dual and single antiplatelet therapy.

Methods: We performed a post hoc analysis on individual patient data from 6 randomized clinica... Read More about Early time course of major bleeding on antiplatelet therapy after TIA or ischemic stroke.

Recruiting ENT and audiology patients into pharmaceutical trials: evaluating the multi-center experience in the UK and USA (2018)
Journal Article
Sanchez, V. A., Hall, D. A., Millar, B., Escabi, C. D., Sharman, A., Watson, J., …Harris, P. (in press). Recruiting ENT and audiology patients into pharmaceutical trials: evaluating the multi-center experience in the UK and USA. International Journal of Audiology, https://doi.org/10.1080/14992027.2018.1425002

Objective: Recruiting into clinical trials on time and on target is a major challenge, and yet often goes unreported. This study evaluated the adjustment to procedures, recruitment, and screening methods in two multi-center pharmaceutical randomized... Read More about Recruiting ENT and audiology patients into pharmaceutical trials: evaluating the multi-center experience in the UK and USA.

Real-time estimation of horizontal gaze angle by saccade integration using in-ear electrooculography (2018)
Journal Article
Hládek, Ľ., Porr, B., & Brimijoin, W. O. (2018). Real-time estimation of horizontal gaze angle by saccade integration using in-ear electrooculography. PLoS ONE, 13(1), Article e0190420. https://doi.org/10.1371/journal.pone.0190420

The manuscript proposes and evaluates a real-time algorithm for estimating eye gaze angle based solely on single-channel electrooculography (EOG), which can be obtained directly from the ear canal using conductive ear moulds. In contrast to conventio... Read More about Real-time estimation of horizontal gaze angle by saccade integration using in-ear electrooculography.