All Outputs (1126)

Lifetime leisure music exposure associated with increased frequency of tinnitus (2016)
Journal Article
Moore, D. R., Zobay, O., Mackinnon, R. C., Whitmer, W. M., & Akeroyd, M. A. (2017). Lifetime leisure music exposure associated with increased frequency of tinnitus. Hearing Research, 347, 18-27. https://doi.org/10.1016/j.heares.2016.10.030

Tinnitus has been linked to noise exposure, a common form of which is listening to music as a leisure activity. The relationship between tinnitus and type and duration of music exposure is not well understood. We conducted an internet-based populatio... Read More about Lifetime leisure music exposure associated with increased frequency of tinnitus.

Baseline characteristics of the 3,096 patients recruited into the 'Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke' (TARDIS) trial (2016)
Journal Article
Bath, P. M., Appleton, J. P., Beridze, M., Christensen, H., Dineen, R. A., Duley, L., …Sprigg, N. (2017). Baseline characteristics of the 3,096 patients recruited into the 'Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke' (TARDIS) trial. International Journal of Stroke, 12(5), 524-538. https://doi.org/10.1177/1747493016677988

Background: The risk of recurrence following ischaemic stroke (IS) or transient ischaemic attack (TIA) is highest immediately after the event. Antiplatelet agents are effective in reducing the risk of recurrence and two agents are superior to one in... Read More about Baseline characteristics of the 3,096 patients recruited into the 'Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke' (TARDIS) trial.

Antiplatelet therapy following ischaemic stroke: continue or change pre-existing therapy? (2016)
Journal Article
Mazlan-Kepli, W., MacIsaac, R. L., Walters, M., Bath, P. M., & Dawson, J. (2017). Antiplatelet therapy following ischaemic stroke: continue or change pre-existing therapy?. European Stroke Journal, 2(1), https://doi.org/10.1177/2396987316678728

Introduction: Antiplatelet therapy is routinely prescribed early after ischaemic stroke. Many patients will already be taking antiplatelet therapy and it is unknown whether these patients should continue the same antiplatelet treatment or switch to a... Read More about Antiplatelet therapy following ischaemic stroke: continue or change pre-existing therapy?.

Effects of noise exposure on young adults with normal audiograms I: Electrophysiology (2016)
Journal Article
Prendergast, G., Guest, H., Munro, K. J., Kluk, K., Léger, A., Hall, D. A., …Plack, C. J. (2017). Effects of noise exposure on young adults with normal audiograms I: Electrophysiology. Hearing Research, 344, 68-81. https://doi.org/10.1016/j.heares.2016.10.028

Noise-induced cochlear synaptopathy has been demonstrated in numerous rodent studies. In these animal models, the disorder is characterized by a reduction in amplitude of wave I of the auditory brainstem response (ABR) to high-level stimuli, whereas... Read More about Effects of noise exposure on young adults with normal audiograms I: Electrophysiology.

Design and implementation of Pharyngeal electrical Stimulation for early de-cannulation in TRACheotomized (PHAST-TRAC) stroke patients with neurogenic dysphagia: a prospective randomized single-blinded interventional study (2016)
Journal Article
Dziewas, R., Mistry, S., Hamdy, S., Minnerup, J., Van Der Tweel, I., Schäbitz, W., & Bath, P. M. (2017). Design and implementation of Pharyngeal electrical Stimulation for early de-cannulation in TRACheotomized (PHAST-TRAC) stroke patients with neurogenic dysphagia: a prospective randomized single-blinded interventional study. International Journal of Stroke, 12(4), https://doi.org/10.1177/1747493016676618

Rationale: Ongoing dysphagia in stroke patients weaned from mechanical ventilation often requires long-term tracheotomy to protect the airway from aspiration. In a recently reported single-centre pilot study, a significantly larger proportion (75%) o... Read More about Design and implementation of Pharyngeal electrical Stimulation for early de-cannulation in TRACheotomized (PHAST-TRAC) stroke patients with neurogenic dysphagia: a prospective randomized single-blinded interventional study.

Have cochlear implant, won’t have to travel: introducing telemedicine to people using cochlear implants (2016)
Journal Article
Cullington, H., Kitterick, P. T., DeBold, L., Weal, M., Clarke, N., Newberry, E., & Aubert, L. (2016). Have cochlear implant, won’t have to travel: introducing telemedicine to people using cochlear implants. American Journal of Audiology, 25, https://doi.org/10.1044/2016_AJA-16-0018

Purpose: This paper describes a planned project to design, implement, and evaluate remote care for adults using cochlear implants and compare their outcomes with those following the standard care pathway.Method: Sixty people with cochlear implants wi... Read More about Have cochlear implant, won’t have to travel: introducing telemedicine to people using cochlear implants.

High PEEP in acute respiratory distress syndrome: quantitative evaluation between improved arterial oxygenation and decreased oxygen delivery (2016)
Journal Article
Chikhani, M., Das, A., Haque, M., Wang, W., Bates, D., & Hardman, J. (2016). High PEEP in acute respiratory distress syndrome: quantitative evaluation between improved arterial oxygenation and decreased oxygen delivery. British Journal of Anaesthesia, 117(5), 650-658. https://doi.org/10.1093/bja/aew314

Background: Positive end-expiratory pressure (PEEP) is widely used to improve oxygenation and prevent alveolar collapse in mechanically ventilated patients with the acute respiratory distress syndrome (ARDS). While PEEP predictably improves arterial... Read More about High PEEP in acute respiratory distress syndrome: quantitative evaluation between improved arterial oxygenation and decreased oxygen delivery.

Effectiveness of alternative listening devices to conventional hearing aids for adults with hearing loss: a systematic review protocol (2016)
Journal Article
Maidment, D. W., Barker, A., Xia, J., & Ferguson, M. A. (2016). Effectiveness of alternative listening devices to conventional hearing aids for adults with hearing loss: a systematic review protocol. BMJ Open, 6(10), Article e011683. https://doi.org/10.1136/bmjopen-2016-011683

Introduction Hearing loss is a major public health concern, affecting over 11 million people in the UK. While hearing aids are the most common clinical intervention for hearing loss, the majority of people that would benefit from using hearing aids d... Read More about Effectiveness of alternative listening devices to conventional hearing aids for adults with hearing loss: a systematic review protocol.

Tinnitus and sleep difficulties after cochlear implantation (2016)
Journal Article
Pierzycki, R. H., Edmondson-Jones, M., Dawes, P., Munro, K. J., Moore, D. R., & Kitterick, P. T. (in press). Tinnitus and sleep difficulties after cochlear implantation. Ear and Hearing, 37(6), Article e402-e408. https://doi.org/10.1097/AUD.0000000000000341

OBJECTIVES: To estimate and compare the prevalence of and associations between tinnitus and sleep difficulties in a sample of UK adult cochlear implant users and those identified as potential candidates for cochlear implantation. DESIGN: The study... Read More about Tinnitus and sleep difficulties after cochlear implantation.

Treatment of intracerebral haemorrhage with tranexamic acid: a review of current evidence and ongoing trials (2016)
Journal Article
Law, Z. K., Meretoja, A., Engelter, S. T., Christensen, H., Muresan, E.-M., Glad, S. B., …Sprigg, N. (in press). Treatment of intracerebral haemorrhage with tranexamic acid: a review of current evidence and ongoing trials. European Stroke Journal, https://doi.org/10.1177/2396987316676610

Purpose Haematoma expansion is a devastating complication of intracerebral haemorrhage with no established treatment. Tranexamic acid had been an effective haemostatic agent in reducing post-operative and traumatic bleeding. We review current evide... Read More about Treatment of intracerebral haemorrhage with tranexamic acid: a review of current evidence and ongoing trials.

Probe-Specific Procedure to Estimate Sensitivity and Detection Limits for 19F Magnetic Resonance Imaging (2016)
Journal Article
Faas, H., Taylor, A. J., Granwehr, J., Lesbats, C., Krupa, J. L., Six, J. S., …Meersmann, T. (2016). Probe-Specific Procedure to Estimate Sensitivity and Detection Limits for 19F Magnetic Resonance Imaging. PLoS ONE, 11(10), e0163704. https://doi.org/10.1371/journal.pone.0163704

© 2016 Taylor et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cre... Read More about Probe-Specific Procedure to Estimate Sensitivity and Detection Limits for 19F Magnetic Resonance Imaging.

Histological basis of laminar MRI patterns in high resolution images of fixed human auditory cortex (2016)
Journal Article
Wallace, M. N., Cronin, M. J., Bowtell, R. W., Scott, I., Palmer, A. R., & Gowland, P. A. (2016). Histological basis of laminar MRI patterns in high resolution images of fixed human auditory cortex. Frontiers in Neuroscience, 10, Article 455. https://doi.org/10.3389/fnins.2016.00455

Functional magnetic resonance imaging (fMRI) studies of the auditory region of the temporal lobe would benefit from the availability of image contrast that allowed direct identification of the primary auditory cortex, as this region cannot be accurat... Read More about Histological basis of laminar MRI patterns in high resolution images of fixed human auditory cortex.

Functional auditory disorders (2016)
Book Chapter
Baguley, D., Cope, T., & McFerran, D. (2016). Functional auditory disorders. In M. Hallett, J. Stone, & A. Carson (Eds.), Handbook of clinical neurology, Volume 139 (367-378). Elsevier. https://doi.org/10.1016/B978-0-12-801772-2.00032-1

There are a number of auditory symptom syndromes that can develop without an organic basis. Some of these, such as nonorganic hearing loss, affect populations similar to those presenting with functional somatosensory and motor symptoms, while others,... Read More about Functional auditory disorders.

Internet competency predicts practical hearing aid knowledge and skills in first-time hearing aid users (2016)
Journal Article
Maidment, D. W., Brassington, W., Wharrad, H., & Ferguson, M. A. (2016). Internet competency predicts practical hearing aid knowledge and skills in first-time hearing aid users. American Journal of Audiology, 25(3S), https://doi.org/10.1044/2016_AJA-16-0022

Purpose. The purpose of the study was to assess whether Internet competency predicted practical hearing aid knowledge and handling skills in first-time hearing aid users. Method. The design was a prospective, randomized controlled trial of a multi... Read More about Internet competency predicts practical hearing aid knowledge and skills in first-time hearing aid users.

Altered whole-brain connectivity in albinism (2016)
Journal Article
Welton, T., Ather, S., Proudlock, F. A., Gottlob, I., & Dineen, R. A. (2017). Altered whole-brain connectivity in albinism. Human Brain Mapping, 38(2), 740-752. https://doi.org/10.1002/hbm.23414

Albinism is a group of congenital disorders of the melanin synthesis pathway. Multiple ocular, white matter and cortical abnormalities occur in albinism, including a greater decussation of nerve fibres at the optic chiasm, foveal hypoplasia and nysta... Read More about Altered whole-brain connectivity in albinism.

Corneal keratocyte transition to mesenchymal stem cell phenotype and reversal using serum-free medium supplemented with FGF-2, TGF-ß3 and retinoic acid (2016)
Journal Article
Sidney, L. E., & Hopkinson, A. (in press). Corneal keratocyte transition to mesenchymal stem cell phenotype and reversal using serum-free medium supplemented with FGF-2, TGF-ß3 and retinoic acid. Journal of Tissue Engineering and Regenerative Medicine, https://doi.org/10.1002/term.2316

Keratocytes of the corneal limbal stroma can derive populations of mesenchymal stem cells (MSC) when expanded in vitro. However, once a corneal MSC (cMSC) phenotype is achieved, regaining the keratocyte phenotype can be challenging, and there is no s... Read More about Corneal keratocyte transition to mesenchymal stem cell phenotype and reversal using serum-free medium supplemented with FGF-2, TGF-ß3 and retinoic acid.

Spatial hearing and hearing aids (2016)
Book Chapter
Akeroyd, M. A., & Whitmer, W. M. (2016). Spatial hearing and hearing aids. In G. R. Popelka, B. C. Moore, R. R. Fay, & A. N. Popper (Eds.), Hearing aids. Springer-Verlag. https://doi.org/10.1007/978-3-319-33036-5_7

The questions of whether hearing-impaired listeners are also impaired for the localization of sounds and what benefits hearing aids can provide are important for understanding the wider effects of hearing impairment. We review here 29 studies publis... Read More about Spatial hearing and hearing aids.

Hearing aid validation (2016)
Book Chapter
Whitmer, W. M., Wright-Whyte, K. F., Holman, J. A., & Akeroyd, M. A. (2016). Hearing aid validation. In G. R. Popelka, B. C. Moore, R. R. Fay, & A. N. Popper (Eds.), Hearing aids. Springer Science+Business Media

Validation provides quality assurance that a hearing aid wearer’s needs are being met—that the solution meets not only their technical requirements (i.e., verification) but also their requirements for everyday communication. In the past 50 years, the... Read More about Hearing aid validation.

Rapid intervention with glyceryl trinitrate in hypertensive stroke trial-2(right-2): safety and efficacy of transdermal glyceryl trinitrate, a nitric oxide donor (2016)
Presentation / Conference Contribution
Dixon, M., Appleton, J., Scutt, P., England, T., Havard, D., Howard, H., …Bath, P. (2016). Rapid intervention with glyceryl trinitrate in hypertensive stroke trial-2(right-2): safety and efficacy of transdermal glyceryl trinitrate, a nitric oxide donor. Emergency Medicine Journal, 33(9), e13-e14. https://doi.org/10.1136/emermed-2016-206139.42

Rationale High blood pressure (BP) is common in acute stroke and is associated with poor outcome. Previous hospital-based trials testing the effects of BP lowering on functional outcome have been inconclusive. The PIL-FAST and RIGHT pilot trials conf... Read More about Rapid intervention with glyceryl trinitrate in hypertensive stroke trial-2(right-2): safety and efficacy of transdermal glyceryl trinitrate, a nitric oxide donor.

Cerebral Cortical Thickness in Chronic Pain Due to Knee Osteoarthritis: The Effect of Pain Duration and Pain Sensitization (2016)
Journal Article
Alshuft, H., Condon, L., Dineen, R. A., & Auer, D. P. (in press). Cerebral Cortical Thickness in Chronic Pain Due to Knee Osteoarthritis: The Effect of Pain Duration and Pain Sensitization. PLoS ONE, 11(9), Article e0161687. https://doi.org/10.1371/journal.pone.0161687

Objective This study investigates associations between cortical thickness and pain duration, and central sensitization as markers of pain progression in painful knee osteoarthritis. Methods Whole brain cortical thickness and pressure pain th... Read More about Cerebral Cortical Thickness in Chronic Pain Due to Knee Osteoarthritis: The Effect of Pain Duration and Pain Sensitization.