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Pathophysiology, diagnosis and treatment of somatosensory tinnitus: a scoping review (2017)
Journal Article
Haider, H., Hoare, D. J., Costa, R. F., Potgieter, I., Kikidis, D., Lapira, A., …Paco, J. C. (2017). Pathophysiology, diagnosis and treatment of somatosensory tinnitus: a scoping review. Frontiers in Neuroscience, https://doi.org/10.3389/fnins.2017.00207

Somatosensory tinnitus is a generally agreed subtype of tinnitus that is associated with activation of the somatosensory, somatomotor, and visual-motor systems. A key characteristic of somatosensory tinnitus is that is modulated by physical contact o... Read More about Pathophysiology, diagnosis and treatment of somatosensory tinnitus: a scoping review.

Effects of hearing impairment and hearing aid amplification on listening effort - a systematic review (2017)
Journal Article
Ohlenforst, B., Zekveld, A., Jansma, E., Wang, Y., Naylor, G., Lorens, A., …Kramer, S. (in press). Effects of hearing impairment and hearing aid amplification on listening effort - a systematic review. Ear and Hearing, 38(3), https://doi.org/10.1097/AUD.0000000000000396

Objectives: To undertake a systematic review of available evidence on the effect of hearing impairment and hearing-aid amplification on listening effort. Two research questions were addressed: Q1) does hearing impairment affect listening effort? and... Read More about Effects of hearing impairment and hearing aid amplification on listening effort - a systematic review.

Cerebral misery perfusion due to carotid occlusive disease (2017)
Journal Article
Maddula, M., Sprigg, N., Bath, P. M., & Munshi, S. K. (in press). Cerebral misery perfusion due to carotid occlusive disease. Stroke and Vascular Neurology, Article e000067. https://doi.org/10.1136/svn-2017-000067

Purpose Cerebral misery perfusion (CMP) is a condition where cerebral autoregulatory capacity is exhausted, and cerebral blood supply in insufficient to meet metabolic demand. We present an educational review of this important condition, which has a... Read More about Cerebral misery perfusion due to carotid occlusive disease.

The incidence of first stroke in pregnant and non-pregnant women of childbearing age: a population-based cohort study from England (2017)
Journal Article
Ban, L., Sprigg, N., Nelson-Piercy, C., Bath, P. M., Ludvigsson, J. F., Stephansson, O., & Tata, L. J. (2017). The incidence of first stroke in pregnant and non-pregnant women of childbearing age: a population-based cohort study from England. Journal of the American Heart Association, 6(4), Article e004601. https://doi.org/10.1161/JAHA.116.004601

Background: Pregnant women may have an increased risk of stroke compared to non-pregnant women of similar age, but the magnitude and the timing of such risk are unclear. We examined the risk of first stroke event in women of childbearing age and comp... Read More about The incidence of first stroke in pregnant and non-pregnant women of childbearing age: a population-based cohort study from England.

Guided Internet-based versus face-to-face clinical care in the management of tinnitus: study protocol for a multi-centre randomised controlled trial (2017)
Journal Article
Beukes, E. W., Baguley, D., Allen, P. M., Manchaiah, V., & Andersson, G. (2017). Guided Internet-based versus face-to-face clinical care in the management of tinnitus: study protocol for a multi-centre randomised controlled trial. Trials, 18, Article 186. https://doi.org/10.1186/s13063-017-1931-6

Background Innovative strategies are required to improve access to evidence-based tinnitus interventions. A guided Internet-based cognitive behavioural therapy (iCBT) intervention for tinnitus was therefore developed for a U.K. population. Initial... Read More about Guided Internet-based versus face-to-face clinical care in the management of tinnitus: study protocol for a multi-centre randomised controlled trial.

The incidence of first stroke in and around pregnancy: A population-based cohort study from Sweden (2017)
Journal Article
Ban, L., Abdul Sultan, A., Stephansson, O., Tata, L. J., Sprigg, N., Nelson-Piercy, C., …Ludvigsson, J. F. (2017). The incidence of first stroke in and around pregnancy: A population-based cohort study from Sweden. European Stroke Journal, 2(3), 250-256. https://doi.org/10.1177/2396987317706600

Introduction: Research has suggested that delivery is associated with an increased risk of stroke in women; however, there is a lack of contemporary estimates on the incidence of stroke in and after pregnancy compared with the baseline risk in women... Read More about The incidence of first stroke in and around pregnancy: A population-based cohort study from Sweden.

Nitric oxide donors (nitrates), L-arginine, or nitric oxide synthase inhibitors for acute stroke (2017)
Journal Article
Bath, P. M., Krishnan, K., & Appleton, J. P. (in press). Nitric oxide donors (nitrates), L-arginine, or nitric oxide synthase inhibitors for acute stroke. Cochrane Database of Systematic Reviews, Article CD000398. https://doi.org/10.1002/14651858.CD000398.pub2

Background:Nitric oxide (NO) has multiple effects that may be beneficial in acute stroke, including lowering blood pressure, and promoting reperfusion and cytoprotection. Some forms of nitric oxide synthase inhibition (NOS-I) may also be beneficial.... Read More about Nitric oxide donors (nitrates), L-arginine, or nitric oxide synthase inhibitors for acute stroke.

The natural history of subjective tinnitus in adults: a systematic review and meta-analysis of ‘no-intervention’ periods in controlled trials (2017)
Journal Article
Phillips, J., McFerran, D., Hall, D. A., & Hoare, D. J. (2018). The natural history of subjective tinnitus in adults: a systematic review and meta-analysis of ‘no-intervention’ periods in controlled trials. Laryngoscope, 128(1), https://doi.org/10.1002/lary.26607

Objectives Tinnitus is a prevalent condition, but little has been published regarding the natural history of the condition. One technique for evaluating the long-term progression of the disease is to examine what happens to participants in the no-... Read More about The natural history of subjective tinnitus in adults: a systematic review and meta-analysis of ‘no-intervention’ periods in controlled trials.

Increasing value and reducing waste in stroke research (2017)
Journal Article
Berge, E., Al-Shahi Salman, R., van der Worp, H. B., Stapf, C., Sandercock, P., Sprigg, N., …Ford, G. A. (2017). Increasing value and reducing waste in stroke research. Lancet Neurology, 16(5), 399-408. https://doi.org/10.1016/S1474-4422%2817%2930078-9

Stroke represents a major burden to patients and society, and resources spent on stroke research must be used efficiently and produce good value in terms of improvements in human health. However, there are many examples of poor value from stroke rese... Read More about Increasing value and reducing waste in stroke research.

Smoking cessation and the reduction of disability progression in Multiple Sclerosis: a cohort study (2017)
Journal Article
Tanasescu, R., Constantinescu, C. S., Tench, C. R., & Manouchehrinia, A. (2018). Smoking cessation and the reduction of disability progression in Multiple Sclerosis: a cohort study. Nicotine and Tobacco Research, 20(5), 589-595. https://doi.org/10.1093/ntr/ntx084

Background: Smoking is associated with a more severe disease course in people with multiple sclerosis (MS). The magnitude of effect of smoking cessation on MS progression is unknown. The aim of this study was to quantify the impact of smoking cessati... Read More about Smoking cessation and the reduction of disability progression in Multiple Sclerosis: a cohort study.

Coordinate based random effect size meta-analysis of neuroimaging studies (2017)
Journal Article
Tench, C. R., Tanasescu, R., Constantinescu, C. S., Auer, D. P., & Cottam, W. J. (in press). Coordinate based random effect size meta-analysis of neuroimaging studies. NeuroImage, 153, https://doi.org/10.1016/j.neuroimage.2017.04.002

Low power in neuroimaging studies can make them difficult to interpret, and Coordinate based meta-analysis (CBMA) may go some way to mitigating this issue. CBMA has been used in many analyses to detect where published functional MRI or voxel-based mo... Read More about Coordinate based random effect size meta-analysis of neuroimaging studies.

Management of acute intracerebral haemorrhage – an update (2017)
Journal Article
Law, Z. K., Appleton, J. P., Bath, P. M., & Sprigg, N. (2017). Management of acute intracerebral haemorrhage – an update. Clinical Medicine, 17(2), https://doi.org/10.7861/clinmedicine.17-2-166

Managing acute intracerebral haemorrhage is a challenging task for physicians. Evidence shows that outcome can be improved with admission to an acute stroke unit and active care, including urgent reversal of anticoagulant effects and, potentially, in... Read More about Management of acute intracerebral haemorrhage – an update.

Limbic grey matter changes in early Parkinson's disease (2017)
Journal Article
Li, X., Xing, Y., Schwarz, S. T., & Auer, D. P. (in press). Limbic grey matter changes in early Parkinson's disease. Human Brain Mapping, https://doi.org/10.1002/hbm.23610

The purpose of this study was to investigate local and network related changes of limbic grey matter in early Parkinson’s disease (PD) and their interrelation with non-motor symptom severity. We applied voxel-based morphometric methods in 538 T1 MRI... Read More about Limbic grey matter changes in early Parkinson's disease.

Focal CA3 hippocampal subfield atrophy following LGI1 VGKC-complex antibody limbic encephalitis (2017)
Journal Article
Miller, T. D., Chong, T. T.-J., Aimola Davies, A. M., Ng, T. W., Johnson, M. R., Irani, S. R., Vincent, A., Husain, M., Jacob, S., Maddison, P., Kennard, C., Gowland, P. A., & Rosenthal, C. R. (2017). Focal CA3 hippocampal subfield atrophy following LGI1 VGKC-complex antibody limbic encephalitis. Brain, 140(5), 1212-1219. https://doi.org/10.1093/brain/awx070

Magnetic resonance imaging has linked chronic voltage-gated potassium channel (VGKC) complex antibody-mediated limbic encephalitis with generalized hippocampal atrophy. However, autoantibodies bind to specific rodent hippocampal subfields. Here, huma... Read More about Focal CA3 hippocampal subfield atrophy following LGI1 VGKC-complex antibody limbic encephalitis.

Genetic susceptibility to bilateral tinnitus in a Swedish twin cohort (2017)
Journal Article
Maas, I. L., Brüggemann, P., Requena, T., Bulla, J., Edvall, N. K., Hjelmborg, J. V., …Cederroth, C. R. (2017). Genetic susceptibility to bilateral tinnitus in a Swedish twin cohort. Genetics in Medicine, 19(9), 1007-1012. https://doi.org/10.1038/gim.2017.4

Purpose:Genetic contributions to tinnitus have been difficult to determine due to the heterogeneity of the condition and its broad etiology. Here, we evaluated the genetic and nongenetic influences on self-reported tinnitus from the Swedish Twin Regi... Read More about Genetic susceptibility to bilateral tinnitus in a Swedish twin cohort.

Heterodimers of photoreceptor-specific nuclear receptor (PNR/NR2E3) and peroxisome proliferator-activated receptor (PPARγ) are disrupted by retinal disease-associated mutations (2017)
Journal Article
Fulton, J., Mazumder, B., Whitchurch, J., Monteiro, C. J., Collins, H. M., Chan, C. M., …Heery, D. M. (2017). Heterodimers of photoreceptor-specific nuclear receptor (PNR/NR2E3) and peroxisome proliferator-activated receptor (PPARγ) are disrupted by retinal disease-associated mutations. Cell Death and Disease, 8, Article e2677. https://doi.org/10.1038/cddis.2017.98

Photoreceptor-specific nuclear receptor (PNR/NR2E3) and Tailless homolog (TLX/NR2E1) are human orthologs of the NR2E group, a subgroup of phylogenetically related members of the Nuclear Receptor (NR) superfamily of transcription factors. We assessed... Read More about Heterodimers of photoreceptor-specific nuclear receptor (PNR/NR2E3) and peroxisome proliferator-activated receptor (PPARγ) are disrupted by retinal disease-associated mutations.

The effect of tonsillectomy on the morbidity from recurrent tonsillitis (2017)
Journal Article
Douglas, C. M., Lang, K., Whitmer, W. M., Wilson, J. A., & Mackenzie, K. (2017). The effect of tonsillectomy on the morbidity from recurrent tonsillitis. Clinical Otolaryngology, 42(6), 1206-1210. https://doi.org/10.1111/coa.12850

Background Tonsillitis is a common condition with an incidence in UK general practice of 37 per 1000 population a year.1 Recurrent tonsillitis results in significant morbidity and impacts on individuals’ quality of life. This study assesses the mo... Read More about The effect of tonsillectomy on the morbidity from recurrent tonsillitis.