Iris Lianne Maas
Genetic susceptibility to bilateral tinnitus in a Swedish twin cohort
Maas, Iris Lianne; Br�ggemann, Petra; Requena, Teresa; Bulla, Jan; Edvall, Niklas K.; Hjelmborg, Jacob v.B.; Szczepek, Agnieszka J.; Canlon, Barbara; Mazurek, Birgit; Lopez-Escamez, Jose A.; Cederroth, Christopher R.
Authors
Petra Br�ggemann
Teresa Requena
Jan Bulla
Niklas K. Edvall
Jacob v.B. Hjelmborg
Agnieszka J. Szczepek
Barbara Canlon
Birgit Mazurek
Jose A. Lopez-Escamez
Christopher R. Cederroth
Abstract
Purpose:Genetic contributions to tinnitus have been difficult to determine due to the heterogeneity of the condition and its broad etiology. Here, we evaluated the genetic and nongenetic influences on self-reported tinnitus from the Swedish Twin Registry (STR).Methods:Cross-sectional data from the STR was obtained. Casewise concordance rates (the risk of one twin being affected given that his/her twin partner has tinnitus) were compared for monozygotic (MZ) and dizygotic (DZ) twin pairs (N = 10,464 concordant and discordant twin pairs) and heritability coefficients (the proportion of the total variance attributable to genetic factors) were calculated using biometrical model fitting procedures.Results:Stratification of tinnitus cases into subtypes according to laterality (unilateral versus bilateral) revealed that heritability of bilateral tinnitus was 0.56; however, it was 0.27 for unilateral tinnitus. Heritability was greater in men (0.68) than in women (0.41). However, when female pairs younger than 40 years of age were selected, heritability of 0.62 was achieved with negligible effects of shared environment.Conclusion:Unlike unilateral tinnitus, bilateral tinnitus is influenced by genetic factors and might constitute a genetic subtype. Overall, our study provides the initial evidence for a tinnitus phenotype with a genetic influence.
Citation
Maas, I. L., Brüggemann, P., Requena, T., Bulla, J., Edvall, N. K., Hjelmborg, J. V., …Cederroth, C. R. (2017). Genetic susceptibility to bilateral tinnitus in a Swedish twin cohort. Genetics in Medicine, 19(9), 1007-1012. https://doi.org/10.1038/gim.2017.4
Journal Article Type | Article |
---|---|
Acceptance Date | Jan 9, 2017 |
Online Publication Date | Mar 23, 2017 |
Publication Date | 2017-09 |
Deposit Date | Nov 24, 2020 |
Publicly Available Date | Nov 24, 2020 |
Journal | Genetics in Medicine |
Print ISSN | 1098-3600 |
Electronic ISSN | 1530-0366 |
Publisher | Nature Publishing Group |
Peer Reviewed | Peer Reviewed |
Volume | 19 |
Issue | 9 |
Pages | 1007-1012 |
DOI | https://doi.org/10.1038/gim.2017.4 |
Public URL | https://nottingham-repository.worktribe.com/output/5068415 |
Publisher URL | https://www.nature.com/articles/gim20174 |
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