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All Outputs (1069)

Predicting 30-day mortality in patients with sepsis: an exploratory analysis of process of care and patient characteristics (2018)
Journal Article
Sanderson, M., Chikhani, M., Blyth, E., Wood, S., Moppett, I. K., McKeever, T., & Simmonds, M. J. (2018). Predicting 30-day mortality in patients with sepsis: an exploratory analysis of process of care and patient characteristics. Journal of the Intensive Care Society, 19(4), 299-304. https://doi.org/10.1177/1751143718758975

Background Sepsis represents a significant public health burden, costing the NHS £2.5 billion annually, with 35% mortality in 2006. The aim of this exploratory study was to investigate risk factors predictive of 30-day mortality amongst patients w... Read More about Predicting 30-day mortality in patients with sepsis: an exploratory analysis of process of care and patient characteristics.

Barriers to voluntary participation in sport for children: a systematic review (2018)
Journal Article
Somerset, S., & Hoare, D. J. (2018). Barriers to voluntary participation in sport for children: a systematic review. BMC Pediatrics, 18(1), Article 47. https://doi.org/10.1186/s12887-018-1014-1

Background Numerous studies have detailed the physical health benefits of children’s participation in sport and a growing body of research also highlights the benefits for mental health. Children who participate in sport have also been shown to be a... Read More about Barriers to voluntary participation in sport for children: a systematic review.

Hyperacusis: major research questions (2018)
Journal Article
Baguley, D. M., & Hoare, D. J. (2018). Hyperacusis: major research questions. HNO, 66(5), 358-363. https://doi.org/10.1007/s00106-017-0464-3

Background: Hyperacusis is a troublesome symptom that can have a marked negative impact on quality of life. Objectives: To identify major research questions in hyperacusis. Materials and methods: Review of gaps in knowledge regarding hyperacusis, a... Read More about Hyperacusis: major research questions.

Statistical analysis plan for the ‘Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2)’ (2018)
Journal Article
Scutt, P., Appleton, J. P., Dixon, M., Woodhouse, L. J., Sprigg, N., Wardlaw, J. M., …Bath, P. M. (2018). Statistical analysis plan for the ‘Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2)’. European Stroke Journal, 3(2), 193-196. https://doi.org/10.1177/2396987318756696

Rationale: Glyceryl trinitrate, a nitric oxide donor, is a candidate treatment for acute stroke; it lowers blood pressure, does not alter cerebral blood flow or platelet function and is neuroprotective in experimental stroke. The ongoing rapid interv... Read More about Statistical analysis plan for the ‘Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2)’.

Does tranexamic acid lead to changes in MRI-measures of brain tissue health in patients with spontaneous intracerebral haemorrhage? An MRI sub-study nested within the double-blind randomised controlled TICH-2 trial (2018)
Journal Article
Dineen, R. A., Pszczolkowski, S., Flaherty, K., Law, Z. K., Morgan, P. S., Roberts, I., …Sprigg, N. (in press). Does tranexamic acid lead to changes in MRI-measures of brain tissue health in patients with spontaneous intracerebral haemorrhage? An MRI sub-study nested within the double-blind randomised controlled TICH-2 trial. BMJ Open, 8(2), Article e019930. https://doi.org/10.1136/bmjopen-2017-019930

Objectives: To test whether administration of the antifibrinolytic drug tranexamic acid (TXA) in patients with spontaneous intracerebral haemorrhage (SICH) leads to increased prevalence of diffusion-weighted MRI defined hyperintense ischaemic lesions... Read More about Does tranexamic acid lead to changes in MRI-measures of brain tissue health in patients with spontaneous intracerebral haemorrhage? An MRI sub-study nested within the double-blind randomised controlled TICH-2 trial.

Cochrane Corner: Hearing aids for mild to moderate hearing loss in adults (2018)
Journal Article
Brennan-Jones, C. G., Weeda, E., & Ferguson, M. A. (in press). Cochrane Corner: Hearing aids for mild to moderate hearing loss in adults. International Journal of Audiology, https://doi.org/10.1080/14992027.2018.1432903

This Cochrane Corner features the review entitled “Hearing aids for mild to moderate hearing loss in adults” published in 2017. In their review, Ferguson et al. identified five randomised controlled trials (RCTs) involving 825 participants, with mode... Read More about Cochrane Corner: Hearing aids for mild to moderate hearing loss in adults.

The application of pupillometry in hearing science to assess listening effort (2018)
Journal Article
Naylor, G., Koelewijn, T., Zekveld, A. A., & Kramer, S. E. (2018). The application of pupillometry in hearing science to assess listening effort. Trends in Hearing, 22, 1-3. https://doi.org/10.1177/2331216518799437

In recent years, the fields of Audiology and Cognitive Sciences have seen a burgeoning of research focusing on the assessment of the effort required during listening. Among approaches to this question, the pupil dilation response has shown to be an i... Read More about The application of pupillometry in hearing science to assess listening effort.

“There are more important things to worry about”:attitudes and behaviours towards leisure noise and use ofhearing protection in young adults (2018)
Journal Article
Hunter, A. (2018). “There are more important things to worry about”:attitudes and behaviours towards leisure noise and use ofhearing protection in young adults. International Journal of Audiology, 57(6), 449-456. https://doi.org/10.1080/14992027.2018.1430383

Objective: Noise-induced hearing problems among young adults are increasing due to participation in activities where music is played at a loud volume. This study explored attitudes towards leisure noise, hearing protection, and perceived susceptibili... Read More about “There are more important things to worry about”:attitudes and behaviours towards leisure noise and use ofhearing protection in young adults.

Early time course of major bleeding on antiplatelet therapy after TIA or ischemic stroke (2018)
Journal Article
Hilkens, N. A., Algra, A., Kappelle, L. J., Bath, P. M., Csiba, L., Rothwell, P. M., & Greving, J. P. (2018). Early time course of major bleeding on antiplatelet therapy after TIA or ischemic stroke. Neurology, 90(8), Article e683-e689. https://doi.org/10.1212/WNL.0000000000004997

Objective: To study the early time course of major bleeding and its subtypes in patients with cerebral ischemia on dual and single antiplatelet therapy. Methods: We performed a post hoc analysis on individual patient data from 6 randomized clinica... Read More about Early time course of major bleeding on antiplatelet therapy after TIA or ischemic stroke.

Recruiting ENT and audiology patients into pharmaceutical trials: evaluating the multi-center experience in the UK and USA (2018)
Journal Article
Sanchez, V. A., Hall, D. A., Millar, B., Escabi, C. D., Sharman, A., Watson, J., …Harris, P. (in press). Recruiting ENT and audiology patients into pharmaceutical trials: evaluating the multi-center experience in the UK and USA. International Journal of Audiology, https://doi.org/10.1080/14992027.2018.1425002

Objective: Recruiting into clinical trials on time and on target is a major challenge, and yet often goes unreported. This study evaluated the adjustment to procedures, recruitment, and screening methods in two multi-center pharmaceutical randomized... Read More about Recruiting ENT and audiology patients into pharmaceutical trials: evaluating the multi-center experience in the UK and USA.

Real-time estimation of horizontal gaze angle by saccade integration using in-ear electrooculography (2018)
Journal Article
Hládek, Ľ., Porr, B., & Brimijoin, W. O. (2018). Real-time estimation of horizontal gaze angle by saccade integration using in-ear electrooculography. PLoS ONE, 13(1), Article e0190420. https://doi.org/10.1371/journal.pone.0190420

The manuscript proposes and evaluates a real-time algorithm for estimating eye gaze angle based solely on single-channel electrooculography (EOG), which can be obtained directly from the ear canal using conductive ear moulds. In contrast to conventio... Read More about Real-time estimation of horizontal gaze angle by saccade integration using in-ear electrooculography.

An observational feasibility study of a new anaesthesia drug storage tray (2018)
Journal Article
Almghairbi, D. S., Sharp, L., Griffiths, R., Evley, R., Gupta, S., & Moppett, I. K. (2018). An observational feasibility study of a new anaesthesia drug storage tray. Anaesthesia, 73(3), 356-364. https://doi.org/10.1111/anae.14187

Drug errors in the anaesthetic domain remains a serious cause of iatrogenic harm. To help reduce this issue, we aimed to explore the potential impact of a simple colour-coded tray to drug preparation and storage on safe drug administration during ana... Read More about An observational feasibility study of a new anaesthesia drug storage tray.

Data-Driven Approach for Auditory Profiling and Characterization of Individual Hearing Loss (2018)
Journal Article
Sanchez Lopez, R., Bianchi, F., Fereczkowski, M., Santurette, S., & Dau, T. (2018). Data-Driven Approach for Auditory Profiling and Characterization of Individual Hearing Loss. Trends in Hearing, 22, https://doi.org/10.1177/2331216518807400

Pure-tone audiometry still represents the main measure to characterize individual hearing loss and the basis for hearing-aid fitting. However, the perceptual consequences of hearing loss are typically associated not only with a loss of sensitivity bu... Read More about Data-Driven Approach for Auditory Profiling and Characterization of Individual Hearing Loss.

Diagnostic Criteria for Somatosensory Tinnitus: A Delphi Process and Face-to-Face Meeting to Establish Consensus (2018)
Journal Article
Michiels, S., Sanchez, T. G., Oron, Y., Gilles, A., Haider, H. F., Erlandsson, S., …Hall, D. A. (2018). Diagnostic Criteria for Somatosensory Tinnitus: A Delphi Process and Face-to-Face Meeting to Establish Consensus. Trends in Hearing, 22, 1-10. https://doi.org/10.1177/2331216518796403

Since somatic or somatosensory tinnitus (ST) was first described as a subtype of subjective tinnitus, where altered somatosensory afference from the cervical spine or temporomandibular area causes or changes a patient’s tinnitus perception, several s... Read More about Diagnostic Criteria for Somatosensory Tinnitus: A Delphi Process and Face-to-Face Meeting to Establish Consensus.

Incremental comprehension of pitch relationships in written music: Evidence from eye movements (2018)
Journal Article
Hadley, L. V., Sturt, P., Eerola, T., & Pickering, M. J. (2018). Incremental comprehension of pitch relationships in written music: Evidence from eye movements. Quarterly Journal of Experimental Psychology, 71(1), 211-219. https://doi.org/10.1080/17470218.2017.1307861

To investigate how proficient pianists comprehend pitch relationships in written music when they first encounter it, we conducted two experiments in which proficient pianists’ eyes were tracked while they read and played single-line melodies. In Expe... Read More about Incremental comprehension of pitch relationships in written music: Evidence from eye movements.

Statistical analysis plan for the ‘Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage’ (TICH-2) trial (2017)
Journal Article
Flaherty, K., Bath, P. M., Dineen, R., Law, Z., Scutt, P., Pocock, S., & Sprigg, N. (in press). Statistical analysis plan for the ‘Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage’ (TICH-2) trial. Trials, 18(1), Article 607. https://doi.org/10.1186/s13063-017-2341-5

Rationale Aside from blood pressure lowering, treatment options for intracerebral haemorrhage remain limited and a proportion of patients will undergo early haematoma expansion with resultant significant morbidity and mortality. Tranexamic acid (T... Read More about Statistical analysis plan for the ‘Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage’ (TICH-2) trial.

Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial (2017)
Journal Article
Bath, P. M., Christensen, L. M., Woodhouse, L. J., Bentsen, L., Appleton, J. P., Krarup Hansen, C., …Farren, P. (2018). Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial. Lancet, 391(10123), 850-859. https://doi.org/10.1016/S0140-6736%2817%2932849-0

Background: Intensive antiplatelet therapy with three agents might be more effective than guideline treatment for preventing recurrent events in patients with acute cerebral ischaemia. We aimed to compare the safety and efficacy of intensive antiplat... Read More about Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial.

Predictors of entering a hearing aid evaluation period: a prospective study in older hearing-help seekers (2017)
Journal Article
Pronk, M., Deeg, D. J., Versfeld, N. J., Heymans, M., Naylor, G., & Kramer, S. E. (in press). Predictors of entering a hearing aid evaluation period: a prospective study in older hearing-help seekers. Trends in Hearing, 21, https://doi.org/10.1177/2331216517744915

This study aimed to determine the predictors of entering a hearing aid evaluation period (HAEP) using a prospective design drawing on the health belief model and the transtheoretical model. In total, 377 older persons who presented with hearing probl... Read More about Predictors of entering a hearing aid evaluation period: a prospective study in older hearing-help seekers.