All Outputs (1069)

Identifying the spatial and temporal dynamics of molecularly-distinct glioblastoma sub-populations (2020)
Journal Article
Morris, B., Curtin, L., Hawkins-Daarud, A., Hubbard, M. E., Rahman, R., Smith, S. J., …Owen, M. R. (2020). Identifying the spatial and temporal dynamics of molecularly-distinct glioblastoma sub-populations. Mathematical Biosciences and Engineering, 17(5), 4905-4941. https://doi.org/10.3934/mbe.2020267

Glioblastomas (GBMs) are the most aggressive primary brain tumours and have no known cure. Each individual tumour comprises multiple sub-populations of genetically-distinct cells that may respond differently to targeted therapies and may contribute t... Read More about Identifying the spatial and temporal dynamics of molecularly-distinct glioblastoma sub-populations.

Methodologies for pragmatic and efficient assessment of benefits and harms: Application to the SOCRATES trial (2020)
Journal Article
Evans, S. R., Knutsson, M., Amarenco, P., Albers, G. W., Bath, P. M., Denison, H., …Johnston, S. C. (2020). Methodologies for pragmatic and efficient assessment of benefits and harms: Application to the SOCRATES trial. Clinical Trials, 17(6), 617-626. https://doi.org/10.1177/1740774520941441

Background/Aims: Standard approaches to trial design and analyses can be inefficient and non-pragmatic. Failure to consider a range of outcomes impedes evidence-based interpretation and reduces power. Traditional approaches synthesizing information o... Read More about Methodologies for pragmatic and efficient assessment of benefits and harms: Application to the SOCRATES trial.

An Exploratory Study of EEG Alpha Oscillation and Pupil Dilation in Hearing-Aid Users During Effortful listening to Continuous Speech (2020)
Journal Article
Seifi Ala, T., Graversen, C., Wendt, D., Alickovic, E., Whitmer, W. M., & Lunner, T. (2020). An Exploratory Study of EEG Alpha Oscillation and Pupil Dilation in Hearing-Aid Users During Effortful listening to Continuous Speech. PLoS ONE, 15(7), Article e0235782. https://doi.org/10.1371/journal.pone.0235782

Individuals with hearing loss allocate cognitive resources to comprehend noisy speech in everyday life scenarios. Such a scenario could be when they are exposed to ongoing speech and need to sustain their attention for a rather long period of time, w... Read More about An Exploratory Study of EEG Alpha Oscillation and Pupil Dilation in Hearing-Aid Users During Effortful listening to Continuous Speech.

Cilostazol for Secondary Prevention of Stroke and Cognitive Decline: Systematic Review and Meta-Analysis (2020)
Journal Article
McHutchison, C., Blair, G. W., Appleton, J. P., Chappell, F. M., Doubal, F., Bath, P. M., & Wardlaw, J. M. (2020). Cilostazol for Secondary Prevention of Stroke and Cognitive Decline: Systematic Review and Meta-Analysis. Stroke, 51(8), 2374-2385. https://doi.org/10.1161/strokeaha.120.029454

Background and Purpose: Cilostazol, a phosphodiesterase 3’ inhibitor, is used in Asia-Pacific countries for stroke prevention, but rarely used elsewhere. In addition to weak antiplatelet effects, it stabilises endothelium, aids myelin repair and astr... Read More about Cilostazol for Secondary Prevention of Stroke and Cognitive Decline: Systematic Review and Meta-Analysis.

Cost-benefit of outcome adjudication in nine randomised stroke trials (2020)
Journal Article
Godolphin, P. J., Bath, P. M., Algra, A., Berge, E., Chalmers, J., Eliasziw, M., …Montgomery, A. A. (2020). Cost-benefit of outcome adjudication in nine randomised stroke trials. Clinical Trials, 17(5), 576-580. https://doi.org/10.1177/1740774520939231

Background: Central adjudication of outcomes is common for randomised trials and should control for differential misclassification. However, few studies have estimated the cost of the adjudication process. Methods: We estimated the cost of adjudicat... Read More about Cost-benefit of outcome adjudication in nine randomised stroke trials.

Connectivity guided theta burst transcranial magnetic stimulation versus repetitive transcranial magnetic stimulation for treatment-resistant moderate to severe depression: study protocol for a randomised double-blind controlled trial (BRIGhTMIND) (2020)
Journal Article
Morriss, R., Webster, L., Abdelghani, M., Auer, D., Barber, S., Bates, P., …Walters, Y. (2020). Connectivity guided theta burst transcranial magnetic stimulation versus repetitive transcranial magnetic stimulation for treatment-resistant moderate to severe depression: study protocol for a randomised double-blind controlled trial (BRIGhTMIND). BMJ Open, 10(7), Article e038430. https://doi.org/10.1136/bmjopen-2020-038430

Introduction The BRIGhTMIND study aims to determine the clinical effectiveness, cost effectiveness and mechanism of action of connectivity guided intermittent Theta Burst Stimulation (cgiTBS) versus standard repetitive Transcranial Magnetic Stimulati... Read More about Connectivity guided theta burst transcranial magnetic stimulation versus repetitive transcranial magnetic stimulation for treatment-resistant moderate to severe depression: study protocol for a randomised double-blind controlled trial (BRIGhTMIND).

A data-driven approach to optimising the encoding for multi-shell diffusion MRI with application to neonatal imaging (2020)
Journal Article
Tournier, J.-D., Christiaens, D., Hutter, J., Price, A. N., Cordero-Grande, L., Hughes, E., …Hajnal, J. V. (2020). A data-driven approach to optimising the encoding for multi-shell diffusion MRI with application to neonatal imaging. NMR in Biomedicine, 33(9), Article e4348. https://doi.org/10.1101/661348

Diffusion MRI has the potential to provide important information about the connectivity and microstructure of the human brain during normal and abnormal development, non-invasively and in vivo. Recent developments in MRI hardware and reconstruction m... Read More about A data-driven approach to optimising the encoding for multi-shell diffusion MRI with application to neonatal imaging.

Optimising Psychoeducation for Transient Ischaemic Attack and Minor Stroke Management (OPTIMISM): Protocol for a feasibility randomised controlled trial (2020)
Journal Article
Kontou, E., Walker, M., Thomas, S., Watkins, C., Griffiths, H., Golding-Day, M., …Sprigg, N. (2020). Optimising Psychoeducation for Transient Ischaemic Attack and Minor Stroke Management (OPTIMISM): Protocol for a feasibility randomised controlled trial. AMRC Open Research, 2, Article 24. https://doi.org/10.12688/amrcopenres.12911.1

Background: A transient ischaemic attack (TIA) and minor stroke are medical emergencies and often a warning sign of future strokes if remain untreated. Few studies have investigated the long-term psychosocial effects of TIA and minor stroke. Secondar... Read More about Optimising Psychoeducation for Transient Ischaemic Attack and Minor Stroke Management (OPTIMISM): Protocol for a feasibility randomised controlled trial.

Pro-organic radical contrast agents (“pro-ORCAs”) for real-time MRI of pro-drug activation in biological systems (2020)
Journal Article
Nguyen, H. V.-T., Detappe, A., Harvey, P., Gallagher, N., Mathieu, C., Agius, M. P., …Johnson, J. A. (2020). Pro-organic radical contrast agents (“pro-ORCAs”) for real-time MRI of pro-drug activation in biological systems. Polymer Chemistry, 11(29), 4768-4779. https://doi.org/10.1039/d0py00558d

Nitroxide-based organic-radical contrast agents (ORCAs) are promising as safe next-generation magnetic resonance imaging (MRI) tools. Nevertheless, stimuli-responsive ORCAs that enable MRI monitoring of prodrug activation have not been reported; such... Read More about Pro-organic radical contrast agents (“pro-ORCAs”) for real-time MRI of pro-drug activation in biological systems.

12-year analysis of incidence, microbiological profiles and in vitro antimicrobial susceptibility of infectious keratitis: the Nottingham Infectious Keratitis Study (2020)
Journal Article
Ting, D. S. J., Ho, C. S., Cairns, J., Elsahn, A., Al-Aqaba, M. A., Boswell, T., …Dua, H. (2021). 12-year analysis of incidence, microbiological profiles and in vitro antimicrobial susceptibility of infectious keratitis: the Nottingham Infectious Keratitis Study. British Journal of Ophthalmology, 105(3), 328-333. https://doi.org/10.1136/bjophthalmol-2020-316128

Background/aims: To examine the incidence, causative microorganisms and in vitro antimicrobial susceptibility and resistance profiles of infectious keratitis (IK) in Nottingham, UK. Methods: A retrospective study of all patients who were diagnosed... Read More about 12-year analysis of incidence, microbiological profiles and in vitro antimicrobial susceptibility of infectious keratitis: the Nottingham Infectious Keratitis Study.

Management of primary blast lung injury: a comparison of airway pressure release versus low tidal volume ventilation (2020)
Journal Article
Scott, T. E., Das, A., Haque, M., Bates, D. G., & Hardman, J. G. (2020). Management of primary blast lung injury: a comparison of airway pressure release versus low tidal volume ventilation. Intensive Care Medicine Experimental, 8(1), Article 26. https://doi.org/10.1186/s40635-020-00314-2

Background Primary blast lung injury (PBLI) presents as a syndrome of respiratory distress and haemoptysis resulting from explosive shock wave exposure and is a frequent cause of mortality and morbidity in both military conflicts and terrorist att... Read More about Management of primary blast lung injury: a comparison of airway pressure release versus low tidal volume ventilation.

Optical coherence tomography in mild cognitive impairment – systematic review and meta-analysis (2020)
Journal Article
Noah, A. M., Almghairbi, D., & Moppett, I. K. (2020). Optical coherence tomography in mild cognitive impairment – systematic review and meta-analysis. Clinical Neurology and Neurosurgery, 196, Article 106036. https://doi.org/10.1016/j.clineuro.2020.106036

Thinning of retinal layers, measured using optical coherence tomography (OCT), is associated with some neurodegenerative disorders such as established Alzheimer’s disease and multiple sclerosis. The evidence for retinal layer thinning in both mild co... Read More about Optical coherence tomography in mild cognitive impairment – systematic review and meta-analysis.

Biopsychosocial intervention for stroke carers (BISC): results of a feasibility randomised controlled trial and nested qualitative interview study (2020)
Journal Article
Walker, M. F., Birchall, S., Cobley, C., Condon, L., Fisher, R., Fletcher-Smith, J., …Whitehead, P. J. (2020). Biopsychosocial intervention for stroke carers (BISC): results of a feasibility randomised controlled trial and nested qualitative interview study. Clinical Rehabilitation, 34(10), 1268-1281. https://doi.org/10.1177/0269215520937039

Objective: To determine the feasibility of recruiting to and delivering a biopsychosocial intervention for carers of stroke survivors. Design: Feasibility randomised controlled study with nested qualitative interview study. Setting: The interventio... Read More about Biopsychosocial intervention for stroke carers (BISC): results of a feasibility randomised controlled trial and nested qualitative interview study.

Profiling ocular surface responses to preserved and non‐preserved topical glaucoma medications: a two‐year randomised evaluation study (2020)
Journal Article
Mohammed, I., Kulkarni, B., Faraj, L. A., Abbas, A., Dua, H. S., & King, A. J. (2020). Profiling ocular surface responses to preserved and non‐preserved topical glaucoma medications: a two‐year randomised evaluation study. Clinical and Experimental Ophthalmology, 48(7), 973-982. https://doi.org/10.1111/ceo.13814

Background Use of topical glaucoma medications has been reported to cause ocular surface (OS) discomfort and inflammation. This study explores the profile of inflammatory cytokines and OS symptoms induced in response to preserved and non‐preserved d... Read More about Profiling ocular surface responses to preserved and non‐preserved topical glaucoma medications: a two‐year randomised evaluation study.

Effect of mental rotation skills training on ultrasound-guided regional anaesthesia task performance by novice operators: a rater-blinded, randomised, controlled study (2020)
Journal Article
Hewson, D. W., Knudsen, R., Shanmuganathan, S., Ferguson, E., Hardman, J. G., Bedforth, N. M., & McCahon, R. A. (2020). Effect of mental rotation skills training on ultrasound-guided regional anaesthesia task performance by novice operators: a rater-blinded, randomised, controlled study. British Journal of Anaesthesia, 125(2), 168-174. https://doi.org/10.1016/j.bja.2020.04.090

Background: The effect of mental rotation training on ultrasound guided regional anaesthesia (UGRA) skill acquisition is currently unknown. In this study we aimed to examine whether mental rotation skill training can improve UGRA task performance by... Read More about Effect of mental rotation skills training on ultrasound-guided regional anaesthesia task performance by novice operators: a rater-blinded, randomised, controlled study.

Effect of mental rotation skills training on ultrasound-guided regional anaesthesia task performance by novice operators: a rater-blinded, randomised, controlled study (2020)
Journal Article
Hewson, D. W., Knudsen, R., Shanmuganathan, S., Ferguson, E., Hardman, J. G., Bedforth, N. M., & McCahon, R. A. (2020). Effect of mental rotation skills training on ultrasound-guided regional anaesthesia task performance by novice operators: a rater-blinded, randomised, controlled study. British Journal of Anaesthesia, 125(2), 168-174. https://doi.org/10.1016/j.bja.2020.04.090

© 2020 British Journal of Anaesthesia Background: The effect of mental rotation training on ultrasound-guided regional anaesthesia (UGRA) skill acquisition is currently unknown. In this study we aimed to examine whether mental rotation skill training... Read More about Effect of mental rotation skills training on ultrasound-guided regional anaesthesia task performance by novice operators: a rater-blinded, randomised, controlled study.

Insomnia, Anxiety and Depression in Adult Cochlear Implant Users With Tinnitus (2020)
Journal Article
Pierzycki, R., & Kitterick, P. (2021). Insomnia, Anxiety and Depression in Adult Cochlear Implant Users With Tinnitus. Ear and Hearing, 42(1), 235-243. https://doi.org/10.1097/aud.0000000000000900

Objective: Determine the prevalence of clinical insomnia and its associations with anxiety, depression, and tinnitus in adult cochlear implant (CI) users. Design: Self-reported information on tinnitus, sleep, and demographic variables was... Read More about Insomnia, Anxiety and Depression in Adult Cochlear Implant Users With Tinnitus.

Hookworm Treatment for Relapsing Multiple Sclerosis: A Randomized Double-Blinded Placebo-Controlled Trial (2020)
Journal Article
Tanasescu, R., Tench, C. R., Constantinescu, C. S., Telford, G., Singh, S., Frakich, N., …Pritchard, D. I. (2020). Hookworm Treatment for Relapsing Multiple Sclerosis: A Randomized Double-Blinded Placebo-Controlled Trial. JAMA Neurology, 77(9), 1089-1098. https://doi.org/10.1001/jamaneurol.2020.1118

© 2020 American Medical Association. All rights reserved. Importance: Studies suggest gut worms induce immune responses that can protect against multiple sclerosis (MS). To our knowledge, there are no controlled treatment trials with helminth in MS.... Read More about Hookworm Treatment for Relapsing Multiple Sclerosis: A Randomized Double-Blinded Placebo-Controlled Trial.

Platelet function/reactivity testing and prediction of risk of recurrent vascular events and outcomes after TIA or ischaemic stroke: systematic review and meta-analysis (2020)
Journal Article
Lim, S. T., Thijs, V., Murphy, S. J. X., Fernandez-Cadenas, I., Montaner, J., Offiah, C., …McCabe, D. J. H. (2020). Platelet function/reactivity testing and prediction of risk of recurrent vascular events and outcomes after TIA or ischaemic stroke: systematic review and meta-analysis. Journal of Neurology, https://doi.org/10.1007/s00415-020-09932-y

Background The prevalence of ex vivo ‘high on-treatment platelet reactivity (HTPR)’ and its relationship with recurrent vascular events/outcomes in patients with ischaemic cerebrovascular disease (CVD) is unclear. Methods A systematic review and... Read More about Platelet function/reactivity testing and prediction of risk of recurrent vascular events and outcomes after TIA or ischaemic stroke: systematic review and meta-analysis.

Consistent use of proactive control and relation with academic achievement in childhood (2020)
Journal Article
Kubota, M., Hadley, L. V., Schaeffner, S., Könen, T., Meaney, J.-A., Auyeunga, B., …Chevalier, N. (2020). Consistent use of proactive control and relation with academic achievement in childhood. Cognition, 203, Article 104329. https://doi.org/10.1016/j.cognition.2020.104329

As children become older, they better maintain task-relevant information in preparation of upcoming cognitive demands. This is referred to as proactive control, which is a key component of cognitive control development. However, it is still uncertain... Read More about Consistent use of proactive control and relation with academic achievement in childhood.