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Multimodal imaging brain markers in early adolescence are linked with a physically active lifestyle (2021)
Journal Article
Salvan, P., Wassenaar, T., Wheatley, C., Beale, N., Cottaar, M., Papp, D., …Johansen-Berg, H. (2021). Multimodal imaging brain markers in early adolescence are linked with a physically active lifestyle. Journal of Neuroscience, 41(5), 1092-1104. https://doi.org/10.1523/JNEUROSCI.1260-20.2020

© 2021 Salvan et al. The World Health Organization promotes physical exercise and a healthy lifestyle as means to improve youth development. However, relationships between physical lifestyle and human brain development are not fully understood. Here,... Read More about Multimodal imaging brain markers in early adolescence are linked with a physically active lifestyle.

The secretome of endothelial progenitor cells: a potential therapeutic strategy for ischemic stroke (2021)
Journal Article
Alwjwaj, M., Kadir, R. R. A., & Bayraktutan, U. (2021). The secretome of endothelial progenitor cells: a potential therapeutic strategy for ischemic stroke. Neural Regeneration Research, 16(8), 1483-1489. https://doi.org/10.4103/1673-5374.303012

Ischemic stroke continues to be a leading cause of mortality and morbidity in the world. Despite recent advances in the field of stroke medicine, thrombolysis with recombinant tissue plasminogen activator remains as the only pharmacological therapy f... Read More about The secretome of endothelial progenitor cells: a potential therapeutic strategy for ischemic stroke.

Infectious keratitis: an update on epidemiology, causative microorganisms, risk factors, and antimicrobial resistance (2021)
Journal Article
Ting, D. S. J., Ho, C. S., Deshmukh, R., Said, D. G., & Dua, H. S. (2021). Infectious keratitis: an update on epidemiology, causative microorganisms, risk factors, and antimicrobial resistance. Eye, 35, 1084-1101. https://doi.org/10.1038/s41433-020-01339-3

Corneal opacity is the 5th leading cause of blindness and visual impairment globally, affecting ~6 million of the world population. In addition, it is responsible for 1.5–2.0 million new cases of monocular blindness per year, highlighting an ongoing... Read More about Infectious keratitis: an update on epidemiology, causative microorganisms, risk factors, and antimicrobial resistance.

Pilot Randomised Evaluation of Singing in Dementia (PRESIDE): protocol for a two-arm, parallel group randomised controlled feasibility study with waiting-list control (2021)
Journal Article
Dowson, B., Schneider, J., Guo, B., Bath, P. M., Mcdermott, O., Haywood, L. J., & Orrell, M. (2021). Pilot Randomised Evaluation of Singing in Dementia (PRESIDE): protocol for a two-arm, parallel group randomised controlled feasibility study with waiting-list control. Pilot and Feasibility Studies, 7, Article 15. https://doi.org/10.1186/s40814-020-00759-y

Background As the number of people living with dementia grows, so does the need to provide them with adequate psychosocial support. Many people with dementia live at home with family carers, who also require social and emotional support to cope wi... Read More about Pilot Randomised Evaluation of Singing in Dementia (PRESIDE): protocol for a two-arm, parallel group randomised controlled feasibility study with waiting-list control.

Can listening-related fatigue influence well-being? Examining associations between hearing loss, fatigue, activity levels and well-being (2021)
Journal Article
Holman, J. A., Hornsby, B. W. Y., Bess, F. H., & Naylor, G. (2021). Can listening-related fatigue influence well-being? Examining associations between hearing loss, fatigue, activity levels and well-being. International Journal of Audiology, 60(sup2), 47-59. https://doi.org/10.1080/14992027.2020.1853261

Objective Well-being is influenced by the activities we undertake. Hearing loss may reduce well-being directly through increased listening-related fatigue due to cognitive and emotional strain in challenging situations. Hearing loss and hearing devi... Read More about Can listening-related fatigue influence well-being? Examining associations between hearing loss, fatigue, activity levels and well-being.

Quantum computing at the frontiers of biological sciences (2021)
Journal Article
Emani, P. S., Warrell, J., Anticevic, A., Bekiranov, S., Gandal, M., McConnell, M. J., …Harrow, A. W. (2021). Quantum computing at the frontiers of biological sciences. Nature Methods, 18, 701-709. https://doi.org/10.1038/s41592-020-01004-3

The search for meaningful structure in biological data has relied on cutting-edge advances in computational technology and data science methods. However, challenges arise as we push the limits of scale and complexity in biological problems. Innovatio... Read More about Quantum computing at the frontiers of biological sciences.

Associations Between Hearing and Cognitive Abilities From Childhood to Middle Age: The National Child Development Study 1958 (2021)
Journal Article
Okely, J. A., Akeroyd, M. A., & Deary, I. J. (2021). Associations Between Hearing and Cognitive Abilities From Childhood to Middle Age: The National Child Development Study 1958. Trends in Hearing, 25, 1-19. https://doi.org/10.1177/23312165211053707

Previous cross-sectional findings indicate that hearing and cognitive abilities are positively correlated in childhood, adulthood, and older age. We used an unusually valuable longitudinal dataset from a single-year birth cohort study, the National C... Read More about Associations Between Hearing and Cognitive Abilities From Childhood to Middle Age: The National Child Development Study 1958.

Neural Fields with Rebound Currents: Novel Routes to Patterning (2021)
Journal Article
Modhara, S., Lai, Y. M., Thul, R., & Coombes, S. (2021). Neural Fields with Rebound Currents: Novel Routes to Patterning. SIAM Journal on Applied Dynamical Systems, 20(3), 1596-1620. https://doi.org/10.1137/20M1364710

The understanding of how spatio-temporal patterns of neural activity may arise in the cortex of the brain has advanced with the development and analysis of neural field models. To replicate this success for sub-cortical tissues, such as the thalamus,... Read More about Neural Fields with Rebound Currents: Novel Routes to Patterning.

Modelling white matter in gyral blades as a continuous vector field (2020)
Journal Article
Cottaar, M., Bastiani, M., Boddu, N., Glasser, M. F., Haber, S., van Essen, D. C., …Jbabdi, S. (2021). Modelling white matter in gyral blades as a continuous vector field. NeuroImage, 227, Article 117693. https://doi.org/10.1016/j.neuroimage.2020.117693

© 2020 Many brain imaging studies aim to measure structural connectivity with diffusion tractography. However, biases in tractography data, particularly near the boundary between white matter and cortical grey matter can limit the accuracy of such st... Read More about Modelling white matter in gyral blades as a continuous vector field.

MicroRNA: An Emerging Predictive, Diagnostic, Prognostic and Therapeutic Strategy in Ischaemic Stroke (2020)
Journal Article
Kadir, R. R. A., Alwjwaj, M., & Bayraktutan, U. (2020). MicroRNA: An Emerging Predictive, Diagnostic, Prognostic and Therapeutic Strategy in Ischaemic Stroke. Cellular and Molecular Neurobiology, https://doi.org/10.1007/s10571-020-01028-5

Stroke continues to be the third-leading cause of death and disability worldwide. The limited availability of diagnostic tools approved therapeutics and biomarkers that help monitor disease progression or predict future events remain as the major cha... Read More about MicroRNA: An Emerging Predictive, Diagnostic, Prognostic and Therapeutic Strategy in Ischaemic Stroke.

Prognostication and contemporary management of clinically isolated syndrome (2020)
Journal Article
Allen, C. M., Mowry, E., Tintore, M., & Evangelou, N. (2021). Prognostication and contemporary management of clinically isolated syndrome. Journal of Neurology, Neurosurgery and Psychiatry, 92(4), 391-397. https://doi.org/10.1136/jnnp-2020-323087

Clinically isolated syndrome (CIS) patients present with a single attack of inflammatory demyelination of the central nervous system. Recent advances in multiple sclerosis (MS) diagnostic criteria have expanded the number of CIS patients eligible for... Read More about Prognostication and contemporary management of clinically isolated syndrome.

Qualitative and quantitative assessment of magnetic vestibular stimulation in humans (2020)
Journal Article
Dewey, R. S., Gomez, R., Degg, C., Baguley, D. M., & Glover, P. (2020). Qualitative and quantitative assessment of magnetic vestibular stimulation in humans. Journal of Vestibular Research, 30(6), 353-361. https://doi.org/10.3233/VES-201538

The sensation of phantom motion or exhibition of bodily sway is often reported in the proximity of an MR scanner. It is proposed that the magnetic field stimulates the vestibular system. There are a number of possible mechanisms responsible, and the... Read More about Qualitative and quantitative assessment of magnetic vestibular stimulation in humans.

Electronic Health Records As a Platform for Audiological Research: Data Validity, Patient Characteristics, and Hearing-Aid Use Persistence Among 731,213 U.S. Veterans (2020)
Journal Article
Saunders, G. H., Dillard, L. K., Zobay, O., Cannon, J. B., & Naylor, G. (2021). Electronic Health Records As a Platform for Audiological Research: Data Validity, Patient Characteristics, and Hearing-Aid Use Persistence Among 731,213 U.S. Veterans. Ear and Hearing, 42(4), 927-940. https://doi.org/10.1097/AUD.0000000000000980

Objectives: This article presents a summary of audiological, general health, and hearing aid (HA) outcome data in a large sample of U.S. Veterans receiving HAs. The current article also provides the foundation for a series of papers that will exp... Read More about Electronic Health Records As a Platform for Audiological Research: Data Validity, Patient Characteristics, and Hearing-Aid Use Persistence Among 731,213 U.S. Veterans.

Evaluating cortical responses to speech in children: A functional near-infrared spectroscopy (fNIRS) study (2020)
Journal Article
Lawrence, R. J., Wiggins, I. M., Hodgson, J. C., & Hartley, D. E. (2021). Evaluating cortical responses to speech in children: A functional near-infrared spectroscopy (fNIRS) study. Hearing Research, 401, Article 108155. https://doi.org/10.1016/j.heares.2020.108155

Functional neuroimaging of speech processing has both research and clinical potential. This work is facilitating an ever-increasing understanding of the complex neural mechanisms involved in the processing of speech. Neural correlates of speech under... Read More about Evaluating cortical responses to speech in children: A functional near-infrared spectroscopy (fNIRS) study.

Blood markers in remote ischaemic conditioning for acute ischaemic stroke: data from the REmote ischaemic Conditioning After Stroke Trial (2020)
Journal Article
Appleton, J. P., O'Sullivan, S. E., Hedstrom, A., May, J. A., Donnelly, R., Sprigg, N., …England, T. J. (2021). Blood markers in remote ischaemic conditioning for acute ischaemic stroke: data from the REmote ischaemic Conditioning After Stroke Trial. European Journal of Neurology, 28(4), 1225-1233. https://doi.org/10.1111/ene.14650

Background and purpose: Remote ischaemic per-conditioning (RIC) is neuroprotective in experimental ischaemic stroke. Several neurohumoral, vascular and inflammatory mediators are implicated. The effect of RIC on plasma biomarkers was assessed using c... Read More about Blood markers in remote ischaemic conditioning for acute ischaemic stroke: data from the REmote ischaemic Conditioning After Stroke Trial.

A Delphi survey to determine a definition and description of hyperacusis by clinician consensus (2020)
Journal Article
Adams, B., Sereda, M., Casey, A., Byrom, P., Stockdale, D., & Hoare, D. J. (2021). A Delphi survey to determine a definition and description of hyperacusis by clinician consensus. International Journal of Audiology, 60(8), 607-613. https://doi.org/10.1080/14992027.2020.1855370

Objective: There is currently no singularly accepted definition of hyperacusis. The aim of this study was to determine a definition and description of hyperacusis by clinician consensus. Design: A three-round Delphi survey involving hearing healthcar... Read More about A Delphi survey to determine a definition and description of hyperacusis by clinician consensus.

Natural history of tinnitus in adults: A cross-sectional and longitudinal analysis (2020)
Journal Article
Dawes, P., Newall, J., Stockdale, D., Baguley, D. M., & Dawes, P. (2020). Natural history of tinnitus in adults: A cross-sectional and longitudinal analysis. BMJ Open, 10(12), Article e041290. https://doi.org/10.1136/bmjopen-2020-041290

Objective To assess incidence and changes in tinnitus and bothersome tinnitus as well as associated risk factors in a large sample of UK adults. Design Prospective cohort study. Setting UK. Participants For cross-sectional analysis, a group of 168 34... Read More about Natural history of tinnitus in adults: A cross-sectional and longitudinal analysis.

Evaluating cortical responses to speech in children: A functional near-infrared spectroscopy (fNIRS) study (2020)
Journal Article
Lawrence, R., Wiggins, I., Hodgson, J., & Hartley, D. (2021). Evaluating cortical responses to speech in children: A functional near-infrared spectroscopy (fNIRS) study. Hearing Research, 401, Article 108155. https://doi.org/10.1016/j.heares.2020.108155

Functional neuroimaging of speech processing has both research and clinical potential. This work is facilitating an ever-increasing understanding of the complex neural mechanisms involved in the processing of speech. Neural correlates of speech under... Read More about Evaluating cortical responses to speech in children: A functional near-infrared spectroscopy (fNIRS) study.

PAF-R on activated T cells: Role in the IL-23/Th17 pathway and relevance to multiple sclerosis (2020)
Journal Article
Midgley, A., Barakat, D., Braitch, M., Nichols, C., Nebozhyn, M., Edwards, L. J., …Constantinescu, C. S. (2021). PAF-R on activated T cells: Role in the IL-23/Th17 pathway and relevance to multiple sclerosis. Immunobiology, 226(1), Article 152023. https://doi.org/10.1016/j.imbio.2020.152023

© 2020 Elsevier GmbH IL-23 is a potent stimulus for Th17 cells. These cells have a distinct developmental pathway from Th1 cells induced by IL-12 and are implicated in autoimmune and inflammatory disorders including multiple sclerosis (MS). TGF-β, IL... Read More about PAF-R on activated T cells: Role in the IL-23/Th17 pathway and relevance to multiple sclerosis.