All Outputs (817)

Atopic Dermatitis (2005)
Journal Article
Williams, H. C. (2005). Atopic Dermatitis

A 10-year-old girl with atopic dermatitis reports itching that has recently become relentless, resulting in sleep loss. Her mother has been reluctant to treat the girl with topical corticosteroids, because she was told that they damage the skin, bu... Read More about Atopic Dermatitis.

Introducing the National Library for Health Skin Conditions Specialist Library (2005)
Journal Article
Grindlay, D. J., Kamel Boulos, M. N., & Williams, H. C. (2005). Introducing the National Library for Health Skin Conditions Specialist Library. BMC Dermatology, 5(4),

Background: This paper introduces the new National Library for Health Skin Conditions Specialist Library http://www.library.nhs.uk/skin. Description: The aims, scope and audience of the new NLH Skin Conditions Specialist Library, and the compositi... Read More about Introducing the National Library for Health Skin Conditions Specialist Library.

How to reply to referees’ comments when submitting manuscripts for publication (2004)
Journal Article
Williams, H. C. (2004). How to reply to referees’ comments when submitting manuscripts for publication. Journal of The American Academy of Dermatology, 51(1),

Background: The publication of articles in peer-reviewed scientific journals is a fairly complex and stepwise process that involves responding to referees’ comments. Little guidance is available in the biomedical literature on how to deal with such c... Read More about How to reply to referees’ comments when submitting manuscripts for publication.

Adaptation of the MacNew quality of life questionnaire after myocardial infarction in an Iranian population (2003)
Journal Article
Asadi-Lari, M., Javadi, H., Melville, M., Oldridge, N., & Gray, D. (2003). Adaptation of the MacNew quality of life questionnaire after myocardial infarction in an Iranian population. Health and Quality of Life Outcomes, 1(1),

BACKGROUND: Health-related quality of life (HRQL) assessment is an important measure of the impact of a wide range of disease process on an individual. To date, no HRQL tool has been evaluated in an Iranian population with cardiovascular disorders, s... Read More about Adaptation of the MacNew quality of life questionnaire after myocardial infarction in an Iranian population.

Home based exercise programme for knee pain and knee osteoarthritis: randomised controlled trial (2002)
Journal Article
Thomas, K., Muir, K., Doherty, M., Jones, A., O'Reilly, S., & Bassey, E. (2002). Home based exercise programme for knee pain and knee osteoarthritis: randomised controlled trial

Objectives To determine whether a home based exercise programme can improve outcomes in patients with knee pain. Design Pragmatic, factorial randomised controlled trial of two years' duration. Setting Two general practices in Nottingham. Partic... Read More about Home based exercise programme for knee pain and knee osteoarthritis: randomised controlled trial.

New treatments for atopic dermatitis (2002)
Journal Article
Williams, H. (2002). New treatments for atopic dermatitis. British medical journal, 324,

Atopic dermatitis now affects 15% to 20% of chil­dren in developed countries, and prevalence in cities in developing countries undergoingrapid demographic changes is quickly following suit. [1] Most cases of atopic dermatitis in a given communityare... Read More about New treatments for atopic dermatitis.

Randomised controlled trial of short bursts of a potent topical corticosteroid versus prolonged use of a mild preparation for children with mild or moderate atopic eczema (2002)
Journal Article
Thomas, K., Armstrong, S., Avery, A., Li Wan Po, A., O'Neill, C., Young, S., & Williams, H. (2002). Randomised controlled trial of short bursts of a potent topical corticosteroid versus prolonged use of a mild preparation for children with mild or moderate atopic eczema. British medical journal, 324(7340),

Objective To determine whether a three day burst of a potent corticosteroid is more effective than a mild preparation used for seven days in children with mild or moderate atopic eczema. Design Randomised, double blind, parallel group study of 1... Read More about Randomised controlled trial of short bursts of a potent topical corticosteroid versus prolonged use of a mild preparation for children with mild or moderate atopic eczema.

In vivo models of lung neutrophil activation. Comparison of mice and hamsters (2002)
Journal Article
Corteling, R., Wyss, D., & Trifilieff, A. (2002). In vivo models of lung neutrophil activation. Comparison of mice and hamsters. BMC Pharmacology, 2(1),

BACKGROUND: Evidence suggests that both the migration and activation of neutrophils into the airway is of importance in pathological conditions such as pulmonary emphysema. In the present study, we describe in vivo models of lung neutrophil infiltrat... Read More about In vivo models of lung neutrophil activation. Comparison of mice and hamsters.

Pharmacogenetics, pharmacogenomics and airway disease (2002)
Journal Article
Hall, I. P. (2002). Pharmacogenetics, pharmacogenomics and airway disease. Respiratory Research, 3(1),

The availability of a draft sequence for the human genome will revolutionise research into airway disease. This review deals with two of the most important areas impinging on the treatment of patients: pharmacogenetics and pharmacogenomics. Considera... Read More about Pharmacogenetics, pharmacogenomics and airway disease.

Angiogenesis in the pathogenesis of inflammatory joint and lung diseases (2001)
Journal Article
Walsh, D., & Pearson, C. (2001). Angiogenesis in the pathogenesis of inflammatory joint and lung diseases

This paper reviews hypotheses about roles of angiogenesis in the pathogenesis of inflammatory disease in two organs, the synovial joint and the lung. Neovascularisation is a fundamental process for growth and tissue repair after injury. Nevertheless,... Read More about Angiogenesis in the pathogenesis of inflammatory joint and lung diseases.

Interleukin-4 receptor alpha gene variants and allergic disease (2000)
Journal Article
Hall, I. P. (2000). Interleukin-4 receptor alpha gene variants and allergic disease. Respiratory Research, 1(1),

The interleukin-4 (IL-4) signalling cascade has been identified as a pathway potentially important in the development of asthma. Genetic variants within this signalling pathway might contribute to the risk of developing asthma in a given individual.... Read More about Interleukin-4 receptor alpha gene variants and allergic disease.

Protocol for the development and validation of risk prediction equations to estimate absolute and conditional survival in patients with cancer
Book
Hippisley-Cox, J., & Coupland, C. Protocol for the development and validation of risk prediction equations to estimate absolute and conditional survival in patients with cancer. University of Nottingham

This is a protocol to describe the development and validation of a set of prediction equations to quantify absolute survival for patients with different types of cancers taking account of other clinical factors available through routine linkage of ca... Read More about Protocol for the development and validation of risk prediction equations to estimate absolute and conditional survival in patients with cancer.

Protocol to assess the effectiveness and safety of novel oral anticoagulants (NOAC) vs warfarin in real world settings: cohort study in primary care
Book
Hippisley-Cox, J., & Coupland, C. Protocol to assess the effectiveness and safety of novel oral anticoagulants (NOAC) vs warfarin in real world settings: cohort study in primary care. University of Nottingham

Anticoagulants are used to treat thrombosis and to prevent thrombosis and stroke among those at high risk. Older anticoagulants such as warfarin can be effective but require regular monitoring and may lead to major bleeding and even death. Newer anti... Read More about Protocol to assess the effectiveness and safety of novel oral anticoagulants (NOAC) vs warfarin in real world settings: cohort study in primary care.

Ensemble learning of colorectal cancer survival rates
Presentation / Conference Contribution
Roadknight, C., Aickelin, U., Scholefield, J., & Durrant, L. Ensemble learning of colorectal cancer survival rates.

In this paper, we describe a dataset relating to cellular and physical conditions of patients who are operated upon to remove colorectal tumours. This data provides a unique insight into immunological status at the point of tumour removal, tumour cla... Read More about Ensemble learning of colorectal cancer survival rates.

Validation of spatial microsimulation models: a proposal to adopt the Bland-Altman method
Journal Article
Timmins, K. A., & Edwards, K. L. (in press). Validation of spatial microsimulation models: a proposal to adopt the Bland-Altman method. International Journal of Microsimulation, 9(2),

Model validation is recognised as crucial to microsimulation modelling. However, modellers encounter difficulty in choosing the most meaningful methods to compare simulated and actual values. The aim of this paper is to introduce and demonstrate a me... Read More about Validation of spatial microsimulation models: a proposal to adopt the Bland-Altman method.

Lost and stolen dogs - the true sacrifice
Book
James, M. Lost and stolen dogs - the true sacrifice. University of Nottingham

A lost \ stolen dog has a devastating affect on an individual and their family this article attempts to quantify the financial cost of such an event in the UK context.

Conflicts of interest in dermatology
Journal Article
Williams, H. C., Naldi, L., Paul, C., Vahlquist, A., Schroter, S., & Jobling, R. Conflicts of interest in dermatology. Acta Dermato-Venereologica, 86(6), https://doi.org/10.2340/00015555-0191

Conflicts of interest exist in dermatology when professional judgement concerning a primary interest, such as research validity, may be influenced by a secondary interest, such as financial gain from a for-profit organization. Conflict of interest... Read More about Conflicts of interest in dermatology.