All Outputs (819)

Automated electrophysiological and pharmacological evaluation of human pluripotent stem cell-derived cardiomyocytes (2016)
Journal Article
Rajamohan, D., Kalra, S., Hoang, M. D., George, V., Staniforth, A., Russell, H., …Denning, C. (2016). Automated electrophysiological and pharmacological evaluation of human pluripotent stem cell-derived cardiomyocytes. Stem Cells and Development, 25(6), https://doi.org/10.1089/scd.2015.0253

Automated planar patch clamp systems are widely used in drug evaluation studies because of their ability to provide accurate, reliable, and reproducible data in a high-throughput manner. Typically, CHO and HEK tumorigenic cell lines overexpressing si... Read More about Automated electrophysiological and pharmacological evaluation of human pluripotent stem cell-derived cardiomyocytes.

The utility of exhaled nitric oxide in patients with suspected asthma (2016)
Journal Article
Martin, M., Wilson, E., Gerrard-Tarpey, W., Meakin, G., Hearson, G., McKeever, T., …Harrison, T. (2016). The utility of exhaled nitric oxide in patients with suspected asthma. Thorax, 71(6), https://doi.org/10.1136/thoraxjnl-2015-208014

The value of FENO measurements in patients with symptoms suggestive of asthma is unclear. We performed an observational study to assess the ability of FENO to diagnose asthma and to predict response to inhaled corticosteroids (ICS). Our findings sugg... Read More about The utility of exhaled nitric oxide in patients with suspected asthma.

Longitudinal analysis of the neurological features of ataxia-telangiectasia (2016)
Journal Article
Jackson, T. J., Chow, G., Suri, M., Byrd, P., Taylor, M. R., & Whitehouse, W. P. (2016). Longitudinal analysis of the neurological features of ataxia-telangiectasia. Developmental Medicine and Child Neurology, 58(7), 690-697. https://doi.org/10.1111/dmcn.13052

Aim: To assess the relationship between genotype and neurological progression in ataxia‐telangiectasia (A‐T).
Methods: Clinical and laboratory data were extracted retrospectively from the records of patients attending the UK National Ataxia‐Telangie... Read More about Longitudinal analysis of the neurological features of ataxia-telangiectasia.

“We don’t worry about diabetes that much”: a qualitative study exploring perceptions of physical activity among children with Type 1 Diabetes (2016)
Journal Article
Quirk, H., Glazebrook, C., Martin, R., & Blake, H. (2016). “We don’t worry about diabetes that much”: a qualitative study exploring perceptions of physical activity among children with Type 1 Diabetes. Advances in Pediatric Research, https://doi.org/10.12715/apr.2016.3.2

Background: Despite the health benefits of physical activity, children across the population are insufficiently active. Physical activity is essential in the management of Type 1 Diabetes Mellitus (T1DM), therefore its promotion should be a priority,... Read More about “We don’t worry about diabetes that much”: a qualitative study exploring perceptions of physical activity among children with Type 1 Diabetes.

In vitro degradation and mechanical properties of PLA-PCL copolymer unit cell scaffolds generated by two-photon polymerization (2016)
Journal Article
Felfel, R. M., Poocza, L., Gimeno-Fabra, M., Milde, T., Hildebrand, G., Ahmed, I., …Liefeith, K. (2016). In vitro degradation and mechanical properties of PLA-PCL copolymer unit cell scaffolds generated by two-photon polymerization. Biomedical Materials, 11(1), Article 015011. https://doi.org/10.1088/1748-6041/11/1/015011

© 2016 IOP Publishing Ltd. The manufacture of 3D scaffolds with specific controlled porous architecture, defined microstructure and an adjustable degradation profile was achieved using two-photon polymerization (TPP) with a size of 2 × 4 × 2 mm3. Sca... Read More about In vitro degradation and mechanical properties of PLA-PCL copolymer unit cell scaffolds generated by two-photon polymerization.

RECQL4 helicase has oncogenic potential in sporadic breast cancers (2016)
Journal Article
Arora, A., Agarwal, D., Abdel-Fatah, T. M., Lu, H., Croteau, D. L., Moseley, P., …Madhusudan, S. (2016). RECQL4 helicase has oncogenic potential in sporadic breast cancers. Journal of Pathology, 238(4), 495-501. https://doi.org/10.1002/path.4681

RECQL4 helicase is a molecular motor that unwinds DNA, a process essential during DNA replication and DNA repair. Germ-line mutations in RECQL4 cause type II Rothmund–Thomson syndrome (RTS), characterized by a premature ageing phenotype and cancer pr... Read More about RECQL4 helicase has oncogenic potential in sporadic breast cancers.

Protocol investigating the clinical outcomes and cost-effectiveness of cognitive–behavioural therapy delivered remotely for unscheduled care users with health anxiety: randomised controlled trial (2016)
Journal Article
Patel, S., Malins, S., Guo, B., James, M., Kai, J., Kaylor-Hughes, C., …Morriss, R. K. (2016). Protocol investigating the clinical outcomes and cost-effectiveness of cognitive–behavioural therapy delivered remotely for unscheduled care users with health anxiety: randomised controlled trial. BJPsych Open, 2, https://doi.org/10.1192/bjpo.bp.115.002220

Background
Health anxiety and medically unexplained symptoms cost the National Health Service (NHS) an estimated £3 billion per year in unnecessary costs with little evidence of patient benefit. Effective treatment is rarely taken up due to issues s... Read More about Protocol investigating the clinical outcomes and cost-effectiveness of cognitive–behavioural therapy delivered remotely for unscheduled care users with health anxiety: randomised controlled trial.

Prognostic factors for long-term outcomes in relapsing–remitting multiple sclerosis (2016)
Journal Article
Traboulsee, A. L., Cornelisse, P., Sandberg-Wollheim, M., Uitdehaag, B. M., Kappos, L., Jongen, P. J., …Li, D. K. (2016). Prognostic factors for long-term outcomes in relapsing–remitting multiple sclerosis. Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2, https://doi.org/10.1177/2055217316666406

Objective: The objective of this article is to investigate potential clinical and MRI predictors of long-term outcomes in multiple sclerosis (MS).

Methods: This was a post hoc analysis using data from all 382 patients in the PRISMS long-term foll... Read More about Prognostic factors for long-term outcomes in relapsing–remitting multiple sclerosis.

Long-term exposure to irinotecan reduces cell migration in glioma cells. (2016)
Journal Article
Al-Ghafari, A. B., Punjaruk, W., Storer, L., Carrier, D., Hussein, D., Coyle, B., & Kerr, I. D. (2016). Long-term exposure to irinotecan reduces cell migration in glioma cells. Journal of Neuro-Oncology, 127(3), 455-462. https://doi.org/10.1007/s11060-016-2058-4

In spite of considerable research into the therapies for glioblastoma multiforme this tumour type remains very difficult to treat. As well as having a tendency to be inherently resistant to chemotherapy, glioblastoma multiforme also displays local in... Read More about Long-term exposure to irinotecan reduces cell migration in glioma cells..

Comprehensive geriatric assessment on an acute medical unit: a qualitative study of older people’s and informal carer’s perspectives of the care and treatment received (2016)
Journal Article
Darby, J., Williamson, T., Logan, P., & Gladman, J. R. (2016). Comprehensive geriatric assessment on an acute medical unit: a qualitative study of older people’s and informal carer’s perspectives of the care and treatment received. Clinical Rehabilitation, 31(1), https://doi.org/10.1177/0269215515624134

Objective: This qualitative study was imbedded in a randomised controlled trial evaluating the addition of geriatricians to usual care to enable the comprehensive geriatric assessment process with older patients on acute medical units. The qualitativ... Read More about Comprehensive geriatric assessment on an acute medical unit: a qualitative study of older people’s and informal carer’s perspectives of the care and treatment received.

The effects of azithromycin in treatment-resistant cough: A randomized, double-blind, placebo-controlled trial (2016)
Journal Article
Hodgson, D., Anderson, J., Reynolds, C., Oborne, J., Meakin, G., Bailey, H., …Harrison, T. (2016). The effects of azithromycin in treatment-resistant cough: A randomized, double-blind, placebo-controlled trial. Chest, 149(4), 1052-1060. https://doi.org/10.1016/j.chest.2015.12.036

Background

Chronic cough is a common clinical problem worldwide. Although many patients have underlying precipitating conditions such as asthma, gastroesophageal reflux, or rhinitis, many remain symptomatic despite treating these conditions. New a... Read More about The effects of azithromycin in treatment-resistant cough: A randomized, double-blind, placebo-controlled trial.

Difficulties experienced by young people with Tourette syndrome in secondary school: a mixed methods description of self, parent and staff perspectives (2016)
Journal Article
Wadman, R., Glazebrook, C., Beer, C. E., & Jackson, G. M. (2016). Difficulties experienced by young people with Tourette syndrome in secondary school: a mixed methods description of self, parent and staff perspectives. BMC Psychiatry, 16(14), https://doi.org/10.1186/s12888-016-0717-9

Background: Tourette syndrome (TS) is a neurodevelopmental disorder characterised by motor and vocal tics. These involuntary movements and vocalizations can have a negative impact in the school environment. The paper presents a mixed methods descript... Read More about Difficulties experienced by young people with Tourette syndrome in secondary school: a mixed methods description of self, parent and staff perspectives.

Caregiving in multiple sclerosis and quality of life: a meta-synthesis of qualitative research (2016)
Journal Article
Topcu, G., Buchanan, H., Aubeeluck, A., & Garip, G. (2016). Caregiving in multiple sclerosis and quality of life: a meta-synthesis of qualitative research. Psychology and Health, 31(6), 693-710. https://doi.org/10.1080/08870446.2016.1139112

Objective:
The lack of adequate conceptualisation and operationalisation of quality of life (QoL) limits the ability to have a consistent body of evidence to improve QoL research and practice in informal caregiving for people with multiple sclerosis... Read More about Caregiving in multiple sclerosis and quality of life: a meta-synthesis of qualitative research.

Manipulation and reduction of paediatric fractures of the distal radius and forearm using intranasal diamorphine and 50% oxygen and nitrous oxide in the emergency department (2016)
Journal Article
Kurien, T., Price, K., Pearson, R. G., & Hunter, J. (in press). Manipulation and reduction of paediatric fractures of the distal radius and forearm using intranasal diamorphine and 50% oxygen and nitrous oxide in the emergency department. Bone and Joint Journal, 98B(1), https://doi.org/10.1302/0301-620X.98B1.36118

A retrospective study was performed in 100 children aged between two and 16 years, with a dorsally angulated stable fracture of the distal radius or forearm, who were treated with manipulation in the emergency department (ED) using intranasal diamorp... Read More about Manipulation and reduction of paediatric fractures of the distal radius and forearm using intranasal diamorphine and 50% oxygen and nitrous oxide in the emergency department.

Antenatal magnetic resonance imaging versus ultrasound for predicting neonatal macrosomia: a systematic review and meta-analysis (2016)
Journal Article
Malin, G., Bugg, G., Takwoingi, Y., Thornton, J., & Jones, N. W. (2016). Antenatal magnetic resonance imaging versus ultrasound for predicting neonatal macrosomia: a systematic review and meta-analysis. BJOG: An International Journal of Obstetrics and Gynaecology, 123(1), https://doi.org/10.1111/1471-0528.13517

BACKGROUND:

Fetal macrosomia is associated with an increased risk of adverse maternal and neonatal outcomes.


OBJECTIVES:

To compare the accuracy of antenatal two-dimensional (2D) ultrasound, three-dimensional (3D) ultrasound, and magnetic... Read More about Antenatal magnetic resonance imaging versus ultrasound for predicting neonatal macrosomia: a systematic review and meta-analysis.

Whole scalp resting state EEG of oscillatory brain activity shows no parametric relationship with psychoacoustic and psychosocial assessment of tinnitus: a repeated measures study (2016)
Journal Article
Pierzycki, R. H., McNamara, A. J., Hoare, D. J., & Hall, D. A. (2016). Whole scalp resting state EEG of oscillatory brain activity shows no parametric relationship with psychoacoustic and psychosocial assessment of tinnitus: a repeated measures study. Hearing Research, 331, https://doi.org/10.1016/j.heares.2015.11.003

Tinnitus is a perception of sound that can occur in the absence of an external stimulus. A brief review of electroencephalography (EEG) and magnetoencephalography (MEG) literature demonstrates that there is no clear relationship between tinnitus pres... Read More about Whole scalp resting state EEG of oscillatory brain activity shows no parametric relationship with psychoacoustic and psychosocial assessment of tinnitus: a repeated measures study.

Researching the lived experiences of cancer patients with malignant fungating wounds (2015)
Journal Article
Rowan, S., Moffatt, C., & Olden, A. (2015). Researching the lived experiences of cancer patients with malignant fungating wounds. International Journal of Palliative Nursing, 21(12), https://doi.org/10.12968/ijpn.2015.21.12.579

Background: Researching the experiences of terminally ill patients with disfiguring wounds is likely to be a challenge anywhere, and this investigation came face-to-face with different attitudes on the part of both patients and nurses and doctors in... Read More about Researching the lived experiences of cancer patients with malignant fungating wounds.

Age-related neuromuscular changes affecting human vastus lateralis: age-related neuromuscular changes affecting human vastus lateralis (2015)
Journal Article
Piasecki, M., Ireland, A., Stashuk, D., Hamilton-Wright, A., Jones, D., & McPhee, J. (2016). Age-related neuromuscular changes affecting human vastus lateralis: age-related neuromuscular changes affecting human vastus lateralis. Journal of Physiology, 594(16), 4525-4536. https://doi.org/10.1113/jp271087

The anterior thigh muscles are particularly susceptible to muscle loss and weakness during ageing, although how this is associated with changes to neuromuscular structure and function in terms of motor unit (MU) number, size and MU potential (MUP) st... Read More about Age-related neuromuscular changes affecting human vastus lateralis: age-related neuromuscular changes affecting human vastus lateralis.

Urine tests for Down's syndrome screening (2015)
Journal Article
Alldred, S. K., Guo, B., Takwoingi, Y., Pennant, M., Wisniewski, S., Deeks, J. J., …Alldred, S. K. (2015). Urine tests for Down's syndrome screening. Cochrane Database of Systematic Reviews, https://doi.org/10.1002/14651858.CD011984

Background

Down's syndrome occurs when a person has three copies of chromosome 21, or the specific area of chromosome 21 implicated in causing Down's syndrome, rather than two. It is the commonest congenital cause of mental disability and also lea... Read More about Urine tests for Down's syndrome screening.

Excess maternal salt or fructose intake programmes sex-specific, stress- and fructose-sensitive hypertension in the offspring (2015)
Journal Article
Gardiner, S. M., Gardner, D. S., Elmes, M., & Gray, C. (2016). Excess maternal salt or fructose intake programmes sex-specific, stress- and fructose-sensitive hypertension in the offspring. British Journal of Nutrition, 115(4), 594-604. https://doi.org/10.1017/S0007114515004936

© Copyright 2015 The Authors. The Western diet is typically high in salt and fructose, which have pressor activity. Maternal diet can affect offspring blood pressure, but the extent to which maternal intake of excess salt and fructose may influence c... Read More about Excess maternal salt or fructose intake programmes sex-specific, stress- and fructose-sensitive hypertension in the offspring.