All Outputs (824)

Adverse effects of anti-tuberculosis drugs on HepG2 cell bioenergetics (2016)
Journal Article
Elmorsy, E., Attalla, S., Fikry, E., Kocon, A., Turner, R., Christie, D., …Carter, W. (in press). Adverse effects of anti-tuberculosis drugs on HepG2 cell bioenergetics. Human and Experimental Toxicology, https://doi.org/10.1177/0960327116660751

Tuberculosis (TB) is an intractable chronic infection. Disease treatment with anti-TB drugs remains challenging due to drug-induced hepatotoxicity. The toxicity of the anti-TB drugs rifampicin (RIF), isoniazid (INH) and pyrazinamide (PZA) either alon... Read More about Adverse effects of anti-tuberculosis drugs on HepG2 cell bioenergetics.

Haemorrhoidal artery ligation versus rubber band ligation for the management of symptomatic second-degree and third-degree haemorrhoids (HubBLe): a multicentre, open-label, randomised controlled trial (2016)
Journal Article
Brown, S. R., Tiernan, J. P., Watson, A. J., Biggs, K., Shephard, N., Wailoo, A. J., Bradburn, M., Alshreef, A., & Hind, D. (2016). Haemorrhoidal artery ligation versus rubber band ligation for the management of symptomatic second-degree and third-degree haemorrhoids (HubBLe): a multicentre, open-label, randomised controlled trial. Lancet, 388(10042), 356-364. https://doi.org/10.1016/S0140-6736%2816%2930584-0

Background

Optimum surgical intervention for low-grade haemorrhoids is unknown. Haemorrhoidal artery ligation (HAL) has been proposed as an efficacious, safe therapy while rubber band ligation (RBL) is a commonly used outpatient treatment. We comp... Read More about Haemorrhoidal artery ligation versus rubber band ligation for the management of symptomatic second-degree and third-degree haemorrhoids (HubBLe): a multicentre, open-label, randomised controlled trial.

Exploiting the Plasticity of Primary and Secondary Response Mechanisms in Artificial Immune Systems (2016)
Presentation / Conference Contribution
Greensmith, J., Jackson, A. M., & Spendlove, I. (2016). Exploiting the Plasticity of Primary and Secondary Response Mechanisms in Artificial Immune Systems. In Proceedings of the 2016 on Genetic and Evolutionary Computation Conference Companion - GECCO '16 Companion (7-8). https://doi.org/10.1145/2908961.2908962

One of the key properties of the human immune system is to detect the presence of pathogens, and as such there are numberous immune algorithm which perform anomaly detection and pattern recognition. An additional facet of the human immune system is t... Read More about Exploiting the Plasticity of Primary and Secondary Response Mechanisms in Artificial Immune Systems.

Immune dysfunction in patients with obstructive jaundice before and after endoscopic retrograde cholangiopancreatography (2016)
Journal Article
Chowdhury, A. H., Camara, M., Martinez-Pomares, L., Zaitoun, A. M., Eremin, O., Aithal, G. P., & Lobo, D. (2016). Immune dysfunction in patients with obstructive jaundice before and after endoscopic retrograde cholangiopancreatography. Clinical Science, 130(17), 1535-1544. https://doi.org/10.1042/CS20160326

© 2016 The Author(s). This prospective observational study investigated monocyte cytokine responses to lipopolysaccharide (LPS) in patients with obstructive jaundice (OJ) before and after endoscopic biliary drainage. Dendritic cell (DC) subsets and t... Read More about Immune dysfunction in patients with obstructive jaundice before and after endoscopic retrograde cholangiopancreatography.

The SAPAS, personality traits, and personality disorder (2016)
Journal Article
Ball, L., Tully, R. J., & Egan, V. (in press). The SAPAS, personality traits, and personality disorder. Journal of Personality Disorders, https://doi.org/10.1521/pedi_2016_30_259

Many argue that current categorical personality disorder (PD) classification systems should be more dimensional and consider personality traits. The present study examined whether a brief PD screening tool, the Standardized Assessment of Personality:... Read More about The SAPAS, personality traits, and personality disorder.

Impact of intratumoural heterogeneity on the assessment of Ki67 expression in breast cancer (2016)
Journal Article
Aleskandarany, M. A., Green, A. R., Ashankyty, I., Elmouna, A., Diez-Rodriguez, M., Nolan, C. C., …Rakha, E. (in press). Impact of intratumoural heterogeneity on the assessment of Ki67 expression in breast cancer. Breast Cancer Research and Treatment, 158(2), https://doi.org/10.1007/s10549-016-3893-x

In breast cancer (BC), the prognostic value of Ki67 expression is well-documented. Intratumoural heterogeneity (ITH) of Ki67 expression is amongst the several technical issues behind the lag of its inclusion into BC prognostic work-up. The immunohist... Read More about Impact of intratumoural heterogeneity on the assessment of Ki67 expression in breast cancer.

Incorporating outlier detection and replacement into a non-parametric framework for movement and distortion correction of diffusion MR images (2016)
Journal Article
Andersson, J. L., Graham, M. S., Zsoldos, E., & Sotiropoulos, S. N. (2016). Incorporating outlier detection and replacement into a non-parametric framework for movement and distortion correction of diffusion MR images. NeuroImage, 141, https://doi.org/10.1016/j.neuroimage.2016.06.058

Despite its great potential in studying brain anatomy and structure, diffusion magnetic resonance imaging (dMRI) is marred by artefacts more than any other commonly used MRI technique. In this paper we present a non-parametric framework for detecting... Read More about Incorporating outlier detection and replacement into a non-parametric framework for movement and distortion correction of diffusion MR images.

The effects of hearing impairment, age, and hearing aids on the use of self motion for determining front/back location (2016)
Journal Article
Brimijoin, W. O., & Akeroyd, M. A. (2016). The effects of hearing impairment, age, and hearing aids on the use of self motion for determining front/back location. Journal of the American Academy of Audiology, 27(7), https://doi.org/10.3766/jaaa.15101

Background:

There are two cues that listeners use to disambiguate the front/back location of a sound source: high-frequency spectral cues associated with the head and pinnae, and self-motion‐related binaural cues. The use of these cues can be comp... Read More about The effects of hearing impairment, age, and hearing aids on the use of self motion for determining front/back location.

A systematic review on the relationship between self-esteem and interrogative suggestibility (2016)
Journal Article
Hooper, V.-R., Chou, S., & Browne, K. D. (in press). A systematic review on the relationship between self-esteem and interrogative suggestibility. Journal of Forensic Psychiatry and Psychology, https://doi.org/10.1080/14789949.2016.1201844

Some factors, such as age, learning disability and mental health difficulties, have been identified as making police suspects more vulnerable to suggestibility and false confessions during interview. However, there has been no systematic review on th... Read More about A systematic review on the relationship between self-esteem and interrogative suggestibility.

Consequences of late-stage non-small cell lung cancer cachexia on muscle metabolic processes (2016)
Journal Article
Murton, A. J., Maddocks, M., Stephens, F. B., Marimuthu, K., England, R., & Wilcock, A. (in press). Consequences of late-stage non-small cell lung cancer cachexia on muscle metabolic processes. Clinical Lung Cancer, https://doi.org/10.1016/j.cllc.2016.06.003

Introduction: Loss of muscle is common in patients with advanced non-small cell lung cancer (NSCLC), and contributes to the high morbidity and mortality of this group. The exact mechanisms behind the loss of muscle are unclear.
Patients and methods... Read More about Consequences of late-stage non-small cell lung cancer cachexia on muscle metabolic processes.

Blood pressure management in acute stroke (2016)
Journal Article
Appleton, J. P., Sprigg, N., & Bath, P. M. (in press). Blood pressure management in acute stroke. Stroke and Vascular Neurology, 1(2), https://doi.org/10.1136/svn-2016-000020

Blood pressure (BP) is elevated in 75% or more of patients with acute stroke and is associated with poor outcomes. Whether to modulate BP in acute stroke has long been debated. With the loss of normal cerebral autoregulation, theoretical concerns are... Read More about Blood pressure management in acute stroke.

Relationship between structural pathology and pain behaviour in a model of osteoarthritis (OA) (2016)
Journal Article
Nwosu, L. N., Mapp, P. I., Chapman, V., & Walsh, D. A. (2016). Relationship between structural pathology and pain behaviour in a model of osteoarthritis (OA). Osteoarthritis and Cartilage, 24(11), 1910-1917. https://doi.org/10.1016/j.joca.2016.06.012

Objectives
To address the hypothesis that different types of established OA pain behaviours have associations with different aspects of articular pathology, we investigated the relationship between structural knee joint pathology and pain behaviour... Read More about Relationship between structural pathology and pain behaviour in a model of osteoarthritis (OA).

Using Diffusion Tractography to Predict Cortical Connection Strength and Distance: A Quantitative Comparison with Tracers in the Monkey (2016)
Journal Article
Donahue, C. J., Sotiropoulos, S. N., Jbabdi, S., Hernandez-Fernandez, M., Behrens, T. E., Dyrby, T. B., …Glasser, M. F. (2016). Using Diffusion Tractography to Predict Cortical Connection Strength and Distance: A Quantitative Comparison with Tracers in the Monkey. Journal of Neuroscience, 36(25), 6758-6770. https://doi.org/10.1523/JNEUROSCI.0493-16.2016

Tractography based on diffusion MRI offers the promise of characterizing many aspects of long-distance connectivity in the brain, but requires quantitative validation to assess its strengths and limitations. Here, we evaluate tractography's ability t... Read More about Using Diffusion Tractography to Predict Cortical Connection Strength and Distance: A Quantitative Comparison with Tracers in the Monkey.

Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury (2016)
Journal Article
Osna, N., Carter, W., Ganesan, M., Kirpich, I. A., McClain, C. J., Petersen, D. R., …Kharbanda, K. (2016). Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury. World Journal of Gastroenterology, 22(27), 6192-6200. https://doi.org/10.3748/wjg.v22.i27.6192

It is likely that the majority of proteins will undergo post-translational modification, be it enzymatic or non-enzymatic. These modified protein(s) regulate activity, localization and interaction with other cellular molecules thereby maintaining cel... Read More about Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury.

Pharmacovigilance in hospice/palliative care: the net immediate and short-term effects of dexamethasone for anorexia (2016)
Journal Article
Hatano, Y., Moroni, M., Wilcock, A., Quinn, S., Csikós, Á., Allan, S. G., …Currow, D. C. (2016). Pharmacovigilance in hospice/palliative care: the net immediate and short-term effects of dexamethasone for anorexia. BMJ Supportive and Palliative Care, 6(3), https://doi.org/10.1136/bmjspcare-2015-001037

Objectives Loss of appetite is prevalent in palliative care and distressing for patients and families. Therapies include corticosteroids or progestogens. This study explores the net effect of dexamethasone on anorexia.
Methods Prospective data were... Read More about Pharmacovigilance in hospice/palliative care: the net immediate and short-term effects of dexamethasone for anorexia.

Effectiveness and cost-effectiveness of a brief school-based group programme for parents of children at risk of ADHD: a cluster randomised controlled trial (2016)
Journal Article
Sayal, K., Taylor, J. A., Valentine, A., Guo, B., Sampson, C. J., Sellman, E., …Daley, D. (2016). Effectiveness and cost-effectiveness of a brief school-based group programme for parents of children at risk of ADHD: a cluster randomised controlled trial. Child: Care, Health and Development, 42(4), 521-533. https://doi.org/10.1111/cch.12349

Background
NICE guidelines recommend a stepped care approach for the identification and management of children with, or at risk of, Attention-Deficit / Hyperactivity Disorder (ADHD). We investigated the effectiveness, cost-effectiveness and acceptab... Read More about Effectiveness and cost-effectiveness of a brief school-based group programme for parents of children at risk of ADHD: a cluster randomised controlled trial.

Adapted DBT programme for individuals with intellectual disabilities and problems managing emotions: staff awareness training (2016)
Journal Article
Ashworth, S., Tully, R., & Mooney, P. (2016). Adapted DBT programme for individuals with intellectual disabilities and problems managing emotions: staff awareness training. Advances in Mental Health and Intellectual Disabilities, 10(3), https://doi.org/10.1108/AMHID-12-2015-0053

Purpose
The purpose of this paper is to present the development and evaluation of an original training package for staff members on an awareness of an adapted Dialectical behaviour Therapy programme, the ‘I Can Feel Good’ programme (Morrissey & Inga... Read More about Adapted DBT programme for individuals with intellectual disabilities and problems managing emotions: staff awareness training.

Micro-costing diabetic eye screening: estimation of personal expense, attendance and health care resource use (2016)
Other
James, M., Sampson, C. J., van Eker, D., & Harding, S. (2016). Micro-costing diabetic eye screening: estimation of personal expense, attendance and health care resource use

Design of study
Microcosting study with collection and analysis of primary and secondary data on resource use and costs.

Purpose
To estimate the cost of screening within the NHS Diabetic Eye Screening Programme from a health service and societal... Read More about Micro-costing diabetic eye screening: estimation of personal expense, attendance and health care resource use.

NightShift simulation to train newly qualified doctors in non-technical skills: a feasibility study (2016)
Journal Article
Brown, M., Pinchin, J., Valand, R., Larkin, C., Pattinson, J., Benning, K., …Blakey, J. (2016). NightShift simulation to train newly qualified doctors in non-technical skills: a feasibility study. Future Hospital Journal, 3(2), https://doi.org/10.7861/futurehosp.3-2-94

There is growing evidence of greater rates of morbidity and mortality in hospitals during out-of-hours shifts, which appears to be exacerbated during the period in which newly qualified doctors commence work. In order to combat this issue, an online... Read More about NightShift simulation to train newly qualified doctors in non-technical skills: a feasibility study.

A systematic review of the reporting of tinnitus prevalence and severity (2016)
Journal Article
McCormack, A., Edmondson-Jones, M., Somerset, S., & Hall, D. (2016). A systematic review of the reporting of tinnitus prevalence and severity. Hearing Research, 337, 70-79. https://doi.org/10.1016/j.heares.2016.05.009

© 2016 Elsevier B.V. Introduction: There is no standard diagnostic criterion for tinnitus, although some clinical assessment instruments do exist for identifying patient complaints. Within epidemiological studies the presence of tinnitus is determine... Read More about A systematic review of the reporting of tinnitus prevalence and severity.