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A case of bovine erythropoietic protoporphyria in a female Limousin calf (2024)
Journal Article
CAPUZZELLO, G., Kaczmarska, A., Gutierrez Quintana, R., Jonsson, N. N., & Viora, L. (2024). A case of bovine erythropoietic protoporphyria in a female Limousin calf. Large Animal Review, 30(5), 223-226

Bovine erythropoietic protoporphyria (BCEPP) is a rare genetic disorder predominantly affecting Limousin and, sporadically, Blonde Aquitaine cattle. It arises from diminished or absent ferrochelatase activity, causing the toxic build up of protoporph... Read More about A case of bovine erythropoietic protoporphyria in a female Limousin calf.

Geometric characteristics of stromal collagen fibres in breast cancer using differential interference contrast microscopy (2024)
Journal Article
Ghannam, S. F., Rutland, C. S., Allegrucci, C., Mather, M. L., Alsaleem, M., Bateman‐Price, T. D., Patke, R., Ball, G., Mongan, N. P., & Rakha, E. (2024). Geometric characteristics of stromal collagen fibres in breast cancer using differential interference contrast microscopy. Journal of Microscopy, https://doi.org/10.1111/jmi.13361

Breast cancer (BC) is characterised by a high level of heterogeneity, which is influenced by the interaction of neoplastic cells with the tumour microenvironment. The diagnostic and prognostic role of the tumour stroma in BC remains to be defined. Di... Read More about Geometric characteristics of stromal collagen fibres in breast cancer using differential interference contrast microscopy.

The expanding role of cap-adjacent modifications in animals (2024)
Journal Article
Bellows, E., Fray, R. G., Knight, H. M., & Archer, N. (2024). The expanding role of cap-adjacent modifications in animals. Frontiers in RNA Research, 2, Article 1485307. https://doi.org/10.3389/frnar.2024.1485307

Eukaryotic mRNA cap structures directly influence mRNA stability, translation, and immune recognition. While the significance of the mRNA cap itself has been well-established, recent research has revealed the intricate modifications to the nucleotide... Read More about The expanding role of cap-adjacent modifications in animals.

Isolation of phage-antibodies against Eimeria species that infect chickens (2024)
Journal Article
Angani, M. T., Owen, J. P., Maddison, B. C., & Gough, K. C. (2024). Isolation of phage-antibodies against Eimeria species that infect chickens. Journal of Immunological Methods, 534, Article 113759. https://doi.org/10.1016/j.jim.2024.113759

Eimeria is one of the most economically important pathogens in poultry production. Diagnosis of infection has the potential to inform treatment and prevention strategies. Here, phage display technology was used to isolate single chain antibodies (scF... Read More about Isolation of phage-antibodies against Eimeria species that infect chickens.

Core and accessory genomic traits of Vibrio cholerae O1 drive lineage transmission and disease severity (2024)
Journal Article
Maciel-Guerra, A., Babaarslan, K., Baker, M., Rahman, A., Hossain, M., Sadique, A., Alam, J., Uzzaman, S., Ferdous, M., Sarker, R., Sultana, N., Khan, A. I., Begum, Y. A., Afrad, H., Senin, N., Habib, Z. H., Shirin, T., Qadri, F., & Dottorini, T. (2024). Core and accessory genomic traits of Vibrio cholerae O1 drive lineage transmission and disease severity. Nature Communications, 15, Article 8231. https://doi.org/10.1038/s41467-024-52238-0

In Bangladesh, Vibrio cholerae lineages are undergoing genomic evolution, with increased virulence and spreading ability. However, our understanding of the genomic determinants influencing lineage transmission and disease severity remains incomplete.... Read More about Core and accessory genomic traits of Vibrio cholerae O1 drive lineage transmission and disease severity.

Communication Skills Influence Horse Owners’ Trust in Their Equine Veterinarian (2024)
Journal Article
Rutherford, D. J., & England, J. .. (in press). Communication Skills Influence Horse Owners’ Trust in Their Equine Veterinarian. Veterinary Record,

Background: Trust is an essential component in the relationship between vets and horse owners.

Methods: Using an anonymous online survey, we asked if horse owners consider their vets to be credible, reliable, empathetic and self-orientated, and th... Read More about Communication Skills Influence Horse Owners’ Trust in Their Equine Veterinarian.

Investigative power of Genomic Informational Field Theory (GIFT) relative to GWAS for genotype-phenotype mapping. (2024)
Journal Article
Kyratzi, P., Matika, O., Brassington, A. H., Clare, C. E., Xu, J., Barrett, D. A., Emes, R. D., Archibald, A. L., Paldi, A., Sinclair, K. D., Wattis, J., & Rauch, C. (in press). Investigative power of Genomic Informational Field Theory (GIFT) relative to GWAS for genotype-phenotype mapping. Physiological Genomics, https://doi.org/10.1152/physiolgenomics.00049.2024

Identifying associations between phenotype and genotype is the fundamental basis of genetic analyses. Inspired by frequentist probability and the work of R.A. Fisher, genome-wide association studies (GWAS) extract information using averages and varia... Read More about Investigative power of Genomic Informational Field Theory (GIFT) relative to GWAS for genotype-phenotype mapping..

High prevalence and risk factors of feline leukemia virus infection in Chilean urban cats (Felis catus). (2024)
Journal Article
Castillo-Aliaga, C., Castro-Seriche, S., Jerez-Morales, A., & Tarlinton, R. (2024). High prevalence and risk factors of feline leukemia virus infection in Chilean urban cats (Felis catus). Research in Veterinary Science, 180, Article 105403. https://doi.org/10.1016/j.rvsc.2024.105403

Feline Leukemia Virus is a retrovirus causing fatal disease in domestic cats. While FeLV has been controlled in many countries, it remains a major concern in Latin American countries. This study conducted an epidemiological survey of FeLV in 182 Chil... Read More about High prevalence and risk factors of feline leukemia virus infection in Chilean urban cats (Felis catus)..

The Conflicting Prognostic Role of the Stroma–Tumor Ratio in Breast Cancer Molecular Subtypes (2024)
Journal Article
Ghannam, S. F., Makhlouf, S., Alsaleem, M., Rutland, C. S., Allegrucci, C., Mongan, N. P., & Rakha, E. (2024). The Conflicting Prognostic Role of the Stroma–Tumor Ratio in Breast Cancer Molecular Subtypes. Modern Pathology, 37(12), Article 100607. https://doi.org/10.1016/j.modpat.2024.100607

The tumor microenvironment plays a key role in tumor progression. The proportion of the stroma-to-tumor cells (stroma-tumor ratio [STR]) has a variable prognostic significance in breast cancer (BC) molecular classes. In this study, we evaluated the m... Read More about The Conflicting Prognostic Role of the Stroma–Tumor Ratio in Breast Cancer Molecular Subtypes.

Effects of weaning‐related stress on the emotional health of horses—A scoping review (2024)
Journal Article
Dwyer, J., L. Roshier, A., Campbell, M., Hill, B., & L. Freeman, S. (2024). Effects of weaning‐related stress on the emotional health of horses—A scoping review. Equine Veterinary Journal, https://doi.org/10.1111/evj.14412

Background
Weaning represents one of the most stressful events in the life of a horse, and may have long-term impacts on behaviour. There are a range of approaches used to wean foals from mares, including abrupt and progressive separation methods. T... Read More about Effects of weaning‐related stress on the emotional health of horses—A scoping review.

Prognostic and clinical significance of the proliferation marker MCM7 in breast cancer (2024)
Journal Article
Lashen, A. G., Toss, M. S., Rutland, C. S., Green, A. R., Mongan, N. P., & Rakha, E. (2024). Prognostic and clinical significance of the proliferation marker MCM7 in breast cancer. Pathobiology, https://doi.org/10.1159/000540790

Introduction: Minichromosome maintenance complex component 7 (MCM7) plays an essential role in proliferation and DNA replication of cancer cells. However, the expression and prognostic significance of MCM7 in breast cancer (BC) remain to be defined.... Read More about Prognostic and clinical significance of the proliferation marker MCM7 in breast cancer.

Scoping review exploring the evidence base on Vitis vinifera toxicity in dogs after ingestion: Clinical effects, treatments and types of V. vinifera (2024)
Journal Article
Downs, J., Zoltowska, A., Hackney, T., Gardner, D. S., Ashmore, A., & Brennan, M. L. (2024). Scoping review exploring the evidence base on Vitis vinifera toxicity in dogs after ingestion: Clinical effects, treatments and types of V. vinifera. Veterinary Record, https://doi.org/10.1002/vetr.4536

Background
Treatment of Vitis vinifera fruit (VVF) ingestion can be challenging due to no clear toxic dose, signalment factors and variable clinical signs. Current treatment guidance is generalised: decontamination, aggressive fluid therapy, monitor... Read More about Scoping review exploring the evidence base on Vitis vinifera toxicity in dogs after ingestion: Clinical effects, treatments and types of V. vinifera.

Investigative power of Genomic Informational Field Theory (GIFT) relative to GWAS for genotype-phenotype mapping (2024)
Preprint / Working Paper
Kyratzi, P., Matika, O., Brassington, A. H., Connie, C. E., Xu, J., Barrett, D. A., Emes, R. D., Archibald, A. L., Paldi, A., Sinclair, K. D., Wattis, J., & Rauch, C. Investigative power of Genomic Informational Field Theory (GIFT) relative to GWAS for genotype-phenotype mapping

Identifying associations between phenotype and genotype is the fundamental basis of genetic analyses. Inspired by frequentist probability and the work of R.A. Fisher, genome-wide association studies (GWAS) extract information using averages and varia... Read More about Investigative power of Genomic Informational Field Theory (GIFT) relative to GWAS for genotype-phenotype mapping.

The role of the ALKBH5 RNA demethylase in invasive breast cancer (2024)
Journal Article
Woodcock, C. L., Alsaleem, M., Toss, M. S., Lothion-Roy, J., Harris, A. E., Jeyapalan, J. N., Blatt, N., Rizvanov, A. A., Miftakhova, R. R., Kariri, Y. A., Madhusudan, S., Green, A. R., Rutland, C. S., Fray, R. G., Rakha, E. A., & Mongan, N. P. (2024). The role of the ALKBH5 RNA demethylase in invasive breast cancer. Discover Oncology, 15(1), Article 343. https://doi.org/10.1007/s12672-024-01205-8

Background: N6-methyladenosine (m6A) is the most common internal RNA modification and is involved in regulation of RNA and protein expression. AlkB family member 5 (ALKBH5) is a m6A demethylase. Given the important role of m6A in biological mechanism... Read More about The role of the ALKBH5 RNA demethylase in invasive breast cancer.

Modelling the influence of climate and vector control interventions on arbovirus transmission (2024)
Journal Article
Fairbanks, E. L., Daly, J. M., & Tildesley, M. J. (2024). Modelling the influence of climate and vector control interventions on arbovirus transmission. Viruses, 16(8), Article 1221. https://doi.org/10.3390/v16081221

Most mathematical models that assess the vectorial capacity of disease-transmitting insects typically focus on the influence of climatic factors to predict variations across different times and locations, or examine the impact of vector control inter... Read More about Modelling the influence of climate and vector control interventions on arbovirus transmission.

Epitranscriptomic mechanisms of androgen signalling and prostate cancer (2024)
Journal Article
Patke, R., Harris, A. E., Woodcock, C. L., Thompson, R., Santos, R., Kumari, A., Allegrucci, C., Archer, N., Gudas, L. J., Robinson, B. D., Persson, J. L., Fray, R., Jeyapalan, J., Rutland, C. S., Rakha, E., Madhusudan, S., Emes, R. D., Muyangwa-Semenova, M., Alsaleem, M., de Brot, S., …Lothion-Roy, J. (2024). Epitranscriptomic mechanisms of androgen signalling and prostate cancer. Neoplasia, 56, Article 101032. https://doi.org/10.1016/j.neo.2024.101032

Prostate cancer (PCa) is the second most common cancer diagnosed in men. While radical prostatectomy and radiotherapy are often successful in treating localised disease, post-treatment recurrence is common. As the androgen receptor (AR) and androgen... Read More about Epitranscriptomic mechanisms of androgen signalling and prostate cancer.

Development of resident and migratory three-spined stickleback, Gasterosteus aculeatus (2024)
Journal Article
Barnes, M., Chakrabarti, L., & MacColl, A. D. C. (2024). Development of resident and migratory three-spined stickleback, Gasterosteus aculeatus. PLoS ONE, 19(7), Article e0295485. https://doi.org/10.1371/journal.pone.0295485

The three-spined stickleback (Gasterosteus aculeatus) is a teleost fish and a model organism in evolutionary ecology, useful for both laboratory and natural experiments. It is especially valued for the substantial intraspecific variation in morpholog... Read More about Development of resident and migratory three-spined stickleback, Gasterosteus aculeatus.