Skip to main content

Research Repository

Advanced Search

All Outputs (126)

Hybrid assembly of an agricultural slurry virome reveals a diverse and stable community with the potential to alter the metabolism and virulence of veterinary pathogens (2021)
Journal Article
Cook, R., Hooton, S., Trivedi, U., King, L., Dodd, C. E., Hobman, J. L., …Millard, A. D. (2021). Hybrid assembly of an agricultural slurry virome reveals a diverse and stable community with the potential to alter the metabolism and virulence of veterinary pathogens. Microbiome, 9, Article 65. https://doi.org/10.1186/s40168-021-01010-3

Viruses are the most abundant biological entities on Earth, known to be crucial components of microbial ecosystems. However, there is little information on the viral community within agricultural waste. There are currently ~ 2.7 million dairy cattle... Read More about Hybrid assembly of an agricultural slurry virome reveals a diverse and stable community with the potential to alter the metabolism and virulence of veterinary pathogens.

Ultra-conserved sequences in the genomes of highly diverse Anopheles mosquitoes, with implications for malaria vector control (2021)
Journal Article
O’Loughlin, S. M., Forster, A. J., Fuchs, S., Dottorini, T., Nolan, T., Crisanti, A., & Burt, A. (2021). Ultra-conserved sequences in the genomes of highly diverse Anopheles mosquitoes, with implications for malaria vector control. G3, 11(6), Article jkab086. https://doi.org/10.1093/g3journal/jkab086

DNA sequences that are exactly conserved over long evolutionary time scales have been observed in a variety of taxa. Such sequences are likely under strong functional constraint and they have been useful in the field of comparative genomics for ident... Read More about Ultra-conserved sequences in the genomes of highly diverse Anopheles mosquitoes, with implications for malaria vector control.

Should Veterinary Practitioners Be Concerned about Acanthamoeba Keratitis? (2021)
Journal Article
Cooper, E., Cowmeadow, W., & Elsheikha, H. M. (2021). Should Veterinary Practitioners Be Concerned about Acanthamoeba Keratitis?. Parasitologia, 1(1), 12-19. https://doi.org/10.3390/parasitologia1010002

When presented with an animal exhibiting signs of keratitis (inflammation of the cornea), such as impaired vision, mucoid discharges, redness, swelling, and corneal oedema, most veterinarians would think of bacteria, viruses, or fungi as the potentia... Read More about Should Veterinary Practitioners Be Concerned about Acanthamoeba Keratitis?.

Skeleton Growth in Guinea Pigs and Humans (2021)
Journal Article
Skinner, Z., Clark, N., Rutland, S., Dawkins, A., & Rutland, C. S. (2021). Skeleton Growth in Guinea Pigs and Humans. Frontiers for Young Minds, 9, Article 561416

Every animal has a skeleton made up of many different bones. Bones are vital. Without bones we would not be able to move, protect our internal organs, store important minerals, or even make some cell types! When we are young, in addition to growing,... Read More about Skeleton Growth in Guinea Pigs and Humans.

Blood Serum Cytokines in Patients with Subacute Spinal Cord Injury: A Pilot Study to Search for Biomarkers of Injury Severity (2021)
Journal Article
Ogurcov, S., Shulman, I., Garanina, E., Sabirov, D., Baichurina, I., Kuznetcov, M., …Mukhamedshina, Y. (2021). Blood Serum Cytokines in Patients with Subacute Spinal Cord Injury: A Pilot Study to Search for Biomarkers of Injury Severity. Brain Sciences, 11(3), Article 322. https://doi.org/10.3390/brainsci11030322

Background: Despite considerable interest in the search for a spinal cord injury (SCI) therapy, there is a critical need to develop a panel of diagnostic biomarkers to determine injury severity. In this regard, there is a requirement for continuing r... Read More about Blood Serum Cytokines in Patients with Subacute Spinal Cord Injury: A Pilot Study to Search for Biomarkers of Injury Severity.

Mink is a highly susceptible host species to circulating human and avian influenza viruses (2021)
Journal Article
Sun, H., Li, F., Liu, Q., Du, J., Liu, L., Li, C., …Liu, J. (2021). Mink is a highly susceptible host species to circulating human and avian influenza viruses. Emerging Microbes & Infections, 10(1), 472-480. https://doi.org/10.1080/22221751.2021.1899058

Pandemic influenza, typically caused by reassortment of human and avian influenza viruses, can result in severe or fatal infections in humans. Timely identification of potential pandemic viruses must be a priority in influenza virus surveillance. How... Read More about Mink is a highly susceptible host species to circulating human and avian influenza viruses.

Vector Transmission of Animal Viruses (2021)
Book Chapter
Attoui, H., Jaafar, F. M., Fragkoudis, R., & Mertens, P. P. (2021). Vector Transmission of Animal Viruses. In Encyclopedia of Virology (542-551). (Fourth edition). Elsevier. https://doi.org/10.1016/b978-0-12-814515-9.00135-1

Animal “arboviruses” include viruses that are transmitted between their vertebrate hosts by arthropod vectors. They replicate in both their haematophagous arthropod vectors and vertebrate hosts. Vectors become infected after feeding on infected hosts... Read More about Vector Transmission of Animal Viruses.

Retroviral integrations contribute to elevated host cancer rates during germline invasion (2021)
Journal Article
McEwen, G. K., Alquezar-Planas, D. E., Dayaram, A., Gillett, A., Tarlinton, R., Mongan, N., …Greenwood, A. D. (2021). Retroviral integrations contribute to elevated host cancer rates during germline invasion. Nature Communications, 12(1), https://doi.org/10.1038/s41467-021-21612-7

© 2021, The Author(s). Repeated retroviral infections of vertebrate germlines have made endogenous retroviruses ubiquitous features of mammalian genomes. However, millions of years of evolution obscure many of the immediate repercussions of retrovira... Read More about Retroviral integrations contribute to elevated host cancer rates during germline invasion.

Promoting Evidence-based Veterinary Medicine through the online resource ‘EBVM Learning’: User feedback (2021)
Journal Article
Sellers, E., Baillie, S., Dean, R., Warman, S., Janicke, H., Arlt, S. P., …Verheyen, K. (2021). Promoting Evidence-based Veterinary Medicine through the online resource ‘EBVM Learning’: User feedback. Veterinary Evidence, 6(1), 1-17. https://doi.org/10.18849/ve.v6i1.392

‘EBVM Learning’ is a freely available resource created in 2015 by an international team with the support of RCVS Knowledge. The resource comprises a series of online modules teaching the fundamental concepts of evidence-based veterinary medicine (EBV... Read More about Promoting Evidence-based Veterinary Medicine through the online resource ‘EBVM Learning’: User feedback.

Contrast-Enhanced Ultrasound Imaging of Prostate Gland in Neutered Dogs (2021)
Journal Article
Spada, S., England, G. C. W., Vignoli, M., Carluccio, A., & Russo, M. (2021). Contrast-Enhanced Ultrasound Imaging of Prostate Gland in Neutered Dogs. Animals, 11(2), Article 559. https://doi.org/10.3390/ani11020559

Prostatic neoplasia (PN) occurs in 5–7% of dogs with prostatic disease, with castrated dogs having the same or higher prevalence when compared to intact dogs. Considering the promising results achieved by performing contrast-enhanced ultrasound (CEUS... Read More about Contrast-Enhanced Ultrasound Imaging of Prostate Gland in Neutered Dogs.

Homeless people and their dogs: Exploring the nature and impact of the human-companion animal bond (2021)
Journal Article
Scanlon, L., Hobson-West, P., Cobb, K., McBride, A., & Stavisky, J. (2021). Homeless people and their dogs: Exploring the nature and impact of the human-companion animal bond. Anthrozoös, 34(1), 77-92. https://doi.org/10.1080/08927936.2021.1878683

Homelessness is a pervasive social issue worldwide. In the UK, it is currently estimated that one in two hundred people are homeless, approximating 0.5% of the population. Pet ownership among this group is thought to be commonplace and has been linke... Read More about Homeless people and their dogs: Exploring the nature and impact of the human-companion animal bond.

A host-independent role for Fasciola hepatica transforming growth factor-like molecule in parasite development (2021)
Journal Article
Musah-Eroje, M., Hoyle, R. C., Japa, O., Hodgkinson, J. E., Haig, D. M., & Flynn, R. J. (2021). A host-independent role for Fasciola hepatica transforming growth factor-like molecule in parasite development. International Journal for Parasitology, 51(6), 481-492. https://doi.org/10.1016/j.ijpara.2020.11.005

The trematode parasite Fasciola hepatica causes chronic infection in hosts, enabled by an immunosuppressed environment. Both host and parasite factors are known to contribute to this suggesting that avoidance of immunopathology is beneficial to both... Read More about A host-independent role for Fasciola hepatica transforming growth factor-like molecule in parasite development.

Cytochalasin B-Induced Membrane Vesicles from Human Mesenchymal Stem Cells Overexpressing IL2 Are Able to Stimulate CD8+ T-Killers to Kill Human Triple Negative Breast Cancer Cells (2021)
Journal Article
Chulpanova, D. S., Gilazieva, Z. E., Kletukhina, S. K., Aimaletdinov, A. M., Garanina, E. E., James, V., …Solovyeva, V. V. (2021). Cytochalasin B-Induced Membrane Vesicles from Human Mesenchymal Stem Cells Overexpressing IL2 Are Able to Stimulate CD8+ T-Killers to Kill Human Triple Negative Breast Cancer Cells. Biology, 10(2), Article 141. https://doi.org/10.3390/biology10020141

Interleukin 2 (IL2) was one of the first cytokines used for cancer treatment due to its ability to stimulate anti-cancer immunity. However, recombinant IL2-based therapy is associated with high systemic toxicity and activation of regulatory T-cells,... Read More about Cytochalasin B-Induced Membrane Vesicles from Human Mesenchymal Stem Cells Overexpressing IL2 Are Able to Stimulate CD8+ T-Killers to Kill Human Triple Negative Breast Cancer Cells.

Bacteriophages as Bio-sanitizers in Food Production and Healthcare Settings (2021)
Book Chapter
Bhandare, S., & Goodridge, L. (2021). Bacteriophages as Bio-sanitizers in Food Production and Healthcare Settings. In D. R. Harper, S. T. Abedon, B. H. Burrowes, & M. L. McConville (Eds.), Bacteriophages: Biology, Technology, Therapy (769-788). Springer International Publishing. https://doi.org/10.1007/978-3-319-41986-2_26

Sanitization is defined as the removal of soil deposits and subsequent application of a sanitizer or disinfectant to reduce the number of residual microorganisms remaining in an environment. Sanitization may be achieved through use of physical (therm... Read More about Bacteriophages as Bio-sanitizers in Food Production and Healthcare Settings.

Cross‐sectional study of UK horse owner's purchase and euthanasia decision‐making for their horse (2021)
Journal Article
Clough, H., Roshier, M., England, G., Burford, J., & Freeman, S. (2021). Cross‐sectional study of UK horse owner's purchase and euthanasia decision‐making for their horse. Veterinary Record, 188(6), Article e56. https://doi.org/10.1002/vetr.56

Background: This cross-sectional study aimed to investigate factors affecting horse owners’ purchase and euthanasia decisions that had been identified in a qualitative study. Methods: An online survey on horse owners’ purchase and euthanasia decisi... Read More about Cross‐sectional study of UK horse owner's purchase and euthanasia decision‐making for their horse.

Lameness Detection in Cows Using Hierarchical Deep Learning and Synchrosqueezed Wavelet Transform (2021)
Journal Article
Jarchi, D., Kaler, J., & Sanei, S. (2021). Lameness Detection in Cows Using Hierarchical Deep Learning and Synchrosqueezed Wavelet Transform. IEEE Sensors Journal, 21(7), 9349-9358. https://doi.org/10.1109/JSEN.2021.3054718

Objectives: Identification of cow lameness is important to farmers to improve and manage cattle health and welfare. No validated tools exist for automatic lameness detection. In this research, we aim to early detect the cow lameness by identifying th... Read More about Lameness Detection in Cows Using Hierarchical Deep Learning and Synchrosqueezed Wavelet Transform.