All Outputs (2303)

Sorption, separation and recycling of ammonium in agricultural soils: A viable application for magnetic biochar? (2021)
Journal Article
Gillingham, M., Gomes, R., Ferrari, R., & West, H. (2022). Sorption, separation and recycling of ammonium in agricultural soils: A viable application for magnetic biochar?. Science of the Total Environment, 812, Article 151440. https://doi.org/10.1016/j.scitotenv.2021.151440

Recent research on the magnetisation of biochar, a carbon-based material that can be used as a sorbent, has opened novel opportunities in the field of environmental remediation, as incorporating magnetic particles into biochar can simplify subsequent... Read More about Sorption, separation and recycling of ammonium in agricultural soils: A viable application for magnetic biochar?.

Sarcopenic obesity is associated with telomere shortening: findings from the NHANES 1999–2002 (2021)
Journal Article
Goddard, T., Tsintzas, K., Stephan, B. C., Prado, C. M., Mazidi, M., & Siervo, M. (2021). Sarcopenic obesity is associated with telomere shortening: findings from the NHANES 1999–2002. International Journal of Obesity, 46, 437–440. https://doi.org/10.1038/s41366-021-00995-z

Sarcopenic obesity (SO) is characterised by the concurrent presence of sarcopenia and excess adiposity. Telomere shortening has been associated with sarcopenia and obesity alone but the association between SO and telomere length (TL) has not been inv... Read More about Sarcopenic obesity is associated with telomere shortening: findings from the NHANES 1999–2002.

What Is the Profile of Overweight Individuals Who Are Unsuccessful Responders to a Low-Energy Diet? A PREVIEW Sub-study (2021)
Journal Article
Tremblay, A., Fogelholm, M., Jalo, E., Westerterp-Plantenga, M. S., Adam, T. C., Huttunen-Lenz, M., …Raben, A. (2021). What Is the Profile of Overweight Individuals Who Are Unsuccessful Responders to a Low-Energy Diet? A PREVIEW Sub-study. Frontiers in Nutrition, 8, Article 707682. https://doi.org/10.3389/fnut.2021.707682

This study was performed to evaluate the profile of overweight individuals with pre-diabetes enrolled in PREVIEW who were unable to achieve a body weight loss of ≥8% of the baseline value in response to a 2-month low-energy diet (LED). Their baseline... Read More about What Is the Profile of Overweight Individuals Who Are Unsuccessful Responders to a Low-Energy Diet? A PREVIEW Sub-study.

Actinomadura graeca sp. nov.: A novel producer of the macrocyclic antibiotic zelkovamycin (2021)
Journal Article
Tarantini, F. S., Brunati, M., Taravella, A., Carrano, L., Parenti, F., Hong, K. W., …Chan, W. C. (2021). Actinomadura graeca sp. nov.: A novel producer of the macrocyclic antibiotic zelkovamycin. PLoS ONE, 16(11), Article e0260413. https://doi.org/10.1371/journal.pone.0260413

As part of a screening programme for antibiotic-producing bacteria, a novel Actinomadura species was discovered from a soil sample collected in Santorini, Greece. Preliminary 16S rRNA gene sequence comparisons highlighted Actinomadura macra as the mo... Read More about Actinomadura graeca sp. nov.: A novel producer of the macrocyclic antibiotic zelkovamycin.

Prevalence of anti-Leptospira antibodies and associated risk factors in the Malaysian refugee communities (2021)
Journal Article
Mohd Hanapi, I. R., Sahimin, N., Maackara, M. J. B., Annisa, A. S., Abdul Mutalib, R. N. S., Lewis, J. W., …Mohd Zain, S. N. (2021). Prevalence of anti-Leptospira antibodies and associated risk factors in the Malaysian refugee communities. BMC Infectious Diseases, 21(1), Article 1128. https://doi.org/10.1186/s12879-021-06830-0

Background Refugees in Malaysia, who are afflicted by poverty, conflict and poor health, are vulnerable to a range of zoonotic infections in the deprived environmental and social conditions under which they live. Exposure to infections such as lepto... Read More about Prevalence of anti-Leptospira antibodies and associated risk factors in the Malaysian refugee communities.

Juxtacellular Labeling of Stellate, Disk and Basket Neurons in the Central Nucleus of the Guinea Pig Inferior Colliculus (2021)
Journal Article
Wallace, M. N., Shackleton, T. M., Thompson, Z., & Palmer, A. R. (2021). Juxtacellular Labeling of Stellate, Disk and Basket Neurons in the Central Nucleus of the Guinea Pig Inferior Colliculus. Frontiers in Neural Circuits, 15, 1-24. https://doi.org/10.3389/fncir.2021.721015

We reconstructed the intrinsic axons of 32 neurons in the guinea pig inferior colliculus (IC) following juxtacellular labeling. Biocytin was injected into cells in vivo, after first analyzing physiological response properties. Based on axonal morphol... Read More about Juxtacellular Labeling of Stellate, Disk and Basket Neurons in the Central Nucleus of the Guinea Pig Inferior Colliculus.

Anxiety enhances pain in a model of osteoarthritis and is associated with altered endogenous opioid function and reduced opioid analgesia (2021)
Journal Article
Lillywhite, A., Woodhams, S. G., Gonçalves, S. V., Watson, D. J. G., Li, L., Burston, J. J., …Chapman, V. (2021). Anxiety enhances pain in a model of osteoarthritis and is associated with altered endogenous opioid function and reduced opioid analgesia. PAIN Reports, 6(4), Article e956. https://doi.org/10.1097/PR9.0000000000000956

Introduction: Negative affect, including anxiety and depression, is prevalent in chronic pain states such as osteoarthritis (OA) and associated with greater use of opioid analgesics, potentially contributing to present and future opioid crises.... Read More about Anxiety enhances pain in a model of osteoarthritis and is associated with altered endogenous opioid function and reduced opioid analgesia.

Parasite DNA detection in water samples enhances crayfish plague monitoring in asymptomatic invasive populations (2021)
Journal Article
Sieber, N., Hartikainen, H., Krieg, R., Zenker, A., & Vorburger, C. (2022). Parasite DNA detection in water samples enhances crayfish plague monitoring in asymptomatic invasive populations. Biological Invasions, 24(1), 281-297. https://doi.org/10.1007/s10530-021-02644-y

Invasive species can facilitate the spread of pathogens by first providing asymptomatic host reservoirs, and then driving disease outbreaks in native populations through pathogen spillover. An example of this are invasive crayfish species in Europe (... Read More about Parasite DNA detection in water samples enhances crayfish plague monitoring in asymptomatic invasive populations.

A Multi-Factorial Observational Study on Sequential Fecal Microbiota Transplant in Patients with Medically Refractory Clostridioides difficile Infection (2021)
Journal Article
Monaghan, T. M., Duggal, N. A., Rosati, E., Griffin, R., Hughes, J., Roach, B., …Kao, D. H. (2021). A Multi-Factorial Observational Study on Sequential Fecal Microbiota Transplant in Patients with Medically Refractory Clostridioides difficile Infection. Cells, 10(11), Article 3234. https://doi.org/10.3390/cells10113234

Fecal microbiota transplantation (FMT) is highly effective in recurrent Clostridioides difficile infection (CDI); increasing evidence supports FMT in severe or fulminant Clostridioides difficile infection (SFCDI). However, the multifactorial mechanis... Read More about A Multi-Factorial Observational Study on Sequential Fecal Microbiota Transplant in Patients with Medically Refractory Clostridioides difficile Infection.

Appraisal of Triglyceride-Related Markers as Early Predictors of Metabolic Outcomes in the PREVIEW Lifestyle Intervention: A Controlled Post-hoc Trial (2021)
Journal Article
Navas-Carretero, S., San-Cristobal, R., Siig Vestentoft, P., Brand-Miller, J. C., Jalo, E., Westerterp-Plantenga, M., …Martinez, J. A. (2021). Appraisal of Triglyceride-Related Markers as Early Predictors of Metabolic Outcomes in the PREVIEW Lifestyle Intervention: A Controlled Post-hoc Trial. Frontiers in Nutrition, 8, Article 733697. https://doi.org/10.3389/fnut.2021.733697

Background: Individuals with pre-diabetes are commonly overweight and benefit from dietary and physical activity strategies aimed at decreasing body weight and hyperglycemia. Early insulin resistance can be estimated via the triglyceride glucose inde... Read More about Appraisal of Triglyceride-Related Markers as Early Predictors of Metabolic Outcomes in the PREVIEW Lifestyle Intervention: A Controlled Post-hoc Trial.

The Effects of Structural Alterations in the Polyamine and Amino Acid Moieties of Philanthotoxins on Nicotinic Acetylcholine Receptor Inhibition in the Locust, Schistocerca gregaria (2021)
Journal Article
Luck, V. L., Richards, D. P., Shaikh, A. Y., Franzyk, H., & Mellor, I. R. (2021). The Effects of Structural Alterations in the Polyamine and Amino Acid Moieties of Philanthotoxins on Nicotinic Acetylcholine Receptor Inhibition in the Locust, Schistocerca gregaria. Molecules, 26(22), Article 7007. https://doi.org/10.3390/molecules26227007

Alterations in the polyamine and amino acid (tyrosine) moieties of philanthotoxin‐343 (PhTX‐343) were investigated for their effects on the antagonism of nicotinic acetylcholine receptors (nAChRs) isolated from the locust (Schistocerca gregaria) mush... Read More about The Effects of Structural Alterations in the Polyamine and Amino Acid Moieties of Philanthotoxins on Nicotinic Acetylcholine Receptor Inhibition in the Locust, Schistocerca gregaria.

Venatorbacter cucullus gen. nov sp. nov a novel bacterial predator (2021)
Journal Article
Saeedi, A., Cummings, N. J., McLean, D., Connerton, I. F., & Connerton, P. L. (2021). Venatorbacter cucullus gen. nov sp. nov a novel bacterial predator. Scientific Reports, 11, Article 21393. https://doi.org/10.1038/s41598-021-00865-8

A novel Gram-stain negative, aerobic, halotolerant, motile, rod-shaped, predatory bacterium ASxL5T, was isolated from a bovine slurry tank in Nottinghamshire, UK using Campylobacter hyointestinalis as prey. Other Campylobacter species and members of... Read More about Venatorbacter cucullus gen. nov sp. nov a novel bacterial predator.

Adherence to a Plant-Based Diet and Consumption of Specific Plant Foods—Associations with 3-Year Weight-Loss Maintenance and Cardiometabolic Risk Factors: A Secondary Analysis of the PREVIEW Intervention Study (2021)
Journal Article
Zhu, R., Fogelholm, M., Poppitt, S. D., Silvestre, M. P., Møller, G., Huttunen-Lenz, M., …Raben, A. (2021). Adherence to a Plant-Based Diet and Consumption of Specific Plant Foods—Associations with 3-Year Weight-Loss Maintenance and Cardiometabolic Risk Factors: A Secondary Analysis of the PREVIEW Intervention Study. Nutrients, 13(11), Article 3916. https://doi.org/10.3390/nu13113916

Plant-based diets are recommended by dietary guidelines. This secondary analysis aimed to assess longitudinal associations of an overall plant-based diet and specific plant foods with weight-loss maintenance and cardiometabolic risk factors. Longitud... Read More about Adherence to a Plant-Based Diet and Consumption of Specific Plant Foods—Associations with 3-Year Weight-Loss Maintenance and Cardiometabolic Risk Factors: A Secondary Analysis of the PREVIEW Intervention Study.

Nitric oxide for the prevention and treatment of viral, bacterial, protozoal and fungal infections (2021)
Journal Article
Bath, P. M., Coleman, C. M., Gordon, A. L., Lim, W. S., & Webb, A. J. (2021). Nitric oxide for the prevention and treatment of viral, bacterial, protozoal and fungal infections. F1000Research, 10, 1-39. https://doi.org/10.12688/f1000research.51270.2

Although the antimicrobial potential of nitric oxide (NO) is widely published, it is little used clinically. NO is a key signalling molecule modulating vascular, neuronal, inflammatory and immune responses. Endogenous antimicrobial activity is largel... Read More about Nitric oxide for the prevention and treatment of viral, bacterial, protozoal and fungal infections.

Viral genome wide association study identifies novel hepatitis C virus polymorphisms associated with sofosbuvir treatment failure (2021)
Journal Article
Smith, D. A., Fernandez-Antunez, C., Magri, A., Bowden, R., Chaturvedi, N., Fellay, J., …Ansari, M. A. (2021). Viral genome wide association study identifies novel hepatitis C virus polymorphisms associated with sofosbuvir treatment failure. Nature Communications, 12(1), Article 6105. https://doi.org/10.1038/s41467-021-25649-6

Persistent hepatitis C virus (HCV) infection is a major cause of chronic liver disease, worldwide. With the development of direct-acting antivirals, treatment of chronically infected patients has become highly effective, although a subset of patients... Read More about Viral genome wide association study identifies novel hepatitis C virus polymorphisms associated with sofosbuvir treatment failure.

Modifying the m6A brain methylome by ALKBH5-mediated demethylation: a new contender for synaptic tagging (2021)
Journal Article
Martinez De La Cruz, B., Markus, R., Malla, S., Haig, M. I., Gell, C., Sang, F., …Knight, H. M. (2021). Modifying the m6A brain methylome by ALKBH5-mediated demethylation: a new contender for synaptic tagging. Molecular Psychiatry, 26(12), 7141-7153. https://doi.org/10.1038/s41380-021-01282-z

Synaptic plasticity processes, which underlie learning and memory formation, require RNA to be translated local to synapses. The synaptic tagging hypothesis has previously been proposed to explain how mRNAs are available at specific activated synapse... Read More about Modifying the m6A brain methylome by ALKBH5-mediated demethylation: a new contender for synaptic tagging.

Designed Antitumor Peptide for Targeted siRNA Delivery into Cancer Spheroids (2021)
Journal Article
Cirillo, S., Tomeh, M. A., Wilkinson, R. N., Hill, C., Brown, S., & Zhao, X. (2021). Designed Antitumor Peptide for Targeted siRNA Delivery into Cancer Spheroids. ACS Applied Materials and Interfaces, 13(42), 49713-49728. https://doi.org/10.1021/acsami.1c14761

Antimicrobial/anticancer peptides (AMPs/ACPs) have shown promising results as new therapeutic agents in cancer thearpy. Among them, the designed amphiphilic α-helical peptide G(IIKK)3I-NH2 (G3) displayed great affinity and specificity in targeting ca... Read More about Designed Antitumor Peptide for Targeted siRNA Delivery into Cancer Spheroids.

Understanding and addressing vaccine hesitancy in the context of COVID-19: development of a digital intervention (2021)
Journal Article
Knight, H., Jia, R., Ayling, K., Bradbury, K., Baker, K., Chalder, T., …Vedhara, K. (2021). Understanding and addressing vaccine hesitancy in the context of COVID-19: development of a digital intervention. Public Health, 201, 98-107. https://doi.org/10.1016/j.puhe.2021.10.006

Objectives: Severe Acute Respiratory Coronavirus 2 (SARS-CoV-2) was identified in late 2019, spreading to over 200 countries and resulting in almost two million deaths worldwide. The emergence of safe and effective vaccines provides a route out of th... Read More about Understanding and addressing vaccine hesitancy in the context of COVID-19: development of a digital intervention.

Customisable Tablet Printing: The Development of Multimaterial Hot Melt Inkjet 3D Printing to Produce Complex and Personalised Dosage Forms (2021)
Journal Article
Lion, A., Wildman, R. D., Alexander, M. R., & Roberts, C. J. (2021). Customisable Tablet Printing: The Development of Multimaterial Hot Melt Inkjet 3D Printing to Produce Complex and Personalised Dosage Forms. Pharmaceutics, 13(10), Article 1679. https://doi.org/10.3390/pharmaceutics13101679

One of the most striking characteristics of 3D printing is its capability to produce multi-material objects with complex geometry. In pharmaceutics this translates to the possibility of dosage forms with multi-drug loading, tailored dosing and releas... Read More about Customisable Tablet Printing: The Development of Multimaterial Hot Melt Inkjet 3D Printing to Produce Complex and Personalised Dosage Forms.

An Antigenically Diverse, Representative Panel of Envelope Glycoproteins for Hepatitis C Virus Vaccine Development (2021)
Journal Article
Salas, J. H., Urbanowicz, R. A., Guest, J. D., Frumento, N., Figueroa, A., Clark, K. E., …Bailey, J. R. (2022). An Antigenically Diverse, Representative Panel of Envelope Glycoproteins for Hepatitis C Virus Vaccine Development. Gastroenterology, 162(2), 562-574. https://doi.org/10.1053/j.gastro.2021.10.005

Background & Aims: Development of a prophylactic hepatitis C virus (HCV) vaccine will require accurate and reproducible measurement of neutralizing breadth of vaccine-induced antibodies. Currently available HCV panels may not adequately represent the... Read More about An Antigenically Diverse, Representative Panel of Envelope Glycoproteins for Hepatitis C Virus Vaccine Development.