All Outputs (177)

DNA replication roadblocks caused by Cascade interference complexes are alleviated by RecG DNA repair helicase (2018)
Journal Article
Howard, J. L., Killelea, T., Hawkins, M., Howard, J., McGlynn, P., & Bolt, E. L. (2019). DNA replication roadblocks caused by Cascade interference complexes are alleviated by RecG DNA repair helicase. RNA Biology, 16(4), 543-548. https://doi.org/10.1080/15476286.2018.1496773

Cascade complexes underpin E. coli CRISPR-Cas immunity systems by stimulating "adaptation" reactions that update immunity and by initiating "interference" reactions that destroy invader DNA. Recognition of invader DNA in Cascade catalysed R-loops pro... Read More about DNA replication roadblocks caused by Cascade interference complexes are alleviated by RecG DNA repair helicase.

Signatures of human-commensalism in the house sparrow genome (2018)
Journal Article
Ravinet, M., Elgvin, T. O., Trier, C., Aliabadian, M., Gavrilov, A., & Sætre, G. (2018). Signatures of human-commensalism in the house sparrow genome. Proceedings of the Royal Society B: Biological Sciences, 285(1884), Article 20181246. https://doi.org/10.1098/rspb.2018.1246

© 2018 The Author(s) Published by the Royal Society. All rights reserved. House sparrows (Passer domesticus) are a hugely successful anthrodependent species; occurring on nearly every continent. Yet, despite their ubiquity and familiarity to humans,... Read More about Signatures of human-commensalism in the house sparrow genome.

Oxytocin attenuates phencyclidine hyperactivity and increases social interaction and nucleus accumben dopamine release in rats (2018)
Journal Article
Kohli, S., King, M. V., Williams, S., Edwards, A., Ballard, T. M., Steward, L. J., …Fone, K. C. F. (2019). Oxytocin attenuates phencyclidine hyperactivity and increases social interaction and nucleus accumben dopamine release in rats. Neuropsychopharmacology, 44(2), 295-305. https://doi.org/10.1038/s41386-018-0171-0

The pituitary neuropeptide oxytocin promotes social behavior, and is a potential adjunct therapy for social deficits in schizophrenia and autism. Oxytocin may mediate pro-social effects by modulating monoamine release in limbic and cortical areas, wh... Read More about Oxytocin attenuates phencyclidine hyperactivity and increases social interaction and nucleus accumben dopamine release in rats.

n−3 polyunsaturated N-acylethanolamines are CB2 cannabinoid receptor-preferring endocannabinoids (2018)
Journal Article
Alharthi, N., Christensen, P., Hourani, W., Ortori, C., Barrett, D. A., Bennett, A. J., …Alexander, S. P. (2018). n−3 polyunsaturated N-acylethanolamines are CB2 cannabinoid receptor-preferring endocannabinoids. Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, 1863(11), 1433-1440. https://doi.org/10.1016/j.bbalip.2018.08.003

Anandamide, the first identified endogenous cannabinoid and TRPV1 agonist, is one of a series of endogenous N-acylethanolamines, NAEs. We have generated novel assays to quantify the levels of multiple NAEs in biological tissues and their rates of hyd... Read More about n−3 polyunsaturated N-acylethanolamines are CB2 cannabinoid receptor-preferring endocannabinoids.

Similar Domains for Different Regulations of p53 Family (2018)
Journal Article
Amelio, I., & Melino, G. (2018). Similar Domains for Different Regulations of p53 Family. Structure, 26(8), 1047-1049. https://doi.org/10.1016/j.str.2018.07.003

Despite the sequence similarity, the p53 family members are involved in different biological processes due to distinct expression patterns and transcriptional programs. In this issue of Structure, Krauskopf et al. (2018) reveal a different structural... Read More about Similar Domains for Different Regulations of p53 Family.

A universal bioluminescence resonance energy transfer sensor design enables high-sensitivity screening of GPCR activation dynamics (2018)
Journal Article
Schihada, H., Vandenabeele, S., Zabel, U., Frank, M., Lohse, M. J., & Maiellaro, I. (2018). A universal bioluminescence resonance energy transfer sensor design enables high-sensitivity screening of GPCR activation dynamics. Communications Biology, 1, Article 105. https://doi.org/10.1038/s42003-018-0072-0

G-protein-coupled receptors (GPCRs) represent one of the most important classes of drug targets. The discovery of new GCPR therapeutics would greatly benefit from the development of a generalizable high-throughput assay to directly monitor their acti... Read More about A universal bioluminescence resonance energy transfer sensor design enables high-sensitivity screening of GPCR activation dynamics.

Uptake of Neisserial autotransporter lipoprotein (NalP) promotes an increase in human brain microvascular endothelial cell metabolic activity (2018)
Journal Article
Mahdavi, J., Ala'Aldeen, D., Wooldridge, K. G., & Oldfield, N. J. (2018). Uptake of Neisserial autotransporter lipoprotein (NalP) promotes an increase in human brain microvascular endothelial cell metabolic activity. Microbial Pathogenesis, 124, 70-75. https://doi.org/10.1016/j.micpath.2018.08.001

Anti-inflammatory potential of thymosin β4 in the central nervous system: implications for progressive neurodegenerative diseases (2018)
Journal Article
Pardon, M. (2018). Anti-inflammatory potential of thymosin β4 in the central nervous system: implications for progressive neurodegenerative diseases. Expert Opinion on Biological Therapy, 18(sup1), 165-169. https://doi.org/10.1080/14712598.2018.1486817

Introduction: The actin-sequestering thymosin beta4 (Tβ4) is the most abundant member of the β-thymosins, and is widely expressed in the central nervous system (CNS), but its functions in the healthy and diseased brain are poorly understood. The expr... Read More about Anti-inflammatory potential of thymosin β4 in the central nervous system: implications for progressive neurodegenerative diseases.

Effect of sodium 4-phenylbutyrate on clenbuterol-mediated muscle growth (2018)
Journal Article
Brown, D. M., Jones, S., Daniel, Z. C., Brearley, M. C., Lewis, J. E., Ebling, F. J., …Brameld, J. M. (2018). Effect of sodium 4-phenylbutyrate on clenbuterol-mediated muscle growth. PLoS ONE, 13(7), Article e0201481. https://doi.org/10.1371/journal.pone.0201481

Previously, we highlighted induction of an integrated stress response (ISR) gene program in skeletal muscle of pigs treated with a beta-adrenergic agonist. Hence we tested the hypothesis that the ER-stress inhibitor, sodium 4-phenylbutyrate (PBA), wo... Read More about Effect of sodium 4-phenylbutyrate on clenbuterol-mediated muscle growth.

A low FODMAP diet is associated with changes in the microbiota and reduction in breath hydrogen but not colonic volume in healthy subjects (2018)
Journal Article
Sloan, T. J., Jalanka, J., Major, G. A. D., Krishnasamy, S., Pritchard, S., Abdelrazig, S., …Spiller, R. C. (2018). A low FODMAP diet is associated with changes in the microbiota and reduction in breath hydrogen but not colonic volume in healthy subjects. PLoS ONE, 13(7), Article e0201410. https://doi.org/10.1371/journal.pone.0201410

Background & aims Ingestion of poorly digested, fermentable carbohydrates (fermentable oligo-, di-, mono-saccharides and polyols; FODMAPs) have been implicated in exacerbating intestinal symptoms and the reduction of intake with symptom alleviatio... Read More about A low FODMAP diet is associated with changes in the microbiota and reduction in breath hydrogen but not colonic volume in healthy subjects.

Differential regulation of the phenazine biosynthetic operons by quorum sensing in Pseudomonas aeruginosa PAO1-N (2018)
Journal Article
Higgins, S., Heeb, S., Rampioni, G., Fletcher, M. P., Williams, P., & Cámara, M. (2018). Differential regulation of the phenazine biosynthetic operons by quorum sensing in Pseudomonas aeruginosa PAO1-N. Frontiers in Cellular and Infection Microbiology, 8, Article 252. https://doi.org/10.3389/fcimb.2018.00252

The Pseudomonas aeruginosa quorum sensing (QS) network plays a key role in the adaptation to environmental changes and the control of virulence factor production in this opportunistic human pathogen. Three interlinked QS systems, namely las, rhl, and... Read More about Differential regulation of the phenazine biosynthetic operons by quorum sensing in Pseudomonas aeruginosa PAO1-N.

Gene-Based Analysis in HRC Imputed Genome Wide Association Data Identifies Three Novel Genes For Alzheimer’s Disease (2018)
Preprint / Working Paper
Baker, E., Sims, R., Leonenko, G., Frizzati, A., Harwood, J., Grozeva, D., …EADI Consortium. Gene-Based Analysis in HRC Imputed Genome Wide Association Data Identifies Three Novel Genes For Alzheimer’s Disease

A novel POLARIS gene-based analysis approach was employed to compute gene-based polygenic risk score (PRS) for all individuals in the latest HRC imputed GERAD (N cases=3332 and N controls=9,832) data using the International Genomics of Alzheimer's Pr... Read More about Gene-Based Analysis in HRC Imputed Genome Wide Association Data Identifies Three Novel Genes For Alzheimer’s Disease.

Whole-Genome Resequencing of Red Junglefowl and Indigenous Village Chicken Reveal New Insights on the Genome Dynamics of the Species (2018)
Journal Article
Lawal, R. A., Al-Atiyat, R. M., Aljumaah, R. S., Silva, P., Mwacharo, J. M., & Hanotte, O. (2018). Whole-Genome Resequencing of Red Junglefowl and Indigenous Village Chicken Reveal New Insights on the Genome Dynamics of the Species. Frontiers in Genetics, 9, Article 264. https://doi.org/10.3389/fgene.2018.00264

© 2018 Lawal, Al-Atiyat, Aljumaah, Silva, Mwacharo and Hanotte. The red junglefowl Gallus gallus is the main progenitor of domestic chicken, the commonest livestock species, outnumbering humans by an approximate ratio of six to one. The genetic contr... Read More about Whole-Genome Resequencing of Red Junglefowl and Indigenous Village Chicken Reveal New Insights on the Genome Dynamics of the Species.

Distribution of vesicle pools in cerebellar parallel fibre terminals after depression of ectopic transmission (2018)
Journal Article
Dobson, K. L., Smith, Z. H., & Bellamy, T. C. (2018). Distribution of vesicle pools in cerebellar parallel fibre terminals after depression of ectopic transmission. PLoS ONE, 13(7), 1-15. https://doi.org/10.1371/journal.pone.0200937

At parallel fibre terminals in the cerebellar cortex, glutamate released outside of the active zone can activate AMPA receptors on juxtaposed Bergmann glial cell processes. This process is termed “ectopic” release, and allows for directed transmissio... Read More about Distribution of vesicle pools in cerebellar parallel fibre terminals after depression of ectopic transmission.

Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid -opioid receptor desensitization (2018)
Journal Article
Miess, E., Gondin, A. B., Yousuf, A., Steinborn, R., Mösslein, N., Yang, Y., …Canals, M. (2018). Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid -opioid receptor desensitization. Science Signaling, 11(539), Article eaas9609. https://doi.org/10.1126/scisignal.aas9609

Copyright © 2018 The Authors. G protein receptor kinases (GRKs) and -arrestins are key regulators of -opioid receptor (MOR) signaling and trafficking. We have previously shown that high-efficacy opioids such as DAMGO stimulate a GRK2/3-mediated multi... Read More about Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid -opioid receptor desensitization.

Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome (2018)
Journal Article
Jimenez-Vargas, N. N., Pattison, L. A., Zhao, P., Lieu, T. M., Latorre, R., Jensen, D. D., …Bunnett, N. W. (2018). Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome. Proceedings of the National Academy of Sciences, 115(31), E7438-E7447. https://doi.org/10.1073/pnas.1721891115

© 2018 National Academy of Sciences. All rights reserved. Once activated at the surface of cells, G protein-coupled receptors (GPCRs) redistribute to endosomes, where they can continue to signal. Whether GPCRs in endosomes generate signals that contr... Read More about Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome.

A comparison of two different software packages for the analysis of body composition using computed tomography images (2018)
Journal Article
Rollins, K. E., Awwad, A., MacDonald, I. A., & Lobo, D. N. (2019). A comparison of two different software packages for the analysis of body composition using computed tomography images. Nutrition, 57, 92-96. https://doi.org/10.1016/j.nut.2018.06.003

Objectives: Body composition analysis from computed tomography (CT) imaging has become widespread. However, the methodology used is far from established. Two main software packages are in common usage for body composition analysis, with results used... Read More about A comparison of two different software packages for the analysis of body composition using computed tomography images.

Omega-6 oxylipins generated by soluble epoxide hydrolase are associated with knee osteoarthritis (2018)
Journal Article
Valdes, A. M., Ravipati, S., Pousinis, P., Menni, C., Mangino, M., Abhishek, A., …Doherty, M. (in press). Omega-6 oxylipins generated by soluble epoxide hydrolase are associated with knee osteoarthritis. Journal of Lipid Research, 59(7), Article jlr.P085118. https://doi.org/10.1194/jlr.P085118

Omega-6 fatty acids are important inflammatory mediators increased in joints with osteoarthritis (OA) joints. To investigate the relationship between omega-6 fatty acids and knee OA 22 omega-6 lipids (arachidonic acid, linoleic acid and 20 oxylipins)... Read More about Omega-6 oxylipins generated by soluble epoxide hydrolase are associated with knee osteoarthritis.

A rare loss-of-function variant of ADAM17 is associated with late-onset familial Alzheimer disease (2018)
Journal Article
Hartl, D., May, P., Gu, W., Mayhaus, M., Pichler, S., Spaniol, C., …Riemenschneider, M. (2020). A rare loss-of-function variant of ADAM17 is associated with late-onset familial Alzheimer disease. Molecular Psychiatry, 25, 629–639. https://doi.org/10.1038/s41380-018-0091-8

Common variants of about 20 genes contributing to AD risk have so far been identified through genome-wide association studies (GWAS). However, there is still a large proportion of heritability that might be explained by rare but functionally importan... Read More about A rare loss-of-function variant of ADAM17 is associated with late-onset familial Alzheimer disease.

Hybrid in silico/in vitro target fishing to assign function to “orphan” compounds of food origin: the case of the fungal metabolite atromentin (2018)
Journal Article
Dellafiora, L., Aichinger, G., Geib, E., Sánchez-Barrionuevo, L., Brock, M., Cánovas, D., …Marko, D. (2019). Hybrid in silico/in vitro target fishing to assign function to “orphan” compounds of food origin: the case of the fungal metabolite atromentin. Food Chemistry, 270, 61-69. https://doi.org/10.1016/j.foodchem.2018.07.027

Many small molecules of food origin may effect human health but lack an adequate description of their biological activity. To fill this knowledge gap, a first-line workflow is needed to assign putative functions, rank the endpoints for testing and gu... Read More about Hybrid in silico/in vitro target fishing to assign function to “orphan” compounds of food origin: the case of the fungal metabolite atromentin.