Skip to main content

Research Repository

Advanced Search

All Outputs (180)

TAp73 is required for spermatogenesis and the maintenance of male fertility (2014)
Journal Article
Inoue, S., Tomasini, R., Rufini, A., Elia, A. J., Agostini, M., Amelio, I., …Mak, T. W. (2014). TAp73 is required for spermatogenesis and the maintenance of male fertility. Proceedings of the National Academy of Sciences, 111(5), 1843-1848. https://doi.org/10.1073/pnas.1323416111

The generation of viable sperm proceeds through a series of coordinated steps, including germ cell self-renewal, meiotic recombination, and terminal differentiation into functional spermatozoa. The p53 family of transcription factors, including p53,... Read More about TAp73 is required for spermatogenesis and the maintenance of male fertility.

Kinetochore assembly and heterochromatin formation occur autonomously in Schizosaccharomyces pombe (2014)
Journal Article
Brown, W. R., Thomas, G., Lee, N. C., Blythe, M., Liti, G., Warringer, J., & Loose, M. W. (2014). Kinetochore assembly and heterochromatin formation occur autonomously in Schizosaccharomyces pombe. Proceedings of the National Academy of Sciences, 111(5), https://doi.org/10.1073/pnas.1216934111

Kinetochores in multicellular eukaryotes are usually associated with heterochromatin. Whether this heterochromatin simply promotes the cohesion necessary for accurate chromosome segregation at cell division or whether it also has a role in kinetochor... Read More about Kinetochore assembly and heterochromatin formation occur autonomously in Schizosaccharomyces pombe.

The mitochondrial 16 s rRNA reveals high anthropogenic influence on land snail diversity in a preliminary island survey (2014)
Journal Article
Abu-Bakar, S. B., Razali, N. M., Naggs, F., Wade, C., Mohd-Nor, S. A., & Aileen-Tan, S. H. (2014). The mitochondrial 16 s rRNA reveals high anthropogenic influence on land snail diversity in a preliminary island survey. Molecular Biology Reports, 41(3), 1799-1805. https://doi.org/10.1007/s11033-014-3029-5

A total of 30 specimens belonging to five species, namely; Cryptozona siamensis, Sarika resplendens and Sarika sp. from the family Ariophantidae as well as Quantula striata and Quantula sp. from the family Dyakiidae were collected from the Langkawi I... Read More about The mitochondrial 16 s rRNA reveals high anthropogenic influence on land snail diversity in a preliminary island survey.

Novel vasocontractile role of the P2Y14receptor: characterization of its signalling in porcine isolated pancreatic arteries (2014)
Journal Article
Alsaqati, M., Latif, M., Chan, S., & Ralevic, V. (2014). Novel vasocontractile role of the P2Y14receptor: characterization of its signalling in porcine isolated pancreatic arteries. British Journal of Pharmacology, 171(3), https://doi.org/10.1111/bph.12473

Background and Purpose: The P2Y14 receptor is the newest member of the P2Y receptor family; it is Gi/o protein-coupled and is activated by UDP and selectively by UDP-glucose and MRS2690 (2-thiouridine-5′-diphosphoglucose) (7–10-fold more potent than... Read More about Novel vasocontractile role of the P2Y14receptor: characterization of its signalling in porcine isolated pancreatic arteries.

STAT1-cooperative DNA binding distinguishes type 1 from type 2 interferon signaling (2014)
Journal Article
Begitt, A., Droescher, M., Meyer, T., Schmid, C. D., Baker, M., Antunes, F., …Vinkemeier, U. (in press). STAT1-cooperative DNA binding distinguishes type 1 from type 2 interferon signaling. Nature Immunology, 15(2), https://doi.org/10.1038/ni.2794

STAT1 is an indispensable component of a heterotrimer (ISGF3) and a STAT1 homodimer (GAF) that function as transcription regulators in type 1 and type 2 interferon signaling, respectively. To investigate the importance of STAT1-cooperative DNA bindin... Read More about STAT1-cooperative DNA binding distinguishes type 1 from type 2 interferon signaling.

Evidence for Batesian mimicry in a polymorphic hoverfly (2014)
Journal Article
Reader, T. (2014). Evidence for Batesian mimicry in a polymorphic hoverfly. Evolution, 68(3), https://doi.org/10.1111/evo.12308

Palatable Batesian mimics are avoided by predators because they resemble noxious or defended species. The striking resemblance of many hoverflies to noxious Hymenoptera is a “textbook” example of Batesian mimicry, but evidence that selection by preda... Read More about Evidence for Batesian mimicry in a polymorphic hoverfly.

Neonatal phencyclidine administration and post-weaning social isolation as a dual-hit model of 'schizophrenia-like' behaviour in the rat (2014)
Journal Article
Gaskin, P. L., Fone, K., & Alexander, S. (2014). Neonatal phencyclidine administration and post-weaning social isolation as a dual-hit model of 'schizophrenia-like' behaviour in the rat. Psychopharmacology, 231(12), 2533-2545. https://doi.org/10.1007/s00213-013-3424-y

Rationale: Schizophrenia is a debilitating disorder comprising positive, negative and cognitive deficits with a poorly defined neurobiological aetiology; therefore, animal models with greater translational reliability are essential to develop improve... Read More about Neonatal phencyclidine administration and post-weaning social isolation as a dual-hit model of 'schizophrenia-like' behaviour in the rat.

CCL3L1 copy number, CCR5 genotype and susceptibility to tuberculosis (2014)
Journal Article
Carpenter, D., Taype, C., Goulding, J., Levin, M., Eley, B., Anderson, S., …Armour, J. A. (in press). CCL3L1 copy number, CCR5 genotype and susceptibility to tuberculosis. BMC Medical Genetics, 15(5), https://doi.org/10.1186/1471-2350-15-5

Background: Tuberculosis is a major infectious disease and functional studies have provided evidence that both the chemokine MIP-1α and its receptor CCR5 play a role in susceptibility to TB. Thus by measuring copy number variation of CCL3L1, one of t... Read More about CCL3L1 copy number, CCR5 genotype and susceptibility to tuberculosis.

The antimalarial drug quinine interferes with serotonin biosynthesis and action (2014)
Journal Article
Islahudin, F., Tindall, S. M., Mellor, I. R., Swift, K., Christensen, H. E., Fone, K. C., …Avery, S. V. (2014). The antimalarial drug quinine interferes with serotonin biosynthesis and action. Scientific Reports, 4(3618), https://doi.org/10.1038/srep03618

The major antimalarial drug quinine perturbs uptake of the essential amino acid tryptophan, and patients with low plasma tryptophan are predisposed to adverse quinine reactions; symptoms of which are similar to indications of tryptophan depletion. As... Read More about The antimalarial drug quinine interferes with serotonin biosynthesis and action.

Copy Number Variation of the Beta-Defensin Genes in Europeans: No Supporting Evidence for Association with Lung Function, Chronic Obstructive Pulmonary Disease or Asthma (2014)
Journal Article
Wain, L. V., Odenthal-Hesse, L., Abujaber, R., Sayers, I., Beardsmore, C., Gaillard, E. A., …Hollox, E. J. (2014). Copy Number Variation of the Beta-Defensin Genes in Europeans: No Supporting Evidence for Association with Lung Function, Chronic Obstructive Pulmonary Disease or Asthma. PLoS ONE, 9(1), Article e84192. https://doi.org/10.1371/journal.pone.0084192

Lung function measures are heritable, predict mortality and are relevant in diagnosis of chronic obstructive pulmonary disease (COPD). COPD and asthma are diseases of the airways with major public health impacts and each have a heritable component. G... Read More about Copy Number Variation of the Beta-Defensin Genes in Europeans: No Supporting Evidence for Association with Lung Function, Chronic Obstructive Pulmonary Disease or Asthma.

Reductions in Endocannabinoid Levels and Enhanced Coupling of Cannabinoid Receptors in the Striatum are Accompanied by Cognitive Impairments in the AβPPswe/PS1ΔE9 Mouse Model of Alzheimer's Disease (2014)
Journal Article
Maroof, N., Ravipati, S., Pardon, M. C., Barrett, D. A., & Kendall, D. A. (2014). Reductions in Endocannabinoid Levels and Enhanced Coupling of Cannabinoid Receptors in the Striatum are Accompanied by Cognitive Impairments in the AβPPswe/PS1ΔE9 Mouse Model of Alzheimer's Disease. Journal of Alzheimer's Disease, 42(1), 227-245. https://doi.org/10.3233/jad-131961

© 2014 - IOS Press and the authors. All rights reserved. Alterations in the endocannabinoid system (ECS) are thought to play a role in learning and memory impairments observed in Alzheimer's disease (AD). We aimed to determine the status of the brain... Read More about Reductions in Endocannabinoid Levels and Enhanced Coupling of Cannabinoid Receptors in the Striatum are Accompanied by Cognitive Impairments in the AβPPswe/PS1ΔE9 Mouse Model of Alzheimer's Disease.

RNA-sequencing reveals the complexities of the transcriptional response to lignocellulosic biofuel substrates in Aspergillus niger (2014)
Journal Article
Archer, D. B. (2014). RNA-sequencing reveals the complexities of the transcriptional response to lignocellulosic biofuel substrates in Aspergillus niger. Fungal Biology and Biotechnology, 1(3), https://doi.org/10.1186/s40694-014-0003-x

Background: Saprobic fungi are the predominant industrial sources of Carbohydrate Active enZymes (CAZymes) used for the saccharification of lignocellulose during the production of second generation biofuels. The production of more effective enzyme co... Read More about RNA-sequencing reveals the complexities of the transcriptional response to lignocellulosic biofuel substrates in Aspergillus niger.

Cooperation, quorum sensing, and evolution of virulence in Staphylococcus aureus (2014)
Journal Article
Pollitt, E. J., West, S. A., Crusz, S. A., Burton-Chellew, M. N., & Diggle, S. P. (2014). Cooperation, quorum sensing, and evolution of virulence in Staphylococcus aureus. Infection and Immunity, 82(3), https://doi.org/10.1128/IAI.01216-13

The virulence and fitness in vivo of the major human pathogen Staphylococcus aureus are associated with a cell-to-cell signaling mechanism known as quorum sensing (QS). QS coordinates the production of virulence factors via the production and sensing... Read More about Cooperation, quorum sensing, and evolution of virulence in Staphylococcus aureus.

Practical detection of a definitive biomarker panel for Alzheimer's disease: comparisons between matched plasma and cerebrospinal fluid (2014)
Journal Article
Richens, J. L., Vere, K., Light, R. A., Soria, D., Garibaldi, J., Smith, A. D., …O’Shea, P. (2014). Practical detection of a definitive biomarker panel for Alzheimer's disease: comparisons between matched plasma and cerebrospinal fluid. International Journal of Molecular Epidemiology and Genetics, IJMEG, 5(2),

Previous mass spectrometry analysis of cerebrospinal fluid (CSF) has allowed the identification of a panel of molecular markers that are associated with Alzheimer’s disease (AD). The panel comprises Amyloid beta, Apolipoprotein E, Fibrinogen alpha ch... Read More about Practical detection of a definitive biomarker panel for Alzheimer's disease: comparisons between matched plasma and cerebrospinal fluid.

The impact of cafeteria feeding during lactation in the rat on novel object discrimination in the offspring (2014)
Journal Article
Wright, T., King, M., Davey, W., Langley-Evans, S. . C., & Voigt, J.-P. (2014). The impact of cafeteria feeding during lactation in the rat on novel object discrimination in the offspring. British Journal of Nutrition, 112, https://doi.org/10.1017/S0007114514003134

There is increasing evidence that hyperenergetic diets impact on memory in rodents. However, it is largely unknown how diets, such as a cafeteria diet (CD), that mimic a Western diet act on learning and memory, in particular when fed during early sta... Read More about The impact of cafeteria feeding during lactation in the rat on novel object discrimination in the offspring.

A conserved set of maternal genes? Insights from a molluscan transcriptome (2014)
Journal Article
Liu, M. M., Davey, J. W., Jackson, D. J., Blaxter, M. L., & Davison, A. (2014). A conserved set of maternal genes? Insights from a molluscan transcriptome. International Journal of Developmental Biology, 58, https://doi.org/10.1387/ijdb.140121ad

The early animal embryo is entirely reliant on maternal gene products for a ‘jump-start’ that transforms a transcriptionally inactive embryo into a fully functioning zygote. Despite extensive work on model species, it has not been possible to perform... Read More about A conserved set of maternal genes? Insights from a molluscan transcriptome.

The ORF4b-encoded accessory proteins of Middle East respiratory syndrome coronavirus and two related bat coronaviruses localize to the nucleus and inhibit innate immune signalling (2014)
Journal Article
Matthews, K. L., Coleman, C. M., van der Meer, Y., Snijder, E. J., & Frieman, M. B. (2014). The ORF4b-encoded accessory proteins of Middle East respiratory syndrome coronavirus and two related bat coronaviruses localize to the nucleus and inhibit innate immune signalling. Journal of General Virology, 95(4), 874-882. https://doi.org/10.1099/vir.0.062059-0

The recently emerged Middle East respiratory syndrome coronavirus (MERS-CoV), a betacoronavirus, is associated with severe pneumonia and renal failure. The environmental origin of MERS-CoV is as yet unknown; however, its genome sequence is closely re... Read More about The ORF4b-encoded accessory proteins of Middle East respiratory syndrome coronavirus and two related bat coronaviruses localize to the nucleus and inhibit innate immune signalling.

Postnatal maturation of endogenous opioid systems within the periaqueductal grey and spinal dorsal horn of the rat (2014)
Journal Article
Bennett, A., Kwok, C. H., Devonshire, I. M., & Hathway, G. J. (2014). Postnatal maturation of endogenous opioid systems within the periaqueductal grey and spinal dorsal horn of the rat. PAIN, 155(1), 168-178. https://doi.org/10.1016/j.pain.2013.09.022

Significant opioid-dependent changes occur during the fourth postnatal week in supraspinal sites (rostroventral medulla [RVM], periaqueductal grey [PAG]) that are involved in the descending control of spinal excitability via the dorsal horn (DH). Her... Read More about Postnatal maturation of endogenous opioid systems within the periaqueductal grey and spinal dorsal horn of the rat.