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Blocking the tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis (2015)
Journal Article
Nwosu, L. N., Mapp, P. I., Chapman, V., & Walsh, D. A. (in press). Blocking the tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis. Annals of the Rheumatic Diseases, 75(6), https://doi.org/10.1136/annrheumdis-2014-207203

Objectives: Tropomyosin receptor kinase A (TrkA) mediates nociceptor sensitisation by nerve growth factor (NGF), but it is unknown whether selective TrkA inhibition will be an effective strategy for treating osteoarthritis (OA) pain. We determined th... Read More about Blocking the tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis.

Intrinsic sequence specificity of the Cas1 integrase directs new spacer acquisition (2015)
Journal Article
Rollie, C., Schneider, S., Brinkmann, A. S., Bolt, E. L., & White, M. F. (2015). Intrinsic sequence specificity of the Cas1 integrase directs new spacer acquisition. eLife, 4, Article e08716. https://doi.org/10.7554/elife.08716

© Rollie et al. The adaptive prokaryotic immune system CRISPR-Cas provides RNA-mediated protection from invading genetic elements. The fundamental basis of the system is the ability to capture small pieces of foreign DNA for incorporation into the ge... Read More about Intrinsic sequence specificity of the Cas1 integrase directs new spacer acquisition.

Tumor necrosis factor receptor I blockade shows that TNF-dependent and independent mechanisms synergise in TNF receptor associated periodic syndrome (2015)
Journal Article
Fairclough, L. C., Stoop, A., Negm, O. H., Radford, P., Tighe, P. J., & Todd, I. (2015). Tumor necrosis factor receptor I blockade shows that TNF-dependent and independent mechanisms synergise in TNF receptor associated periodic syndrome. European Journal of Immunology, 45(10), 2937-2944. https://doi.org/10.1002/eji.201545769

TNF receptor associated periodic syndrome (TRAPS) is an autoinflammatory disease involving recurrent episodes of fever and inflammation. It is associated with autosomal dominant mutations in TNF receptor superfamily 1A gene localised to exons encodin... Read More about Tumor necrosis factor receptor I blockade shows that TNF-dependent and independent mechanisms synergise in TNF receptor associated periodic syndrome.

A 1,000-year-old antimicrobial remedy with antistaphylococcal activity (2015)
Journal Article
Harrison, F., Roberts, A., Gabrilska, R., Rumbaugh, K., Lee, C., & Diggle, S. P. (2015). A 1,000-year-old antimicrobial remedy with antistaphylococcal activity. mBio, 6(4), 1-7. https://doi.org/10.1128/mBio.01129-15

Plant-derived compounds and other natural substances are a rich potential source of compounds that kill or attenuate pathogens that are resistant to current antibiotics. Medieval so- cieties used a range of these natural substances to treat condition... Read More about A 1,000-year-old antimicrobial remedy with antistaphylococcal activity.

Development of a heptaplex PCR assay for identification of Staphylococcus aureus and CoNS with simultaneous detection of virulence and antibiotic resistance genes (2015)
Journal Article
Okolie, C. E., Wooldridge, K. G., Turner, D. P., Cockayne, A., & James, R. (2015). Development of a heptaplex PCR assay for identification of Staphylococcus aureus and CoNS with simultaneous detection of virulence and antibiotic resistance genes. BMC Microbiology, 15(1), Article 157. https://doi.org/10.1186/s12866-015-0490-9

Background Staphylococcal toxicity and antibiotic resistance (STAAR) have been menacing public health. Although vancomycin-resistant Staphylococcus aureus (VRSA) is currently not as widespread as methicillin-resistant S. aureus (MRSA), genome evolut... Read More about Development of a heptaplex PCR assay for identification of Staphylococcus aureus and CoNS with simultaneous detection of virulence and antibiotic resistance genes.

Developmental alterations in noxious-evoked EEG activity recorded from rat primary somatosensory cortex (2015)
Journal Article
Devonshire, I. M., Greenspon, C. M., & Hathway, G. J. (2015). Developmental alterations in noxious-evoked EEG activity recorded from rat primary somatosensory cortex. Neuroscience, 305, https://doi.org/10.1016/j.neuroscience.2015.08.004

Primary somatosensory cortex (S1) contains a nociceptive map that localizes potential tissue damage on the body and encodes stimulus intensity. An objective and specific biomarker of pain however is currently lacking and is urgently required for use... Read More about Developmental alterations in noxious-evoked EEG activity recorded from rat primary somatosensory cortex.

Vascular endothelial growth factor-A165b is protective and restores endothelial glycocalyx in diabetic nephropathy (2015)
Journal Article

Diabetic nephropathy is the leading cause of ESRD in high-income countries and a growing problem across the world. Vascular endothelial growth factor-A (VEGF-A) is thought to be a critical mediator of vascular dysfunction in diabetic nephropathy, yet... Read More about Vascular endothelial growth factor-A165b is protective and restores endothelial glycocalyx in diabetic nephropathy.

Dopamine D1 receptor stimulation modulates the formation and retrieval of novel object recognition memory: role of the prelimbic cortex. (2015)
Journal Article
Cassaday, H., Pezze, M., Marshall, H., & Fone, K. (2015). Dopamine D1 receptor stimulation modulates the formation and retrieval of novel object recognition memory: role of the prelimbic cortex. European Neuropsychopharmacology, 25(11), 2145-2156. https://doi.org/10.1016/j.euroneuro.2015.07.018

© 2015 The Authors. Previous studies have shown that dopamine D1 receptor antagonists impair novel object recognition memory but the effects of dopamine D1 receptor stimulation remain to be determined. This study investigated the effects of the selec... Read More about Dopamine D1 receptor stimulation modulates the formation and retrieval of novel object recognition memory: role of the prelimbic cortex..

TAp73 transcriptionally represses BNIP3 expression (2015)
Journal Article
Petrova, V., Mancini, M., Agostini, M., Knight, R. A., Annicchiarico-Petruzzelli, M., Barlev, N. A., …Amelio, I. (2015). TAp73 transcriptionally represses BNIP3 expression. Cell Cycle, 14(15), 2484-2493. https://doi.org/10.1080/15384101.2015.1044178

TAp73 is a tumor suppressor transcriptional factor, belonging to p53 family. Alteration of TAp73 in tumors might lead to reduced DNA damage response, cell cycle arrest and apoptosis. Carcinogen-induced TAp73−/− tumors display also increased angiogene... Read More about TAp73 transcriptionally represses BNIP3 expression.

Genetic diversity underlying the envelope glycoproteins of hepatitis C virus: Structural and functional consequences and the implications for vaccine design (2015)
Journal Article
Tarr, A. W., Khera, T., Hueging, K., Sheldon, J., Steinmann, E., Pietschmann, T., & Brown, R. J. (2015). Genetic diversity underlying the envelope glycoproteins of hepatitis C virus: Structural and functional consequences and the implications for vaccine design. Viruses, 7(7), 3995-4046. https://doi.org/10.3390/v7072809

© 2015 by the authors. In the 26 years since the discovery of Hepatitis C virus (HCV) a major global research effort has illuminated many aspects of the viral life cycle, facilitating the development of targeted antivirals. Recently, effective direct... Read More about Genetic diversity underlying the envelope glycoproteins of hepatitis C virus: Structural and functional consequences and the implications for vaccine design.

Localization of Presynaptic Plasticity Mechanisms Enables Functional Independence of Synaptic and Ectopic Transmission in the Cerebellum. (2015)
Journal Article

In the cerebellar molecular layer parallel fibre terminals release glutamate from both the active zone and from extrasynaptic “ectopic” sites. Ectopic release mediates transmission to the Bergmann glia that ensheathe the synapse, activating Ca2+-perm... Read More about Localization of Presynaptic Plasticity Mechanisms Enables Functional Independence of Synaptic and Ectopic Transmission in the Cerebellum..

Profiling Humoral Immune Responses to Clostridium difficile-Specific Antigens by Protein Microarray Analysis (2015)
Journal Article
Negm, O. H., Hamed, M. R., Dilnot, E. M., Shone, C. C., Marszalowska, I., Lynch, M., …Monaghan, T. M. (2015). Profiling Humoral Immune Responses to Clostridium difficile-Specific Antigens by Protein Microarray Analysis. Clinical and Vaccine Immunology, 22(9), 1033-1039. https://doi.org/10.1128/CVI.00190-15

Clostridium difficile is an anaerobic, Gram-positive, and spore-forming bacterium that is the leading worldwide infective cause of hospital-acquired and antibiotic-associated diarrhea. Several studies have reported associations between humoral immuni... Read More about Profiling Humoral Immune Responses to Clostridium difficile-Specific Antigens by Protein Microarray Analysis.

Phytotoxin production in Aspergillus terreus is regulated by independent environmental signals (2015)
Journal Article
Gressler, M., Meyer, F., Heine, D., Hortschansky, P., Hertweck, C., & Brock, M. (2015). Phytotoxin production in Aspergillus terreus is regulated by independent environmental signals. eLife, 4, Article e07861. https://doi.org/10.7554/eLife.07861.001

Secondary metabolites have a great potential as pharmaceuticals, but there are only a few examples where regulation of gene cluster expression has been correlated with ecological and physiological relevance for the producer. Here, signals, mediators,... Read More about Phytotoxin production in Aspergillus terreus is regulated by independent environmental signals.

Sail or sink: novel behavioural adaptations on water in aerially dispersing species (2015)
Journal Article
Hayashi, M., Bakkali, M., Hyde, A., & Goodacre, S. L. (2015). Sail or sink: novel behavioural adaptations on water in aerially dispersing species. BMC Evolutionary Biology, 15, 1-8. https://doi.org/10.1186/s12862-015-0402-5

© 2015 Hayashi et al. Background: Long-distance dispersal events have the potential to shape species distributions and ecosystem diversity over large spatial scales, and to influence processes such as population persistence and the pace and scale of... Read More about Sail or sink: novel behavioural adaptations on water in aerially dispersing species.

Impact of voluntary exercise and housing conditions on hippocampal glucocorticoid receptor, miR-124 and anxiety (2015)
Journal Article
Pan-Vazquez, A., Rye, N., Ameri, M., McSparron, B., Smallwood, G., Bickerdyke, J., …Toledo-Rodriguez, M. (2015). Impact of voluntary exercise and housing conditions on hippocampal glucocorticoid receptor, miR-124 and anxiety. Molecular Brain, 8(1), https://doi.org/10.1186/s13041-015-0128-8

Background: Lack of physical activity and increased levels of stress contribute to the development of multiple physical and mental disorders. An increasing number of studies relate voluntary exercise with greater resilience to psychological stress, a... Read More about Impact of voluntary exercise and housing conditions on hippocampal glucocorticoid receptor, miR-124 and anxiety.

Structure–activity study of N-((trans)-4-(2-(7-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1H-indole-2-carboxamide (SB269652), a bitopic ligand that acts as a negative allosteric modulator of the dopamine D2 receptor (2015)
Journal Article
Shonberg, J., Draper-Joyce, C., Mistry, S. N., Christopoulos, A., Scammells, P. J., Lane, J. R., & Capuano, B. (2015). Structure–activity study of N-((trans)-4-(2-(7-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1H-indole-2-carboxamide (SB269652), a bitopic ligand that acts as a negative allosteric modulator of the dopamine D2 receptor. Journal of Medicinal Chemistry, 58(13), 5287-5307. https://doi.org/10.1021/acs.jmedchem.5b00581

We recently demonstrated that SB269652 (1) engages one protomer of a dopamine D2 receptor (D2R) dimer in a bitopic mode to allosterically inhibit the binding of dopamine at the other protomer. Herein, we investigate structural deter- minants for allo... Read More about Structure–activity study of N-((trans)-4-(2-(7-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1H-indole-2-carboxamide (SB269652), a bitopic ligand that acts as a negative allosteric modulator of the dopamine D2 receptor.